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1. 发明授权

US08372587B2 Proliferative disease detection method 失效
标题翻译：增生病检测方法
公开(公告)号：US08372587B2
公开(公告)日：2013-02-12
申请号：US12937407
申请日：2009-04-14
申请人： Hiroki Nagase , Yui Shinojima , Tadashi Terui
发明人： Hiroki Nagase , Yui Shinojima , Tadashi Terui
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/156
摘要： In the present invention, the methylation of the genomic DNA a Zar1 gene specifically found in proliferative disease is used as a marker. Specifically, the present invention provides a method for detecting proliferative disease, which comprises detecting the methylation of the genomic DNA of a Zar1 gene in a biological sample. There is thereby provided a method for detecting proliferative disease, using a marker having a high detection rate and a low false positive rate.
摘要翻译：在本发明中，使用在增殖性疾病中特异性发现的Zar1基因的基因组DNA的甲基化作为标记。具体地，本发明提供了检测增殖性疾病的方法，其包括检测生物样品中Zar1基因的基因组DNA的甲基化。由此提供了使用具有高检测率和低假阳性率的标记物来检测增殖性疾病的方法。

2. 发明申请

US20110033864A1 PROLIFERATIVE DISEASE DETECTION METHOD 失效
标题翻译：增殖性疾病检测方法
公开(公告)号：US20110033864A1
公开(公告)日：2011-02-10
申请号：US12937407
申请日：2009-04-14
申请人： Hiroki Nagase , Yui Shinojima , Tadashi Terui
发明人： Hiroki Nagase , Yui Shinojima , Tadashi Terui
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/156
摘要： In the present invention, the methylation of the genomic DNA a Zar1 gene specifically found in proliferative disease is used as a marker. Specifically, the present invention provides a method for detecting proliferative disease, which comprises detecting the methylation of the genomic DNA of a Zar1 gene in a biological sample. There is thereby provided a method for detecting proliferative disease, using a marker having a high detection rate and a low false positive rate.
摘要翻译：在本发明中，使用在增殖性疾病中特异性发现的Zar1基因的基因组DNA的甲基化作为标记。具体地，本发明提供了检测增殖性疾病的方法，其包括检测生物样品中Zar1基因的基因组DNA的甲基化。由此提供了使用具有高检测率和低假阳性率的标记物来检测增殖性疾病的方法。

3. 发明申请

US20120071628A1 TOPICAL THERAPEUTIC AGENT FOR OPHTHALMIC DISEASES COMPRISING COMPOUND CAPABLE OF BINDING SPECIFICALLY TO DNA SEQUENCE 审中-公开
标题翻译：适用于DNA序列特异性结合的化合物的眼科治疗药物的局部治疗剂
公开(公告)号：US20120071628A1
公开(公告)日：2012-03-22
申请号：US13256012
申请日：2009-09-15
申请人： Hiroki Nagase , Min Chen , Tohru Sakimoto , Takayoshi Watanabe , Noboru Fukuda
发明人： Hiroki Nagase , Min Chen , Tohru Sakimoto , Takayoshi Watanabe , Noboru Fukuda
IPC分类号： C07K7/08 , C07K2/00
CPC分类号： C07D403/14 , A61K9/0048 , A61K31/787 , C12N15/11 , C12N15/111 , C12N15/113 , C12N15/1136 , C12N15/1137 , C12N2310/15 , C12N2310/18 , C12N2320/30
摘要： Disclosed is a topical therapeutic agent for ophthalmic diseases, which comprises a compound capable of binding specifically to a DNA sequence. More preferably disclosed is a topical therapeutic agent for ophthalmic diseases, which comprise a pyrrole-imidazole polyamide having a specific structure. The topical therapeutic agent for ophthalmic diseases comprises a pyrrole-imidazole polyamide which can inhibit transforming growth factor-β gene and matrix metalloproteinase 9 gene.
摘要翻译：公开了一种眼科疾病的局部治疗剂，其包含能够特异性结合DNA序列的化合物。更优选地公开的是用于眼科疾病的局部治疗剂，其包含具有特定结构的吡咯 - 咪唑聚酰胺。用于眼科疾病的局部治疗剂包括可抑制转化生长因子-bgr的吡咯 - 咪唑聚酰胺; 基因和基质金属蛋白酶9基因。

4. 发明申请

US20110046070A1 GENE EXPRESSION INHIBITOR SELECTIVE FOR MATRIX METALLOPROTEINASE-9 GENE 审中-公开
标题翻译：基因表达抑制剂选择性基因金属蛋白酶-9基因
公开(公告)号：US20110046070A1
公开(公告)日：2011-02-24
申请号：US12988163
申请日：2009-04-17
申请人： Hiroki Nagase , Xiaofei Wang
发明人： Hiroki Nagase , Xiaofei Wang
IPC分类号： A61K38/10 , C07K7/08 , A61P35/00 , C12N5/00
CPC分类号： C07D403/14 , A61K31/787
摘要： Disclosed are: an inhibitor of the expression of matrix metalloproteinase-9 gene; a therapeutic agent for a disease associated with matrix metalloproteinase-9; and a carcinostatic agent. Each of the agents comprises a pyrrole-imidazole polyamide having an N-methylpyrrole unit, an N-methylimidazole unit and a γ-aminobutyric acid unit. The pyrrole-imidazole polyamide can be folded at the site of the γ-aminobutyric acid unit to form a U-shaped conformation in a minor groove of a double-stranded domain comprising a part or the whole of a specific nucleotide sequence (SEQ ID NO:2, SEQ ID NO:4) included in a human matrix metalloproteinase-9 gene promoter and a strand complementary to the part or the whole of the specific nucleotide sequence. In the U-shaped conformation, a Py-Im pair, an Im/Py pair and a Py/Py pair in the pyrrole-imidazole polyamide target a C-G base pair, a G-C base pair, and both of an A-T base pair and a T-A base pair in the minor groove, respectively.
摘要翻译：公开了：基质金属蛋白酶-9基因表达的抑制剂; 用于与基质金属蛋白酶-9相关的疾病的治疗剂; 和制癌剂。每种试剂包括具有N-甲基吡咯单元，N-甲基咪唑单元和γ-氨基丁酸单元的吡咯 - 咪唑聚酰胺。吡咯 - 咪唑聚酰胺可以在γ-氨基丁酸单元的位置处折叠以在双链结构域的小沟中形成U形构象，其包含部分或全部特定核苷酸序列（SEQ ID NO ：2，SEQ ID NO：4），以及与该特定核苷酸序列的一部分或全部互补的链。在U形构象中，吡咯 - 咪唑聚酰胺靶中的Py-Im对，Im / Py对和Py / Py对为CG碱基对，GC碱基对，AT碱基对和分别在小槽中的TA碱基对。

5. 发明申请

US20110160399A1 HISTONE MODIFICATION INHIBITOR SPECIFIC TO TARGET GENE 审中-公开
标题翻译： HISTONE修饰抑制剂特异性靶向基因
公开(公告)号：US20110160399A1
公开(公告)日：2011-06-30
申请号：US13000950
申请日：2009-07-01
申请人： Hiroki Nagase , Hiroshi Sugiyama , Tukasa Suzuki , Toshikazu Bando , Makoto Kimura , Akimichi Ohtsuki
发明人： Hiroki Nagase , Hiroshi Sugiyama , Tukasa Suzuki , Toshikazu Bando , Makoto Kimura , Akimichi Ohtsuki
IPC分类号： C08G69/48
CPC分类号： C07D403/14 , A61K45/06 , A61K47/595 , A61K47/60 , A61K47/62
摘要： The present invention provides a target gene-specific histone modification regulator, which comprises a conjugate between a histone modification regulator and a polyamide capable of recognizing a regulatory region in a target gene. This enables the provision of a target gene-specific histone modification regulator.
摘要翻译：本发明提供了靶基因特异性组蛋白修饰调节剂，其包含组蛋白修饰调节剂和能够识别靶基因中调节区的聚酰胺之间的缀合物。这使得能够提供靶基因特异性组蛋白修饰调节剂。

6. 发明授权

US08869774B2 Small engine and engine work machine including the same 有权
标题翻译：小发动机和发动机工作机器包括相同
公开(公告)号：US08869774B2
公开(公告)日：2014-10-28
申请号：US13155294
申请日：2011-06-07
申请人： Toshihide Sasaki , Shigetoshi Ishida , Hiroki Nagase
发明人： Toshihide Sasaki , Shigetoshi Ishida , Hiroki Nagase
IPC分类号： F02D11/10 , F02M35/10 , F02B27/00 , F02D35/00 , F02B63/02 , F02B75/02
CPC分类号： F02M35/10275 , F02B27/003 , F02B63/02 , F02B2075/025 , F02D11/10 , F02D35/0053 , F02D2400/04 , F02D2400/06 , Y02T10/146
摘要： An engine includes: a carburetor configured to supply an air-fuel mixture of fuel and air; a crank case defining a crank chamber; a cylinder block which includes: a cylinder bore in which a reciprocable piston is disposed; and an intake port which supplies the air-fuel mixture supplied from the carburetor to the crank chamber; a control valve configured to open and close the intake port; and a controller configured to control the control valve. The controller controls the number of times that the control valve closes the intake port with respect to the number of times that the piston moves up to thereby reduce pressure of the crank chamber.
摘要翻译：发动机包括：化油器，其构造成供应燃料和空气的空气燃料混合物; 限定曲柄室的曲轴箱; 气缸体，其包括：气缸孔，其中布置有往复活塞; 以及将从所述化油器供给的所述空气燃料混合物供给到所述曲柄室的进气口; 构造成打开和关闭进气口的控制阀; 以及配置成控制所述控制阀的控制器。控制器控制控制阀相对于活塞向上移动的次数关闭进气口的次数，从而减小曲柄室的压力。

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