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1. 发明授权

US08211422B2 Chimeric receptor genes and cells transformed therewith 失效
标题翻译：嵌合受体基因和转化的细胞
公开(公告)号：US08211422B2
公开(公告)日：2012-07-03
申请号：US08547263
申请日：1995-10-24
申请人： Zelig Eshhar , Daniel Schindler , Tova Waks , Gideon Gross , Steven A. Rosenberg , Patrick Hwu
发明人： Zelig Eshhar , Daniel Schindler , Tova Waks , Gideon Gross , Steven A. Rosenberg , Patrick Hwu
IPC分类号： A61K48/00
CPC分类号： C07K14/7155 , A61K35/17 , A61K38/00 , C07K14/7051 , C07K14/70535 , C07K16/1045 , C07K16/3046 , C07K16/32 , C07K16/4291 , C07K16/44 , C07K2319/00 , C12N2799/027
摘要： Chimeric receptor genes suitable for endowing lymphocytes with antibody-type specificity include a first gene segment encoding a single-chain Fv domain of a specific antibody and a second gene segment encoding all or part of the transmembrane and cytoplasmic domains, and optionally the extracellular domain, of an immune cell-triggering molecule. The chimeric receptor gene, when transfected to immune cells, expresses the antibody-recognition site and the immune cell-triggering moiety into one continuous chain. The transformed lymphocytes are useful in therapeutic treatment methods.
摘要翻译：适于赋予具有抗体型特异性的淋巴细胞的嵌合受体基因包括编码特异性抗体的单链Fv结构域的第一基因片段和编码全部或部分跨膜和细胞质结构域的第二基因片段，以及任选的细胞外结构域，的免疫细胞触发分子。嵌合受体基因当转染到免疫细胞时，将抗体识别位点和免疫细胞触发部分表达到一个连续的链中。转化的淋巴细胞可用于治疗方法。

2. 发明申请

US20120093842A1 CHIMERIC RECEPTOR GENES AND CELLS TRANSFORMED THEREWITH 审中-公开
标题翻译： CHIMERIC受体基因和细胞转化
公开(公告)号：US20120093842A1
公开(公告)日：2012-04-19
申请号：US13281560
申请日：2011-10-26
申请人： Zelig Eshhar , Daniel Schindler , Tova Waks , Gideon Gross , Steven A. Rosenberg , Patrick Hwu
发明人： Zelig Eshhar , Daniel Schindler , Tova Waks , Gideon Gross , Steven A. Rosenberg , Patrick Hwu
IPC分类号： A61K35/00 , A61P35/00
CPC分类号： C07K14/7155 , A61K35/17 , A61K38/00 , C07K14/7051 , C07K14/70535 , C07K16/1045 , C07K16/3046 , C07K16/32 , C07K16/4291 , C07K16/44 , C07K2319/00 , C12N2799/027
摘要： Chimeric receptor genes suitable for endowing lymphocytes with antibody-type specificity include a first gene segment encoding a single-chain Fv domain of a specific antibody and a second gene segment encoding all or part of the transmembrane and cytoplasmic domains, and optionally the extracellular domain, of an immune cell-triggering molecule. The chimeric receptor gene, when transfected to immune cells, expresses the antibody-recognition site and the immune cell-triggering moiety into one continuous chain. The transformed lymphocytes are useful in therapeutic treatment methods.
摘要翻译：适于赋予具有抗体型特异性的淋巴细胞的嵌合受体基因包括编码特异性抗体的单链Fv结构域的第一基因片段和编码全部或部分跨膜和细胞质结构域的第二基因片段，以及任选的细胞外结构域，的免疫细胞触发分子。嵌合受体基因当转染到免疫细胞时，将抗体识别位点和免疫细胞触发部分表达到一个连续的链中。转化的淋巴细胞可用于治疗方法。

3. 发明授权

US07741465B1 Chimeric receptor genes and cells transformed therewith 失效
标题翻译：嵌合受体基因和转化的细胞
公开(公告)号：US07741465B1
公开(公告)日：2010-06-22
申请号：US08084994
申请日：1993-07-02
申请人： Zelig Eshhar , Daniel Schindler , Tova Waks , Gideon Gross
发明人： Zelig Eshhar , Daniel Schindler , Tova Waks , Gideon Gross
IPC分类号： C07H21/04 , C12N15/74 , C12N5/00
CPC分类号： C07K16/32 , C07K16/4291 , C07K16/44 , C07K2317/52 , C07K2317/622
摘要： Chimeric receptor genes suitable for endowing lymphocytes with antibody-type specificity include a first gene segment encoding a single-chain Fv domain of a specific antibody and a second gene segment encoding all or part of the transmembrane and cytoplasmic domains, and optionally the extracellular domain, of an immune cell-triggering molecule. The chimeric receptor gene, when transfected to immune cells, expresses the antibody-recognition site and the immune cell-triggering moiety into one continuous chain. The transformed lymphocytes are useful in therapeutic treatment methods.
摘要翻译：适于赋予具有抗体型特异性的淋巴细胞的嵌合受体基因包括编码特异性抗体的单链Fv结构域的第一基因片段和编码全部或部分跨膜和细胞质结构域的第二基因片段，以及任选的细胞外结构域，的免疫细胞触发分子。嵌合受体基因当转染到免疫细胞时，将抗体识别位点和免疫细胞触发部分表达到一个连续的链中。转化的淋巴细胞可用于治疗方法。

4. 发明授权

US09295965B2 Methods and devices for nucleic acid synthesis 有权
标题翻译：用于核酸合成的方法和装置
公开(公告)号：US09295965B2
公开(公告)日：2016-03-29
申请号：US13884463
申请日：2011-11-10
申请人： Joseph Jacobson , Li-yun A. Kung , Andrew Kirk Wilson , Senthil Ramu , Daniel Schindler , Mike Hudson
发明人： Joseph Jacobson , Li-yun A. Kung , Andrew Kirk Wilson , Senthil Ramu , Daniel Schindler , Mike Hudson
IPC分类号： C12Q1/68 , B01J19/00 , C12N15/10 , C12N15/66 , C12P19/34
CPC分类号： B01J19/0046 , B01J2219/00585 , B01J2219/00596 , B01J2219/00722 , C12N15/10 , C12N15/1031 , C12N15/66 , C12P19/34 , C12Q2521/343 , C12Q2521/50 , C12Q2521/501 , C12N15/64
摘要： Methods and apparatus relate to the synthesis of polynucleotides having a predefined sequence on a support. Assembly methods include primer extension to generate overlapping construction oligonucleotides and assembly of the polynucleotides of interest onto an anchor support-bound oligonucleotides. Methods and apparatus for selection of polynucleotides having the predefined sequence and/or length are disclosed.
摘要翻译：方法和装置涉及在载体上具有预定序列的多核苷酸的合成。组装方法包括产生重叠构建寡核苷酸的引物延伸和目标多核苷酸组装到锚定载体结合的寡核苷酸上。公开了用于选择具有预定义的序列和/或长度的多核苷酸的方法和装置。

5. 发明授权

US09187777B2 Methods and devices for in situ nucleic acid synthesis 有权
标题翻译：用于原位核酸合成的方法和装置
公开(公告)号：US09187777B2
公开(公告)日：2015-11-17
申请号：US13700291
申请日：2011-05-26
申请人： Joseph Jacobson , Senthil Ramu , Daniel Schindler
发明人： Joseph Jacobson , Senthil Ramu , Daniel Schindler
IPC分类号： C12Q1/68 , C12P19/34 , C12N15/10 , C12N15/66
CPC分类号： C12N15/1068 , C12N15/1093 , C12N15/66 , C12P19/34
摘要： Disclosed are compositions, methods and devices for the in situ synthesis of nucleic acids. In an exemplary embodiment, a support-bound oligonucleotide is elongated by addition of one or more nucleotides by hybridization of a partially double-stranded oligonucleotide, ligation and removal of unwanted nucleotides.
摘要翻译：公开了用于原位合成核酸的组合物，方法和装置。在一个示例性实施方案中，通过部分双链寡核苷酸的杂交，连接和去除不需要的核苷酸，加入一个或多个核苷酸来延伸载体结合的寡核苷酸。

6. 发明申请

US20150203839A1 Compositions and Methods for High Fidelity Assembly of Nucleic Acids 审中-公开
标题翻译：核酸高保真组装的组成和方法
公开(公告)号：US20150203839A1
公开(公告)日：2015-07-23
申请号：US14241242
申请日：2012-08-23
申请人： Joseph Jacobson , Daniel Schindler , Scott S. Lawton
发明人： Joseph Jacobson , Daniel Schindler , Scott S. Lawton
IPC分类号： C12N15/10
CPC分类号： C12N15/1031 , C12N15/10 , C12N15/1027 , C12N15/1089 , C12N15/1093 , C12N15/66 , C12P19/34 , C12Q2521/301 , C12Q2521/501
摘要： Aspects of the invention relate to methods, compositions and algorithms for designing and producing a target nucleic acid. The method can include: (1) providing a plurality of blunt-end double-stranded nucleic acid fragments having a restriction enzyme recognition sequence at both ends thereof; (2) producing via enzymatic digestion a plurality of cohesive-end double-stranded nucleic acid fragments each having two different and non-complementary overhangs; (3) ligating the plurality of cohesive-end double-stranded nucleic acid fragments with a ligase; and (4) forming a linear arrangement of the plurality of cohesive-end double-stranded nucleic acid fragments, wherein the unique arrangement comprises the target nucleic acid. In certain embodiments, the plurality of blunt-end double-stranded nucleic acid fragments can be provided by: releasing a plurality of oligonucleotides synthesized on a solid support; and synthesizing complementary strands of the plurality of oligonucleotides using a polymerase based reaction.
摘要翻译：本发明的方面涉及用于设计和产生靶核酸的方法，组合物和算法。该方法可以包括：（1）提供多个在其两端具有限制酶识别序列的平末端双链核酸片段; （2）通过酶消化产生多个具有两个不同和非互补突出端的粘性末端双链核酸片段; （3）用连接酶连接多个内聚端双链核酸片段; 和（4）形成多个内聚端双链核酸片段的线性排列，其中独特的排列包含靶核酸。在某些实施方案中，多个平末端双链核酸片段可以通过以下方式提供：释放在固体支持物上合成的多种寡核苷酸; 并使用基于聚合酶的反应合成多个寡核苷酸的互补链。

7. 发明申请

US20130296194A1 Methods and Devices for Nucleic Acid Synthesis 有权
标题翻译：核酸合成的方法和装置
公开(公告)号：US20130296194A1
公开(公告)日：2013-11-07
申请号：US13884463
申请日：2011-11-10
申请人： Joseph Jacobson , Li-yun A. Kung , Andrew Kirk Wilson , Senthil Ramu , Daniel Schindler , Mike Hudson
发明人： Joseph Jacobson , Li-yun A. Kung , Andrew Kirk Wilson , Senthil Ramu , Daniel Schindler , Mike Hudson
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00585 , B01J2219/00596 , B01J2219/00722 , C12N15/10 , C12N15/1031 , C12N15/66 , C12P19/34 , C12Q2521/343 , C12Q2521/50 , C12Q2521/501 , C12N15/64
摘要： Methods and apparatus relate to the synthesis of polynucleotides having a predefined sequence on a support. Assembly methods include primer extension to generate overlapping construction oligonucleotides and assembly of the polynucleotides of interest onto an anchor support-bound oligonucleotides. Methods and apparatus for selection of polynucleotides having the predefined sequence and/or length are disclosed.
摘要翻译：方法和装置涉及在载体上具有预定序列的多核苷酸的合成。组装方法包括产生重叠构建寡核苷酸的引物延伸和目标多核苷酸组装到锚定载体结合的寡核苷酸上。公开了用于选择具有预定义的序列和/或长度的多核苷酸的方法和装置。

8. 发明申请

US20130309725A1 Methods and Devices for In Situ Nucleic Acid Synthesis 有权
标题翻译：用于原位核酸合成的方法和装置
公开(公告)号：US20130309725A1
公开(公告)日：2013-11-21
申请号：US13700291
申请日：2011-05-26
申请人： Joseph Jacobson , Senthil Ramu , Daniel Schindler
发明人： Joseph Jacobson , Senthil Ramu , Daniel Schindler
IPC分类号： C12P19/34
CPC分类号： C12N15/1068 , C12N15/1093 , C12N15/66 , C12P19/34
摘要： Disclosed are compositions, methods and devices for the in situ synthesis of nucleic acids. In an exemplary embodiment, a support-bound oligonucleotide is elongated by addition of one or more nucleotides by hybridization of a partially double-stranded oligonucleotide, ligation and removal of unwanted nucleotides.
摘要翻译：公开了用于原位合成核酸的组合物，方法和装置。在一个示例性实施方案中，通过部分双链寡核苷酸的杂交，连接和去除不需要的核苷酸，加入一个或多个核苷酸来延伸载体结合的寡核苷酸。

9. 发明申请

US20130244884A1 Methods for Nucleotide Sequencing and High Fidelity Polynucleotide Synthesis 审中-公开
标题翻译：核苷酸测序和高保真多核苷酸合成方法
公开(公告)号：US20130244884A1
公开(公告)日：2013-09-19
申请号：US13697182
申请日：2011-05-13
申请人： Joseph Jacobson , Daniel Schindler
发明人： Joseph Jacobson , Daniel Schindler
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q2563/107 , C12Q2525/204 , C12Q2521/101 , C12Q2533/107 , C12Q2525/121 , C12Q2521/501
摘要： Methods of obtaining sequence information about target polynucleotide having a predefined sequence are disclosed. The methods include sequencing by ligation and sequencing by polymerase.
摘要翻译：公开了获得具有预定序列的靶多核苷酸的序列信息的方法。所述方法包括通过连接测序和通过聚合酶测序。

10. 发明申请

US20120322681A1 Methods for Preparative In Vitro Cloning 有权
标题翻译：制备体外克隆方法
公开(公告)号：US20120322681A1
公开(公告)日：2012-12-20
申请号：US13524164
申请日：2012-06-15
申请人： Li-yun A. Kung , Daniel Schindler , Joseph Jacobson
发明人： Li-yun A. Kung , Daniel Schindler , Joseph Jacobson
IPC分类号： C40B30/04 , C40B50/14 , C40B50/06
CPC分类号： C12Q1/6806 , C12N15/1034 , C12N15/1065 , C12Q1/6855 , C12Q2525/191 , C12Q2533/107 , C12Q2563/179
摘要： Methods and devices relate to the isolation of nucleic acids of interest from within a population of nucleic acids such as libraries of nucleic acid sequences.
摘要翻译：方法和装置涉及从诸如核酸序列文库的核酸群体中分离所关注的核酸。

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