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1. 发明授权

US08211422B2 Chimeric receptor genes and cells transformed therewith 失效
标题翻译：嵌合受体基因和转化的细胞
公开(公告)号：US08211422B2
公开(公告)日：2012-07-03
申请号：US08547263
申请日：1995-10-24
申请人： Zelig Eshhar , Daniel Schindler , Tova Waks , Gideon Gross , Steven A. Rosenberg , Patrick Hwu
发明人： Zelig Eshhar , Daniel Schindler , Tova Waks , Gideon Gross , Steven A. Rosenberg , Patrick Hwu
IPC分类号： A61K48/00
CPC分类号： C07K14/7155 , A61K35/17 , A61K38/00 , C07K14/7051 , C07K14/70535 , C07K16/1045 , C07K16/3046 , C07K16/32 , C07K16/4291 , C07K16/44 , C07K2319/00 , C12N2799/027
摘要： Chimeric receptor genes suitable for endowing lymphocytes with antibody-type specificity include a first gene segment encoding a single-chain Fv domain of a specific antibody and a second gene segment encoding all or part of the transmembrane and cytoplasmic domains, and optionally the extracellular domain, of an immune cell-triggering molecule. The chimeric receptor gene, when transfected to immune cells, expresses the antibody-recognition site and the immune cell-triggering moiety into one continuous chain. The transformed lymphocytes are useful in therapeutic treatment methods.
摘要翻译：适于赋予具有抗体型特异性的淋巴细胞的嵌合受体基因包括编码特异性抗体的单链Fv结构域的第一基因片段和编码全部或部分跨膜和细胞质结构域的第二基因片段，以及任选的细胞外结构域，的免疫细胞触发分子。嵌合受体基因当转染到免疫细胞时，将抗体识别位点和免疫细胞触发部分表达到一个连续的链中。转化的淋巴细胞可用于治疗方法。

2. 发明授权

US07741465B1 Chimeric receptor genes and cells transformed therewith 失效
标题翻译：嵌合受体基因和转化的细胞
公开(公告)号：US07741465B1
公开(公告)日：2010-06-22
申请号：US08084994
申请日：1993-07-02
申请人： Zelig Eshhar , Daniel Schindler , Tova Waks , Gideon Gross
发明人： Zelig Eshhar , Daniel Schindler , Tova Waks , Gideon Gross
IPC分类号： C07H21/04 , C12N15/74 , C12N5/00
CPC分类号： C07K16/32 , C07K16/4291 , C07K16/44 , C07K2317/52 , C07K2317/622
摘要： Chimeric receptor genes suitable for endowing lymphocytes with antibody-type specificity include a first gene segment encoding a single-chain Fv domain of a specific antibody and a second gene segment encoding all or part of the transmembrane and cytoplasmic domains, and optionally the extracellular domain, of an immune cell-triggering molecule. The chimeric receptor gene, when transfected to immune cells, expresses the antibody-recognition site and the immune cell-triggering moiety into one continuous chain. The transformed lymphocytes are useful in therapeutic treatment methods.
摘要翻译：适于赋予具有抗体型特异性的淋巴细胞的嵌合受体基因包括编码特异性抗体的单链Fv结构域的第一基因片段和编码全部或部分跨膜和细胞质结构域的第二基因片段，以及任选的细胞外结构域，的免疫细胞触发分子。嵌合受体基因当转染到免疫细胞时，将抗体识别位点和免疫细胞触发部分表达到一个连续的链中。转化的淋巴细胞可用于治疗方法。

3. 发明授权

US6090923A Murine monoclonal antibody binding TNF.alpha. 失效
标题翻译：鼠单克隆抗体结合TNFα
公开(公告)号：US6090923A
公开(公告)日：2000-07-18
申请号：US794365
申请日：1991-11-13
申请人： David Wallach , Talia Hahn , Zelig Eshhar
发明人： David Wallach , Talia Hahn , Zelig Eshhar
IPC分类号： G01N33/53 , A61K35/12 , A61K35/14 , A61K38/16 , A61K38/21 , A61K38/36 , A61K39/00 , A61K39/395 , C07K1/22 , C07K14/005 , C07K14/195 , C07K14/47 , C07K14/52 , C07K16/00 , C07K16/18 , C07K16/24 , C12N5/00 , C12N5/10 , C12N5/20 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/569 , G01N33/577
CPC分类号： G01N33/56972 , A61K38/21 , C07K14/47 , C07K16/24 , G01N33/56966 , G01N2333/525
摘要： A cytotoxic protein expressed by human peripheral blood mononuclear cells is isolated in essentially homogenous form. This protein may be used to elicit production of polyclonal or monoclonal anti-cytotoxin antibodies.Hybridomas secreting anti-cytotoxin antibodies are identified by a solid phase bioassay. The antibodies are useful in the immunopurification of cytotoxins. The purified cytotoxic proteins are useful for the treatment of virus-infected or tumor target cells, either alone or in combination with interferon or a metabolic blocker.
摘要翻译：由人外周血单核细胞表达的细胞毒性蛋白以基本均匀的形式被分离。该蛋白质可用于引发多克隆或单克隆抗细胞毒素抗体的产生。通过固相生物测定法鉴定分泌抗细胞毒素抗体的杂交瘤。抗体可用于细胞毒素的免疫纯化。纯化的细胞毒性蛋白质可用于单独或与干扰素或代谢阻断剂组合治疗病毒感染或肿瘤靶细胞。

4. 发明申请

US20120093842A1 CHIMERIC RECEPTOR GENES AND CELLS TRANSFORMED THEREWITH 审中-公开
标题翻译： CHIMERIC受体基因和细胞转化
公开(公告)号：US20120093842A1
公开(公告)日：2012-04-19
申请号：US13281560
申请日：2011-10-26
申请人： Zelig Eshhar , Daniel Schindler , Tova Waks , Gideon Gross , Steven A. Rosenberg , Patrick Hwu
发明人： Zelig Eshhar , Daniel Schindler , Tova Waks , Gideon Gross , Steven A. Rosenberg , Patrick Hwu
IPC分类号： A61K35/00 , A61P35/00
CPC分类号： C07K14/7155 , A61K35/17 , A61K38/00 , C07K14/7051 , C07K14/70535 , C07K16/1045 , C07K16/3046 , C07K16/32 , C07K16/4291 , C07K16/44 , C07K2319/00 , C12N2799/027
摘要： Chimeric receptor genes suitable for endowing lymphocytes with antibody-type specificity include a first gene segment encoding a single-chain Fv domain of a specific antibody and a second gene segment encoding all or part of the transmembrane and cytoplasmic domains, and optionally the extracellular domain, of an immune cell-triggering molecule. The chimeric receptor gene, when transfected to immune cells, expresses the antibody-recognition site and the immune cell-triggering moiety into one continuous chain. The transformed lymphocytes are useful in therapeutic treatment methods.
摘要翻译：适于赋予具有抗体型特异性的淋巴细胞的嵌合受体基因包括编码特异性抗体的单链Fv结构域的第一基因片段和编码全部或部分跨膜和细胞质结构域的第二基因片段，以及任选的细胞外结构域，的免疫细胞触发分子。嵌合受体基因当转染到免疫细胞时，将抗体识别位点和免疫细胞触发部分表达到一个连续的链中。转化的淋巴细胞可用于治疗方法。

5. 发明授权

US5912172A Endowing lymphocytes with antibody specificity 失效
公开(公告)号：US5912172A
公开(公告)日：1999-06-15
申请号：US474819
申请日：1995-06-07
申请人： Zelig Eshhar , Gideon Gross , Tova Waks
发明人： Zelig Eshhar , Gideon Gross , Tova Waks
IPC分类号： C07K14/725 , C07K16/44 , C12N15/13 , C07H21/04 , C07K16/46
CPC分类号： C07K14/7051 , C07K16/44 , C07K2317/56 , C07K2319/00 , C07K2319/02
摘要： There are produced recombinant gene pairs which endow mononuclear cells, mainly various lymphocyte type cells, with antibody-type specificity. In specific gene pairs the rearranged gene pairs code for a binding site of an antibody molecule from the same species, of the T-cell receptor gene, or another species. Gene pairs of the invention code, for example, for antibodies specific towards tumor-specific antigens, viral antigens, modified self antigens, bacterial or fungal antigens, autoimmune type disease antigens and the like. The invention further relates to expression vectors for the effective transfection of such cell types comprising such a recombinant gene pair, to methods for producing same and to pharmaceutical compositions comprising as active ingredient an effective quantity of lymphocytes transfected with such gene pairs.

6. 发明申请

US20100135974A1 REDIRECTED, GENETICALLY-ENGINEERED T REGULATORY CELLS AND THEIR USE IN SUPPRESSION OF AUTOIMMUNE AND INFLAMMATORY DISEASE 审中-公开
标题翻译：重定向，遗传工程化的T细胞及其在抑制自身免疫和炎症疾病中的应用
公开(公告)号：US20100135974A1
公开(公告)日：2010-06-03
申请号：US12525270
申请日：2008-01-31
申请人： Zelig Eshhar , Eran Elinav
发明人： Zelig Eshhar , Eran Elinav
IPC分类号： A61K35/12 , C12N5/10 , C07H21/04 , C07K16/00 , A61P29/00 , A61P37/00
CPC分类号： C12N5/0636 , A61K39/0008 , A61K39/0011
摘要： A redirected Treg cell is endowed with specificity toward a selected target antigen or ligand. The cell contains a chimeric receptor polypeptide that is expressed in a single, continuous chain, with an extracellular recognition region displayed on the surface of the cell, a transmembrane region and an intracellular signaling region. The extracellular recognition region is specific for the selected target antigen or ligand. The intracellular signaling region includes a combination of T-cell signaling polypeptide moieties, which combination, upon binding of the extracellular recognition region to the selected target antigen or ligand, triggers activation of the redirected Treg cells to cause suppression of T-cell mediated immunity. Such redirected Treg cells may be used to suppress undesired activity of T effector cells thereby mediating an immune or inflammatory response. They are particularly useful in treating T effector cell-mediated diseases, such as inflammatory bowel disease, transplant rejection and GVH disease.
摘要翻译：重定向的Treg细胞被赋予对所选靶抗原或配体的特异性。细胞含有在单个连续链中表达的嵌合受体多肽，细胞外识别区域显示在细胞表面，跨膜区和胞内信号传导区。细胞外识别区域对于所选择的靶抗原或配体是特异性的。细胞内信号传导区域包括T细胞信号传导多肽部分的组合，当细胞外识别区域与所选择的靶抗原或配体结合时，其组合触发重定向的Treg细胞的激活以引起T细胞介导的免疫的抑制。这种重定向的Treg细胞可以用于抑制T效应细胞的不期望的活性，从而介导免疫或炎症反应。它们特别可用于治疗T效应细胞介导的疾病，例如炎症性肠病，移植排斥和GVH疾病。

7. 发明授权

US07135295B1 Detection of small molecules by use of a piezoelectric sensor 失效
标题翻译：通过使用压电传感器检测小分子
公开(公告)号：US07135295B1
公开(公告)日：2006-11-14
申请号：US09889936
申请日：2000-01-25
申请人： Itamar Willner , Zelig Eshhar
发明人： Itamar Willner , Zelig Eshhar
IPC分类号： G01N33/53
CPC分类号： C07K16/00 , G01N33/54373
摘要： A protein comprising an antigen-binding portion formed by two cooperating peptide sequences of FIGS. 3A and 3B of the application. The protein may alternatively comprise an altered antigen-binding portion where at least one of the peptide sequences is an altered sequence, an altered sequence being a sequence of FIG. 3A or 3B in which one or more of an amino acid residue has been added, deleted or replaced by another amino acid residue. The altered antigen-binding portion retains substantially the same antigen-binding specificity as said antigen-binding portion. Also disclosed are apparatus, systems and methods for detecting small assayed molecules in a sample using the protein.
摘要翻译：包含由图1和2的两个协同肽序列形成的抗原结合部分的蛋白质。 3 A和3 B的应用程序。蛋白质可以可选地包含改变的抗原结合部分，其中至少一个肽序列是改变的序列，改变的序列是图1的序列。 3 A或3 B，其中一个或多个氨基酸残基已经被另一个氨基酸残基加入，缺失或替换。改变的抗原结合部分保持与所述抗原结合部分基本相同的抗原结合特异性。还公开了用于使用蛋白质检测样品中的小测定分子的装置，系统和方法。

8. 发明授权

US5906936A Endowing lymphocytes with antibody specificity 失效
标题翻译：赋予淋巴细胞抗体特异性
公开(公告)号：US5906936A
公开(公告)日：1999-05-25
申请号：US55396
申请日：1993-05-04
申请人： Zelig Eshhar , Gideon Gross , Tova Waks
发明人： Zelig Eshhar , Gideon Gross , Tova Waks
IPC分类号： C07K14/725 , C07K16/44 , C12N15/13 , C07H21/04 , C07K16/46
CPC分类号： C07K14/7051 , C07K16/44 , C07K2317/56 , C07K2319/00 , C07K2319/02
摘要： There are produced recombinant gene pairs which endow mononuclear cells, mainly various lymphocyte type cells, with antibody-type specificity. In specific gene pairs the rearranged gene pairs code for a binding site of an antibody molecule from the same species, of the T-cell receptor gene, or another species. Gene pairs of the invention code, for example, for antibodies specific towards tumor-specific antigens, viral antigens, modified self antigens, bacterial or fungal antigens, autoimmune type disease antigens and the like. The invention further relates to expression vectors for the effective transfection of such cell types comprising such a recombinant gene pair, to methods for producing same and to pharmaceutical compositions comprising as active ingredient an effective quantity of lymphocytes transfected with such gene pairs.
摘要翻译：产生了具有抗体型特异性的单核细胞，主要是各种淋巴细胞型细胞的重组基因对。在特定基因对中，重排的基因对编码来自相同物种，T细胞受体基因或其他物种的抗体分子的结合位点。本发明的基因对编码例如针对肿瘤特异性抗原特异性抗体，病毒抗原，修饰的自身抗原，细菌或真菌抗原，自身免疫型疾病抗原等。本发明进一步涉及用于有效转染包含这种重组基因对的这种细胞类型的表达载体，其生产方法和包含作为活性成分的有效量的用这种基因对转染的淋巴细胞的药物组合物。

9. 发明授权

US5766861A Method for screening catalytic non-enzyme polypeptides and proteins 失效
标题翻译：筛选催化非酶多肽和蛋白质的方法
公开(公告)号：US5766861A
公开(公告)日：1998-06-16
申请号：US481277
申请日：1995-08-22
申请人： Zelig Eshhar , Bernard S. Green , Dan S. Tawfik
发明人： Zelig Eshhar , Bernard S. Green , Dan S. Tawfik
IPC分类号： G01N33/68 , G01N33/573
CPC分类号： G01N33/68 , G01N33/6854 , G01N2333/901
摘要： A method for screening or detection of a non-enzyme catalytic polypeptide or protein for the conversion of a substrate S to a product P is provided, in which a preparation containing the potential catalyst is contacted with the substrate S immobilized to a support and the immobilized product P obtained is detected, preferably by immunoassay. The method is preferably used for the screening of hybridoma supernatants for catalytic monoclonal antibodies that catalyze acyl transfer reactions, e.g., hydrolysis or aminolysis, condensation reactions and resolution of enantiomers.
摘要翻译： PCT No.PCT / US94 / 00424 Sec。 371日期：1995年8月22日 102（e）日期1995年8月22日PCT 1994年1月12日PCT PCT。 WO94 / 16332 PCT出版物日期1994年7月21日提供了用于筛选或检测用于将底物S转化为产物P的非酶催化多肽或蛋白质的方法，其中将含有潜在催化剂的制剂与固定至检测支持物和获得的固定化产物P，优选通过免疫测定法检测。该方法优选用于筛选用于催化酰基转移反应（例如水解或氨解，缩合反应和拆分对映体）的催化单克隆抗体的杂交瘤上清液。

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