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1. 发明授权

US08211422B2 Chimeric receptor genes and cells transformed therewith 失效
标题翻译：嵌合受体基因和转化的细胞
公开(公告)号：US08211422B2
公开(公告)日：2012-07-03
申请号：US08547263
申请日：1995-10-24
申请人： Zelig Eshhar , Daniel Schindler , Tova Waks , Gideon Gross , Steven A. Rosenberg , Patrick Hwu
发明人： Zelig Eshhar , Daniel Schindler , Tova Waks , Gideon Gross , Steven A. Rosenberg , Patrick Hwu
IPC分类号： A61K48/00
CPC分类号： C07K14/7155 , A61K35/17 , A61K38/00 , C07K14/7051 , C07K14/70535 , C07K16/1045 , C07K16/3046 , C07K16/32 , C07K16/4291 , C07K16/44 , C07K2319/00 , C12N2799/027
摘要： Chimeric receptor genes suitable for endowing lymphocytes with antibody-type specificity include a first gene segment encoding a single-chain Fv domain of a specific antibody and a second gene segment encoding all or part of the transmembrane and cytoplasmic domains, and optionally the extracellular domain, of an immune cell-triggering molecule. The chimeric receptor gene, when transfected to immune cells, expresses the antibody-recognition site and the immune cell-triggering moiety into one continuous chain. The transformed lymphocytes are useful in therapeutic treatment methods.
摘要翻译：适于赋予具有抗体型特异性的淋巴细胞的嵌合受体基因包括编码特异性抗体的单链Fv结构域的第一基因片段和编码全部或部分跨膜和细胞质结构域的第二基因片段，以及任选的细胞外结构域，的免疫细胞触发分子。嵌合受体基因当转染到免疫细胞时，将抗体识别位点和免疫细胞触发部分表达到一个连续的链中。转化的淋巴细胞可用于治疗方法。

2. 发明授权

US07741465B1 Chimeric receptor genes and cells transformed therewith 失效
标题翻译：嵌合受体基因和转化的细胞
公开(公告)号：US07741465B1
公开(公告)日：2010-06-22
申请号：US08084994
申请日：1993-07-02
申请人： Zelig Eshhar , Daniel Schindler , Tova Waks , Gideon Gross
发明人： Zelig Eshhar , Daniel Schindler , Tova Waks , Gideon Gross
IPC分类号： C07H21/04 , C12N15/74 , C12N5/00
CPC分类号： C07K16/32 , C07K16/4291 , C07K16/44 , C07K2317/52 , C07K2317/622
摘要： Chimeric receptor genes suitable for endowing lymphocytes with antibody-type specificity include a first gene segment encoding a single-chain Fv domain of a specific antibody and a second gene segment encoding all or part of the transmembrane and cytoplasmic domains, and optionally the extracellular domain, of an immune cell-triggering molecule. The chimeric receptor gene, when transfected to immune cells, expresses the antibody-recognition site and the immune cell-triggering moiety into one continuous chain. The transformed lymphocytes are useful in therapeutic treatment methods.
摘要翻译：适于赋予具有抗体型特异性的淋巴细胞的嵌合受体基因包括编码特异性抗体的单链Fv结构域的第一基因片段和编码全部或部分跨膜和细胞质结构域的第二基因片段，以及任选的细胞外结构域，的免疫细胞触发分子。嵌合受体基因当转染到免疫细胞时，将抗体识别位点和免疫细胞触发部分表达到一个连续的链中。转化的淋巴细胞可用于治疗方法。

3. 发明申请

US20120093842A1 CHIMERIC RECEPTOR GENES AND CELLS TRANSFORMED THEREWITH 审中-公开
标题翻译： CHIMERIC受体基因和细胞转化
公开(公告)号：US20120093842A1
公开(公告)日：2012-04-19
申请号：US13281560
申请日：2011-10-26
申请人： Zelig Eshhar , Daniel Schindler , Tova Waks , Gideon Gross , Steven A. Rosenberg , Patrick Hwu
发明人： Zelig Eshhar , Daniel Schindler , Tova Waks , Gideon Gross , Steven A. Rosenberg , Patrick Hwu
IPC分类号： A61K35/00 , A61P35/00
CPC分类号： C07K14/7155 , A61K35/17 , A61K38/00 , C07K14/7051 , C07K14/70535 , C07K16/1045 , C07K16/3046 , C07K16/32 , C07K16/4291 , C07K16/44 , C07K2319/00 , C12N2799/027
摘要： Chimeric receptor genes suitable for endowing lymphocytes with antibody-type specificity include a first gene segment encoding a single-chain Fv domain of a specific antibody and a second gene segment encoding all or part of the transmembrane and cytoplasmic domains, and optionally the extracellular domain, of an immune cell-triggering molecule. The chimeric receptor gene, when transfected to immune cells, expresses the antibody-recognition site and the immune cell-triggering moiety into one continuous chain. The transformed lymphocytes are useful in therapeutic treatment methods.
摘要翻译：适于赋予具有抗体型特异性的淋巴细胞的嵌合受体基因包括编码特异性抗体的单链Fv结构域的第一基因片段和编码全部或部分跨膜和细胞质结构域的第二基因片段，以及任选的细胞外结构域，的免疫细胞触发分子。嵌合受体基因当转染到免疫细胞时，将抗体识别位点和免疫细胞触发部分表达到一个连续的链中。转化的淋巴细胞可用于治疗方法。

4. 发明授权

US5912172A Endowing lymphocytes with antibody specificity 失效
公开(公告)号：US5912172A
公开(公告)日：1999-06-15
申请号：US474819
申请日：1995-06-07
申请人： Zelig Eshhar , Gideon Gross , Tova Waks
发明人： Zelig Eshhar , Gideon Gross , Tova Waks
IPC分类号： C07K14/725 , C07K16/44 , C12N15/13 , C07H21/04 , C07K16/46
CPC分类号： C07K14/7051 , C07K16/44 , C07K2317/56 , C07K2319/00 , C07K2319/02
摘要： There are produced recombinant gene pairs which endow mononuclear cells, mainly various lymphocyte type cells, with antibody-type specificity. In specific gene pairs the rearranged gene pairs code for a binding site of an antibody molecule from the same species, of the T-cell receptor gene, or another species. Gene pairs of the invention code, for example, for antibodies specific towards tumor-specific antigens, viral antigens, modified self antigens, bacterial or fungal antigens, autoimmune type disease antigens and the like. The invention further relates to expression vectors for the effective transfection of such cell types comprising such a recombinant gene pair, to methods for producing same and to pharmaceutical compositions comprising as active ingredient an effective quantity of lymphocytes transfected with such gene pairs.

5. 发明授权

US5906936A Endowing lymphocytes with antibody specificity 失效
标题翻译：赋予淋巴细胞抗体特异性
公开(公告)号：US5906936A
公开(公告)日：1999-05-25
申请号：US55396
申请日：1993-05-04
申请人： Zelig Eshhar , Gideon Gross , Tova Waks
发明人： Zelig Eshhar , Gideon Gross , Tova Waks
IPC分类号： C07K14/725 , C07K16/44 , C12N15/13 , C07H21/04 , C07K16/46
CPC分类号： C07K14/7051 , C07K16/44 , C07K2317/56 , C07K2319/00 , C07K2319/02
摘要： There are produced recombinant gene pairs which endow mononuclear cells, mainly various lymphocyte type cells, with antibody-type specificity. In specific gene pairs the rearranged gene pairs code for a binding site of an antibody molecule from the same species, of the T-cell receptor gene, or another species. Gene pairs of the invention code, for example, for antibodies specific towards tumor-specific antigens, viral antigens, modified self antigens, bacterial or fungal antigens, autoimmune type disease antigens and the like. The invention further relates to expression vectors for the effective transfection of such cell types comprising such a recombinant gene pair, to methods for producing same and to pharmaceutical compositions comprising as active ingredient an effective quantity of lymphocytes transfected with such gene pairs.
摘要翻译：产生了具有抗体型特异性的单核细胞，主要是各种淋巴细胞型细胞的重组基因对。在特定基因对中，重排的基因对编码来自相同物种，T细胞受体基因或其他物种的抗体分子的结合位点。本发明的基因对编码例如针对肿瘤特异性抗原特异性抗体，病毒抗原，修饰的自身抗原，细菌或真菌抗原，自身免疫型疾病抗原等。本发明进一步涉及用于有效转染包含这种重组基因对的这种细胞类型的表达载体，其生产方法和包含作为活性成分的有效量的用这种基因对转染的淋巴细胞的药物组合物。

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