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1. 发明授权

US08846968B2 Intermediate of lycopene and preparation method of intermediate thereof 有权
标题翻译：番茄红素中间体及其中间体的制备方法
公开(公告)号：US08846968B2
公开(公告)日：2014-09-30
申请号：US13692694
申请日：2012-12-03
申请人： ZheJiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory , Shaoxing University
发明人： Runpu Shen , Chunlei Lv , Xiaoyue Jiang , Xuejun Lao , Weidong Ye , Luo Liu , Xiaohua Song , Chunlei Wu
IPC分类号： C07C43/303 , C07F9/40 , C07B47/00 , C07C41/50 , C07C41/48
CPC分类号： C07C41/50 , C07B47/00 , C07C41/48 , C07C43/303 , C07F9/4015 , C07F9/4078
摘要： The present invention relates to an intermediate (12) of lycopene of 2,6,10-trimethyl-1,1-dialkoxyl-3,5,9-undecantriene of formula, (12) and its intermediate of 4-methyl-5,5-dialkoxyl-1-pentenyl-1-phosphonic acid dialkyl ester of formula (10), and their preparation methods. The process route is simple, the starting materials are available easily, the cost is low, and it is valuable in industry.
摘要翻译：本发明涉及式（12）的2,6,10-三甲基-1,1-二烷氧基-3,5,9-十一三烯的番茄红素中间体（12）及其4-甲基-5的中间体，式（10）的5-二烷氧基-1-戊烯基-1-膦酸二烷基酯及其制备方法。工艺路线简单，起始材料易于使用，成本低廉，在工业上是有价值的。

2. 发明申请

US20140005434A1 INTERMEDIATE OF LYCOPENE AND PREPARATION METHOD OF INTERMEDIATE THEREOF 有权
标题翻译：中间体及其中间体的制备方法
公开(公告)号：US20140005434A1
公开(公告)日：2014-01-02
申请号：US13692694
申请日：2012-12-03
申请人： ZHEJIANG MEDICINE CO., LTD. XINCHANG , SHAOXING UNIVERSITY
发明人： Runpu Shen , Chunlei LV , Xiaoyue Jiang , Xuejun Lao , Weidong Ye , Luo Liu , Xiaohua Song , Chunlei Wu
IPC分类号： C07C41/50 , C07F9/40 , C07C43/303
CPC分类号： C07C41/50 , C07B47/00 , C07C41/48 , C07C43/303 , C07F9/4015 , C07F9/4078
摘要： The present invention relates to an intermediate (12) of lycopene of 2,6,10-trimethyl-1,1-dialkoxyl-3,5,9-undecantriene of formula, (12) and its intermediate of 4-methyl-5,5-dialkoxyl-1-pentenyl-1-phosphonic acid dialkyl ester of formula (10), and their preparation methods. The process route is simple, the starting materials are available easily, the cost is low, and it is valuable in industry.
摘要翻译：本发明涉及式（12）的2,6,10-三甲基-1,1-二烷氧基-3,5,9-十一三烯的番茄红素中间体（12）及其4-甲基-5的中间体，式（10）的5-二烷氧基-1-戊烯基-1-膦酸二烷基酯及其制备方法。工艺路线简单，起始材料易于使用，成本低廉，在工业上是有价值的。

3. 发明申请

US20140005442A1 INTERMEDIATE OF LYCOPENE AND PREPARATION METHOD OF INTERMEDIATE 有权
标题翻译：中间体的中间体和中间体的制备方法
公开(公告)号：US20140005442A1
公开(公告)日：2014-01-02
申请号：US13692658
申请日：2012-12-03
申请人： Zhaoxing University , ZheJiang Medicine Co., Ltd. Xinchang
发明人： Runpu Shen , Chunlei LV , Xiaoyue Jiang , Xuejun Lao , Weidong Ye , Luo Liu , Xiaohua Song , Chunlei Wu
IPC分类号： C07C45/42
CPC分类号： C07C45/42 , C07C45/515 , C07C47/21
摘要： The present invention relates to 2,6,10-trimethyl-3,5,9-undecatrienyl-1-aldehyde represented by formula (3), and a method for preparing this intermediate. The process route of the present invention is simple, the starting materials are available easily, and the cost is low.
摘要翻译：本发明涉及由式（3）表示的2,6,10-三甲基-3,5,9-十一碳三烯-1-醛及其制备方法。本发明的工艺路线简单，起始材料易于使用，成本低廉。

4. 发明申请

US20160264620A1 Separation And Purification Method For Vancomycin Hydrochloride Of High Purity 审中-公开
标题翻译：万古霉素高纯度分离纯化方法
公开(公告)号：US20160264620A1
公开(公告)日：2016-09-15
申请号：US15033116
申请日：2014-10-27
申请人： ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICA FACTORY
发明人： Enmin Li , Yiyun Zhuang , Jue Wang , Xinqiang Sun , Xuejun Lao , Biwang Jiang
IPC分类号： C07K1/36 , C07K1/34 , C07K9/00 , C07K1/20
CPC分类号： C07K1/36 , A61K38/14 , C07K1/20 , C07K1/34 , C07K9/008
摘要： Provided is a separation and purification method for vancomycin hydrochloride of high purity. The method comprises the following steps: (1) obtaining a vancomycin hydrochloride solution from a crude vancomycin product by ion exchange chromatography and obtaining a concentrate by nanofiltration desalination and concentration; (2) adjusting the concentrate with a hydrochloric acid solution and then performing a column chromatography using a reverse chromatography column for the adjusted concentrate; (3) collecting the chromatographic solution of vancomycin to obtain a mixed chromatographic solution; (4) adjusting the mixed chromatographic solution, and separating the solution and the salts by nanofiltration desalination and concentration to obtain a concentrate; and (5) obtaining a vancomycin dry powder with a chromatographic purity of up to 99% and a pure white appearance by dehydrating and drying the concentrate of step (4), or by solvent crystallization or salting-out crystallization.
摘要翻译：本发明提供了高纯度盐酸万古霉素的分离纯化方法。该方法包括以下步骤：（1）通过离子交换色谱从粗万古霉素产品中获得盐酸万古霉素溶液，并通过纳滤脱盐和浓缩获得浓缩物; （2）用盐酸溶液调节浓缩物，然后使用反相层析柱进行柱色谱用于调整浓缩物; （3）收集万古霉素的色谱溶液，得到混合色谱溶液; （4）调整混合色谱溶液，并通过纳滤过滤脱盐浓缩分离溶液和盐，得到浓缩物; 和（5）通过使步骤（4）的浓缩物脱水干燥，或通过溶剂结晶或盐析结晶，得到色谱纯度高达99％，纯白色外观的万古霉素干粉。

5. 发明授权

US11920175B2 Method for extracting and isolating lutein crystal from vegetable oil resin containing lutein diester 有权
公开(公告)号：US11920175B2
公开(公告)日：2024-03-05
申请号：US17259161
申请日：2019-07-09
申请人： Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： Xinde Xu , Tian Xie , Shengfan Wang , Qiuyan Wang , Jianyong Zheng , Zhaowu Zeng , Xiaopu Yin , Xuejun Lao , Kangzhong Shao
IPC分类号： C07C403/24 , C12P23/00
CPC分类号： C12P23/00 , C07C403/24 , C07B2200/13 , C07C2601/16
摘要： A method for extracting and isolating a lutein crystal from a vegetable oil resin containing a lutein diester, comprises: dissolving lipase into deionized water to form an enzyme solution; dissolving a lutein extract into an alcohol solvent containing the deionized water to form a uniform alcohol solution; adding the enzyme solution to the alcohol solution for performing hydrolysis, and stirring same to obtain a lutein solution; filtering and performing filtration isolation on the lutein solution to obtain a crystalline; re-dissolving the crystalline into a non-polar organic solvent, and using deionized water for washing a water-soluble impurity; recycling and cooling the organic solvent to obtain a recrystallization; and isolating and drying the recrystallization to obtain the lutein crystal. In this method, selectivity is strong, reaction time is short, no waste water is produced, process is environment-friendly and suitable for industrial production, and obtained lutein crystal is high in purity and yield.

6. 发明授权

US10131689B2 Separation and purification method for vancomycin hydrochloride of high purity 有权
公开(公告)号：US10131689B2
公开(公告)日：2018-11-20
申请号：US15033116
申请日：2014-10-27
申请人： Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： Enmin Li , Yiyun Zhuang , Jue Wang , Xinqiang Sun , Xuejun Lao , Biwang Jiang
IPC分类号： C07K1/36 , C07K9/00 , A61K38/14 , C07K1/20 , C07K1/34
摘要： Provided is a separation and purification method for vancomycin hydrochloride of high purity. The method comprises the following steps: (1) obtaining a vancomycin hydrochloride solution from a crude vancomycin product by ion exchange chromatography and obtaining a concentrate by nanofiltration desalination and concentration; (2) adjusting the concentrate with a hydrochloric acid solution and then performing a column chromatography using a reverse chromatography column for the adjusted concentrate; (3) collecting the chromatographic solution of vancomycin to obtain a mixed chromatographic solution; (4) adjusting the mixed chromatographic solution, and separating the solution and the salts by nanofiltration desalination and concentration to obtain a concentrate; and (5) obtaining a vancomycin dry powder with a chromatographic purity of up to 99% and a pure white appearance by dehydrating and drying the concentrate of step (4), or by solvent crystallization or salting-out crystallization.

7. 发明授权

US10028914B2 Reduction type coenzyme Q10 powder, composition thereof, and preparation method thereof 有权
公开(公告)号：US10028914B2
公开(公告)日：2018-07-24
申请号：US14786974
申请日：2014-03-14
申请人： Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： Xinde Xu , Gang Chen , Xuejun Lao , Lihua Zhang , Xiaoxia Sun , Xiaoyue Jiang
IPC分类号： A61K31/122 , A61K9/16 , C07C41/26 , C07C41/34 , A61K9/00 , A61K9/48 , A61K31/09 , C12P7/66 , A23L33/10
摘要： The present invention describes a reduction type coenzyme Q10 powder, a composition thereof, and a preparation method thereof. The reduction type coenzyme Q10 powder is obtained by reacting an oxidation type coenzyme Q10 with the presence of a reducing agent, removing an organic solvent and other purities from a reaction solution after the reaction is finished to obtain an oil-soluble reduction type coenzyme Q10 liquid, and then directly performing prill formation with cold wind on an obtained reduction type coenzyme Q10 greasy substance. The obtained reduction type coenzyme Q10 powder has a lower crystallinity, and in a Cu-K[alpha] X-ray diffraction spectrum, has a strong peak at a diffraction angle 2[theta] being 18.9 DEG, and has a very strong absorption peak at a diffraction angle 2[theta] being 22.8 DEG. The reduction type coenzyme Q10 powder obtained in the present invention is in an incompletely crystallized state, has desirable stability and desirable oral bioavailability, and is suitable for use in applications such as dietary supplements, cosmetics or pharmaceuticals.

8. 发明授权

US08697918B2 Intermediate of lycopene and preparation method of intermediate 有权
标题翻译：番茄红素中间体及其制备方法
公开(公告)号：US08697918B2
公开(公告)日：2014-04-15
申请号：US13692658
申请日：2012-12-03
申请人： ZheJiang Medicine Co., Ltd. Xinchang , Zhaoxing University
发明人： Runpu Shen , Chunlei Lv , Xiaoyue Jiang , Xuejun Lao , Weidong Ye , Luo Liu , Xiaohua Song , Chunlei Wu
IPC分类号： C07C45/00
CPC分类号： C07C45/42 , C07C45/515 , C07C47/21
摘要： The present invention relates to 2,6,10-trimethyl-3,5,9-undecatrienyl-1-aldehyde represented by formula (3), and a method for preparing this intermediate. The process route of the present invention is simple, the starting materials are available easily, and the cost is low.
摘要翻译：本发明涉及由式（3）表示的2,6,10-三甲基-3,5,9-十一碳三烯-1-醛及其制备方法。本发明的工艺路线简单，起始材料易于使用，成本低廉。

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