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1. 发明申请

US20100104459A1 MICROPUMP ACTUATED BY DROPLETS 审中-公开
标题翻译：由DROPLETS执行的MICROPUMP
公开(公告)号：US20100104459A1
公开(公告)日：2010-04-29
申请号：US12582063
申请日：2009-10-20
申请人： Yves Fouillet , Guillaume Delapierre , Olivier Fuchs
发明人： Yves Fouillet , Guillaume Delapierre , Olivier Fuchs
IPC分类号： F04B17/03
CPC分类号： F04B19/006 , F04B43/043
摘要： The invention relates to a micropump for which the pressure force is not limited by the electrowetting saturation angle, while being simple to manufacture. According to the invention, the microchannel (10) comprises an inlet orifice (11) and has a hydrophilic wall (12) extending from said inlet orifice (11). Displacement means are provided to displace a droplet (51) of liquid (L1) by electrowetting on a hydrophobic surface (22) until said droplet (51) is brought into contact with said hydrophilic wall (12), such that said droplet (51) enters into said microchannel (10) through said inlet orifice (11) by wetting, causing displacement of said fluid (F1).
摘要翻译：本发明涉及一种微型泵，其中压力不受电润湿饱和度的限制，同时制造简单。根据本发明，微通道（10）包括入口孔（11），并且具有从所述入口孔（11）延伸的亲水壁（12）。提供位移装置以通过电润湿在疏水表面（22）上移动液体（L1）的液滴（51），直到所述液滴（51）与所述亲水壁（12）接触，使得所述液滴（51）通过润湿通过所述入口孔（11）进入所述微通道（10），引起所述流体（F1）的移位。

2. 发明申请

US20100244855A1 Microdevice for the In Situ Detection of Particles of Interest in a Fluid Medium and Operating Method 失效
标题翻译：用于在流体介质中感兴趣的颗粒的原位检测的微型设备和操作方法
公开(公告)号：US20100244855A1
公开(公告)日：2010-09-30
申请号：US12731963
申请日：2010-03-25
申请人： Vincent Agache , Guillaume Delapierre
发明人： Vincent Agache , Guillaume Delapierre
IPC分类号： G01R27/04
CPC分类号： G01N27/127 , B82Y15/00 , G01N27/122
摘要： The invention relates to a detection device of small size, allowing direct in situ detection of particles with no labelling, enabling the particles to be rapidly analysed, and having both a specificity and a sensitivity that are at least equivalent to the existing devices. In one embodiment, the invention provides a device having a nanowire, intended for interacting with the particles of interest, which is suspended between two anchors that define a source and a drain, the source and the drain are configured to be connected to an AC voltage generator and to a DC voltage generator, respectively, in order to generate a first input signal; an excitation electrode, placed laterally facing the nanowire and configured to be connected to an AC voltage generator, in order to generate a second input signal; and a measurement electrode placed opposite the excitation electrode relative to the nanowire and generating a single output signal representative of the particles of interest.
摘要翻译：本发明涉及一种小尺寸的检测装置，允许直接原位检测没有标记的颗粒，使得能够快速分析颗粒，同时具有至少等同于现有装置的特异性和灵敏度。在一个实施例中，本发明提供了一种具有纳米线的装置，其旨在与感兴趣的颗粒相互作用，所述颗粒悬挂在限定源极和漏极的两个锚点之间，源极和漏极被配置为连接到AC电压发电机和DC电压发生器，以便产生第一输入信号; 激励电极，横向面对纳米线并且被配置为连接到AC电压发生器，以便产生第二输入信号; 以及与激发电极相对于纳米线放置的测量电极，并产生表示感兴趣的颗粒的单个输出信号。

3. 发明申请

US20090053481A1 METHOD FOR SUCCESSIVELY FUNCTIONALIZING A SUBSTRATE AND MICROSTRUCTURE IS OBTAINABLE BY SAID METHOD 审中-公开
标题翻译：方法功能化基底和微结构的方法可以通过方法获得
公开(公告)号：US20090053481A1
公开(公告)日：2009-02-26
申请号：US11997477
申请日：2006-08-02
申请人： Guillaume Delapierre , Cyril Delattre
发明人： Guillaume Delapierre , Cyril Delattre
IPC分类号： B32B3/10 , B05D3/10 , H01L21/30
CPC分类号： B01J19/0046 , B01J2219/00387 , B01J2219/00529 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , Y10T428/24802
摘要： A method for successively functionalizing a substrate whose surface is provided with at least two areas (1, 2) made up of different materials, with at least one chemical substrate, characterized in that the functionalization is carried out without masking and consists (a) in functionalizing a first area (1) without masking the second area (2) or possible successive areas by transforming the substrate with the aid of a chemical substance X1, wherein the first area material reactivity is greater with respect to the reactivity of the substance X1 than the reactivity of the other possible successive areas with respect thereto, and (b1) in treating the second area (2) or the other possible successive areas with a chemical substance Y1 for removing reaction products deposited on said areas during the functionalization from the areas of the substance X1 and/or the possible successive areas without damaging the functionalized surface of the first area.
摘要翻译：一种用于使表面设置有由不同材料构成的至少两个区域（1,2）的衬底与至少一个化学衬底相连地功能化的方法，其特征在于，所述功能化在不掩蔽下进行，并且包括（a）通过借助于化学物质X1转化所述衬底而不掩蔽所述第二区域（2）或可能的连续区域来功能化第一区域（1），其中所述第一区域材料反应性相对于所述物质X1的反应性更大相对于其它可能的连续区域的反应性，和（b1）在用于除去在功能化过程中沉积在所述区域上的反应产物的化学物质Y1处理第二区域（2）或其它可能的连续区域时物质X1和/或可能的连续区域，而不损害第一区域的官能化表面。

4. 发明授权

US09588084B2 Device for detecting gases and/or volatile organic compounds (VOC) 有权
标题翻译：用于检测气体和/或挥发性有机化合物（VOC）的装置
公开(公告)号：US09588084B2
公开(公告)日：2017-03-07
申请号：US13497962
申请日：2010-09-24
申请人： Guillaume Delapierre , Yanxia Hou-Broutin , Heather McCaig , Edward Myers , Michael L. Roukes
发明人： Guillaume Delapierre , Yanxia Hou-Broutin , Heather McCaig , Edward Myers , Michael L. Roukes
IPC分类号： G01N27/30 , G01N29/036 , G01N29/02
CPC分类号： G01N29/036 , G01N29/022 , G01N2291/0255 , G01N2291/0256 , G01N2291/0426
摘要： The present invention concerns a device for detecting gases or volatile organic compounds (VOC) comprising an electrically conducting or semiconducting zone functionalized with an organic film resulting from the polymerization of aromatic diazonium salt derived monomer.
摘要翻译：本发明涉及一种用于检测气体或挥发性有机化合物（VOC）的装置，其包括由芳族重氮盐衍生的单体的聚合产生的由有机膜官能化的导电或半导电区域。

5. 发明授权

US08592619B2 Bifunctional molecules comprising a cycloalkyne or heterocycloalkyne group and a redox group 有权
标题翻译：包含环炔或杂环炔基和氧化还原基团的双功能分子
公开(公告)号：US08592619B2
公开(公告)日：2013-11-26
申请号：US13257365
申请日：2010-03-16
申请人： Guillaume Delapierre , Regis Barattin , Aude Bernardin , Isabelle Texier-Nogues
发明人： Guillaume Delapierre , Regis Barattin , Aude Bernardin , Isabelle Texier-Nogues
IPC分类号： C07F17/02 , H01L45/00 , H01L21/312
CPC分类号： C07F17/02
摘要： The invention relates to compounds comprising a cycloalkyne or heterocycloalkyne group and a redox group. Said compounds are of general formula (I) wherein Z is a cycloalkyne or heterocycloalkyne with at least 8 links, optionally substituted by a halogen atom or a linear or branched C1 to C5 alkyl, A is an organic structure having oxidation-reduction properties, and B is an organic link between the cycloalkyne or heterocycloalkyne cycle and the organic structure A. The invention is especially applicable to the field of molecular electronics.
摘要翻译：本发明涉及包含环炔或杂环炔基和氧化还原基团的化合物。所述化合物具有通式（I），其中Z是具有至少8个连接的环烯烃或杂环炔基，任选被卤素原子或直链或支链C 1至C 5烷基取代，A是具有氧化还原性质的有机结构，和 B是环炔或杂环炔环与有机结构A之间的有机连接。本发明特别适用于分子电子领域。

6. 发明申请

US20080185339A1 Method For Extracting At Least One Compound From A Liquid Phase Comprising A Functionalized Ionic Liquid, And Microfluidic System For Implementing Said Method 有权
标题翻译：从包含官能化离子液体的液相中提取至少一种化合物的方法和用于实施所述方法的微流体系统
公开(公告)号：US20080185339A1
公开(公告)日：2008-08-07
申请号：US11912077
申请日：2006-04-06
申请人： Guillaume Delapierre , Nicolas Sarrut , Gilles Marchand
发明人： Guillaume Delapierre , Nicolas Sarrut , Gilles Marchand
IPC分类号： B01D15/00 , B01D11/04
CPC分类号： B01D11/04 , B01D11/0496
摘要： (EN) The invention concerns a method for extracting at least one chemical or biological compound from a liquid phase comprising at least one functionalized ionic liquid, via a liquid extracting fluid (F) which is miscible with said ionic liquid(s), and a microfluidic system (10) for implementing said method. The inventive extraction method includes moving, on one surface (12) of a microfluidic system (19), at least one microdrop (14) of said liquid phase into an extraction solution (20) which comprises said extracting fluid and which is localized on said surface to obtain in output of said solution, under the effect of an electric field, an extract (E) moving away from said surface which is rich in extracting fluid and enriched in said or at least one of said compound(s), and a raffinate (R) moving on said surface which is rich in ionic liquid(s) and deleted in said or one of said compound(s).
摘要翻译：（EN）本发明涉及通过与所述离子液体混溶的液体提取液（F）从包含至少一种官能化离子液体的液相中提取至少一种化学或生物化合物的方法，以及用于实现所述方法的微流体系统（10）。本发明的提取方法包括在微流体系统（19）的一个表面（12）上移动所述液相的至少一个微滴（14）至包含所述提取流体并且位于所述液相在所述溶液的作用下获得所述溶液的输出，所述提取物（E）在电场的作用下离开所述表面移动，所述提取物（E）富含提取流体并富集所述化合物或所述化合物中的至少一种，并且所述提取物所述残液在所述表面上移动，所述表面富含离子液体并在所述化合物或所述化合物之一中缺失。

7. 发明授权

US08546598B2 Silane compounds having a cyclic carbon chain including an alkyne function for functionalizing solid substrates and immobilizing biological molecules on said substrates 失效
标题翻译：具有环状碳链的硅烷化合物，其包括用于官能化固体底物并将生物分子固定在所述基材上的炔官能团
公开(公告)号：US08546598B2
公开(公告)日：2013-10-01
申请号：US13257326
申请日：2010-03-16
申请人： Aude Bernardin , Guillaume Delapierre , Antoine Hoang , Isabelle Texier-Nogues
发明人： Aude Bernardin , Guillaume Delapierre , Antoine Hoang , Isabelle Texier-Nogues
IPC分类号： C07F7/04 , C40B60/00 , C12M1/34
CPC分类号： C07F7/1804
摘要： The invention relates to a silane compound including a cycloalkyne functionality, to a method for functionalising a solid substrate, and to the solid substrate thus produced. The silane compound of the invention corresponds to the formula X-E-A-Z where X is a silyl group, E is an organic spacer group, A is a single bond or a —CONH—, —NHCO—, —OCH2CONH—, —NHCOCH2O—, —O— or —S— group, and Z is a cycloalkyne or heterocycloalkyne with at least 8 members. The invention is particularly suitable for use in the field of medicine.
摘要翻译：本发明涉及包括环炔官能团的硅烷化合物，固体基质的功能化方法以及如此制备的固体基质。本发明的硅烷化合物对应于式XEAZ，其中X是甲硅烷基，E是有机间隔基团，A是单键或-CONH-，-NHCO-，-OCH 2 CONH-，-NHCOCH 2 O-，-O - 或-S-基团，Z是具有至少8个成员的环炔或杂环炔。本发明特别适用于医药领域。

8. 发明授权

US08334702B2 Microdevice for the in situ detection of particles of interest in a fluid medium and operating method 失效
标题翻译：用于在流体介质中原位检测感兴趣的颗粒的微型装置和操作方法
公开(公告)号：US08334702B2
公开(公告)日：2012-12-18
申请号：US12731963
申请日：2010-03-25
申请人： Vincent Agache , Guillaume Delapierre
发明人： Vincent Agache , Guillaume Delapierre
IPC分类号： G01R27/32 , G01N11/00
CPC分类号： G01N27/127 , B82Y15/00 , G01N27/122
摘要： The invention relates to a detection device of small size, allowing direct in situ detection of particles with no labelling, enabling the particles to be rapidly analysed, and having both a specificity and a sensitivity that are at least equivalent to the existing devices. In one embodiment, the invention provides a device havinga nanowire, intended for interacting with the particles of interest, which is suspended between two anchors that define a source and a drain, the source and the drain are configured to be connected to an AC voltage generator and to a DC voltage generator, respectively, in order to generate a first input signal;an excitation electrode, placed laterally facing the nanowire and configured to be connected to an AC voltage generator, in order to generate a second input signal; anda measurement electrode placed opposite the excitation electrode relative to the nanowire and generating a single output signal representative of the particles of interest.
摘要翻译：本发明涉及一种小尺寸的检测装置，允许直接原位检测没有标记的颗粒，使得能够快速分析颗粒，同时具有至少等同于现有装置的特异性和灵敏度。在一个实施例中，本发明提供了一种具有纳米线的装置，其旨在与感兴趣的颗粒相互作用，所述颗粒悬挂在限定源极和漏极的两个锚点之间，源极和漏极被配置为连接到AC电压发电机和DC电压发生器，以便产生第一输入信号; 激励电极，横向面对纳米线并且被配置为连接到AC电压发生器，以便产生第二输入信号; 以及与激发电极相对于纳米线放置的测量电极，并产生表示感兴趣的颗粒的单个输出信号。

9. 发明申请

US20100124791A1 METHOD TO FABRICATE A CHIP FOR THE DETECTION OF BIOLOGICAL ELEMENTS 有权
标题翻译：用于制作用于检测生物元素的芯片的方法
公开(公告)号：US20100124791A1
公开(公告)日：2010-05-20
申请号：US12620881
申请日：2009-11-18
申请人： Julien BUCKLEY , Olivier Billoint , Guillaume Delapierre
发明人： Julien BUCKLEY , Olivier Billoint , Guillaume Delapierre
IPC分类号： H01L21/336
CPC分类号： G01N27/4145
摘要： Improved method to fabricate a microelectronic device provided with at least one circuit to detect biological elements, comprising the steps of: a) forming transistors, depositing at least one layer in at least one insulating material (141) coating said transistors, forming one or more holes (143) in said layer of insulating material (141), so as to expose the upper face of the respective gate (135) of first-type transistors, filling the holes with a gate material, b) removing, at least in part, the respective gate (135) of the first-type transistors, whilst the gate of second-type transistors is protected, the method prior to or at the same time as said removal conducted at step b) further comprising the removal of said gate material.
摘要翻译：制造具有检测生物元件的至少一个电路的微电子器件的改进方法包括以下步骤：a）形成晶体管，在涂覆所述晶体管的至少一个绝缘材料（141）中沉积至少一层，形成一个或多个在所述绝缘材料层（141）中的孔（143）中，以露出第一型晶体管的各个栅极（135）的上表面，用栅极材料填充孔，b）至少部分地去除，第一型晶体管的相应栅极（135），同时第二型晶体管的栅极被保护，该方法在与在步骤b）进行的所述去除之前或同时进一步包括去除所述栅极材料。

10. 发明申请

US20080009123A1 Method for Bonding Two Free Surfaces, Respectively of First and Second Different Substrates 审中-公开
标题翻译：分别接合第一和第二不同基板的两个自由表面的方法
公开(公告)号：US20080009123A1
公开(公告)日：2008-01-10
申请号：US11667919
申请日：2005-12-06
申请人： Marek Kostrzewa , Lea Di Cioccio , Guillaume Delapierre
发明人： Marek Kostrzewa , Lea Di Cioccio , Guillaume Delapierre
IPC分类号： H01L21/30
CPC分类号： C09J5/02
摘要： A method for bonding two free surfaces, respectively of first and second different substrates, includes a formation step, on the free surface of the first substrate, of a self-assembled mono-molecular layer consisting of a thiol compound of the SH—R—X type, where —R is a carbonaceous chain and —X is a group selected from the group consisting in —H, —OH and —COOH, at least said free surface of the first substrate being formed by a material able to form molecular bonds with the —SH group of the thiol compound. The method also includes preparing the free surface of the second substrate consisting in saturating the free surface of the second substrate with —H groups if —X is a —H group or with —OH groups if —X is selected from the group consisting in —OH and —COOH, and placing the two free surfaces in contact.
摘要翻译：分别用于接合第一和第二不同基板的两个自由表面的方法包括在第一基板的自由表面上形成由SH-RX型硫醇化合物组成的自组装单分子层的形成步骤，其中-R是碳质链，-X是选自-H，-OH和-COOH的基团，所述第一基底的至少所述自由表面由能够与所述第一基底形成分子键的材料形成 -SH组的硫醇化合物。该方法还包括制备第二衬底的自由表面，其组成为：如果-X为-H基团则用-H基团饱和第二衬底的自由表面，如果-X选自 - OH和-COOH，并将两个自由表面接触。

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