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1. 发明授权

US08968673B2 Method for functionalising fluid lines contained in a micromechanical device, micromechanical device including functionalised lines, and method for manufacturing same 有权
标题翻译：包含在微机械装置中的流体线的功能化方法，包括功能化线的微机械装置及其制造方法
公开(公告)号：US08968673B2
公开(公告)日：2015-03-03
申请号：US13805491
申请日：2011-06-29
申请人： Vincent Agache , Antoine Hoang , Françoise Vinet
发明人： Vincent Agache , Antoine Hoang , Françoise Vinet
IPC分类号： G01N33/00 , G03F7/24 , B81C1/00 , F04B19/00
CPC分类号： G03F7/24 , B81B2201/0214 , B81B2201/058 , B81B2201/06 , B81C1/00206 , B81C2201/0154 , F04B19/006
摘要： The present invention relates to a method for functionalizing fluid lines (1b) in a micromechanical device, the walls of which include an opaque layer. For this purpose, the invention provides a method for functionalizing a micromechanical device provided with a fluid line including a peripheral wall (5) having a surface (2) outside the line and an inner surface (3) defining a space (1b) in which a fluid can circulate, the peripheral wall at least partially including a silicon layer (5a). The method includes the following steps: a) providing a device, the peripheral wall (5) of which at least partially includes a silicon layer (5a) having, at least locally, a thickness (e) of more than 100 nm and less than 200 nm, advantageously of 160 to 180 nm; c) silanizing at least the inner surface of the fluid line; d) the localized, selective photo-deprotection on at least the inner surface of the silanized device by exposing the peripheral wall (5) at the point at which said wall has a thickness (e) of more than 100 nm and less than 200 nm, advantageously of 160 to 180 nm.
摘要翻译：本发明涉及一种在微机械装置中功能化流体管线（1b）的方法，该方法的壁包括不透明层。为此，本发明提供了一种功能化微机械装置的方法，该微机械装置具有流体管线，该流体管线包括在管线外部具有表面（2）的周壁（5）和限定空间（1b）的内表面（3）流体可以循环，周壁至少部分地包括硅层（5a）。该方法包括以下步骤：a）提供一种器件，其外围壁（5）至少部分地包括硅层（5a），该硅层至少局部地具有大于100nm的厚度（e）并且小于 200nm，有利地为160〜180nm; c）至少使流体管线的内表面硅烷化; d）通过在所述壁的厚度（e）大于100nm且小于200nm的点处暴露外围壁（5），至少在硅烷化装置的内表面上进行局部选择性光 - 去保护，有利地为160至180nm。

2. 发明申请

US20120095203A1 NOVEL SILANE COMPOUNDS HAVING A CYCLIC CARBON CHAIN INCLUDING AN ALKYNE FUNCTION FOR FUNCTIONALISING SOLID SUBSTRATES AND IMMOBILISING BIOLOGICAL MOLECULES ON SAID SUBSTRATES 失效
标题翻译：具有循环碳链的新型硅烷化合物，其包括用于功能性固体基底的碱性官能团和固体底物上的生物分子生物学分子
公开(公告)号：US20120095203A1
公开(公告)日：2012-04-19
申请号：US13257326
申请日：2010-03-16
申请人： Aude Bernardin , Guillaume Delapierre , Antoine Hoang , Isabelle Texier-Nogues
发明人： Aude Bernardin , Guillaume Delapierre , Antoine Hoang , Isabelle Texier-Nogues
IPC分类号： C07H3/02 , C07F7/08
CPC分类号： C07F7/1804
摘要： The invention relates to a silane compound including a cycloalkyne functionality, to a method for functionalising a solid substrate, and to the solid substrate thus produced. The silane compound of the invention corresponds to the formula X-E-A-Z where X is a silyl group, E is an organic spacer group, A is a single bond or a —CONH—, —NHCO—, —OCH2CONH—, —NHCOCH2O—, —0— or —S— group, and Z is a cycloalkyne or heterocycloalkyne with at least 8 members. The invention is particularly suitable for use in the field of medicine.
摘要翻译：本发明涉及包括环炔官能团的硅烷化合物，固体基质的功能化方法以及如此制备的固体基质。本发明的硅烷化合物对应于式XEAZ，其中X为甲硅烷基，E为有机间隔基，A为单键或-CONH-，-NHCO-，-OCH2CONH-，-NHCOCH2O-，-O - 或-S-基团，Z是具有至少8个成员的环炔或杂环炔。本发明特别适用于医药领域。

3. 发明授权

US07846875B2 Coupling agents comprising a photolabile protecting group and uses thereof, such as for the functionalisation of solid supports 有权
标题翻译：包含光不稳定保护基团的偶联剂及其用途，例如固体载体的功能化
公开(公告)号：US07846875B2
公开(公告)日：2010-12-07
申请号：US11572668
申请日：2005-07-11
申请人： Antoine Hoang , Françoise Vinet , Eric Defrancq , Pascal Dumy
发明人： Antoine Hoang , Françoise Vinet , Eric Defrancq , Pascal Dumy
IPC分类号： C04B50/18
CPC分类号： C07C271/08 , C07D207/46 , C07F7/1804 , C07F9/2408 , Y02P20/55
摘要： The invention relates to compounds comprising a photolabile protecting group and to the use thereof as coupling agents for the functionalisation of solid supports. The invention also relates to the solid supports functionalised by said compounds and to the use of same for the immobilisation of biological molecules of interest, such as nucleic acid molecules.
摘要翻译：本发明涉及包含光不稳定保护基团的化合物及其作为用于固体支持物官能化的偶联剂的用途。本发明还涉及由所述化合物官能化的固体支持物及其用于固定目标生物分子例如核酸分子的用途。

4. 发明申请

US20100035353A1 PROCESS FOR THE MANUFACTURING OF GLYCOCHIPS 审中-公开
标题翻译：制糖厂的工艺
公开(公告)号：US20100035353A1
公开(公告)日：2010-02-11
申请号：US12498678
申请日：2009-07-07
申请人： Véronique Mourier , Antoine Hoang , Shinsuke Yamasaki
发明人： Véronique Mourier , Antoine Hoang , Shinsuke Yamasaki
IPC分类号： C07H1/00 , C07H3/00 , G01N33/00
CPC分类号： G01N33/54386 , B01J2219/00317 , B01J2219/00427 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00731 , C07H1/00 , G01N33/54353 , G01N33/54393 , G01N2400/00 , Y02P20/55 , Y10T436/143333
摘要： The present invention relates to a process for the manufacturing of solid supports functionalized by saccharide type molecules (glycochips or carbohydrate arrays or alternatively oligosaccharide arrays). The present invention also relates to the glycochips directly obtained by such a manufacturing process and to their use, in particular for biological analysis and especially for the screening of saccharides or proteins such as Hepatocyte Growth Factors (HGFs) or for the study of saccharides/proteins interactions.
摘要翻译：本发明涉及一种制备由糖型分子官能化的固体支持物（糖基片或碳水化合物阵列或另外是寡糖阵列）的方法。本发明还涉及通过这样的制造方法直接获得的糖芯片及其用于特别是用于生物分析，特别是用于筛选糖或蛋白质如肝细胞生长因子（HGF）或用于糖/蛋白质研究的用途互动

5. 发明申请

US20090221449A1 Presentation of Recognition Motifs by a Multivalent Matrix Grafted Onto a Solid Support 审中-公开
标题翻译：通过嫁接在固体支持上的多元矩阵来呈现识别主题
公开(公告)号：US20090221449A1
公开(公告)日：2009-09-03
申请号：US12224191
申请日：2007-02-20
申请人： Eric Defrancq , Pascal Dumy , Olivier Renaudet , Francoise Vinet , Antoine Hoang
发明人： Eric Defrancq , Pascal Dumy , Olivier Renaudet , Francoise Vinet , Antoine Hoang
IPC分类号： C40B40/10 , C40B50/14
CPC分类号： C07K9/006 , C07K7/56 , C07K7/64 , C07K17/02 , C07K17/06
摘要： The invention relates to a method for preparing a grafted homodetic cyclopeptide forming a frame defining two surfaces, one surface being known as the upper surface and the other surface being known as the lower surface, both surfaces being grafted, characterized in the a linear peptide is synthesized, said synthesis is being carried out on modified amino acids or not, some of which include orthogonal protector groups, intramolecular cyclization of the protected linear peptide thus obtained is performed, all or part of the orthogonal protector groups are substituted by a protected precursor, and at least one molecule of therapeutic interest is grafted on one and/or the other surface of the frame by means of an oxime link.
摘要翻译：本发明涉及一种制备接枝的均质环肽的方法，其形成限定两个表面的框架，一个表面被称为上表面，另一个表面被称为下表面，两个表面被接枝，其特征在于线性肽所述合成是在修饰的氨基酸上进行的，其中一些包括正交保护基团，由此得到的受保护的线性肽的分子内环化进行，全部或部分正交保护基被被保护的前体所取代，并且通过肟链接将至少一种具有治疗兴趣的分子嫁接在框架的一个和/或另一个表面上。

6. 发明授权

US08546598B2 Silane compounds having a cyclic carbon chain including an alkyne function for functionalizing solid substrates and immobilizing biological molecules on said substrates 失效
标题翻译：具有环状碳链的硅烷化合物，其包括用于官能化固体底物并将生物分子固定在所述基材上的炔官能团
公开(公告)号：US08546598B2
公开(公告)日：2013-10-01
申请号：US13257326
申请日：2010-03-16
申请人： Aude Bernardin , Guillaume Delapierre , Antoine Hoang , Isabelle Texier-Nogues
发明人： Aude Bernardin , Guillaume Delapierre , Antoine Hoang , Isabelle Texier-Nogues
IPC分类号： C07F7/04 , C40B60/00 , C12M1/34
CPC分类号： C07F7/1804
摘要： The invention relates to a silane compound including a cycloalkyne functionality, to a method for functionalising a solid substrate, and to the solid substrate thus produced. The silane compound of the invention corresponds to the formula X-E-A-Z where X is a silyl group, E is an organic spacer group, A is a single bond or a —CONH—, —NHCO—, —OCH2CONH—, —NHCOCH2O—, —O— or —S— group, and Z is a cycloalkyne or heterocycloalkyne with at least 8 members. The invention is particularly suitable for use in the field of medicine.
摘要翻译：本发明涉及包括环炔官能团的硅烷化合物，固体基质的功能化方法以及如此制备的固体基质。本发明的硅烷化合物对应于式XEAZ，其中X是甲硅烷基，E是有机间隔基团，A是单键或-CONH-，-NHCO-，-OCH 2 CONH-，-NHCOCH 2 O-，-O - 或-S-基团，Z是具有至少8个成员的环炔或杂环炔。本发明特别适用于医药领域。

7. 发明申请

US20140046076A1 Surface Functionalization of a Substrate in an Ionic Liquid Medium 审中-公开
标题翻译：离子液体介质中底物的表面官能化
公开(公告)号：US20140046076A1
公开(公告)日：2014-02-13
申请号：US14003195
申请日：2012-03-02
申请人： Gilles Marchand , Antoine Hoang , Olivier Zaouak , Carole Sauer
发明人： Gilles Marchand , Antoine Hoang , Olivier Zaouak , Carole Sauer
IPC分类号： B05D1/00
CPC分类号： B05D1/00 , B01J20/286 , B01J20/3204 , B01J20/3208 , B01J20/3217 , B01J20/3248 , B01J20/3257 , B05D1/185 , B05D2201/02 , B05D2202/00 , B05D2203/30 , B05D2350/10 , B82Y30/00 , B82Y40/00
摘要： The present invention relates to a process that is useful for surface functionalization of a substrate comprising at least one hydroxyl function, in which one or more point regions of said surface are brought into contact with an ionic liquid matrix containing at least one reactive molecule, as it is known, that carries at least one reactive function, under conditions that are suitable for the creation of a covalent bond between said reactive function of the molecule and a hydroxyl function of said surface.
摘要翻译：本发明涉及一种可用于包含至少一个羟基官能团的基材的表面官能化的方法，其中所述表面的一个或多个点区域与含有至少一个反应性分子的离子液体基质接触，作为在适于在所述分子的反应性功能和所述表面的羟基官能团之间产生共价键的条件下，已知其具有至少一个反应性官能团。

8. 发明申请

US20130149196A1 Method for Functionalising Fluid Lines Contained in a Micromechanical Device, Micromechanical Device Including Functionalised Lines, and Method for Manufacturing Same 有权
标题翻译：包含在机械装置中的流体线的功能化方法，包括功能化线的微机械装置及其制造方法
公开(公告)号：US20130149196A1
公开(公告)日：2013-06-13
申请号：US13805491
申请日：2011-06-29
申请人： Vincent Agache , Antoine Hoang , Francoise Vinet
发明人： Vincent Agache , Antoine Hoang , Francoise Vinet
IPC分类号： G03F7/24
CPC分类号： G03F7/24 , B81B2201/0214 , B81B2201/058 , B81B2201/06 , B81C1/00206 , B81C2201/0154 , F04B19/006
摘要： The present invention relates to a method for functionalising fluid lines (1b) in a micromechanical device, the walls of which include an opaque layer. For this purpose, the invention provides a method for functionalising a micromechanical device provided with a fluid line including a peripheral wall (5) having a surface (2) outside the line and an inner surface (3) defining a space (1b) in which a fluid can circulate, the peripheral wall at least partially including a silicon layer (5a). The method includes the following steps: a) providing a device, the peripheral wall (5) of which at least partially includes a silicon layer (5a) having, at least locally, a thickness (e) of more than 100 nm and less than 200 nm, advantageously of 160 to 180 nm; c) silanising at least the inner surface of the fluid line; d) the localised, selective photo-deprotection on at least the inner surface of the silanised device by exposing the peripheral wall (5) at the point at which said wall has a thickness (e) of more than 100 nm and less than 200 nm, advantageously of 160 to 180 nm.
摘要翻译：本发明涉及一种在微机械装置中功能化流体管线（1b）的方法，其中壁部包括不透明层。为此，本发明提供了一种功能化微机械装置的方法，该微机械装置具有流体管线，该流体管线包括具有在管线外部的表面（2）的周壁（5）和限定空间（1b）的内表面（3），其中流体可以循环，周壁至少部分地包括硅层（5a）。该方法包括以下步骤：a）提供一种器件，其外围壁（5）至少部分地包括硅层（5a），该硅层至少局部地具有大于100nm的厚度（e）并且小于 200nm，有利地为160〜180nm; c）至少对流体管线的内表面进行硅烷化; d）通过在所述壁的厚度（e）大于100nm且小于200nm的点处暴露周壁（5），至少在硅烷化装置的内表面上进行局部选择性光 - 去保护，有利地为160至180nm。

9. 发明授权

US08093307B2 Silane compounds carrying a hydrazone or diazo functional group in order to functionalize solid supports and immobilize biological molecules on these supports 有权
标题翻译：携带腙或重氮官能团的硅烷化合物以使固体支持物官能化并将生物分子固定在这些载体上
公开(公告)号：US08093307B2
公开(公告)日：2012-01-10
申请号：US12299968
申请日：2007-05-18
申请人： Franck Martin , Antoine Hoang
发明人： Franck Martin , Antoine Hoang
IPC分类号： C08G61/04
CPC分类号： C07F7/1804
摘要： The invention relates to novel silane compounds corresponding to the following formula (I): in which R1 can represent a methyl group, R2 and R3 can represent a hydrogen atom, A can represent —O—, E can represent an alkylene group, X can represent a methoxysilane group, Z can represent a simple bond and Y can represent an —N2 or —N—NH2 group. Use of these silane compounds to functionalize solid supports and to immobilize biological molecules on these supports.
摘要翻译：本发明涉及对应于下式（I）的新型硅烷化合物：其中R1可以表示甲基，R2和R3可以表示氢原子，A可以表示-O-，E可以表示亚烷基，X可以表示甲氧基硅烷基，Z可以表示简单键，Y可以表示-N2或-N-NH2基。使用这些硅烷化合物将固体支持物官能化并将生物分子固定在这些载体上。

10. 发明申请

US20090208374A1 Novel silane compounds carrying a hydrazone or diazo functional group in order to functionalize solid supports and immobilize biological molecules on these supports 有权
标题翻译：携带腙或重氮官能团的新型硅烷化合物以使固体支持物官能化并将生物分子固定在这些载体上
公开(公告)号：US20090208374A1
公开(公告)日：2009-08-20
申请号：US12299968
申请日：2007-05-18
申请人： Franck Martin , Antoine Hoang
发明人： Franck Martin , Antoine Hoang
IPC分类号： C07F7/18 , B05D3/10 , G01N33/48
CPC分类号： C07F7/1804
摘要： The invention relates to novel silane compounds corresponding to the following formula (I): in which R1 can represent a methyl group, R2 and R3 can represent a hydrogen atom, A can represent —O—, E can represent an alkylene group, X can represent a methoxysilane group, Z can represent a simple bond and Y can represent an —N2 or —N—NH2 group.Use of these silane compounds to functionalize solid supports and to immobilize biological molecules on these supports.
摘要翻译：本发明涉及对应于下式（I）的新型硅烷化合物：其中R1可以表示甲基，R2和R3可以表示氢原子，A可以表示-O-，E可以表示亚烷基，X可以表示甲氧基硅烷基，Z可以表示简单键，Y可以表示-N2或-N-NH2基。使用这些硅烷化合物将固体支持物官能化并将生物分子固定在这些载体上。

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