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1. 发明授权

US6066459A Method for simultaneous detection of multiple fluorophores for in situ hybridization and multicolor chromosome painting and banding 失效
标题翻译：同时检测原位杂交和多色染色体绘制和条带的多种荧光团的方法
公开(公告)号：US6066459A
公开(公告)日：2000-05-23
申请号：US100104
申请日：1998-06-19
申请人： Yuval Garini , Dario Cabib , Robert A. Buckwald , Thomas Ried , Dirk G. Soenksen
发明人： Yuval Garini , Dario Cabib , Robert A. Buckwald , Thomas Ried , Dirk G. Soenksen
IPC分类号： C12N15/09 , C12Q1/68 , G01J3/02 , G01J3/12 , G01J3/26 , G01J3/28 , G01J3/44 , G01J3/453 , G01N21/64 , G01N33/50 , G01N33/569 , G01N33/58 , G02B21/16 , G06K9/00 , G06K9/76 , C07H21/04
CPC分类号： G01N21/6452 , C12Q1/6841 , C12Q1/6883 , G01J3/12 , G01J3/1256 , G01J3/26 , G01J3/2823 , G01J3/4406 , G01J3/453 , G01N21/6428 , G01N21/6458 , G01N33/5005 , G01N33/56966 , G01N33/582 , G06K9/00127 , G06K9/76 , C12Q2600/156 , G01J2003/2866 , G01J3/02 , G01N2021/6417 , G01N2021/6441
摘要： A spectral imaging method for simultaneous detection of multiple fluorophores aimed at detecting and analyzing fluorescent in situ hybridizations employing numerous chromosome paints and/or loci specific probes each labeled with a different fluorophore or a combination of fluorophores for color karyotyping, and at multicolor chromosome banding, wherein each chromosome acquires a specifying banding pattern, which pattern is established using groups of chromosome fragments labeled with various fluorophore or combinations of fluorophores.
摘要翻译：用于同时检测多个荧光团的光谱成像方法，其目的是检测和分析使用多种染色体涂料和/或基因座特异性探针的荧光原位杂交，每个染色体涂料和/或基因座特异性探针用不同的荧光团或用于颜色核型分析的荧光团的组合以及多色染色体条带标记，其中每个染色体获得指定的条带图案，使用由各种荧光团标记的染色体片段或荧光团的组合来建立该图案。

2. 发明授权

US5817462A Method for simultaneous detection of multiple fluorophores for in situ hybridization and multicolor chromosome painting and banding 失效
公开(公告)号：US5817462A
公开(公告)日：1998-10-06
申请号：US635820
申请日：1996-04-22
申请人： Yuval Garini , Dario Cabib , Robert A. Buckwald , Thomas Ried , Dirk G. Soenksen
发明人： Yuval Garini , Dario Cabib , Robert A. Buckwald , Thomas Ried , Dirk G. Soenksen
IPC分类号： C12N15/09 , C12Q1/68 , G01J3/02 , G01J3/12 , G01J3/26 , G01J3/28 , G01J3/44 , G01J3/453 , G01N21/64 , G01N33/50 , G01N33/569 , G01N33/58 , G02B21/16 , G06K9/00 , G06K9/76 , C07H23/00 , G02B21/00
CPC分类号： G01N21/6452 , C12Q1/6841 , C12Q1/6883 , G01J3/12 , G01J3/1256 , G01J3/26 , G01J3/2823 , G01J3/4406 , G01J3/453 , G01N21/6428 , G01N21/6458 , G01N33/5005 , G01N33/56966 , G01N33/582 , G06K9/00127 , G06K9/76 , C12Q2600/156 , G01J2003/2866 , G01J3/02 , G01N2021/6417 , G01N2021/6441
摘要： A spectral imaging method for simultaneous detection of multiple fluorophores aimed at detecting and analyzing fluorescent in situ hybridizations employing numerous chromosome paints and/or loci specific probes each labeled with a different fluorophore or a combination of fluorophores for color karyotyping, and at multicolor chromosome banding, wherein each chromosome acquires a specifying banding pattern, which pattern is established using groups of chromosome fragments labeled with various fluorophore or combinations of fluorophores.

3. 发明授权

US6055325A Color display of chromosomes or portions of chromosomes 失效
标题翻译：染色体或染色体部分的彩色显示
公开(公告)号：US6055325A
公开(公告)日：2000-04-25
申请号：US942327
申请日：1997-10-01
申请人： Yuval Garini , Dario Cabib , Robert A. Buckwald , Dirk G. Soenksen , Nir Katzir , David Wine , Moshe Lavi
发明人： Yuval Garini , Dario Cabib , Robert A. Buckwald , Dirk G. Soenksen , Nir Katzir , David Wine , Moshe Lavi
IPC分类号： G01B9/02 , A61B3/12 , A61B5/00 , C12Q1/68 , G01B11/06 , G01J3/02 , G01J3/12 , G01J3/26 , G01J3/28 , G01J3/44 , G01J3/453 , G01N21/27 , G01N21/64 , G01N33/48 , G01N33/50 , G01N33/569 , G01N33/58 , G06K9/00 , G06K9/76
CPC分类号： G01N21/6458 , A61B3/12 , C12Q1/6816 , C12Q1/6841 , C12Q1/6883 , G01B11/0675 , G01J3/12 , G01J3/1256 , G01J3/26 , G01J3/2823 , G01J3/4406 , G01J3/453 , G01J3/4535 , G01N21/6428 , G01N33/5005 , G01N33/56966 , G01N33/582 , G06K9/00127 , G06K9/76 , A61B3/1241 , C12Q2600/156 , G01J2003/2866 , G01J3/02 , G01N2021/6417 , G01N2021/6441
摘要： A color display comprising an image of all chromosomes or portions of chromosomes of a cell, each of the chromosomes or portions of chromosomes being painted with a different fluorophore or a combination of fluorophores, the image presenting the chromosomes or portions of chromosomes in different distinctive colors, wherein each of the chromosomes or portions of chromosomes is associated with one of the different distinctive colors.
摘要翻译：一种彩色显示器，其包括所有染色体或细胞染色体部分的图像，每个染色体或染色体部分用不同的荧光团或荧光团的组合进行染色，所述染色体或染色体的部分以不同的特征呈现其中每个染色体或染色体的部分与不同的独特颜色之一相关联。

4. 发明授权

US08055042B2 Fully automatic rapid microscope slide scanner 有权
公开(公告)号：US08055042B2
公开(公告)日：2011-11-08
申请号：US12344037
申请日：2008-12-24
申请人： Dirk G. Soenksen
发明人： Dirk G. Soenksen
IPC分类号： G06K9/00
CPC分类号： G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , G06F19/00 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
摘要： Apparatus for and method of fully automatic rapid scanning and digitizing of an entire microscope sample, or a substantially large portion of a microscope sample, using a linear array detector synchronized with a positioning stage that is part of a computer controlled microscope slide scanner. The invention provides a method for composing the image strips obtained from successive scans of the sample into a single contiguous digital image. The invention also provides a method for statically displaying sub-regions of this large digital image at different magnifications, together with a reduced magnification macro-image of the entire sample. The invention further provides a method for dynamically displaying, with or without operator interaction, portions of the contiguous digital image. In one preferred embodiment of the invention, all elements of the scanner are part of a single-enclosure that has a primary connection to the Internet or to a local intranet. In this embodiment, the preferred sample type is a microscope slide and the illumination and imaging optics are consistent with transmission mode optics optimized for diffraction-limited digital imaging.

5. 发明申请

US20100141753A1 Optimizing Virtual Slide Image Quality 有权
标题翻译：优化虚拟幻灯片图像质量
公开(公告)号：US20100141753A1
公开(公告)日：2010-06-10
申请号：US12711157
申请日：2010-02-23
申请人： Allen Olson , Kiran Saligrama , Dirk G. Soenksen
发明人： Allen Olson , Kiran Saligrama , Dirk G. Soenksen
IPC分类号： H04N7/18
CPC分类号： G02B21/245 , G02B21/002 , G02B21/244 , G02B21/365 , G02B21/367 , G06K9/40 , H04N5/23212
摘要： Systems and methods for assessing and optimizing virtual microscope slide image quality are provided. In order to determine whether a virtual slide image has any out of focus areas and is therefore a candidate for manual inspection, the various focus points used to scan the virtual slide image are used to calculate a best fit surface for the virtual slide image. The distance of each focus point from the best fit surface is then calculated and the largest distance is compared to a predetermined value. If the largest distance from a focus point to the best fit surface is larger than the predetermined value, then the virtual slide image is designated as needing a manual inspection and possible re-scan.
摘要翻译：提供了评估和优化虚拟显微镜载玻片图像质量的系统和方法。为了确定虚拟幻灯片图像是否具有任何偏离焦点区域，因此是用于手动检查的候选者，用于扫描虚拟幻灯片图像的各种对焦点用于计算虚拟幻灯片图像的最佳拟合曲面。然后计算每个对焦点与最佳拟合表面的距离，并将最大距离与预定值进行比较。如果从焦点到最佳配合曲面的最大距离大于预定值，则虚拟幻灯片图像被指定为需要手动检查和可能的重新扫描。

6. 发明授权

US07646495B2 System and computer readable medium for pre-focus of digital slides 有权
标题翻译：用于数字幻灯片预聚焦的系统和计算机可读介质
公开(公告)号：US07646495B2
公开(公告)日：2010-01-12
申请号：US12547386
申请日：2009-08-25
申请人： Allen Olsen , Greg Crandall , Dirk G. Soenksen
发明人： Allen Olsen , Greg Crandall , Dirk G. Soenksen
IPC分类号： G01B11/14
CPC分类号： G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , G06F19/00 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
摘要： Methods and apparatus are provided for computing focus information prior to scanning digital microscope slides with a line scan camera. The methods include a point-focus procedure that works by moving the slide to the desired measurement location, moving the objective lens through a predefined set of height values, acquiring imagery data at each height, and determining the height of maximum contrast. The methods also include a ribbon-focus procedure whereby imagery data are acquired continuously, while the slide and objective lens are in motion. Both methods may be applied with either a static or a dynamic implementation.
摘要翻译：提供了用扫描数字显微镜幻灯片与线扫描相机之前计算焦点信息的方法和装置。这些方法包括通过将滑块移动到期望的测量位置，通过预定义的一组高度值移动物镜，获取每个高度处的图像数据以及确定最大对比度的高度而起作用的点对焦过程。所述方法还包括色带聚焦程序，其中在幻灯片和物镜运动时连续获取图像数据。两种方法都可以应用于静态或动态实现。

7. 发明申请

US20090141126A1 Fully Automatic Rapid Microscope Slide Scanner 有权
标题翻译：全自动快速显微镜幻灯片
公开(公告)号：US20090141126A1
公开(公告)日：2009-06-04
申请号：US12344037
申请日：2008-12-24
申请人： Dirk G. Soenksen
发明人： Dirk G. Soenksen
IPC分类号： H04N7/18
CPC分类号： G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , G06F19/00 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
摘要： Apparatus for and method of fully automatic rapid scanning and digitizing of an entire microscope sample, or a substantially large portion of a microscope sample, using a linear array detector synchronized with a positioning stage that is part of a computer controlled microscope slide scanner. The invention provides a method for composing the image strips obtained from successive scans of the sample into a single contiguous digital image. The invention also provides a method for statically displaying sub-regions of this large digital image at different magnifications, together with a reduced magnification macro-image of the entire sample. The invention further provides a method for dynamically displaying, with or without operator interaction, portions of the contiguous digital image. In one preferred embodiment of the invention, all elements of the scanner are part of a single-enclosure that has a primary connection to the Internet or to a local intranet. In this embodiment, the preferred sample type is a microscope slide and the illumination and imaging optics are consistent with transmission mode optics optimized for diffraction-limited digital imaging.
摘要翻译：使用与作为计算机控制的显微镜幻灯片扫描器的一部分的定位台同步的线性阵列检测器，全自动快速扫描和数字化整个显微镜样品或显微镜样本的大部分的装置和方法。本发明提供了一种用于组合从样本的连续扫描获得的图像条带到单个邻接数字图像中的方法。本发明还提供了一种用于以不同放大率静态显示该大数字图像的子区域的方法，以及整个样本的缩小的放大宏图像。本发明还提供了一种用于在或不与操作者交互的情况下动态显示邻接数字图像的部分的方法。在本发明的一个优选实施例中，扫描器的所有元件都是具有到互联网或本地内部网的主要连接的单个外壳的一部分。在该实施例中，优选的样品类型是显微镜载玻片，并且照明和成像光学元件与针对衍射极限数字成像优化的透射模式光学元件一致。

8. 发明申请

US20090028414A1 Data Management in a Linear-Array-Based Microscope Slide Scanner 有权
标题翻译：基于线性阵列的显微镜幻灯片扫描仪中的数据管理
公开(公告)号：US20090028414A1
公开(公告)日：2009-01-29
申请号：US12235479
申请日：2008-09-22
申请人： Greg J. Crandall , Ole Eichhorn , Allen H. Olson , Dirk G. Soenksen
发明人： Greg J. Crandall , Ole Eichhorn , Allen H. Olson , Dirk G. Soenksen
IPC分类号： G06K9/00
CPC分类号： G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , G06F19/00 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
摘要： Systems and methods for processing, storing, and viewing extremely large imagery data rapidly produced by a linear-array-based microscope slide scanner are provided. The system receives, processes, and stores imagery data produced by the linear scanner as a series of overlapping image stripes and combines the data into a seamless and contiguous baseline image. The baseline image is logically mapped into a plurality of regions that are individually addressed to facilitate viewing and manipulation of the baseline image. The system enables dynamic imagery data compression while scanning and capturing new image stripes that eliminates the overhead associated with storing uncompressed image stripes. The system also creates intermediate level images, thereby organizing the baseline image into a variable level pyramid structure referred to as a virtual slide. The system facilitates the use of virtual slides in applications such as telemedicine, telepathology, microscopy education, and analysis of high value specimens like tissue arrays.
摘要翻译：提供了用于处理，存储和查看由基于线性阵列的显微镜幻灯片扫描仪快速生成的超大图像数据的系统和方法。该系统接收，处理和存储由线性扫描仪产生的图像数据作为一系列重叠的图像条纹，并将数据组合成无缝和连续的基线图像。基线图像被逻辑地映射到单独寻址的多个区域中，以便于观察和操纵基线图像。该系统能够在扫描和捕获新的图像条纹时消除与存储未压缩图像条纹相关的开销的动态图像数据压缩。该系统还创建中间级图像，从而将基线图像组织成称为虚拟幻灯片的可变级金字塔结构。该系统有助于虚拟幻灯片在诸如远程医疗，远程病理学，显微镜教育等应用中的使用，以及对组织阵列等高价值标本的分析。

9. 发明申请

US20120113242A1 Data Management in a Linear-Array-Based Microscope Slide Scanner 有权
标题翻译：基于线性阵列的显微镜幻灯片扫描仪中的数据管理
公开(公告)号：US20120113242A1
公开(公告)日：2012-05-10
申请号：US13347077
申请日：2012-01-10
申请人： Greg J. Crandall , Ole Eichhorn , Allen H. Olson , Dirk G. Soenksen
发明人： Greg J. Crandall , Ole Eichhorn , Allen H. Olson , Dirk G. Soenksen
IPC分类号： H04N7/18
CPC分类号： G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , G06F19/00 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
摘要： Systems and methods for processing, storing, and viewing extremely large imagery data rapidly produced by a linear-array-based microscope slide scanner are provided. The system receives, processes, and stores imagery data produced by the linear scanner as a series of overlapping image stripes and combines the data into a seamless and contiguous baseline image. The baseline image is logically mapped into a plurality of regions that are individually addressed to facilitate viewing and manipulation of the baseline image. The system enables dynamic imagery data compression while scanning and capturing new image stripes that eliminates the overhead associated with storing uncompressed image stripes. The system also creates intermediate level images, thereby organizing the baseline image into a variable level pyramid structure referred to as a virtual slide. The system facilitates the use of virtual slides in applications such as telemedicine, telepathology, microscopy education, and analysis of high value specimens like tissue arrays.
摘要翻译：提供了用于处理，存储和查看由基于线性阵列的显微镜幻灯片扫描仪快速生成的超大图像数据的系统和方法。该系统接收，处理和存储由线性扫描仪产生的图像数据作为一系列重叠的图像条纹，并将数据组合成无缝和连续的基线图像。基线图像被逻辑地映射到单独寻址的多个区域中，以便于观察和操纵基线图像。该系统能够在扫描和捕获新的图像条纹时消除与存储未压缩图像条纹相关的开销的动态图像数据压缩。该系统还创建中间级图像，从而将基线图像组织成称为虚拟幻灯片的可变级金字塔结构。该系统有助于虚拟幻灯片在诸如远程医疗，远程病理学，显微镜教育等应用中的使用，以及对组织阵列等高价值标本的分析。

10. 发明申请

US20110037847A1 Fully Automatic Rapid Microscope Slide Scanner 有权
标题翻译：全自动快速显微镜幻灯片
公开(公告)号：US20110037847A1
公开(公告)日：2011-02-17
申请号：US12910696
申请日：2010-10-22
申请人： Dirk G. Soenksen
发明人： Dirk G. Soenksen
IPC分类号： H04N7/18
CPC分类号： G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , G06F19/00 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
摘要： Apparatus for and method of fully automatic rapid scanning and digitizing of an entire microscope sample, or a substantially large portion of a microscope sample, using a linear array detector synchronized with a positioning stage that is part of a computer controlled microscope slide scanner. The invention provides a method for composing the image strips obtained from successive scans of the sample into a single contiguous digital image. The invention also provides a method for statically displaying sub-regions of this large digital image at different magnifications, together with a reduced magnification macro-image of the entire sample. The invention further provides a method for dynamically displaying, with or without operator interaction, portions of the contiguous digital image. In one preferred embodiment of the invention, all elements of the scanner are part of a single-enclosure that has a primary connection to the Internet or to a local intranet. In this embodiment, the preferred sample type is a microscope slide and the illumination and imaging optics are consistent with transmission mode optics optimized for diffraction-limited digital imaging.
摘要翻译：使用与作为计算机控制的显微镜幻灯片扫描器的一部分的定位台同步的线性阵列检测器，全自动快速扫描和数字化整个显微镜样品或显微镜样本的大部分的装置和方法。本发明提供了一种用于组合从样本的连续扫描获得的图像条带到单个邻接数字图像中的方法。本发明还提供了一种用于以不同放大率静态显示该大数字图像的子区域的方法，以及整个样本的缩小的放大宏图像。本发明还提供了一种用于在或不与操作者交互的情况下动态显示邻接数字图像的部分的方法。在本发明的一个优选实施例中，扫描器的所有元件都是具有到互联网或本地内部网的主要连接的单个外壳的一部分。在该实施例中，优选的样品类型是显微镜载玻片，并且照明和成像光学元件与针对衍射极限数字成像优化的透射模式光学元件一致。

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