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1. 发明授权

US08055042B2 Fully automatic rapid microscope slide scanner 有权
公开(公告)号：US08055042B2
公开(公告)日：2011-11-08
申请号：US12344037
申请日：2008-12-24
申请人： Dirk G. Soenksen
发明人： Dirk G. Soenksen
IPC分类号： G06K9/00
CPC分类号： G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , G06F19/00 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
摘要： Apparatus for and method of fully automatic rapid scanning and digitizing of an entire microscope sample, or a substantially large portion of a microscope sample, using a linear array detector synchronized with a positioning stage that is part of a computer controlled microscope slide scanner. The invention provides a method for composing the image strips obtained from successive scans of the sample into a single contiguous digital image. The invention also provides a method for statically displaying sub-regions of this large digital image at different magnifications, together with a reduced magnification macro-image of the entire sample. The invention further provides a method for dynamically displaying, with or without operator interaction, portions of the contiguous digital image. In one preferred embodiment of the invention, all elements of the scanner are part of a single-enclosure that has a primary connection to the Internet or to a local intranet. In this embodiment, the preferred sample type is a microscope slide and the illumination and imaging optics are consistent with transmission mode optics optimized for diffraction-limited digital imaging.

2. 发明申请

US20100141753A1 Optimizing Virtual Slide Image Quality 有权
标题翻译：优化虚拟幻灯片图像质量
公开(公告)号：US20100141753A1
公开(公告)日：2010-06-10
申请号：US12711157
申请日：2010-02-23
申请人： Allen Olson , Kiran Saligrama , Dirk G. Soenksen
发明人： Allen Olson , Kiran Saligrama , Dirk G. Soenksen
IPC分类号： H04N7/18
CPC分类号： G02B21/245 , G02B21/002 , G02B21/244 , G02B21/365 , G02B21/367 , G06K9/40 , H04N5/23212
摘要： Systems and methods for assessing and optimizing virtual microscope slide image quality are provided. In order to determine whether a virtual slide image has any out of focus areas and is therefore a candidate for manual inspection, the various focus points used to scan the virtual slide image are used to calculate a best fit surface for the virtual slide image. The distance of each focus point from the best fit surface is then calculated and the largest distance is compared to a predetermined value. If the largest distance from a focus point to the best fit surface is larger than the predetermined value, then the virtual slide image is designated as needing a manual inspection and possible re-scan.
摘要翻译：提供了评估和优化虚拟显微镜载玻片图像质量的系统和方法。为了确定虚拟幻灯片图像是否具有任何偏离焦点区域，因此是用于手动检查的候选者，用于扫描虚拟幻灯片图像的各种对焦点用于计算虚拟幻灯片图像的最佳拟合曲面。然后计算每个对焦点与最佳拟合表面的距离，并将最大距离与预定值进行比较。如果从焦点到最佳配合曲面的最大距离大于预定值，则虚拟幻灯片图像被指定为需要手动检查和可能的重新扫描。

3. 发明授权

US07646495B2 System and computer readable medium for pre-focus of digital slides 有权
标题翻译：用于数字幻灯片预聚焦的系统和计算机可读介质
公开(公告)号：US07646495B2
公开(公告)日：2010-01-12
申请号：US12547386
申请日：2009-08-25
申请人： Allen Olsen , Greg Crandall , Dirk G. Soenksen
发明人： Allen Olsen , Greg Crandall , Dirk G. Soenksen
IPC分类号： G01B11/14
CPC分类号： G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , G06F19/00 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
摘要： Methods and apparatus are provided for computing focus information prior to scanning digital microscope slides with a line scan camera. The methods include a point-focus procedure that works by moving the slide to the desired measurement location, moving the objective lens through a predefined set of height values, acquiring imagery data at each height, and determining the height of maximum contrast. The methods also include a ribbon-focus procedure whereby imagery data are acquired continuously, while the slide and objective lens are in motion. Both methods may be applied with either a static or a dynamic implementation.
摘要翻译：提供了用扫描数字显微镜幻灯片与线扫描相机之前计算焦点信息的方法和装置。这些方法包括通过将滑块移动到期望的测量位置，通过预定义的一组高度值移动物镜，获取每个高度处的图像数据以及确定最大对比度的高度而起作用的点对焦过程。所述方法还包括色带聚焦程序，其中在幻灯片和物镜运动时连续获取图像数据。两种方法都可以应用于静态或动态实现。

4. 发明申请

US20090141126A1 Fully Automatic Rapid Microscope Slide Scanner 有权
标题翻译：全自动快速显微镜幻灯片
公开(公告)号：US20090141126A1
公开(公告)日：2009-06-04
申请号：US12344037
申请日：2008-12-24
申请人： Dirk G. Soenksen
发明人： Dirk G. Soenksen
IPC分类号： H04N7/18
CPC分类号： G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , G06F19/00 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
摘要： Apparatus for and method of fully automatic rapid scanning and digitizing of an entire microscope sample, or a substantially large portion of a microscope sample, using a linear array detector synchronized with a positioning stage that is part of a computer controlled microscope slide scanner. The invention provides a method for composing the image strips obtained from successive scans of the sample into a single contiguous digital image. The invention also provides a method for statically displaying sub-regions of this large digital image at different magnifications, together with a reduced magnification macro-image of the entire sample. The invention further provides a method for dynamically displaying, with or without operator interaction, portions of the contiguous digital image. In one preferred embodiment of the invention, all elements of the scanner are part of a single-enclosure that has a primary connection to the Internet or to a local intranet. In this embodiment, the preferred sample type is a microscope slide and the illumination and imaging optics are consistent with transmission mode optics optimized for diffraction-limited digital imaging.
摘要翻译：使用与作为计算机控制的显微镜幻灯片扫描器的一部分的定位台同步的线性阵列检测器，全自动快速扫描和数字化整个显微镜样品或显微镜样本的大部分的装置和方法。本发明提供了一种用于组合从样本的连续扫描获得的图像条带到单个邻接数字图像中的方法。本发明还提供了一种用于以不同放大率静态显示该大数字图像的子区域的方法，以及整个样本的缩小的放大宏图像。本发明还提供了一种用于在或不与操作者交互的情况下动态显示邻接数字图像的部分的方法。在本发明的一个优选实施例中，扫描器的所有元件都是具有到互联网或本地内部网的主要连接的单个外壳的一部分。在该实施例中，优选的样品类型是显微镜载玻片，并且照明和成像光学元件与针对衍射极限数字成像优化的透射模式光学元件一致。

5. 发明申请

US20090028414A1 Data Management in a Linear-Array-Based Microscope Slide Scanner 有权
标题翻译：基于线性阵列的显微镜幻灯片扫描仪中的数据管理
公开(公告)号：US20090028414A1
公开(公告)日：2009-01-29
申请号：US12235479
申请日：2008-09-22
申请人： Greg J. Crandall , Ole Eichhorn , Allen H. Olson , Dirk G. Soenksen
发明人： Greg J. Crandall , Ole Eichhorn , Allen H. Olson , Dirk G. Soenksen
IPC分类号： G06K9/00
CPC分类号： G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , G06F19/00 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
摘要： Systems and methods for processing, storing, and viewing extremely large imagery data rapidly produced by a linear-array-based microscope slide scanner are provided. The system receives, processes, and stores imagery data produced by the linear scanner as a series of overlapping image stripes and combines the data into a seamless and contiguous baseline image. The baseline image is logically mapped into a plurality of regions that are individually addressed to facilitate viewing and manipulation of the baseline image. The system enables dynamic imagery data compression while scanning and capturing new image stripes that eliminates the overhead associated with storing uncompressed image stripes. The system also creates intermediate level images, thereby organizing the baseline image into a variable level pyramid structure referred to as a virtual slide. The system facilitates the use of virtual slides in applications such as telemedicine, telepathology, microscopy education, and analysis of high value specimens like tissue arrays.
摘要翻译：提供了用于处理，存储和查看由基于线性阵列的显微镜幻灯片扫描仪快速生成的超大图像数据的系统和方法。该系统接收，处理和存储由线性扫描仪产生的图像数据作为一系列重叠的图像条纹，并将数据组合成无缝和连续的基线图像。基线图像被逻辑地映射到单独寻址的多个区域中，以便于观察和操纵基线图像。该系统能够在扫描和捕获新的图像条纹时消除与存储未压缩图像条纹相关的开销的动态图像数据压缩。该系统还创建中间级图像，从而将基线图像组织成称为虚拟幻灯片的可变级金字塔结构。该系统有助于虚拟幻灯片在诸如远程医疗，远程病理学，显微镜教育等应用中的使用，以及对组织阵列等高价值标本的分析。

6. 发明授权

US6055325A Color display of chromosomes or portions of chromosomes 失效
标题翻译：染色体或染色体部分的彩色显示
公开(公告)号：US6055325A
公开(公告)日：2000-04-25
申请号：US942327
申请日：1997-10-01
申请人： Yuval Garini , Dario Cabib , Robert A. Buckwald , Dirk G. Soenksen , Nir Katzir , David Wine , Moshe Lavi
发明人： Yuval Garini , Dario Cabib , Robert A. Buckwald , Dirk G. Soenksen , Nir Katzir , David Wine , Moshe Lavi
IPC分类号： G01B9/02 , A61B3/12 , A61B5/00 , C12Q1/68 , G01B11/06 , G01J3/02 , G01J3/12 , G01J3/26 , G01J3/28 , G01J3/44 , G01J3/453 , G01N21/27 , G01N21/64 , G01N33/48 , G01N33/50 , G01N33/569 , G01N33/58 , G06K9/00 , G06K9/76
CPC分类号： G01N21/6458 , A61B3/12 , C12Q1/6816 , C12Q1/6841 , C12Q1/6883 , G01B11/0675 , G01J3/12 , G01J3/1256 , G01J3/26 , G01J3/2823 , G01J3/4406 , G01J3/453 , G01J3/4535 , G01N21/6428 , G01N33/5005 , G01N33/56966 , G01N33/582 , G06K9/00127 , G06K9/76 , A61B3/1241 , C12Q2600/156 , G01J2003/2866 , G01J3/02 , G01N2021/6417 , G01N2021/6441
摘要： A color display comprising an image of all chromosomes or portions of chromosomes of a cell, each of the chromosomes or portions of chromosomes being painted with a different fluorophore or a combination of fluorophores, the image presenting the chromosomes or portions of chromosomes in different distinctive colors, wherein each of the chromosomes or portions of chromosomes is associated with one of the different distinctive colors.
摘要翻译：一种彩色显示器，其包括所有染色体或细胞染色体部分的图像，每个染色体或染色体部分用不同的荧光团或荧光团的组合进行染色，所述染色体或染色体的部分以不同的特征呈现其中每个染色体或染色体的部分与不同的独特颜色之一相关联。

7. 发明申请

US20120113242A1 Data Management in a Linear-Array-Based Microscope Slide Scanner 有权
标题翻译：基于线性阵列的显微镜幻灯片扫描仪中的数据管理
公开(公告)号：US20120113242A1
公开(公告)日：2012-05-10
申请号：US13347077
申请日：2012-01-10
申请人： Greg J. Crandall , Ole Eichhorn , Allen H. Olson , Dirk G. Soenksen
发明人： Greg J. Crandall , Ole Eichhorn , Allen H. Olson , Dirk G. Soenksen
IPC分类号： H04N7/18
CPC分类号： G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , G06F19/00 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
摘要： Systems and methods for processing, storing, and viewing extremely large imagery data rapidly produced by a linear-array-based microscope slide scanner are provided. The system receives, processes, and stores imagery data produced by the linear scanner as a series of overlapping image stripes and combines the data into a seamless and contiguous baseline image. The baseline image is logically mapped into a plurality of regions that are individually addressed to facilitate viewing and manipulation of the baseline image. The system enables dynamic imagery data compression while scanning and capturing new image stripes that eliminates the overhead associated with storing uncompressed image stripes. The system also creates intermediate level images, thereby organizing the baseline image into a variable level pyramid structure referred to as a virtual slide. The system facilitates the use of virtual slides in applications such as telemedicine, telepathology, microscopy education, and analysis of high value specimens like tissue arrays.
摘要翻译：提供了用于处理，存储和查看由基于线性阵列的显微镜幻灯片扫描仪快速生成的超大图像数据的系统和方法。该系统接收，处理和存储由线性扫描仪产生的图像数据作为一系列重叠的图像条纹，并将数据组合成无缝和连续的基线图像。基线图像被逻辑地映射到单独寻址的多个区域中，以便于观察和操纵基线图像。该系统能够在扫描和捕获新的图像条纹时消除与存储未压缩图像条纹相关的开销的动态图像数据压缩。该系统还创建中间级图像，从而将基线图像组织成称为虚拟幻灯片的可变级金字塔结构。该系统有助于虚拟幻灯片在诸如远程医疗，远程病理学，显微镜教育等应用中的使用，以及对组织阵列等高价值标本的分析。

8. 发明申请

US20110037847A1 Fully Automatic Rapid Microscope Slide Scanner 有权
标题翻译：全自动快速显微镜幻灯片
公开(公告)号：US20110037847A1
公开(公告)日：2011-02-17
申请号：US12910696
申请日：2010-10-22
申请人： Dirk G. Soenksen
发明人： Dirk G. Soenksen
IPC分类号： H04N7/18
CPC分类号： G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , G06F19/00 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
摘要： Apparatus for and method of fully automatic rapid scanning and digitizing of an entire microscope sample, or a substantially large portion of a microscope sample, using a linear array detector synchronized with a positioning stage that is part of a computer controlled microscope slide scanner. The invention provides a method for composing the image strips obtained from successive scans of the sample into a single contiguous digital image. The invention also provides a method for statically displaying sub-regions of this large digital image at different magnifications, together with a reduced magnification macro-image of the entire sample. The invention further provides a method for dynamically displaying, with or without operator interaction, portions of the contiguous digital image. In one preferred embodiment of the invention, all elements of the scanner are part of a single-enclosure that has a primary connection to the Internet or to a local intranet. In this embodiment, the preferred sample type is a microscope slide and the illumination and imaging optics are consistent with transmission mode optics optimized for diffraction-limited digital imaging.
摘要翻译：使用与作为计算机控制的显微镜幻灯片扫描器的一部分的定位台同步的线性阵列检测器，全自动快速扫描和数字化整个显微镜样品或显微镜样本的大部分的装置和方法。本发明提供了一种用于组合从样本的连续扫描获得的图像条带到单个邻接数字图像中的方法。本发明还提供了一种用于以不同放大率静态显示该大数字图像的子区域的方法，以及整个样本的缩小的放大宏图像。本发明还提供了一种用于在或不与操作者交互的情况下动态显示邻接数字图像的部分的方法。在本发明的一个优选实施例中，扫描器的所有元件都是具有到互联网或本地内部网的主要连接的单个外壳的一部分。在该实施例中，优选的样品类型是显微镜载玻片，并且照明和成像光学元件与针对衍射极限数字成像优化的透射模式光学元件一致。

9. 发明授权

US07502519B2 Systems and methods for image pattern recognition 有权
标题翻译：图像模式识别的系统和方法
公开(公告)号：US07502519B2
公开(公告)日：2009-03-10
申请号：US11836713
申请日：2007-08-09
申请人： Ole Eichhorn , Dirk G. Soenksen
发明人： Ole Eichhorn , Dirk G. Soenksen
IPC分类号： G06K9/36 , G06K9/00
CPC分类号： G06K9/6218 , G06K9/00147 , G06T9/008 , G06T9/40 , H04N19/94 , H04N19/96
摘要： Systems and methods for image pattern recognition comprise digital image capture and encoding using vector quantization (“VQ”) of the image. A vocabulary of vectors is built by segmenting images into kernels and creating vectors corresponding to each kernel. Images are encoded by creating a vector index file having indices that point to the vectors stored in the vocabulary. The vector index file can be used to reconstruct an image by looking up vectors stored in the vocabulary. Pattern recognition of candidate regions of images can be accomplished by correlating image vectors to a pre-trained vocabulary of vector sets comprising vectors that correlate with particular image characteristics. In virtual microscopy, the systems and methods are suitable for rare-event finding, such as detection of micrometastasis clusters, tissue identification, such as locating regions of analysis for immunohistochemical assays, and rapid screening of tissue samples, such as histology sections arranged as tissue microarrays (TMAs).
摘要翻译：用于图像模式识别的系统和方法包括使用图像的矢量量化（“VQ”）的数字图像捕获和编码。通过将图像分割为内核并创建与每个内核相对应的向量来构建向量的词汇表。通过创建具有指向存储在词汇表中的向量的索引的向量索引文件对图像进行编码。向量索引文件可用于通过查找存储在词汇表中的向量来重建图像。可以通过将图像向量与包括与特定图像特征相关的向量的预先训练的矢量集合的词汇相关联来实现图像候选区域的模式识别。在虚拟显微镜中，系统和方法适用于罕见事件发现，例如检测微转移簇，组织鉴定，例如免疫组织化学测定的分析区域以及组织样品的快速筛选，例如排列成组织的组织切片微阵列（TMA）。

10. 发明授权

US07428324B2 System and method for data management in a linear-array-based microscope slide scanner 有权
标题翻译：基于线性阵列的显微镜幻灯片扫描仪的数据管理系统和方法
公开(公告)号：US07428324B2
公开(公告)日：2008-09-23
申请号：US11379648
申请日：2006-04-21
申请人： Greg J. Crandall , Ole Eichhorn , Allen H. Olson , Dirk G. Soenksen
发明人： Greg J. Crandall , Ole Eichhorn , Allen H. Olson , Dirk G. Soenksen
IPC分类号： G06K9/00
CPC分类号： G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , G06F19/00 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
摘要： A data management system and method for processing, storing, and viewing the extremely large imagery data that is rapidly produced by a linear-array-based microscope slide scanner is provided. The system receives, processes, and stores imagery data produced by the linear-array-based microscope slide scanner at approximately 3 GB per minute. The data are received as a series of overlapping image stripes and combined into a seamless and contiguous baseline image. The baseline image is logically mapped into a plurality of regions that are individually addressed to facilitate viewing and manipulation of the baseline image. The data management system enables imagery data compression while scanning and capturing new image stripes. This advantageously eliminates the overhead associated with storing uncompressed image stripes. The image compression also creates intermediate level images, thereby organizing the baseline image into a variable level pyramid structure referred to as a virtual slide. The data management system efficiently converts image stripes into a high quality virtual slide that allows rapid panning and zooming by image viewing software in accordance with the individually addressed regions. The virtual slide also allows efficient processing by an algorithm framework. The data management system is costs effective and saleable, employs standard image file formats and supports the use of virtual slides in desirable applications such as telemedicine, telepath logy, microscopy education, and the analysis of high value specimens such as tissue arrays.
摘要翻译：提供了一种用于处理，存储和查看由基于线性阵列的显微镜幻灯片扫描仪快速产生的极大图像数据的数据管理系统和方法。系统以每分钟3 GB的速度接收，处理和存储由基于线性阵列的显微镜幻灯片扫描仪生成的图像数据。数据被接收为一系列重叠的图像条纹并组合成无缝和连续的基线图像。基线图像被逻辑地映射到单独寻址的多个区域中，以便于观察和操纵基线图像。数据管理系统在扫描和捕获新的图像条纹时可以进行图像数据压缩。这有利地消除了与存储未压缩图像条纹相关联的开销。图像压缩还创建中间级图像，从而将基线图像组织成称为虚拟幻灯片的可变级金字塔结构。数据管理系统有效地将图像条纹转换成高质量的虚拟幻灯片，其允许通过图像查看软件根据单独寻址的区域进行快速平移和缩放。虚拟幻灯片还允许通过算法框架进行有效的处理。数据管理系统具有成本效益和可销售性，采用标准图像文件格式，并支持虚拟幻灯片在理想应用中的使用，如远程医疗，远程信息逻辑，显微镜教育，以及高价值标本（如组织阵列）的分析。

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