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1. 发明授权

US08705825B2 Signal to noise ratio in digital pathology image analysis 有权
标题翻译：数字病理图像分析中的信噪比
公开(公告)号：US08705825B2
公开(公告)日：2014-04-22
申请号：US13370124
申请日：2012-02-09
申请人： Allen Olson , Ole Eichhorn
发明人： Allen Olson , Ole Eichhorn
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06F19/00 , G06F19/321 , G06T2207/10056 , G06T2207/30024
摘要： A digital slide analysis system comprises an algorithm server that maintains or has access to a plurality of image processing and analysis routines. The algorithm server additionally has access to a plurality of digital slide images. The algorithm server executes a selected routine on an identified digital slide and provides the resulting data. Prior to the application of selected routine, the system employs a digital pre-processing module to create a metadata mask that reduces undesirable image data such that the image data processed by the selected routine has an improved signal to noise ratio. The pre-processing module uses a classifier that may be implemented as a pattern recognition module, for example. Undesirable image data is therefore excluded from the image data that is processed by the digital pathology image processing and analysis routine, which significantly improves the digital pathology image analysis.
摘要翻译：数字幻灯片分析系统包括维护或者可以访问多个图像处理和分析程序的算法服务器。算法服务器还可以访问多个数字幻灯片图像。算法服务器在识别的数字幻灯片上执行所选择的例程，并提供所得到的数据。在应用所选程序之前，系统采用数字预处理模块来创建一个减少不需要的图像数据的元数据掩码，使得由所选程序处理的图像数据具有改善的信噪比。预处理模块使用例如可以被实现为模式识别模块的分类器。因此，不希望的图像数据被排除在由数字病理图像处理和分析程序处理的图像数据中，这显着地改善了数字病理图像分析。

2. 发明授权

US08456522B2 Achieving focus in a digital pathology system 有权
标题翻译：实现数字病理系统的重点
公开(公告)号：US08456522B2
公开(公告)日：2013-06-04
申请号：US13031994
申请日：2011-02-22
申请人： Allen Olson , Greg Crandall , Dirk G. Soenksen
发明人： Allen Olson , Greg Crandall , Dirk G. Soenksen
IPC分类号： H04N7/18 , G03B13/00
CPC分类号： G02B21/365 , G02B21/002 , G02B21/244
摘要： Methods and apparatus are provided for computing focus information prior to scanning digital microscope slide data with a line scan camera. The methods include a point-focus procedure that works by moving the slide to the desired measurement location, moving the objective lens through a predefined set of height values, acquiring imagery data at each height, and determining the height of maximum contrast. The methods also include a ribbon-focus procedure whereby imagery data are acquired continuously, while the slide and objective lens are in motion. Both methods may be applied with either a static or a dynamic implementation.
摘要翻译：提供了使用线扫描相机扫描数字显微镜幻灯片数据之前计算焦点信息的方法和装置。这些方法包括通过将滑块移动到期望的测量位置，通过预定义的一组高度值移动物镜，获取每个高度处的图像数据以及确定最大对比度的高度而起作用的点对焦过程。所述方法还包括色带聚焦程序，其中在幻灯片和物镜运动时连续获取图像数据。两种方法都可以应用于静态或动态实现。

3. 发明申请

US20120281931A1 Image Processing and Analysis Framework 有权
标题翻译：图像处理与分析框架
公开(公告)号：US20120281931A1
公开(公告)日：2012-11-08
申请号：US13494715
申请日：2012-06-12
申请人： Ole Eichhorn , Allen Olson
发明人： Ole Eichhorn , Allen Olson
IPC分类号： G06K9/36
CPC分类号： G06K9/46 , G06T1/00
摘要： A system and method for processing and analyzing virtual microscopy digital images (“digital slides”) is provided. The system comprises an algorithm server that accesses a plurality of image processing and analysis routines. The algorithm server additionally accesses a plurality of digital slides. The algorithm server executes a selected routine on an identified digital slide and provides the resulting data. The digital slide is accessed locally or remotely across a network. Similarly, the image processing and analysis routines are accessed locally or remotely across a network, or both. Advantageously, certain common sub-routines may be stored locally for inclusion in other local or remotely accessed routines. Use of image processing and analysis routines may be restricted through a monitor process that authenticates requests to process or view digital slides. Variations in restrictions to images provide rich diversity in access levels that allow sharing of digital slides and demonstrations of image processing algorithms.
摘要翻译：提供了一种用于处理和分析虚拟显微数字图像（数字幻灯片）的系统和方法。该系统包括访问多个图像处理和分析例程的算法服务器。算法服务器还访问多个数字幻灯片。算法服务器在识别的数字幻灯片上执行所选择的例程，并提供所得到的数据。数字幻灯片可以通过网络在本地或远程访问。类似地，图像处理和分析例程通过网络本地或远程访问，或两者兼而有之。有利地，某些公共子例程可以被本地存储以包含在其他本地或远程访问的例程中。图像处理和分析程序的使用可能会通过对进程或查看数字幻灯片的请求进行验证的监视进程来限制。对图像限制的变化提供了访问级别丰富的多样性，允许共享数字幻灯片和图像处理算法的演示。

4. 发明授权

US07893988B2 Method for pre-focus of digital slides 有权
标题翻译：数字幻灯片预聚焦方法
公开(公告)号：US07893988B2
公开(公告)日：2011-02-22
申请号：US12423571
申请日：2009-04-14
申请人： Allen Olson , Greg Crandall , Dirk G. Soenksen
发明人： Allen Olson , Greg Crandall , Dirk G. Soenksen
IPC分类号： H04N5/232 , G06K9/00
CPC分类号： G02B21/365 , G02B21/002 , G02B21/244
摘要： Methods and apparatus are provided for computing focus information prior to scanning digital microscope slides with a line scan camera. The methods include a point-focus procedure that works by moving the slide to the desired measurement location, moving the objective lens through a predefined set of height values, acquiring imagery data at each height, and determining the height of maximum contrast. The methods also include a ribbon-focus procedure whereby imagery data are acquired continuously, while the slide and objective lens are in motion. Both methods may be applied with either a static or a dynamic implementation.
摘要翻译：提供了用扫描数字显微镜幻灯片与线扫描相机之前计算焦点信息的方法和装置。这些方法包括通过将滑块移动到期望的测量位置，通过预定义的一组高度值移动物镜，获取每个高度处的图像数据以及确定最大对比度的高度而起作用的点对焦过程。所述方法还包括色带聚焦程序，其中在幻灯片和物镜运动时连续获取图像数据。两种方法都可以应用于静态或动态实现。

5. 发明授权

US07668362B2 System and method for assessing virtual slide image quality 有权
标题翻译：用于评估虚拟幻灯片图像质量的系统和方法
公开(公告)号：US07668362B2
公开(公告)日：2010-02-23
申请号：US11140589
申请日：2005-05-26
申请人： Allen Olson , Kiran Saligrama , Dirk G. Soenksen
发明人： Allen Olson , Kiran Saligrama , Dirk G. Soenksen
IPC分类号： G06K9/00
CPC分类号： G02B21/245 , G02B21/002 , G02B21/244 , G02B21/365 , G02B21/367 , G06K9/40 , H04N5/23212
摘要： Systems and methods for assessing virtual microscope slide image quality are provided. In order to determine whether a virtual slide image has any out of focus areas and is therefore a candidate for manual inspection, the various focus points used to scan the virtual slide image are used to calculate a best fit surface for the virtual slide image. The distance of each focus point from the best fit surface is then calculated and the largest distance is compared to a predetermined value. If the largest distance from a focus point to the best fit surface is larger than the predetermined value, then the virtual slide image is designated as needing a manual inspection and possible re-scan.
摘要翻译：提供了评估虚拟显微镜幻灯片图像质量的系统和方法。为了确定虚拟幻灯片图像是否具有任何偏离焦点区域，因此是用于手动检查的候选者，用于扫描虚拟幻灯片图像的各种对焦点用于计算虚拟幻灯片图像的最佳拟合曲面。然后计算每个对焦点与最佳拟合表面的距离，并将最大距离与预定值进行比较。如果从焦点到最佳配合曲面的最大距离大于预定值，则虚拟幻灯片图像被指定为需要手动检查和可能的重新扫描。

6. 发明申请

US20100027856A1 Method for Pre-focus of Digital Slides 有权
标题翻译：数字幻灯片预聚焦方法
公开(公告)号：US20100027856A1
公开(公告)日：2010-02-04
申请号：US12423571
申请日：2009-04-14
申请人： Allen Olson , Greg Crandall , Dirk G. Soenksen
发明人： Allen Olson , Greg Crandall , Dirk G. Soenksen
IPC分类号： G06K9/00
CPC分类号： G02B21/365 , G02B21/002 , G02B21/244
摘要： Methods and apparatus are provided for computing focus information prior to scanning digital microscope slides with a line scan camera. The methods include a point-focus procedure that works by moving the slide to the desired measurement location, moving the objective lens through a predefined set of height values, acquiring imagery data at each height, and determining the height of maximum contrast. The methods also include a ribbon-focus procedure whereby imagery data are acquired continuously, while the slide and objective lens are in motion. Both methods may be applied with either a static or a dynamic implementation.
摘要翻译：提供了用扫描数字显微镜幻灯片与线扫描相机之前计算焦点信息的方法和装置。这些方法包括通过将滑块移动到期望的测量位置，通过预定义的一组高度值移动物镜，获取每个高度处的图像数据以及确定最大对比度的高度而起作用的点对焦过程。所述方法还包括色带聚焦程序，其中在幻灯片和物镜运动时连续获取图像数据。两种方法都可以应用于静态或动态实现。

7. 发明授权

US07518652B2 Method and apparatus for pre-focus in a linear array based slide scanner 有权
标题翻译：用于基于线性阵列的幻灯片扫描仪中预聚焦的方法和装置
公开(公告)号：US07518652B2
公开(公告)日：2009-04-14
申请号：US10827207
申请日：2004-04-16
申请人： Allen Olson , Greg Crandall , Dirk G. Soenksen
发明人： Allen Olson , Greg Crandall , Dirk G. Soenksen
IPC分类号： H04N5/232 , H04N7/18
CPC分类号： G02B21/365 , G02B21/002 , G02B21/244
摘要： Methods and apparatus are provided for computing focus information prior to scanning microscope slides with a line scan camera. The methods include a point-focus procedure that works by moving the slide to the desired measurement location, moving the objective lens through a predefined set of height values, acquiring imagery data at each height, and determining the height of maximum contrast. The methods also include a ribbon-focus procedure whereby imagery data are acquired continuously, while the slide and objective lens are in motion. Both methods may be applied with either a static or a dynamic implementation.
摘要翻译：提供用于在使用线扫描相机扫描显微镜幻灯片之前计算焦点信息的方法和装置。这些方法包括通过将滑块移动到期望的测量位置，通过预定义的一组高度值移动物镜，获取每个高度处的图像数据以及确定最大对比度的高度而起作用的点对焦过程。所述方法还包括色带聚焦程序，其中在幻灯片和物镜运动时连续获取图像数据。两种方法都可以应用于静态或动态实现。

8. 发明授权

US06673645B2 Method and apparatus for a monolithic integrated mesfet and p-i-n optical receiver 失效
标题翻译：单片集成滤波器和p-i-n光接收机的方法和装置
公开(公告)号：US06673645B2
公开(公告)日：2004-01-06
申请号：US10142093
申请日：2002-05-08
申请人： Randolph B. Heineke , William K. Hogan , Scott Allen Olson , Clint Lee Schow
发明人： Randolph B. Heineke , William K. Hogan , Scott Allen Olson , Clint Lee Schow
IPC分类号： H01L2100
CPC分类号： H01L31/105 , H01L27/1443 , H01L31/03529 , Y02E10/50
摘要： Disclosed is a semiconductor structure and manufacturing process for making an integrated FET and photodetector optical receiver on a semiconductor substrate. A FET is formed by forming at least one p channel in a p-well of the substrate and forming at least one n channel in the p-well of the substrate. A p-i-n photodetector is formed in the substrate by forming at least one p channel in an absorption region of the substrate when forming the at least one p channel in the p well of the FET and forming at least one n channel in the absorption region of the substrate when forming the at least one n channel in the p-well of the FET.
摘要翻译：公开了用于在半导体衬底上制造集成的FET和光电检测器光接收器的半导体结构和制造工艺。通过在基板的p阱中形成至少一个p沟道并在衬底的p阱中形成至少一个n沟道而形成FET。当在FET的p阱中形成至少一个p沟道并且在该阱的吸收区域中形成至少一个n沟道时，通过在衬底的吸收区域中形成至少一个p沟道而在衬底中形成pin光电检测器在FET的p阱中形成至少一个n沟道时的衬底。

9. 发明授权

US06513206B1 Retaining clip for panel mounted input/output connector 有权
标题翻译：面板安装式输入/输出连接器固定夹
公开(公告)号：US06513206B1
公开(公告)日：2003-02-04
申请号：US09910674
申请日：2001-07-20
申请人： Terry Fredrick Banitt , Gary Allen Olson
发明人： Terry Fredrick Banitt , Gary Allen Olson
IPC分类号： A41F100
CPC分类号： H01R13/745 , Y10T24/44034 , Y10T24/44769 , Y10T24/44923
摘要： A retainer clip is shown for retaining a device through an opening in a panel such as a printed circuit board, enclosure wall or similar structure. The clip surrounds the portion of the device projecting through the aperture and by a single longitudinal motion engages cooperating portions of the device to secure the device at the panel opening. The clip includes means for detenting in the assembled, locking position to prevent accidental release of the device from the secured, mounted condition.
摘要翻译：示出了用于通过诸如印刷电路板，外壳壁或类似结构的面板中的开口保持器件的保持夹。夹子围绕穿过孔突出的装置的部分并且通过单个纵向运动接合装置的协作部分以将装置固定在面板开口处。夹具包括用于在组装好的锁定位置处的止动装置，以防止装置从固定的安装状态意外释放。

10. 发明授权

US06433638B1 Fully balanced transimpedance amplifier for high speed and low voltage applications 失效
标题翻译：用于高速和低电压应用的全平衡跨阻放大器
公开(公告)号：US06433638B1
公开(公告)日：2002-08-13
申请号：US09655816
申请日：2000-09-06
申请人： Randolph B. Heineke , Scott Allen Olson , David Peter Swart , Gerald Wayne Swift
发明人： Randolph B. Heineke , Scott Allen Olson , David Peter Swart , Gerald Wayne Swift
IPC分类号： H03F345
CPC分类号： H03F3/082 , H03F1/226 , H03F3/45376 , H03F2203/45394 , H03F2203/45511 , H03F2203/45518 , H03F2203/45528 , H03F2203/45652 , H03F2203/45711
摘要： A fully balanced transimpedance amplifier for high speed and low voltage applications is provided. An input stage of the amplifier uses a matched pair of common source connected transistors with sources tied directly to ground to eliminate the Vds overhead usually found in differential pairs. The ground connection minimizes a source resistance noise component, while matching minimizes power supply noise generation and susceptibility for an array of amplifiers. Feedback resistors along with diode connected MESFETS determine the transimpedance of the amplifier. The nonlinearity of diodes helps to soften clipping. Transresistance also determined the noise generated by the amplifier, and the diode connected MESFETS offer lower noise than resistors for the same impedance. Stability is achieved through use of only a single stage of gain in a loop of the input stage, while additional gain is achieved through cascading in the input stage. A differential stage minimizes any difference in amplitude between two sides of the amplifier input stage. Two stages of source followers provide buffering to drive a relatively low impedance load at the output of the amplifier. Single integrated capacitor coupling, for high bandwidth, low noise, low voltage operation with an integrated detector is provided.
摘要翻译：提供了用于高速和低电压应用的完全平衡的跨阻抗放大器。放大器的输入级使用一对公共源极连接的晶体管，源极直接与地相连，以消除通常在差分对中发现的Vds开销。接地连接最小化源电阻噪声分量，同时匹配可最大限度地减少放大器阵列的电源噪声产生和敏感性。反馈电阻和二极管连接的MESFETS决定了放大器的跨导阻抗。二极管的非线性有助于软化削波。 Transresistance还确定了放大器产生的噪声，并且连接的二极管MESFETS的阻抗比同一阻抗的电阻低。通过在输入级的环路中仅使用单级增益实现稳定性，而在输入级中通过级联实现附加增益。差分级使放大器输入级两侧之间的幅度差异最小化。源级跟随器的两级提供缓冲以在放大器的输出处驱动相对较低的阻抗负载。提供单集成电容耦合，用于高带宽，低噪声，低电压操作与集成检测器。

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