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1. 发明授权

US07015029B2 Process for producing optically active (4R)-1,3-tiazolidine-4-carboxylic acid 失效
标题翻译：光学活性（4R）-1,3-噻唑烷-4-羧酸的制备方法
公开(公告)号：US07015029B2
公开(公告)日：2006-03-21
申请号：US10203664
申请日：2001-12-11
申请人： Yutaka Tamura , Takahiro Kato , Go Nakamura , Toshio Kondo
发明人： Yutaka Tamura , Takahiro Kato , Go Nakamura , Toshio Kondo
IPC分类号： C12P41/00
CPC分类号： C12P41/006 , C12P17/14
摘要： There is provided a novel method for producing an optically active (4R)-1,3-thiazolidine-4-carboxylic acid by allowing cells of a microorganism or a preparation obtained from cells of a microorganism having activity for stereoselectively hydrolyzing an optically active (4R)-1,3-thiazolidine-4-carboxylic acid amide to act on a mixture of (4R)- and (4S)-enantiomers of a 1,3-thiazolidine-4-carboxylic acid amide to produce the optically active (4R)-1,3-thiazolidine-4-carboxylic acid and separating the optically active (4R)-1,3-thiazolidine-4-carboxylic acid.
摘要翻译：提供了一种制备光学活性（4R）-1,3-噻唑烷-4-羧酸的新方法，该方法是通过使微生物细胞或从具有立体选择性水解光学活性的活性的微生物细胞获得的制剂（4R ）-1,3-噻唑烷-4-羧酸酰胺，作用于1,3-噻唑烷-4-羧酸酰胺的（4R） - 和（4S） - 对映体的混合物以产生光学活性（4R） -1,3-噻唑烷-4-羧酸，分离光学活性（4R）-1,3-噻唑烷-4-羧酸。

2. 发明申请

US20090111146A1 Antibody Drug 审中-公开
标题翻译：抗体药物
公开(公告)号：US20090111146A1
公开(公告)日：2009-04-30
申请号：US10570143
申请日：2004-09-02
申请人： Eiko Ohtsuka , Yutaka Tamura
发明人： Eiko Ohtsuka , Yutaka Tamura
IPC分类号： C12P21/04 , C12N15/00 , C07K16/18 , C12N15/11 , C12N5/06
CPC分类号： C07K14/7155 , C07K2319/30
摘要： Means for effectively performing therapies at a low cost is provided in which an antibody drug including a fusion protein fusing an extracellular region of IL-10 receptor 1 with a human antibody is used. A gene encoding a fusion protein fusing an extracellular region of IL-10 receptor 1 with a constant region of human IgG1 is incorporated into an expression vector to provide an expression vector for gene therapies and vaccines.
摘要翻译：提供了以低成本有效进行治疗的方法，其中使用包含融合IL-10受体1的细胞外区域的融合蛋白的抗体药物与人抗体。将编码融合蛋白质的融合蛋白质融合到表达载体中以提供IL-10受体1的细胞外区域与人IgG1的恒定区域以提供用于基因治疗和疫苗的表达载体。

3. 发明授权

US07208592B2 Process for alkali saponification of cellulose ester film surface 有权
标题翻译：纤维素酯薄膜表面碱皂化工艺
公开(公告)号：US07208592B2
公开(公告)日：2007-04-24
申请号：US10368391
申请日：2003-02-20
申请人： Naoyuki Kawanishi , Kazuhiko Fujiwara , Hitoshi Namikawa , Takahiro Moto , Yutaka Tamura
发明人： Naoyuki Kawanishi , Kazuhiko Fujiwara , Hitoshi Namikawa , Takahiro Moto , Yutaka Tamura
IPC分类号： C08B3/00 , C08B5/00 , C07H1/00
CPC分类号： C08B3/24
摘要： A process for alkali saponification of polymer film is disclosed. The process comprises the steps of applying solution of an alkali onto a polymer film having a temperature of not lower than room temperature, and washing away the alkaline solution from the film.
摘要翻译：公开了一种聚合物薄膜的碱皂化方法。该方法包括以下步骤：将碱溶液施加到温度不低于室温的聚合物膜上，并从该膜上洗涤碱性溶液。

4. 发明授权

US5302501A Silver halide photographic material 失效
标题翻译：卤化银照相材料
公开(公告)号：US5302501A
公开(公告)日：1994-04-12
申请号：US966383
申请日：1992-10-26
申请人： Yutaka Tamura , Yasuyuki Takagi , Junichi Yamanouchi
发明人： Yutaka Tamura , Yasuyuki Takagi , Junichi Yamanouchi
IPC分类号： G03C1/005 , G03C1/053 , G03C1/76
CPC分类号： G03C1/7614 , G03C1/0051 , G03C1/053 , Y10S430/164
摘要： A silver halide photographic material comprising a support having thereon at least one silver halide emulsion layer, wherein the swelling ratio of the entire hydrophilic colloid layers on the acid polymer-containing layer side of the support of the silver halide photographic material having a hydrophilic colloid layer containing at least one acid polymer (having a carboxyl group-containing monomer unit content of at least 15 mol % or an acid value of at least 1.5 meq/g) on at least one silver halide emulsion layer-coated side thereof is at least 200% in distilled water, said acid polymer being dissolved in water and added to said hydrophilic colloid layer, and the swollen thickness of the above entire hydrophilic colloid layers at the time of the completion of the rinsing stage is not more than 8 .mu.m when said silver halide photographic material is processed (the swelling ratio in distilled water is a value obtained by incubating the photographic material at 40.degree. C. and 60% RH (percent relative humidity) for 16 hours, immersing it in distilled water at 21.degree. C. for 3 minutes and measuring the change of the thickness thereof).
摘要翻译：一种卤化银照相材料，包括其上具有至少一个卤化银乳剂层的载体，其中具有亲水胶体层的卤化银照相材料的载体的含酸性聚合物层层上的整个亲水胶体层的溶胀比含有至少一种酸性聚合物（具有含羧基的单体单元含量为至少15mol％或酸值至少为1.5meq / g）在至少一个卤化银乳剂层涂覆侧上为至少200 在蒸馏水中，所述酸性聚合物溶于水中并加入到所述亲水胶体层中，并且在漂洗阶段完成时上述整个亲水胶体层的溶胀厚度不大于8（m）当所述卤化银照相材料被处理时（蒸馏水中的溶胀比是通过将照相材料在40℃和60％RH下温育获得的值（相对湿度百分比）16小时，将其浸入21℃的蒸馏水中3分钟并测量其厚度变化）。

5. 发明授权

US5225508A Optical resin obtained from diethylenically unsaturated monomer 失效
标题翻译：由烯属不饱和单体得到的光学树脂
公开(公告)号：US5225508A
公开(公告)日：1993-07-06
申请号：US710447
申请日：1991-06-05
申请人： Yutaka Tamura , Fumie Watari
发明人： Yutaka Tamura , Fumie Watari
IPC分类号： C07C321/20 , C07C321/28 , C08F12/34 , G02B1/04
CPC分类号： C08F12/34 , C07C321/20 , C07C321/28 , G02B1/04
摘要： Disclosed are a diethylenicallyunsaturated monomer represented by the following formula [Ia]: ##STR1## wherein n is an integer of from 1 to 10, and a and b each represent 0 or an integer of from 1 to 4,and an optical resin which is substantially insoluble and infusible and has a refractive index .eta..sub.D of at least 1.62, and which is obtained by polymerizing a monomer comprising 50 to 100% by weight of this diethylenically unsaturated monomer.
摘要翻译：公开了由下式[Ia]表示的二烯类不饱和单体：其中n为1〜10的整数，a和b各自表示0或1〜4的整数，树脂，其基本上不溶和不熔，折射率ηD至少为1.62，其通过聚合包含50-100重量％的该烯键式不饱和单体的单体而获得。

6. 发明授权

US4536605A Process for the production of tertiary olefin 失效
标题翻译：生产叔烯烃的方法
公开(公告)号：US4536605A
公开(公告)日：1985-08-20
申请号：US371424
申请日：1982-04-23
申请人： Koichi Kida , Yoshio Kawai , Yutaka Tamura , Yoshiharu Suzuki
发明人： Koichi Kida , Yoshio Kawai , Yutaka Tamura , Yoshiharu Suzuki
IPC分类号： B01J21/12 , C07C1/20 , C07C1/00
CPC分类号： B01J21/12 , C07C1/20 , C07C2521/12
摘要： A tertiary olefin is produced by contacting a gaseous tertiary ether usually represented by the following general formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are alkyl groups each having 1-4 carbon atoms which may be same or different and R.sup.4 is an alkyl group having 1-3 carbon atoms, with a catalyst obtained by calcining a silica-alumina compound at 700.degree.-1100.degree. C. in order to effect cracking of the tertiary ether. This reaction may be carried out in the presence of steam to result in further improvements.
摘要翻译：通过与通常由以下通式表示的气态叔醚接触来制备叔烯烃：其中R 1，R 2和R 3是可以相同或不同的1-4个碳原子的烷基，R 4是烷基具有1-3个碳原子，与通过在700℃-1100℃煅烧二氧化硅 - 氧化铝化合物而获得的催化剂以实现叔乙醚的裂化。该反应可以在蒸汽存在下进行，以进一步改进。

7. 发明授权

US08791385B2 High speed laser scribing method of fragile material 有权
标题翻译：高速激光划线法脆性材料
公开(公告)号：US08791385B2
公开(公告)日：2014-07-29
申请号：US12417112
申请日：2009-04-02
申请人： Yutaka Tamura
发明人： Yutaka Tamura
IPC分类号： B23K26/36
CPC分类号： B28D1/221 , B23K26/0608 , B23K26/0676 , B23K26/14 , B23K26/146 , B23K26/364 , B23K26/40 , B23K26/705 , B23K2103/50 , C03B33/0222 , C03B33/093 , G02F1/133351 , H01S3/005
摘要： In a method for scribing fragile material, a laser beam is irradiated onto a work plate of the fragile material. The work plate is heated by absorption of the irradiated laser beam and generating thermal stress by the heating. The laser beam is formed by a plurality of laser beam groups arranged along a beam scanning direction on a same line, and the plurality of laser beam groups are divided into two groups. One takes charge of initial heating and rising up temperature of the work plate, and another takes charge of temperature holding of the work plate. The laser beam intensity corresponding to each of the laser beam groups is adjusted so as to obtain optimum values.By the method, it is possible to remarkably increase scribing speed of the work plate of the fragile materials without increasing heating temperature.
摘要翻译：在用于划伤易碎材料的方法中，将激光束照射到脆性材料的工作板上。通过吸收照射的激光束来加热工作板，并通过加热产生热应力。激光束由在同一条线上沿着光束扫描方向排列的多个激光束组形成，并且将多个激光束组分成两组。负责工作板的初始加热和上升温度，另一个负责工作板的温度保持。调整对应于每个激光束组的激光束强度，以获得最佳值。通过该方法，可以在不增加加热温度的情况下显着增加脆性材料的工作板的划线速度。

8. 发明授权

US06627411B2 Method for evaluating matrix metalloprotease inhibitory activity 有权
标题翻译：评估基质金属蛋白酶抑制活性的方法
公开(公告)号：US06627411B2
公开(公告)日：2003-09-30
申请号：US09979510
申请日：2002-02-28
申请人： Ryuji Maekawa , Takayuki Yoshioka , Rhoichi Nemori , Yutaka Tamura
发明人： Ryuji Maekawa , Takayuki Yoshioka , Rhoichi Nemori , Yutaka Tamura
IPC分类号： C12Q137
CPC分类号： A61K49/00 , C12Q1/37 , G01N2333/8146 , G01N2333/96486 , G01N2500/02
摘要： A method for checking a matrix metalloproteinase-inhibitory activity present in a mammal that has received a compound exhibiting matrix metalloproteinase-inhibitory activity, which comprises utilizing in situ zymography, is provided.
摘要翻译：本发明提供一种用于检查已经接受了具有基质金属蛋白酶抑制活性的化合物的哺乳动物中存在的基质金属蛋白酶抑制活性的方法，该方法包括利用原位酶谱法。

9. 发明授权

US5424339A Method for producing an optical material having a high refractive index 失效
$Method for producing an optical material having a high refractive index$
标题翻译：具有高折射率的光学材料的制造方法
公开(公告)号：US5424339A
公开(公告)日：1995-06-13
申请号：US177387
申请日：1994-01-05
申请人： Yukihito Zanka , Tsutomu Isaka , Yutaka Tamura
发明人： Yukihito Zanka , Tsutomu Isaka , Yutaka Tamura
IPC分类号： C08G18/67 , C08F2/46 , C08F220/38 , G02B1/04 , G02C7/02
CPC分类号： C08F220/38 , G02B1/041
摘要： An optical material with a high refractive index comprising a resin which is obtainable by polymerization and curing of a composition comprising the following components (A), (B) and (C):component (A): a sulfur-containing (meth)acrylic monomer represented by the following formula [I], or a mixture of the monomer [I] and a sulfur-containing (meth)acrylic monomer represented by the following formula [II]: ##STR1## in each of which formulas, R.sup.1 represents a hydrogen atom or a methyl group, R.sup.2 and R.sup.3 independently represent a hydrocarbyl group of 1 to 12 carbon atoms, X represents a halogen atom except fluorine, and n represents 0 or an integer of 1 to 4, provided that those groups which are in plurality may be the same or different,the weight ratio of the compound [I]/the compound [II] being from 10/0 to 1/9;component (B): a hydroxy(meth)acrylic monomer represented by the following formula [III]: ##STR2## wherein R.sup.5 represents a hydrogen atom or a methyl group, R.sup.4 represents a hydrocarbyl group of 1 to 20 carbon atoms which may or may not contain an ether oxygen atom, Y represents a halogen atom except fluorine, and m represents 0 or an integer of 1 or 2, provided that those groups which are in plurality may be the same or different, and p is 1 or 2,the weight ratio of the component (A)/the component (B) being from 95/5 to 50/50; andcomponent (C): an isocyanate compound having a plurality of --NCO groups,the ratio (--NCO/--OH) of the number of --NCO group in the component (C) to the total number of --OH group in the components (A) and (B) being from 0.2 to 3.The above material for lenses has a low specific gravity and improved refractive index, transparency and impact resistance.
摘要翻译：具有高折射率的光学材料，其包含通过聚合和固化包含以下组分（A），（B）和（C）的组合物获得的树脂：组分（A）：含硫（甲基）丙烯酸由下式[I]表示的单体或由下式[II]表示的单体[I]和含硫（甲基）丙烯酸类单体的混合物的组合：＆lt; IMAGE＆gt; 在每个式中，R 1表示氢原子或甲基，R 2和R 3独立地表示1〜12个碳原子的烃基，X表示氟以外的卤素原子，n表示0或1〜4的整数如果化合物[I] /化合物[II]的重量比为10/0〜1/9，则多个的那些基团可以相同或不同，组分（B）：由下式[III]表示的羟基（甲基）丙烯酸类单体：其中，R 5表示氢原子或甲基，R 4表示碳原子数1〜20的烃基，可以含有或不含有醚氧原子，Y表示除氟以外的卤素原子，m表示0或1或2的整数，条件是这些基团可以相同或不同，p为1或 2，成分（A）/成分（B）的重量比为95/5〜50/50; 和（C）成分：具有多个-NCO基的异氰酸酯化合物，（C）成分中的-NCO基数与成分中的-OH基总数的比（-NCO / -OH）（A）和（B）为0.2至3.上述用于透镜的材料具有低比重和改善的折射率，透明度和耐冲击性。

10. 发明授权

US5389172A Method of carrying out exposed aggregate textured concrete finishes 失效
标题翻译：执行暴露的骨料纹理混凝土表面处理的方法
公开(公告)号：US5389172A
公开(公告)日：1995-02-14
申请号：US126715
申请日：1993-09-27
申请人： Teruaki Kobayashi , Masahito Oyama , Hiroyuki Enomoto , Hiroyuki Ogawa , Yutaka Tamura
发明人： Teruaki Kobayashi , Masahito Oyama , Hiroyuki Enomoto , Hiroyuki Ogawa , Yutaka Tamura
IPC分类号： B28B11/02 , B28B19/00 , B28B23/00 , E04F13/14 , B28B1/16 , B28B3/00 , B32B31/00
CPC分类号： B28B23/0075 , B28B19/0007 , B28B19/0076 , Y10S156/93 , Y10T156/1179
摘要： A method of carrying out aggregate exposed finish for concrete capable of extremely reducing the usage amount of decorative aggregates, and of facilitating the work without requiring the long working time and the technique of a high level is as follows. The method includes the steps of: loading aggregates on an adhesive sheet; burying part of the aggregates in an adhesive layer of the adhesive sheet; casting mortar or concrete onto an aggregate loading surface of the aggregate loading adhesive sheet; hardening the mortar or concrete; and removing the adhesive sheet.
摘要翻译：对于能够极大地减少装饰性聚集体的使用量的混凝土进行聚合物露出处理的方法，并且不需要长工作时间和高水平的技术便于工作的方法如下。该方法包括以下步骤：将聚集体装载在粘合片上; 将一部分聚集体埋在粘合片的粘合剂层中; 铸造砂浆或混凝土到聚集装载粘合片的骨料装载表面上; 硬化砂浆或混凝土; 并除去粘合片。

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