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1. 发明授权

US11780819B2 Aromatic substituted alkane-core monomers and polymers thereof for volume Bragg gratings 有权
公开(公告)号：US11780819B2
公开(公告)日：2023-10-10
申请号：US17098130
申请日：2020-11-13
申请人： META PLATFORMS TECHNOLOGIES, LLC
发明人： Lafe Purvis , Austin Lane , Matthew E. Colburn
IPC分类号： C07D303/18 , C07C321/28 , C07C271/54 , C07C271/58 , C07C333/04 , G03H1/02 , C07C321/20 , C08L33/14
CPC分类号： C07D303/18 , C07C271/54 , C07C271/58 , C07C321/20 , C07C321/28 , C07C333/04 , C08L33/14 , G03H1/0248 , G03H2001/0264 , G03H2223/24 , G03H2260/12
摘要： The disclosure provides recording materials including aromatic substituted alkane-core derivatized monomers and polymers for use in volume Bragg gratings, including, but not limited to, volume Bragg gratings for holography applications. Several structures are disclosed, including Formula I. When used in Bragg gratings applications, the monomers and polymers disclosed lead to materials with higher refractive index, low birefringence, and high transparency. The disclosed derivatized monomers and polymers can be used in any volume Bragg gratings materials, including two-stage polymer materials where a matrix is cured in a first step, and then the volume Bragg grating is written by way of a second curing step of a monomer.

2. 发明授权

US11643394B2 Krüppel-like factor 15 (KLF15) small molecule agonists in kidney disease 有权
公开(公告)号：US11643394B2
公开(公告)日：2023-05-09
申请号：US17244762
申请日：2021-04-29
申请人： United States Government as represented by the Department of Veterans Affairs , Icahn School of Medicine at Mount Sinai , The Research Foundation for The State University of New York
发明人： Sandeep Mallipattu , Bhaskar Das
IPC分类号： C07D213/85 , C07D213/74 , A61K31/573 , C07C321/20
CPC分类号： C07D213/85 , A61K31/573 , C07C321/20 , C07D213/74
摘要： The present disclosure is concerned with small molecule modulators of KLF15 signaling useful for treating various disorders such as, for example, kidney disease (e.g., chronic kidney disease), heart disease, obesity, or a neurodegenerative disorder (e.g., amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, spinal muscular atrophy, traumatic brain injury, vascular dementia, Huntington's disease, mental retardation, and attention deficit and hyperactivity disorder (ADHD)). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

3. 发明授权

US11230525B2 Organic sulfur compound, method for preparing same, and pharmaceutical composition for preventing or treating cancer or an inflammatory disease, containing same as active ingredient 有权
公开(公告)号：US11230525B2
公开(公告)日：2022-01-25
申请号：US16317805
申请日：2017-07-17
申请人： SOOKMYUNG WOMENS UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人： Raok Jeon , Jae-Ha Ryu , Hyewon Cho , Yoon-Jung Kim , Sang-Hyun Min , Ji-Hoon Yu
IPC分类号： C07C321/20 , A61P35/00
摘要： A novel organic sulfur compound, a method for preparing the same, and a pharmaceutical composition for preventing or treating cancer or inflammatory diseases, containing the same as an active ingredient are provided. The novel organic sulfur compound is capable of excellently inhibiting histone deacetylated (HDAC) enzymes in a concentration of nanomolar or micromolar units and has been found to have an excellent effect against inflammatory diseases, and has been found to be capable of inhibiting the proliferation of cancer.

4. 发明授权

US10851117B2 Methods of preparing cytotoxic benzodiazepine derivatives 有权
公开(公告)号：US10851117B2
公开(公告)日：2020-12-01
申请号：US16679563
申请日：2019-11-11
申请人： IMMUNOGEN, INC.
发明人： Michael Reardon , Richard A. Silva
IPC分类号： C07D487/04 , C07C231/12 , C07C319/22 , C07D519/00 , C07C233/07 , C07C319/20 , C07C321/20
摘要： The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.

5. 发明授权

US10526283B2 Prodrugs of dithiol mucolytic agents 有权
公开(公告)号：US10526283B2
公开(公告)日：2020-01-07
申请号：US15144288
申请日：2016-05-02
申请人： PARION SCIENCES, INC.
发明人： Michael Ross Johnson , William R. Thelin
IPC分类号： A61K31/265 , C07C327/36 , C07C327/28 , C07C327/22 , C07C323/16 , C12P19/60 , C12N9/02 , C12N9/10 , C12P17/16 , A61K9/00 , A61K9/16 , A61K31/047 , A61K31/133 , A61K31/341 , A61K31/385 , A61K31/683 , A61K33/14 , C07D307/68 , C07D339/00 , C07D339/08 , C07F9/6578 , C07C321/20 , C07D241/12 , C07C329/12 , C07D307/64
摘要： Provided are mucolytic compounds that are more effective, and/or absorbed less rapidly from mucosal surfaces, and/or are better tolerated as compared to N-acetylcysteine (NAC) and DTT. The compounds are represented by compounds of Formula I which embrace structures (Ia)-(Ib): where the structural variables are as defined herein.

6. 发明申请

US20180305307A1 COMPOUNDS AS L-CYSTINE CRYSTALLIZATION INHIBITORS AND USES THEREOF 审中-公开
公开(公告)号：US20180305307A1
公开(公告)日：2018-10-25
申请号：US15926657
申请日：2018-03-20
申请人： Michael D. WARD , Zina ZHU
发明人： Michael D. WARD , Zina ZHU
IPC分类号： C07C321/20 , C07C321/18 , C07C321/14 , A61K31/132 , A61K31/095 , A61K31/225 , A61K31/195 , C07C229/22
摘要： A method of preventing or inhibiting L-cystine crystallization is disclosed, using the compounds of formula I: R1a—[O]v-(-A-L-)m-A-[O]v—R1b wherein A, L, R1a, R1b, m, and v are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to L-cystine crystallization, such as comprising (but not limited to) kidney stones.

7. 发明申请

US20180134633A1 THIOETHER COMPOUNDS AS NITRIFICATION INHIBITORS 审中-公开
公开(公告)号：US20180134633A1
公开(公告)日：2018-05-17
申请号：US15573224
申请日：2016-05-11
申请人： BASF SE
发明人： Barbara Nave , Joachim Dickhaut , Peter Nesvadba , Mihiret Tekeste Sisay , Alexander Wissemeier , Wolfram Zerulla , Gregor Pasda , Olof Wallquist , Allan F. Cunningham
IPC分类号： C05G3/08 , C07C323/48 , C07D249/12 , C07D233/42 , C07D235/28 , C07D239/38 , C07C317/08 , C07C323/47 , C07D495/04 , C07D221/04 , C07D285/125 , C07D405/04 , C07D417/04 , C07D277/74 , C07D401/04 , C07C317/18 , C07C317/10 , C07C323/07 , C07C321/20 , C07D285/135 , C07C321/28 , C07D241/18 , C07D241/44 , C05C3/00 , C05F11/00 , C05C9/00
CPC分类号： C05G3/08 , C05C3/00 , C05C9/00 , C05F11/00 , C07C317/08 , C07C317/10 , C07C317/18 , C07C321/20 , C07C321/28 , C07C323/07 , C07C323/47 , C07C323/48 , C07C337/08 , C07D221/04 , C07D233/42 , C07D235/28 , C07D239/38 , C07D241/18 , C07D241/44 , C07D249/12 , C07D277/74 , C07D285/125 , C07D285/135 , C07D401/04 , C07D405/04 , C07D417/04 , C07D495/04 , Y02E50/343 , Y02P60/218 , Y02W30/47
摘要： Provided herein are a use of thioether compounds of formula I as nitrification inhibitors, and agricultural mixtures and compositions including the thioether compounds.

8. 发明授权

US08871805B2 Compound, composition and uses thereof 有权
标题翻译：化合物，组合物及用途
公开(公告)号：US08871805B2
公开(公告)日：2014-10-28
申请号：US13858045
申请日：2013-04-06
申请人： Mahesh Kandula
发明人： Mahesh Kandula
IPC分类号： A61K31/21 , C07C233/00 , C07C327/30 , C07C321/10 , C07C323/41 , C07C321/20
CPC分类号： C07C321/10 , C07C321/20 , C07C323/41 , C07C327/22 , C07C327/30
摘要： The disclosure herein provides the compounds of Formulas 1 and its pharmaceutical acceptable salts, as well as polymorphs, solvates, and hydrates thereof. These salts may be formulated as pharmaceutical compositions. The pharmaceutical compositions may be formulated for oral administration, transdermal administration, and/or injection. Such compositions may be used for the treatment of metabolic conditions, cystinosis, non-alcoholic Steatohepatitis, hypertriglyceridemia, and/or neurodegenerative disorders, and/or their associated complications.
摘要翻译：本文的公开内容提供式1的化合物及其药学上可接受的盐，以及其多晶型物，溶剂合物和水合物。这些盐可以配制成药物组合物。药物组合物可以配制用于口服给药，透皮给药和/或注射。这些组合物可用于治疗代谢病症，胱氨酸沉积症，非酒精性脂肪性肝炎，高甘油三酯血症和/或神经变性疾病和/或其相关并发症。

9. 发明授权

US08658833B2 Garlic processing 有权
标题翻译：大蒜加工
公开(公告)号：US08658833B2
公开(公告)日：2014-02-25
申请号：US12514171
申请日：2007-11-09
申请人： Eric Block , Murree Groom
发明人： Eric Block , Murree Groom
IPC分类号： C07C319/24 , C07C321/20
CPC分类号： C07C321/18 , C07C319/24
摘要： A method of producing polysulfides comprising the step of adding elemental sulphur to an allicin-containing plant extract. In preferred embodiments, the plant extract is mechanically treated members of the genus Allium, especially garlic. In further preferred aspects of the invention, the plant extract and sulphur mixture is heated, and the pH is controlled to allow manipulation of the polysulfide chain length. The addition of organic bases, containing nitrogen lone pairs, allows further control of polysulfide chain length.
摘要翻译：一种生产多硫化物的方法，包括向含大蒜素的植物提取物中加入元素硫的步骤。在优选的实施方案中，植物提取物是Allium属的机械处理的成员，特别是大蒜。在本发明的进一步优选方面，加热植物提取物和硫混合物，并且控制pH以允许操纵多硫链长度。加入含有氮离子对的有机碱可以进一步控制多硫链长度。

10. 发明授权

US08431626B2 Disulfide monomers comprising ethylenically unsaturated norbornyl groups suitable for dental compositions 有权
标题翻译：包含适用于牙齿组合物的烯属不饱和降冰片基的二硫化物单体
公开(公告)号：US08431626B2
公开(公告)日：2013-04-30
申请号：US13110898
申请日：2011-05-18
申请人： Christopher N. Bowman , Hee Young Park , Christopher J. Kloxin , Ahmed S. Abuelyaman , Joel D. Oxman , Yizhong Wang
发明人： Christopher N. Bowman , Hee Young Park , Christopher J. Kloxin , Ahmed S. Abuelyaman , Joel D. Oxman , Yizhong Wang
IPC分类号： A61K6/083 , C07C321/20 , C07C321/16 , C08F232/06 , C08F236/20
CPC分类号： C08F2/50 , A61K6/083 , C07C321/20 , C07C2602/42 , C08F232/08 , C08L33/06
摘要： Dental compositions and disulfide monomers described. The disulfide monomer comprises a disulfide backbone group wherein each of the sulfur atoms are bonded to a group terminating with an ethylenically unsaturated norbornyl group; and at least one other monomer comprising at least two ethylenically unsaturated groups.
摘要翻译：描述牙科组合物和二硫单体。二硫化物单体包含二硫主链基团，其中每个硫原子与以乙烯不饱和降冰片基为终止的基团结合; 和至少一种包含至少两个烯属不饱和基团的其它单体。

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