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1. 发明授权

US07125489B2 HPLC column design and method of making same 有权
标题翻译： HPLC柱设计及其制作方法
公开(公告)号：US07125489B2
公开(公告)日：2006-10-24
申请号：US10797587
申请日：2004-03-11
申请人： Yury Zelechonok , Mikhail Alkhovsky , Vladislav Orlovsky
发明人： Yury Zelechonok , Mikhail Alkhovsky , Vladislav Orlovsky
IPC分类号： B01D15/08
CPC分类号： G01N30/6039
摘要： The disclosed HPLC column is formed with overlying concentric inner and outer tubes. The flow path is established via the inner tube bore that holds packed absorbent, end filters and capping sealing members, and end coupling members cooperate with the inner tube at its ends. The sealing and end coupling members have conventional configurations for establishing a sealed connection with capillary lines and their fittings, for the series flow testing use through the column. The inventive method and manner of assembly provides that the outer tube overlies all of the inner tube and both sealing members, but only part of each end coupling member. The ends of the outer tube are then deformed radially inward to become mechanically interlocked with the end coupling members, as the column, holding also the filters and sealing members within the inner tube.
摘要翻译：公开的HPLC柱由上部同心的内管和外管形成。通过内管孔建立流动路径，该内管孔保持填充的吸收剂，端部过滤器和封盖密封构件，并且端部联接构件在其端部与内管配合。密封和端部联接构件具有用于建立与毛细管线及其配件的密封连接的常规构造，用于通过塔的串联流量测试。本发明的组装方法和方式规定，外管覆盖所有内管和两个密封构件，但仅覆盖每个端部联接构件的一部分。然后，外管的端部径向向内变形，以与端部联接构件机械地互锁，作为柱，也将过滤器和密封构件保持在内管内。

2. 发明申请

US20050199540A1 HPLC column design and method of making same 有权
标题翻译： HPLC柱设计及其制作方法
公开(公告)号：US20050199540A1
公开(公告)日：2005-09-15
申请号：US10797587
申请日：2004-03-11
申请人： Yury Zelechonok , Mikhail Alkhovsky , Vladislav Orlovsky
发明人： Yury Zelechonok , Mikhail Alkhovsky , Vladislav Orlovsky
IPC分类号： B01D15/08
CPC分类号： G01N30/6039
摘要： The disclosed HPLC column is formed with overlying concentric inner and outer tubes. The flow path is established via the inner tube bore that holds packed absorbent, end filters and capping sealing members, and end coupling members cooperate with the inner tube at its ends. The sealing and end coupling members have conventional configurations for establishing a sealed connection with capillary lines and their fittings, for the series flow testing use through the column. The inventive method and manner of assembly provides that the outer tube overlies all of the inner tube and both sealing members, but only part of each end coupling member. The ends of the outer tube are then deformed radially inward to become mechanically interlocked with the end coupling members, as the column, holding also the filters and sealing members within the inner tube.
摘要翻译：公开的HPLC柱由上部同心的内管和外管形成。通过内管孔建立流动路径，该内管孔保持填充的吸收剂，端部过滤器和封盖密封构件，并且端部联接构件在其端部与内管配合。密封和端部联接构件具有用于建立与毛细管线及其配件的密封连接的常规构造，用于通过塔的串联流量测试。本发明的组装方法和方式规定，外管覆盖所有内管和两个密封构件，但仅覆盖每个端部联接构件的一部分。然后，外管的端部径向向内变形，以与端部联接构件机械地互锁，作为柱，也将过滤器和密封构件保持在内管内。

3. 发明授权

US07862716B2 HPLC schematic with integrated sample cleaning system 有权
标题翻译： HPLC示意图，集成样品清洗系统
公开(公告)号：US07862716B2
公开(公告)日：2011-01-04
申请号：US12384994
申请日：2009-04-13
申请人： Yury Zelechonok , Vladislav Orlovsky
发明人： Yury Zelechonok , Vladislav Orlovsky
IPC分类号： B01D15/08
CPC分类号： G01N30/40 , G01N35/1004
摘要： The disclosed HPLC flow schematic back-flushes the guard column with mobile phase once every operating cycle, the regular cleaning maintaining its effectiveness and useful life. This mobile phase flow reversal is accomplished by imposing a two position multiple port switching valve between the guard and separation columns. In one valve position, the mobile phase is pumped in one flow direction through both the separation and guard columns, but the switched valve maintains the same flow direction only through the separation column and reverses the mobile phase flow direction through the guard column, for effectively cleaning the guard column. Moreover, the mobile phase back flow is directed over the emptied sample drawing needle for cleaning it to reduce possible sample cross contamination. The improved flow circuits use basically only the typical HPLC system components, except for some insignificant modifications from existing injector designs.
摘要翻译：所公开的HPLC流程示意图每个操作循环一次性地将流动相反冲洗保护柱，定期清洗保持其有效性和使用寿命。该流动相流逆转通过在保护和分离柱之间施加两位多端口切换阀来实现。在一个阀位置，流动相通过分离柱和保护柱通过一个流动方向泵送，但开关阀仅通过分离柱保持相同的流动方向，并将流动相流动方向反向通过保护柱，以有效地清洁保护柱。此外，流动相回流被引导到空的样品拉伸针上，以清洁它，以减少可能的样品交叉污染。改进的流量回路基本上仅使用典型的HPLC系统组件，除了现有喷油器设计的一些不太重要的修改之外。

4. 发明申请

US20110025047A1 End fitting for holding a high pressure capillary tube 审中-公开
标题翻译：用于固定高压毛细管的端部接头
公开(公告)号：US20110025047A1
公开(公告)日：2011-02-03
申请号：US12462309
申请日：2009-08-03
申请人： Yury Zelechonok , Vladislav Orlovsky
发明人： Yury Zelechonok , Vladislav Orlovsky
IPC分类号： F16L5/00
CPC分类号： F16L37/138 , G01N30/6026 , G01N30/6039
摘要： The disclosed fitting has a tubular body externally threaded at one end, to allow the fitting to be positioned over a capillary tube and connected to a cooperating component. The fitting has opposed gripping jaws at its other end suited for being flexed against the capillary tube for holding it relative to the fitting. A tubular nut fits over the gripping jaws, and cam faces provided between the nut and jaws serve to tighten or release the jaws relative to the tube, depending on which direction the nut is shifted axially along the body. The outside tubular face of the actuating member is knurled, providing for reliable manual gripping and axial shifting the actuating member.
摘要翻译：所公开的配件在一端具有外螺纹的管状体，以允许配件定位在毛细管上方并连接到协作部件。配件在其另一端处具有相对的夹爪，其适于弯曲抵靠毛细管以相对于配件保持。管状螺母装配在夹爪上，并且设置在螺母和夹爪之间的凸轮面用于相对于管紧固或释放夹爪，这取决于螺母沿着主体轴向移动的方向。致动构件的外部管状表面被滚花，提供可靠的手动夹紧和轴向移动致动构件。

5. 发明申请

US20060169638A1 Chromatography method for ion detection and analysis 审中-公开
标题翻译：色谱法用于离子检测和分析
公开(公告)号：US20060169638A1
公开(公告)日：2006-08-03
申请号：US11045191
申请日：2005-01-31
申请人： Yury Zelechonok , Vladislav Orlovsky
发明人： Yury Zelechonok , Vladislav Orlovsky
IPC分类号： B01D15/08
CPC分类号： B01D15/363 , B01D15/327 , B01D15/362 , B01D15/426 , B01J20/3285 , G01N30/02
摘要： This ion chromatography method utilizes a HPLC column having a stationary phase with two functional groups permanently attached thereto, respectively for ion-exchange and for hydrophobic interaction. The mobile phase will have an organic modifier, and an ionic modifier and will carry sample ions. The mobile phase organic modifier can be conventional HPLC organic solvent, while the mobile phase ionic modifier can be a weak hydrophobic base (for cation-exchange) or a weak hydrophobic acid (for anion-exchange). The stationary phase ion-exchange group can be a base or acid residue and the hydrophobic functional group can be an alkyl chain. The hydrophobic group of ionic modifier has a strong non-ionic interaction with the hydrophobic group of the stationary phase, which facilitates the ion-exchange process and the ion separation as the result.
摘要翻译：该离子色谱方法使用具有固定相的HPLC柱，其中两个官能团分别与其永久连接，用于离子交换和疏水相互作用。流动相将具有有机改性剂和离子改性剂，并将携带样品离子。流动相有机改性剂可以是常规的HPLC有机溶剂，而流动相离子改性剂可以是弱疏水碱（用于阳离子交换）或弱疏水酸（用于阴离子交换）。固定相离子交换基团可以是碱或酸残基，疏水官能团可以是烷基链。离子改性剂的疏水基与固定相的疏水基具有很强的非离子相互作用，有利于离子交换过程和离子分离。

6. 发明申请

US20100258487A1 HPLC schematic with integrated sample cleaning system 有权
标题翻译： HPLC示意图，集成样品清洗系统
公开(公告)号：US20100258487A1
公开(公告)日：2010-10-14
申请号：US12384994
申请日：2009-04-13
申请人： Yury Zelechonok , Vladislav Orlovsky
发明人： Yury Zelechonok , Vladislav Orlovsky
IPC分类号： B01D15/40 , B01D15/22
CPC分类号： G01N30/40 , G01N35/1004
摘要： The disclosed HPLC flow schematic back-flushes the guard column with mobile phase once every operating cycle, the regular cleaning maintaining its effectiveness and useful life. This mobile phase flow reversal is accomplished by imposing a two position multiple port switching valve between the guard and separation columns. In one valve position, the mobile phase is pumped in one flow direction through both the separation and guard columns, but the switched valve maintains the same flow direction only through the separation column and reverses the mobile phase flow direction through the guard column, for effectively cleaning the guard column. Moreover, the mobile phase back flow is directed over the emptied sample drawing needle for cleaning it to reduce possible sample cross contamination. The improved flow circuits use basically only the typical HPLC system components, except for some insignificant modifications from existing injector designs.
摘要翻译：所公开的HPLC流程示意图每个操作循环一次性地将流动相反冲洗保护柱，定期清洗保持其有效性和使用寿命。该流动相流逆转通过在保护和分离柱之间施加两位多端口切换阀来实现。在一个阀位置，流动相通过分离柱和保护柱通过一个流动方向泵送，但开关阀仅通过分离柱保持相同的流动方向，并将流动相流动方向反向通过保护柱，以有效地清洁保护柱。此外，流动相回流被引导到空的样品拉伸针上，以清洁它，以减少可能的样品交叉污染。改进的流量回路基本上仅使用典型的HPLC系统组件，除了现有喷油器设计的一些不太重要的修改之外。

7. 发明申请

US20100156089A1 End fitting for high pressure capillary tube 审中-公开
标题翻译：适用于高压毛细管
公开(公告)号：US20100156089A1
公开(公告)日：2010-06-24
申请号：US12317271
申请日：2008-12-22
申请人： Yury Zelechonok , Vladislav Orlovsky
发明人： Yury Zelechonok , Vladislav Orlovsky
IPC分类号： F16L35/00
CPC分类号： G01N30/6026 , G01N30/6039
摘要： The fitting includes an elongated cylindrical body with a conical ferrule secured to its forward end, and with the body and ferrule having aligned through bores sized to allow a capillary tube to be passed through them. The elongated body has medially located external helical threads, and a knurled nut is rotatably coupled to these threads. The body also has elongated axially directed gripping fingers with inwardly facing gripping regions thereon normally spaced from but suited to be biased radially against the capillary tube in the fitting bores. A tubular gripping nut is threaded onto the external body threads, suited to be axially shifted along the body upon relative nut/body rotation. The nut and body have cooperating cam surfaces suited to engage upon relative nut/body rotation and bias the finger gripping regions tightly against the capillary tube for securely retaining tube as positioned within the fitting.
摘要翻译：配件包括细长的圆柱形主体，其具有固定到其前端的锥形套圈，并且主体和套圈具有对齐的通孔，其大小允许毛细管通过它们。细长的主体具有内部定位的外螺旋形螺纹，并且滚花螺母可旋转地联接到这些螺纹。主体还具有细长的轴向夹持指状物，其具有向内的夹持区域，其上通常间隔开但适于径向地抵靠配合孔中的毛细管。管状夹紧螺母被拧到外部主体螺纹上，适于在相对螺母/主体旋转时沿主体轴向移动。螺母和主体具有配合的凸轮表面，其适于在相对的螺母/主体旋转时啮合，并将手指夹紧区域紧紧地对着毛细管进行偏压，以将管定位在配件内。

8. 发明授权

US07045059B2 Universal bonded phase material for chromatographic separation 失效
标题翻译：用于色谱分离的通用键合相材料
公开(公告)号：US07045059B2
公开(公告)日：2006-05-16
申请号：US10627636
申请日：2003-07-28
申请人： Vladislav Orlovsky , Yury Zelechonok
发明人： Vladislav Orlovsky , Yury Zelechonok
IPC分类号： B01D15/08
CPC分类号： B01J20/287 , B01J20/288 , B01J20/3285 , B01J39/26 , B01J41/20
摘要： The invention provides a new universal bonded phase material used for separation of a wide variety of organic and inorganic substances by liquid chromatography. The material is produced by bonding a charge-bearing hydrophobic functional group to the surface of a supporting material. The process of preparation of such material and advantages of using the material are described.
摘要翻译：本发明提供了用于通过液相色谱分离各种有机和无机物质的新的通用键合相材料。该材料通过将带电荷的疏水性官能团结合到支撑材料的表面来制造。描述了制备这种材料的过程和使用该材料的优点。

9. 发明申请

US20050023203A1 Universal bonded phase materialfor chromatographic separation 失效
标题翻译：用于色谱分离的通用键合相材料
公开(公告)号：US20050023203A1
公开(公告)日：2005-02-03
申请号：US10627636
申请日：2003-07-28
申请人： Vladislav Orlovsky , Yury Zelechonok
发明人： Vladislav Orlovsky , Yury Zelechonok
IPC分类号： B01D15/08 , B01J20/287 , B01J20/288 , B01J39/26 , B01J41/20
CPC分类号： B01J20/287 , B01J20/288 , B01J20/3285 , B01J39/26 , B01J41/20
摘要： The invention provides a new universal bonded phase material used for separation of a wide variety of organic and inorganic substances by liquid chromatography. The material is produced by bonding a charge-bearing hydrophobic functional group to the surface of a supporting material. The process of preparation of such material and advantages of using the material are described.
摘要翻译：本发明提供了用于通过液相色谱分离各种有机和无机物质的新的通用键合相材料。该材料通过将带电荷的疏水性官能团结合到支撑材料的表面来制造。描述了制备这种材料的过程和使用该材料的优点。

10. 发明申请

US20100089811A1 HPLC preparative column design 审中-公开
标题翻译： HPLC制备柱设计
公开(公告)号：US20100089811A1
公开(公告)日：2010-04-15
申请号：US12287652
申请日：2008-10-14
申请人： Yury Zelechonok , Vladislav Orlovsky
发明人： Yury Zelechonok , Vladislav Orlovsky
IPC分类号： B01D15/10
CPC分类号： G01N30/606 , B01D15/22 , G01N30/30 , G01N2030/3007
摘要： The preparative column has an inner thin wall HPLC compatible material tube, packed with absorbent particles, with filters and end fittings of HPLC compatible material at the tube ends. An aluminum outer sleeve tightly overlies and reinforces the inner tube, aluminum end caps overlie the end fittings and are secured to the outer sleeve. End connections in the end fittings allow solvent and sample flow through the packed absorbent. Exterior axial flats on the aluminum sleeve and end caps provide broad contact against flat thermal surfaces of conventional temperature controllers, thereby yielding effective thermal transfer there between. The flats further minimize column rolling on flat level surfaces and provide favorable locations for connection taps for conveying coolant flow through passages formed in the sleeve.
摘要翻译：制备柱具有内部薄壁HPLC相容的材料管，填充有吸收颗粒，过滤器和管端的HPLC相容材料的端部配件。铝外套紧紧地覆盖并加强内管，铝端盖覆盖端部配件并固定到外套筒上。端部接头端接件允许溶剂和样品流过填料吸收剂。铝套筒和端盖上的外部轴向平面与常规温度控制器的平坦热表面提供宽接触，从而在其间产生有效的热传递。这些平板进一步减少了在平坦的平面表面上的列滚动，并为连接龙头提供了有利的位置，用于将冷却剂流通过形成在套筒中的通道。

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