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1. 发明授权

US10371141B1 Gradient high pressure syringe pump 有权
公开(公告)号：US10371141B1
公开(公告)日：2019-08-06
申请号：US15219084
申请日：2016-07-25
申请人： Yury Zelechonok
发明人： Yury Zelechonok
IPC分类号： F04B19/22 , F04B49/22 , F04B3/00 , F04B19/00 , F04B53/14 , F04B13/02 , G01N30/32 , G01N30/38
摘要： A gradient high pressure syringe pump usable in a high pressure liquid chromatography system includes a housing defining an internal cavity, a drive piston, and a floating piston unconnected from the drive piston dividing the internal cavity into first and second pumping chambers. Each pumping chamber has an intake inlet with an upstream no-return valve communicating with a source of fluid and a discharge outlet communicating with an inlet of a downstream control valve. The control valve is operable to selectively direct fluid from either of the upstream pumping chambers downstream. In one embodiment, the first pumping chamber defines a cylinder section for the drive piston having an internal diameter smaller than the cylinder section defined by the second pumping chamber for the floating piston. The drive piston is moved linearly between suction and discharge strokes by an attached screw operatively coupled with a controllable stepper motor.

2. 发明授权

US08454399B1 Amphibious vehicle 失效
标题翻译：两栖车
公开(公告)号：US08454399B1
公开(公告)日：2013-06-04
申请号：US13029491
申请日：2011-02-17
申请人： Yury Zelechonok
发明人： Yury Zelechonok
IPC分类号： B60F3/00 , B63H19/08
CPC分类号： B60F3/0038 , B60F3/0069
摘要： An amphibious vehicle that may be driven directly between land and water includes a vehicle with an opposed pair of flotation side hulls and a rear hull. The side hulls are movable between a stowed position above the vehicle and a lowered deployed position outboard thereof. Each side hull is mounted by arm assemblies including an upright bracket fixed to the vehicle and an arm pivotally connected to the bracket that can be extended or retracted linearly by actuators to raise and lower the side hulls. A locking mechanism prevents the extended side hulls from moving laterally but allows vertical adjustment thereof. The side hulls may be horizontally adjusted between compact contracted and extended protracted positions. The rear hull assembly is pivotally mounted to the back of vehicle permitting raising and lowering thereof and includes jet drives providing propulsion for water operation.
摘要翻译：可以在陆地和水之间直接驱动的两栖车辆包括具有相对的一对浮选侧船体和后船体的车辆。侧船体可以在车辆上方的收起位置和其外侧的降低的展开位置之间移动。每个侧面船体由臂组件安装，其包括固定到车辆的直立支架和枢转地连接到支架的臂，其可以通过致动器线性地延伸或缩回以升高和降低侧船体。锁定机构防止延伸侧船体横向移动，但允许其垂直调节。侧面船体可以在紧凑收缩和延长的持续位置之间水平调整。后船体组件枢转地安装到车辆的后部，允许其升高和降低，并且包括提供用于水操作的推进的喷射驱动。

3. 发明授权

US07862716B2 HPLC schematic with integrated sample cleaning system 有权
标题翻译： HPLC示意图，集成样品清洗系统
公开(公告)号：US07862716B2
公开(公告)日：2011-01-04
申请号：US12384994
申请日：2009-04-13
申请人： Yury Zelechonok , Vladislav Orlovsky
发明人： Yury Zelechonok , Vladislav Orlovsky
IPC分类号： B01D15/08
CPC分类号： G01N30/40 , G01N35/1004
摘要： The disclosed HPLC flow schematic back-flushes the guard column with mobile phase once every operating cycle, the regular cleaning maintaining its effectiveness and useful life. This mobile phase flow reversal is accomplished by imposing a two position multiple port switching valve between the guard and separation columns. In one valve position, the mobile phase is pumped in one flow direction through both the separation and guard columns, but the switched valve maintains the same flow direction only through the separation column and reverses the mobile phase flow direction through the guard column, for effectively cleaning the guard column. Moreover, the mobile phase back flow is directed over the emptied sample drawing needle for cleaning it to reduce possible sample cross contamination. The improved flow circuits use basically only the typical HPLC system components, except for some insignificant modifications from existing injector designs.
摘要翻译：所公开的HPLC流程示意图每个操作循环一次性地将流动相反冲洗保护柱，定期清洗保持其有效性和使用寿命。该流动相流逆转通过在保护和分离柱之间施加两位多端口切换阀来实现。在一个阀位置，流动相通过分离柱和保护柱通过一个流动方向泵送，但开关阀仅通过分离柱保持相同的流动方向，并将流动相流动方向反向通过保护柱，以有效地清洁保护柱。此外，流动相回流被引导到空的样品拉伸针上，以清洁它，以减少可能的样品交叉污染。改进的流量回路基本上仅使用典型的HPLC系统组件，除了现有喷油器设计的一些不太重要的修改之外。

4. 发明授权

US11957997B1 Liquid chromatography method for separation of multicharged ions 有权
公开(公告)号：US11957997B1
公开(公告)日：2024-04-16
申请号：US17582821
申请日：2022-01-24
申请人： Yury Zelechonok
发明人： Yury Zelechonok
IPC分类号： B01D15/36 , B01D15/16
CPC分类号： B01D15/166 , B01D15/362 , B01D15/363
摘要： The present invention pertains to a liquid chromatography method of separating multicharged ions, and more particularly, to separating both positively charged and negatively charged ions by using a mobile phase composition with doubly charged ions and an ion-exchange column with a charged stationary phase surface.

5. 发明授权

US08387817B1 Container for holding multiple fluids in isolation 有权
标题翻译：用于隔离多个流体的容器
公开(公告)号：US08387817B1
公开(公告)日：2013-03-05
申请号：US13300230
申请日：2011-11-18
申请人： Yury Zelechonok
发明人： Yury Zelechonok
IPC分类号： B65D25/04 , B65D35/22
CPC分类号： B65D77/065 , Y10T137/0898 , Y10T137/474
摘要： A container for holding fluids in isolation includes an outer container and two deformable inner containers carried within the internal space of the outer container. The outer container is provided with a view port enabling the user to visually examine the inner containers. The inner containers have respective ports communicating with their interiors. As fluid is withdrawn from the first inner container its volume is reduced so that the second container may receive a like amount of fluid. The second inner container may hold colorants or absorbents. The container may be used with various chemical applications, such as high performance liquid chromatography or fluid injection analysis, wherein supply fluid is withdrawn from the first inner container, used, and returned as waste fluid to the second inner container so that the overall volume of fluids remains relatively constant.
摘要翻译：用于保持隔离流体的容器包括外部容器和在外部容器的内部空间内承载的两个可变形的内部容器。外部容器设置有能够使用户目视检查内部容器的视图端口。内部容器具有与其内部连通的各个端口。当流体从第一内部容器中排出时，其体积减小，使得第二容器可以接收相同量的流体。第二内容器可以容纳着色剂或吸收剂。容器可以用于各种化学应用，例如高效液相色谱或流体注射分析，其中供应流体从第一内部容器中取出，使用并作为废液返回到第二内部容器，使得总体积流体保持相对恒定。

6. 发明授权

US07125489B2 HPLC column design and method of making same 有权
标题翻译： HPLC柱设计及其制作方法
公开(公告)号：US07125489B2
公开(公告)日：2006-10-24
申请号：US10797587
申请日：2004-03-11
申请人： Yury Zelechonok , Mikhail Alkhovsky , Vladislav Orlovsky
发明人： Yury Zelechonok , Mikhail Alkhovsky , Vladislav Orlovsky
IPC分类号： B01D15/08
CPC分类号： G01N30/6039
摘要： The disclosed HPLC column is formed with overlying concentric inner and outer tubes. The flow path is established via the inner tube bore that holds packed absorbent, end filters and capping sealing members, and end coupling members cooperate with the inner tube at its ends. The sealing and end coupling members have conventional configurations for establishing a sealed connection with capillary lines and their fittings, for the series flow testing use through the column. The inventive method and manner of assembly provides that the outer tube overlies all of the inner tube and both sealing members, but only part of each end coupling member. The ends of the outer tube are then deformed radially inward to become mechanically interlocked with the end coupling members, as the column, holding also the filters and sealing members within the inner tube.
摘要翻译：公开的HPLC柱由上部同心的内管和外管形成。通过内管孔建立流动路径，该内管孔保持填充的吸收剂，端部过滤器和封盖密封构件，并且端部联接构件在其端部与内管配合。密封和端部联接构件具有用于建立与毛细管线及其配件的密封连接的常规构造，用于通过塔的串联流量测试。本发明的组装方法和方式规定，外管覆盖所有内管和两个密封构件，但仅覆盖每个端部联接构件的一部分。然后，外管的端部径向向内变形，以与端部联接构件机械地互锁，作为柱，也将过滤器和密封构件保持在内管内。

7. 发明授权

US06893569B2 Method and apparatus for high pressure liquid chromatography 有权
标题翻译：高压液相色谱法及方法
公开(公告)号：US06893569B2
公开(公告)日：2005-05-17
申请号：US10462057
申请日：2003-06-16
申请人： Yury Zelechonok
发明人： Yury Zelechonok
IPC分类号： G01N30/32 , G01N30/34 , G01N30/36 , B01D15/08
CPC分类号： G01N30/36 , G01N2030/324 , G01N2030/326 , G01N2030/347
摘要： This modified HPLC instrument has the HPLC pump force only solvent through the serial flow line including a sampler, column, and detector; while buffer is discharged into the solvent from a syringe pump via a tee connection in the flow line downstream from the HPLC pump. A stepper motor drives the syringe pump at a discharge rate to yield an intended buffer/solvent dilution ratio compared to the steady HPLC pump flow rate. A pressure transducer detects variances of the flow line pressures, and servo controls the stepper motor for increasing the flow rate upon increased pressures and decreasing the flow rate upon decreased pressures, to hold the dilution ratio constant.
摘要翻译：该改性的HPLC仪器具有HPLC泵力仅通过串联流线的溶剂，包括采样器，色谱柱和检测器; 而缓冲液通过来自HPLC泵下游的流动管道中的T形连接从注射泵排出到溶剂中。步进电机以排出速率驱动注射泵，以产生与稳定HPLC泵流量相比的预期缓冲液/溶剂稀释比。压力传感器检测流路压力的变化，并且伺服控制步进电机，以在增加的压力时增加流速并且在降低的压力时降低流量，以保持稀释比恒定。

8. 发明授权

US5906137A Linear drive with screw and threaded follower 失效
标题翻译：带螺纹和螺纹跟随器的直线驱动
公开(公告)号：US5906137A
公开(公告)日：1999-05-25
申请号：US980642
申请日：1997-12-01
申请人： Yury Zelechonok
发明人： Yury Zelechonok
IPC分类号： F16H25/20 , F16H25/02
CPC分类号： F16H25/20 , F16H25/2204 , Y10T74/19702
摘要： This linear drive has cooperating threaded screw and follower components suited to be rotated relative to one another to create a corresponding axial shift between the components, where the follower is improved by having spaced drive members each threadably cooperating with the screw and capable of carrying the maximum axial linear drive force between the components. Anti-friction structures support the drive members for allowing relatively effortless component rotation, frictionwise, even under this maximum driving force. Ramp structures cyclically expand and contract the axial separation between the drive members, which both generates the maximum axial driving force and effectively shifts the axial driving force alternately between the drive members. The force-carrying drive member will be thread friction bound relative to the screw, and the substantially loadfree drive member will be easily rotatable with the follower rotation suited to be axially advanced along the screw. Relative component rotation and repeated expanding and contracting shift cycles incrementally and alternately advance, with an inch-worm like action, the drive members along the screw to provide the axial shift and force generation between the components, the loadfree drive member being advanced and the force-carrying drive member remaining stationary relative to the screw.
摘要翻译：该线性驱动器具有适合相对于彼此旋转的配合螺纹螺钉和从动部件，以在部件之间产生相应的轴向移动，其中随动件通过具有间隔开的驱动构件而被改善，每个驱动构件与螺钉螺纹地配合并且能够承载最大部件之间的轴向线性驱动力。抗摩擦结构支撑驱动构件，即使在该最大驱动力下也允许相对轻松的部件旋转，摩擦。斜坡结构循环地膨胀和收缩驱动构件之间的轴向间隔，这两者都产生最大的轴向驱动力并且有效地在驱动构件之间交替地移动轴向驱动力。承载力驱动构件将相对于螺钉与螺纹摩擦，并且基本上无载荷的驱动构件将容易地旋转，随着适于沿着螺钉轴向前进的随动旋转。相对分量旋转和反复扩张和收缩换档循环递增地并且交替地前进，以英寸蜗杆为动作，沿螺杆的驱动构件提供部件之间的轴向移动和力产生，无载驱动构件前进，力承载的驱动构件相对于螺钉保持固定。

9. 发明授权

US11307181B1 HPLC system with mixed-mode columns for measuring charged analytes in complex mixtures 有权
公开(公告)号：US11307181B1
公开(公告)日：2022-04-19
申请号：US16510913
申请日：2019-07-13
申请人： Yury Zelechonok
发明人： Yury Zelechonok
IPC分类号： G01N30/46 , G01N30/22 , G01N30/36 , G01N30/02 , G01N30/20
摘要： Disclosed is a HPLC system including a first dimension column, a second dimension column, a high pressure switching valve installed along the mobile phase flow path with the usual detector. At a predetermined time after injection of a sample into the mobile phase stream, the valve is actuated so that late eluted components, while still in the first dimension column, are back-flushed to waste by the flow of mobile phase while the analytes get separated in the second dimension column. Mixed-mode cation exchange and anion exchange columns are particularly suited for this application.

10. 发明授权

US08449274B1 Magnetic reciprocating pump 有权
标题翻译：磁性往复泵
公开(公告)号：US08449274B1
公开(公告)日：2013-05-28
申请号：US13045360
申请日：2011-03-10
申请人： Yury Zelechonok
发明人： Yury Zelechonok
IPC分类号： F04B17/04
CPC分类号： F04B17/04
摘要： A magnetic reciprocating pump includes a tube having ends defining intake and discharge ports, first and second magnetic plungers axially aligned within the tube of corresponding cross section for reciprocation therewithin, and a plurality of longitudinally spaced coils circumscribing the tube for driving the plungers axially when electrically energized. A gap is defined between the plungers so that the first plunger is slidable between one tube end and the second plunger and the second plunger is slidable between the other tube end and the first plunger. The first plunger closes one port when moved thereagainst and has a peripheral flow path permitting flow when moved away. The second plunger closes the other port when moved thereagainst and has an outer peripheral flow path and a communicating inner axial flow path permitting flow when moved away. The plungers when moved together close the second plunger axial flow path.
摘要翻译：磁性往复泵包括具有限定入口和排出口的端部的管，在对应横截面的管中轴向对准的第一和第二磁性柱塞，用于在其中往复运动;以及多个纵向间隔的线圈，其围绕管，用于在电气时轴向驱动柱塞通电。在柱塞之间限定间隙，使得第一柱塞可在一个管端和第二柱塞之间滑动，并且第二柱塞可在另一管端与第一柱塞之间滑动。当第一柱塞移动时，第一柱塞关闭一个端口，并具有当移动时允许流动的外围流动路径。当第二柱塞移动时，第二柱塞封闭另一个端口，并且具有外周流动路径和当移动时允许流动的连通内轴流动路径。柱塞一起移动时闭合第二柱塞轴向流动路径。

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