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1. 发明授权

US5241053A Fused proteins comprising glycoprotein gD of HSV-1 and LTB 失效
标题翻译：包含HSV-1和LTB的糖蛋白gD的融合蛋白
公开(公告)号：US5241053A
公开(公告)日：1993-08-31
申请号：US577915
申请日：1990-09-05
申请人： Yukio Fujisawa , Shuji Hinuma , Aki Mayumi , Tatsuo Yamamoto
发明人： Yukio Fujisawa , Shuji Hinuma , Aki Mayumi , Tatsuo Yamamoto
IPC分类号： A61K39/00 , A61K47/48 , C07K14/035 , C07K14/245
CPC分类号： C07K14/245 , A61K47/4833 , C07K14/005 , A61K39/00 , C07K2319/40 , C07K2319/55 , C12N2710/16622
摘要： Disclosed are (1) a fused protein comprising heat-labile enterotoxin B subunit and a protein heterologous to heat-labile enterotoxin, (2) a recombinant DNA containing a nucleotide sequence coding for the above fused protein, (3) a transformant harboring the above recombinant DNA, (4) a method for producing the fused protein which comprises cultivating the above transformant, producing and accumulating the above fused protein in a culture, and collecting the fused protein, and (5) a method for purifying a fused protein comprising a herpes simplex virus surface antigen and heat-labile enterotoxin B subunit, which comprises cultivating a transformant harboring a recombinant DNA containing a nucleotide sequence coding for the fused protein, producing an accumulating the fused protein in a culture, collecting the fused protein and subjecting the collected fused protein to purification processes comprising cationic exchange chromatography and gel permeation chromatography.
摘要翻译：公开了（1）包含热不稳定肠毒素B亚基和与热不稳定肠毒素异源的蛋白质的融合蛋白，（2）含有编码上述融合蛋白的核苷酸序列的重组DNA，（3）含有上述重组DNA，（4）生产融合蛋白的方法，包括培养上述转化体，在培养物中产生和积累上述融合蛋白，并收集融合蛋白，和（5）纯化融合蛋白的方法，单纯疱疹病毒表面抗原和热不稳定肠毒素B亚基，其包括培养含有编码融合蛋白的核苷酸序列的重组DNA的转化体，产生在培养物中积聚融合蛋白，收集融合蛋白并使收集的融合蛋白与包含阳离子交换层析和凝胶渗透色谱的纯化方法。

2. 发明授权

US5728552A DNA encoding a fusion protein comprising a viral antigen and lymphokine 失效
标题翻译：编码包含病毒抗原和淋巴因子的融合蛋白的DNA
公开(公告)号：US5728552A
公开(公告)日：1998-03-17
申请号：US600545
申请日：1996-02-13
申请人： Yukio Fujisawa , Shuji Hinuma , Aki Mayumi
发明人： Yukio Fujisawa , Shuji Hinuma , Aki Mayumi
IPC分类号： A61K39/00 , C07K14/035 , C07K14/04 , C07K14/16 , C07K14/55 , C07K16/08 , C12N1/21 , C12N15/26 , C12N15/38 , C12N15/48 , C12N15/33 , C12N15/62
CPC分类号： C07K16/08 , C07K14/005 , C07K14/55 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/75 , C12N2710/16122 , C12N2710/16622 , C12N2710/16722 , C12N2740/16122 , C12N2740/16222
摘要： Disclosed are (1) a fused protein obtained by combining an antigen used for vaccine and a lymphokine by the application of gene engineering, (2) a recombinant DNA containing a nucleotide sequence coding for the above fused protein, (3) a transformant bearing the above recombinant DNA, (4) a method for producing the fused protein which comprises cultivating the above transformant, producing and accumulating the above fused protein in a culture, and collecting the fused protein, and (5) a hybrid protein obtained by chemically combining an antigen used for vaccine with a lymphokine. The resulting fused and hybrid proteins have strong immunogenicity.
摘要翻译：公开的（1）通过应用基因工程将用于疫苗的抗原与淋巴因子组合而获得的融合蛋白，（2）含有编码上述融合蛋白的核苷酸序列的重组DNA，（3）（4）生产融合蛋白的方法，其包括培养上述转化体，在培养物中产生和积累上述融合蛋白，并收集融合蛋白，和（5）将化合物用于具有淋巴因子的疫苗的抗原。所得的融合蛋白和杂交蛋白具有很强的免疫原性。

3. 发明授权

US5556946A Interleukin-2/viral antigen protein chimers 失效
标题翻译：白细胞介素-2 /病毒抗原蛋白质切割器
公开(公告)号：US5556946A
公开(公告)日：1996-09-17
申请号：US386354
申请日：1995-02-08
申请人： Yukio Fujisawa , Shuji Hinuma , Aki Aono
发明人： Yukio Fujisawa , Shuji Hinuma , Aki Aono
IPC分类号： A61K39/00 , C07K14/035 , C07K14/04 , C07K14/16 , C07K14/55 , C07K16/08 , C12N1/21 , C12N15/26 , C12N15/38 , C12N15/48 , A61K38/20 , C12N15/62
CPC分类号： C07K16/08 , C07K14/005 , C07K14/55 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/75 , C12N2710/16122 , C12N2710/16622 , C12N2710/16722 , C12N2740/16122 , C12N2740/16222
摘要： Disclosed are (1) a fused protein obtained by combining an antigen used for vaccine and a lymphokine by the application of gene engineering, (2) a recombinant DNA containing a nucleotide sequence coding for the above fused protein, (3) a transformant bearing the above recombinant DNA, (4) a method for producing the fused protein which comprises cultivating the above transformant, producing and accumulating the above fused protein in a culture, and collecting the fused protein, and (5) a hybrid protein obtained by chemically combining an antigen used for vaccine with a lymphokine. The resulting fused and hybrid proteins have strong immunogenicity.
摘要翻译：公开的（1）通过应用基因工程将用于疫苗的抗原与淋巴因子组合而获得的融合蛋白，（2）含有编码上述融合蛋白的核苷酸序列的重组DNA，（3）（4）生产融合蛋白的方法，其包括培养上述转化体，在培养物中产生和积累上述融合蛋白，并收集融合蛋白，和（5）将化合物用于具有淋巴因子的疫苗的抗原。所得的融合蛋白和杂交蛋白具有很强的免疫原性。

4. 发明授权

US08265087B2 Gateway apparatus and data transfer control method 有权
标题翻译：网关设备和数据传输控制方法
公开(公告)号：US08265087B2
公开(公告)日：2012-09-11
申请号：US11976687
申请日：2007-10-26
申请人： Kaoru Noumi , Susumu Nishihashi , Tomoyuki Katou , Yukio Ishikawa , Yasuyuki Umezaki , Hidetaka Ebeshu , Shigeo Koide , Yukio Fujisawa , Hiroaki Shimauchi
发明人： Kaoru Noumi , Susumu Nishihashi , Tomoyuki Katou , Yukio Ishikawa , Yasuyuki Umezaki , Hidetaka Ebeshu , Shigeo Koide , Yukio Fujisawa , Hiroaki Shimauchi
IPC分类号： H04L12/28
CPC分类号： H04L12/66 , H04L12/4135 , H04L12/4625 , H04L2012/40215 , H04L2012/40273
摘要： A gateway apparatus for performing transfer control of frame data between communication channels includes a routing map that stores ID information about the frame data and information about a communication channel that uses the ID information, and a search engine unit that routes the frame data to a transfer destination on the basis of the ID information of the frame data received and the routing map. The search engine unit does not transfer the frame data to the transfer destination when the ID information about the frame data received is ID information that is not used in the communication channel through which the frame data is received.
摘要翻译：用于在通信信道之间执行帧数据的传输控制的网关装置包括存储关于帧数据的ID信息和关于使用该ID信息的通信信道的信息的路由图，以及将帧数据路由到传送的搜索引擎单元基于接收的帧数据的ID信息和路由图。当接收到的帧数据的ID信息是在接收帧数据的通信信道中未使用的ID信息时，搜索引擎单元不将帧数据传送到传送目的地。

5. 发明申请

US20080101394A1 Gateway apparatus and data transfer control method 有权
标题翻译：网关设备和数据传输控制方法
公开(公告)号：US20080101394A1
公开(公告)日：2008-05-01
申请号：US11976687
申请日：2007-10-26
申请人： Kaoru Noumi , Susumu Nishihashi , Tomoyuki Katou , Yukio Ishikawa , Yasuyuki Umezaki , Hidetaka Ebeshu , Shigeo Koide , Yukio Fujisawa , Hiroaki Shimauchi
发明人： Kaoru Noumi , Susumu Nishihashi , Tomoyuki Katou , Yukio Ishikawa , Yasuyuki Umezaki , Hidetaka Ebeshu , Shigeo Koide , Yukio Fujisawa , Hiroaki Shimauchi
IPC分类号： H04L12/28
CPC分类号： H04L12/66 , H04L12/4135 , H04L12/4625 , H04L2012/40215 , H04L2012/40273
摘要： A gateway apparatus for performing transfer control of frame data between communication channels includes a routing map that stores ID information about the frame data and information about a communication channel that uses the ID information, and a search engine unit that routes the frame data to a transfer destination on the basis of the ID information of the frame data received and the routing map. The search engine unit does not transfer the frame data to the transfer destination when the ID information about the frame data received is ID information that is not used in the communication channel through which the frame data is received.
摘要翻译：用于在通信信道之间执行帧数据的传输控制的网关装置包括存储关于帧数据的ID信息和关于使用该ID信息的通信信道的信息的路由图，以及将帧数据路由到传送的搜索引擎单元基于接收的帧数据的ID信息和路由图。当接收到的帧数据的ID信息是在接收帧数据的通信信道中未使用的ID信息时，搜索引擎单元不将帧数据传送到传送目的地。

6. 发明授权

US5675240A All digital switching regulator for use in power supplies, battery chargers, and DC motor control circuits 失效
标题翻译：用于电源，电池充电器和直流电机控制电路的所有数字开关稳压器
公开(公告)号：US5675240A
公开(公告)日：1997-10-07
申请号：US495391
申请日：1995-06-28
申请人： Yukio Fujisawa , Isao Takinoue
发明人： Yukio Fujisawa , Isao Takinoue
IPC分类号： H02P7/29 , G05F1/575 , H02M3/155 , H02M3/157 , G05F1/40
CPC分类号： H02M3/157 , G05F1/575
摘要： A switching regulator is composed of digital circuits only. A switching regulator (30) comprises a driver (2) for directly controlling the operation of a switching transistor (1), and an OR gate (6) for determining the logic issued by the driver (2). An output terminal (Q) of an RS flip-flop (5) is connected to one input end of the OR gate (6), the output of a timer (40c) is applied to a set terminal (S) of the RS flip-flop (5), and the output of a comparator (4) is applied to a reset terminal (R1) through an OR gate (7). At a non-reverse input end of the comparator (4), a reference voltage (VE) is applied by a D/A convertor (40b), while a feedback voltage (VFB) is applied to a reverse input end. Accordingly, chopping of the switching transistor (1) is done on the basis of a rectangular pulse.
摘要翻译：开关稳压器仅由数字电路组成。开关调节器（30）包括用于直接控制开关晶体管（1）的操作的驱动器（2）和用于确定由驱动器（2）发出的逻辑的或门（6）。 RS触发器（5）的输出端（Q）连接到或门（6）的一个输入端，定时器（40c）的输出被施加到RS翻转的设定端（S）（5），并且比较器（4）的输出通过或门（7）施加到复位端子（R1）。在比较器（4）的非反相输入端，由D / A转换器（40b）施加参考电压（VE），而反馈电压（VFB）施加到反向输入端。因此，开关晶体管（1）的斩波是基于矩形脉冲进行的。

7. 发明授权

US5550138A Condensed thiadiazole derivative, method of its production, and use thereof 失效
标题翻译：缩合噻二唑衍生物，其制备方法及其用途
公开(公告)号：US5550138A
公开(公告)日：1996-08-27
申请号：US039579
申请日：1993-03-23
申请人： Takashi Sohda , Zen-ichi Terashita , Yu Momose , Yukio Fujisawa , Junji Mizoguchi
发明人： Takashi Sohda , Zen-ichi Terashita , Yu Momose , Yukio Fujisawa , Junji Mizoguchi
IPC分类号： C07D513/04 , A61K31/435
CPC分类号： C07D513/04
摘要： (1) a compound represented by the following formula (I): ##STR1## wherein R represents a hydrocarbon group or heterocyclic group which may be substituted; the ring A represents a pyridine ring having a substituent or a thiazole ring which may be substituted; or a pharmaceutically acceptable salt thereof, and a method of its production, and(2) an endothelin receptor antagonist, an cathepsin B inhibitor or a bone resorption suppressor having as an active ingredient a compound represented by the following formula (I'): ##STR2## wherein R has the same definition as in term (1); the ring A' represents a pyridine ring or thiazole ring which may be substituted; or a pharmaceutically acceptable salt thereof.
摘要翻译：（1）由下式（I）表示的化合物：其中R表示可被取代的烃基或杂环基; 环A表示具有取代基的吡啶环或可被取代的噻唑环; 或其药学上可接受的盐及其制备方法，和（2）作为活性成分的下式（I'）表示的化合物的内皮素受体拮抗剂，组织蛋白酶B抑制剂或骨吸收抑制剂：（I'）其中R与术语（1）具有相同的定义; 环A'表示可被取代的吡啶环或噻唑环; 或其药学上可接受的盐。

8. 发明授权

US5498728A Derivatives of L-tryptophanal and their use as medicinals 失效
标题翻译： L-色氨酸的衍生物及其作为药物的用途
公开(公告)号：US5498728A
公开(公告)日：1996-03-12
申请号：US192038
申请日：1994-02-04
申请人： Takashi Sohda , Yukio Fujisawa , Tsuneo Yasuma , Junji Mizoguchi , Masakuni Kori , Masayuki Takizawa
发明人： Takashi Sohda , Yukio Fujisawa , Tsuneo Yasuma , Junji Mizoguchi , Masakuni Kori , Masayuki Takizawa
IPC分类号： A61K38/55 , A61K31/16 , A61K31/165 , A61K31/18 , A61K31/27 , A61K38/00 , A61P3/00 , A61P3/02 , A61P43/00 , C07C231/12 , C07C233/18 , C07C233/22 , C07C233/31 , C07C237/10 , C07C237/22 , C07C271/16 , C07C271/18 , C07C271/22 , C07C303/40 , C07C311/19 , C07C337/02 , C07D209/14 , C07D209/16 , C07K1/113 , C07K5/06 , C07K5/062 , C07K14/81 , A61K31/40
CPC分类号： C07D209/16 , C07C233/18 , C07C233/22 , C07C233/31 , C07C271/16 , C07C271/18 , C07C271/22 , C07C311/19 , C07K5/06034 , A61K38/00 , Y02P20/55
摘要： The present invention provides a cathepsin L inhibitor containing a compound of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or an arylalkyl, heterocyclic-alkyl or lower alkyl group which may be substituted; R.sup.2 and R.sup.3 independently are a hydrogen atom or a hydrocarbon residue which may be substituted; R.sup.4 is an alkanoyl, sulfonyl, carbonyloxy, carbamoyl or thiocarbamoyl group which may be substituted; X is formula: --CHO or --CH.sub.2 OB (wherein B is a hydrogen atom or a protecting group of hydroxyl group); m and n independently are an integer of 0 or 1; provided that R.sup.4 is an alkanoyl group substituted by aryl, a sulfonyl group substituted by aryl having more than 9 carbon atoms or by lower alkyl, or a carbamoyl or thiocarbamoyl group which may be substituted when R.sup.1 is an unsubstituted lower alkyl, arylalkyl on methylthioethyl group, R.sup.2 and R.sup.3 independently are a lower alkyl or arylalkyl, X is --CHO, m is 1 and n is 0 or 1, or a salt thereof.Compound (I) is useful as a prophylactic/therapeutic agent for osteoporosis.
摘要翻译：本发明提供了含有下式化合物的组蛋白酶L抑制剂：其中R1是氢原子或可被取代的芳基烷基，杂环烷基或低级烷基; R2和R3独立地是氢原子或可以被取代的烃残基; R4是可以被取代的烷酰基，磺酰基，羰基氧基，氨基甲酰基或硫代氨基甲酰基; X是式：-CHO或-CHOOB（其中B是氢原子或羟基保护基）; m和n独立地为0或1的整数; 条件是R4是被芳基取代的烷酰基，被具有多于9个碳原子的芳基取代的磺酰基或低级烷基，或当R 1是未取代的低级烷基时可被取代的氨基甲酰基或硫代氨基甲酰基，甲基硫代乙基上的芳基烷基，R2和R3独立地是低级烷基或芳烷基，X是-CHO，m是1，n是0或1，或其盐。化合物（I）可用作骨质疏松症的预防/治疗剂。

9. 发明申请

US20080141074A1 Error detector and error detection method 有权
标题翻译：误差检测器和误差检测方法
公开(公告)号：US20080141074A1
公开(公告)日：2008-06-12
申请号：US11976544
申请日：2007-10-25
申请人： Kaoru Noumi , Susumu Nishihashi , Tomoyuki Katou , Yukio Ishikawa , Yasuyuki Umezaki , Hidetaka Ebeshu , Shigeo Koide , Yukio Fujisawa , Hiroaki Shimauchi
发明人： Kaoru Noumi , Susumu Nishihashi , Tomoyuki Katou , Yukio Ishikawa , Yasuyuki Umezaki , Hidetaka Ebeshu , Shigeo Koide , Yukio Fujisawa , Hiroaki Shimauchi
IPC分类号： G06F11/00
CPC分类号： H04L1/0045 , G06F11/10 , H04L1/0063 , H04L1/243 , H04L1/244
摘要： An error detector has a parity bit generator which generates error detection data for data strings sent from a CPU I/F to a memory, a parity checker which detects an error in the data strings output from the memory based on the error detection data, and a selector circuit which switchingly outputs the data from the parity bit generator and the data from a CPU which sends diagnostic data. While the selector circuit is switched to output the data from the CPU, based on the error detection data output from the selector circuit, the error detector conducts a failure diagnosis of error detection functions including at least one of the parity bit generator and the parity checker.
摘要翻译：错误检测器具有产生从CPU I / F向存储器发送的数据串的错误检测数据的奇偶校验位产生器，基于检错数据检测从存储器输出的数据串中的错误的奇偶检验器，以及选择器电路，其切换地输出来自奇偶位产生器的数据和来自发送诊断数据的CPU的数据。当选择器电路被切换以从CPU输出数据时，基于从选择器电路输出的错误检测数据，误差检测器进行包括奇偶位产生器和奇偶校验器中的至少一个的错误检测功能的故障诊断。

10. 发明授权

US06314099B1 Address match determining device, communication control system, and address match determining method 失效
标题翻译：地址匹配确定装置，通信控制系统和地址匹配确定方法
公开(公告)号：US06314099B1
公开(公告)日：2001-11-06
申请号：US09146044
申请日：1998-09-02
申请人： Yukio Fujisawa , Kazutoshi Miyamoto , Christoph Gottschalk , Hans-Michael Loch
发明人： Yukio Fujisawa , Kazutoshi Miyamoto , Christoph Gottschalk , Hans-Michael Loch
IPC分类号： H04L1256
CPC分类号： H04L29/06 , H04L45/742 , H04L69/22
摘要： An address match determining device has an address filter memory (22) for storing a matrix or table having a plurality of elements each of which is a 1-bit address match determination data indicating whether or not a corresponding N-bit address code is available, and is distinguished by a pair of a first index composed of the m most significant or high-order m bits of the corresponding address code and a second index composed of the remaining lowest or low-order (N−m) bits of the corresponding address code. A received-address latch (21) extracts the high-order m bits and remaining low-order (N−m) bits from an address code latched thereinto. The device searches through the table for one 1-bit address match determination data specified by the first index composed of the extracted high-order m bits and the second index composed of the extracted low-order (N−m) bits, and then determines whether or not the latched address is available on the basis of the 1-bit address match determination data searched for.
摘要翻译：地址匹配确定装置具有用于存储具有多个元素的矩阵或表的地址过滤存储器（22），每个元素是表示对应的N位地址码是否可用的1位地址匹配确定数据，并且由一对由相应地址码的m个最高有效位或高位m位组成的第一索引和由相应地址码的剩余最低位或低阶（Nm）位组成的第二索引来区分。接收地址锁存器（21）从锁存在其中的地址码提取高阶m位和剩余低位（N-m）位。设备通过表格搜索由提取的高阶m位组成的第一索引和由提取的低阶（Nm）位组成的第二索引指定的一个1位地址匹配确定数据，然后确定是否或基于搜索到的1位地址匹配确定数据，不是锁存地址可用。

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