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1. 发明申请

US20110065094A1 METHOD AND KIT FOR DETECTION/IDENTIFICATION OF VIRUS-INFECTED CELL 审中-公开
标题翻译：用于检测/鉴定病毒感染细胞的方法和工具包
公开(公告)号：US20110065094A1
公开(公告)日：2011-03-17
申请号：US12933736
申请日：2009-03-17
申请人： Hiroshi Kimura , Yukihiro Nishiyama
发明人： Hiroshi Kimura , Yukihiro Nishiyama
IPC分类号： C12Q1/70
CPC分类号： C12Q1/701 , C12Q1/6804 , G01N33/56994 , G01N2333/05 , C12Q2565/626
摘要： Disclosed is a means for specifically detecting and identifying a virus-infected cell in a floating cell system by a simple manipulation and with high sensitivity. A virus-infected cell can be detected and identified by the following steps (1) to (5): (1) adding a first labeled antibody which has been labeled with a first labeling substance and is directed against a cell surface antigen specific to a target cell to a sample and allowing the mixture to react; (2) immobilizing a protein in the presence of an RNAstabilizing agent; (3) treating the protein with a surfactant; (4) adding a labeled nucleic acid probe for a nucleic acid specific to a target virus to cause the hybridization; and (5) detecting a cell labeled with both the first labeled antibody and the labeled nucleic acid probe by flow cytometry.
摘要翻译：公开了通过简单的操作和高灵敏度来特异性检测和识别浮游细胞系统中的病毒感染细胞的方法。可以通过以下步骤（1）至（5）检测和鉴定病毒感染的细胞：（1）加入已经用第一标记物质标记的第一标记抗体，并针对特异性的细胞表面抗原靶细胞至样品并使混合物反应; （2）在RNA稳定剂存在下固定蛋白质; （3）用表面活性剂处理蛋白质; （4）为靶病毒特异性的核酸加入标记的核酸探针以引起杂交; 和（5）通过流式细胞术检测用第一标记抗体和标记的核酸探针两者标记的细胞。

2. 发明授权

US5283331A 2-halogeno-oxetanocin A and phosphoric ester thereof 失效
标题翻译： 2-卤代 - 氧杂环鸟素A及其磷酸酯
公开(公告)号：US5283331A
公开(公告)日：1994-02-01
申请号：US804773
申请日：1991-12-09
申请人： Seiichi Saito , Akira Masuda , Masayuki Kitagawa , Nobuyoshi Shimada , Jun-ichi Seki , Hiroo Hoshino , Yukihiro Nishiyama
发明人： Seiichi Saito , Akira Masuda , Masayuki Kitagawa , Nobuyoshi Shimada , Jun-ichi Seki , Hiroo Hoshino , Yukihiro Nishiyama
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P31/12 , C07H19/02 , C07H19/16 , C07D473/40 , A61K31/52 , C07F7/18 , C07F9/09
CPC分类号： C07H19/02
摘要： It was found that 2-halogeno-oxetanocin A and 4'-phosphate thereof represented by the following general formula (1): ##STR1## wherein X represents a halogen atom and R represents a hydrogen atom or a phosphoric acid residue ##STR2## or salts thereof exhibit a strong antiviral activity and are useful as an active ingredient of therapeutic drug for viral diseases. Further, it was also found that the compounds of this invention are characterized in that they are not inactivated by adenosine deaminase widely present in living bodies and exhibit a high residual activity.
摘要翻译：发现由以下通式（1）表示的2-卤代 - 氧杂环鸟菌素A和4'-磷酸酯：（*化学结构*）（1）其中X表示卤素原子，R表示氢原子或磷酸酸性残基（*化学结构*）或其盐表现出强的抗病毒活性，可用作病毒性疾病的治疗药物的活性成分。此外，还发现本发明的化合物的特征在于它们不被广泛存在于活体中的腺苷脱氨酶灭活，并且表现出高的残留活性。

3. 发明授权

US07701099B2 Axial-gap motor/generator 有权
标题翻译：轴向电机/发电机
公开(公告)号：US07701099B2
公开(公告)日：2010-04-20
申请号：US11508106
申请日：2006-08-22
申请人： Yuichi Shibukawa , Yukihiro Nishiyama
发明人： Yuichi Shibukawa , Yukihiro Nishiyama
IPC分类号： H02K11/00 , H02K23/66
CPC分类号： H02K21/24 , H02K3/50
摘要： An axial-gap motor/generator that has a stator equipped with a plurality of polyphase coils from which are led output lead wires, wherein wire connectors 16 for each of coil 12 are divided and arranged on the front side and rear side of the side surface of stator 10.
摘要翻译：一种轴向间隙电动机/发电机，其具有配置有多个多相线圈的定子，其中由所述定子配置有多个引线输出引线，其中线圈12中的每一个的线连接器16被分配并布置在侧表面的前侧和后侧的定子10。

4. 发明申请

US20080069837A1 Composition and method for treating cancer using herpes virus 审中-公开
标题翻译：使用疱疹病毒治疗癌症的组合物和方法
公开(公告)号：US20080069837A1
公开(公告)日：2008-03-20
申请号：US11827108
申请日：2007-07-09
申请人： Yukihiro Nishiyama
发明人： Yukihiro Nishiyama
IPC分类号： A61K39/00 , A61K35/00
CPC分类号： C12N7/00 , A61K31/337 , A61K31/4745 , A61K31/522 , A61K35/763 , A61K2039/541 , C12N15/86 , C12N2710/16032 , C12N2710/16062 , C12N2710/16632 , C12N2710/16643 , C12N2710/16651 , A61K2300/00
摘要： The present invention provides a herpes virus in which a non-essential gene for replication is inactivated. More particularly, the present invention provides a herpes virus in which a non-essential gene for replication present in a UL or US region is inactivated. More preferably, the non-essential gene for replication contains US3 or UL56. The herpes virus may be preferably a herpes simplex virus, and more preferably herpes simplex virus 1 or herpes simplex virus 2. The present invention provides a method, composition and use for treating various diseases or disorders including tumor and infectious diseases. The present invention also provides a method, composition and use for activating a prodrug.
摘要翻译：本发明提供了一种疱疹病毒，其中用于复制的非必需基因被灭活。更具体地，本发明提供了一种疱疹病毒，其中存在于UL或US区域中的非必需基因用于失活。更优选地，用于复制的非必需基因包含US3或UL56。疱疹病毒可以优选为单纯疱疹病毒，更优选为单纯疱疹病毒1或单纯疱疹病毒2.本发明提供治疗各种疾病或病症（包括肿瘤和感染性疾病）的方法，组合物和用途。本发明还提供了用于活化前药的方法，组合物和用途。

5. 发明申请

US20070046140A1 Axial-gap motor/generator 有权
标题翻译：轴向电机/发电机
公开(公告)号：US20070046140A1
公开(公告)日：2007-03-01
申请号：US11508106
申请日：2006-08-22
申请人： Yuichi Shibukawa , Yukihiro Nishiyama
发明人： Yuichi Shibukawa , Yukihiro Nishiyama
IPC分类号： H02K3/00 , H02K1/22
CPC分类号： H02K21/24 , H02K3/50
摘要： An axial-gap motor/generator that has a stator equipped with a plurality of polyphase coils from which are led output lead wires, wherein wire connectors 16 for each of coil 12 are divided and arranged on the front side and rear side of the side surface of stator 10.
摘要翻译：一种轴向间隙电动机/发电机，其具有配置有多个多相线圈的定子，其中由所述定子配置有多个引线输出引线，其中线圈12中的每一个的线连接器16被分配并布置在侧表面的前侧和后侧的定子10。

6. 发明申请

US20050265971A1 Agent for treatment of breast cancer and pancreatic cancer comprising herpes simplex virus mutant 审中-公开
标题翻译：用于治疗包括单纯疱疹病毒突变体的乳腺癌和胰腺癌的药剂
公开(公告)号：US20050265971A1
公开(公告)日：2005-12-01
申请号：US11076871
申请日：2005-03-11
申请人： Akimasa Nakao , Yukihiro Nishiyama
发明人： Akimasa Nakao , Yukihiro Nishiyama
IPC分类号： C12N7/00 , A61K35/76 , A61K39/245 , A61K48/00 , A61P35/00 , A61P35/04 , C12N15/869 , C12R1/93
CPC分类号： C12N7/00 , A61K35/763 , C12N15/86 , C12N2710/16632 , C12N2710/16643
摘要： There is provided a novel therapeutic agent for pancreatic cancer, metastatic breast cancer and recurrent breast cancer in human. The present invention provides a method for treating a patient having pancreatic cancer, metastatic breast cancer or recurrent breast cancer comprising administrating to the patient a herpes simplex virus mutant where UL56 gene Is inactivated. Preferably, the herpes simplex virus mutant is a herpes simplex virus type 1 HF10 strain.
摘要翻译：提供了一种新型的胰腺癌治疗剂，转移性乳腺癌和人类复发性乳腺癌。本发明提供了一种治疗患有胰腺癌，转移性乳腺癌或复发性乳腺癌的患者的方法，其包括向患者施用UL56基因失活的单纯疱疹病毒突变体。优选地，单纯疱疹病毒突变体是1型HF10菌株的单纯疱疹病毒。

7. 发明授权

US5041447A Oxetanocin-related compounds and pharmaceutical compositions containing them 失效
标题翻译：含有氧杂环鸟胺的化合物和含有它们的药物组合物
公开(公告)号：US5041447A
公开(公告)日：1991-08-20
申请号：US325230
申请日：1989-03-17
申请人： Seiichi Saito , Shigeru Hasegawa , Katsutoshi Takahashi , Nobuyoshi Shimada , Jun-ichi Seki , Hiroo Hoshino , Yukihiro Nishiyama , Kenichi Matsubara , Takemitsu Nagahata
发明人： Seiichi Saito , Shigeru Hasegawa , Katsutoshi Takahashi , Nobuyoshi Shimada , Jun-ichi Seki , Hiroo Hoshino , Yukihiro Nishiyama , Kenichi Matsubara , Takemitsu Nagahata
IPC分类号： C07D305/06 , C07D305/08 , C07D305/10 , C07H19/02
CPC分类号： C07H19/02 , C07D305/06 , C07D305/08 , C07D305/10
摘要： This invention relates to oxetanocin-related compounds represented by the following formula (I): ##STR1## [in formula (I), R.sub.1, Y and B have the following meanings: (a) R.sub.1 represents --CH.sub.2 OH or --CH.sub.2 OCO-(alkyl),(b) Y represents ##STR2## provided that R.sub.2 is --H, --OH or --CH.sub.2 OH and R.sub.3 is --H, --OH, halogen atom, --CH.sub.2 OH, lower alkyl group, --CH.sub.2 -N.sub.3, --CH.sub.2 -F, --N.sub.3, --COOH, --NH.sub.2, --CH.sub.2 OSO.sub.3 H or --CH.sub.2 OCO-(lower alkyl), and(c) B represents a residue of purine base,(d) provided that R.sub.1 and R.sub.3 cannot simultaneously represents --CH.sub.2 OH]and their salts which have activities such as an antiviral activity and the like and are expectedly useful as a pharmaceutical and the like.

8. 发明授权

US07264814B2 Composition and method for treating cancer using herpes virus 有权
标题翻译：使用疱疹病毒治疗癌症的组合物和方法
公开(公告)号：US07264814B2
公开(公告)日：2007-09-04
申请号：US10477444
申请日：2002-05-09
申请人： Yukihiro Nishiyama
发明人： Yukihiro Nishiyama
IPC分类号： A61K39/12
CPC分类号： C12N7/00 , A61K31/337 , A61K31/4745 , A61K31/522 , A61K35/763 , A61K2039/541 , C12N15/86 , C12N2710/16032 , C12N2710/16062 , C12N2710/16632 , C12N2710/16643 , C12N2710/16651 , A61K2300/00
摘要： The present invention provides a herpes virus in which a non-essential gene for replication is inactivated More particularly, the present invention provides a herpes virus in which a non-essential gene for replication present in a UL or US region is inactivated. More preferably, the non-essential gene for replication contains US3 or UL56. The herpes virus may be preferably a herpes simplex virus, and more preferably herpes simplex virus 1 or herpes simplex virus 2. The present invention provides a method, composition and use for treating various diseases or disorders including tumor and infectious diseases. The present invention also provides a method, composition and use for activating a prodrug.
摘要翻译：本发明提供其中非必需基因用于复制的疱疹病毒更特别地，本发明提供了其中存在于UL或US区域中的非必需基因用于失活的疱疹病毒。更优选地，用于复制的非必需基因包含US3或UL56。疱疹病毒可以优选为单纯疱疹病毒，更优选为单纯疱疹病毒1或单纯疱疹病毒2.本发明提供治疗各种疾病或病症（包括肿瘤和感染性疾病）的方法，组合物和用途。本发明还提供了用于活化前药的方法，组合物和用途。

9. 发明申请

US20050220806A1 Method of transporting physiological polymer using protein having rxp repeated sequence 审中-公开
标题翻译：使用具有rxp重复序列的蛋白质输送生理性聚合物的方法
公开(公告)号：US20050220806A1
公开(公告)日：2005-10-06
申请号：US10482803
申请日：2002-07-02
申请人： Yukihiro Nishiyama , Tetsuo Koshizuka
发明人： Yukihiro Nishiyama , Tetsuo Koshizuka
IPC分类号： A61K38/02 , A61K47/48 , A61K48/00 , A61P29/00 , A61P31/00 , A61P33/00 , A61P43/00 , C07K14/03 , C12N15/87 , A61K39/29 , C07K14/035
CPC分类号： C12N15/87 , A61K38/02 , A61K47/62 , A61K48/0008 , C07K14/005 , C12N2710/16622
摘要： The present invention provides a method for efficiently transporting useful protein, peptide, gene, etc. to a target cell such as a diseased cell, which is characterized by that a complex in which protein having a structure of peptide unit repetition represented by the formula Arg-Xaa-Pro (in the formula, Xaa is a hydrophobic or acidic amino acid residue) at the C-terminal of the protein is bound to at least one of useful protein, peptide, gene, etc. is administered to a living body.
摘要翻译：本发明提供了将有用的蛋白质，肽，基因等有效地输送到患病细胞等靶细胞的方法，其特征在于，具有由式Arg表示的肽单位重复结构的蛋白质的复合物将Xaa-Pro（在该式中，Xaa是疏水性或酸性氨基酸残基）在蛋白质的C-末端与至少一种有用的蛋白质，肽，基因等结合施用于生物体。

10. 发明授权

US5324730A Phenoxyphosphoryloxymethyl cyclobutyl purines 失效
标题翻译：苯氧基磷酰氧基甲基环丁基嘌呤
公开(公告)号：US5324730A
公开(公告)日：1994-06-28
申请号：US704085
申请日：1991-05-22
申请人： Yuh-ichiro Ichikawa , Hiroshi Akaba , Yuka Sugawara , Hideo Sugimura , Kazuhisa Narita , Akira Shiozawa , Kouwa Yamashita , Sayuri Kato , Yukihiro Nishiyama , Kenichi Matsubara , Takemitsu Nagahata
发明人： Yuh-ichiro Ichikawa , Hiroshi Akaba , Yuka Sugawara , Hideo Sugimura , Kazuhisa Narita , Akira Shiozawa , Kouwa Yamashita , Sayuri Kato , Yukihiro Nishiyama , Kenichi Matsubara , Takemitsu Nagahata
IPC分类号： C07D473/00 , C07F9/6558 , C07F9/6561 , A61K31/52 , C07D473/18 , C07D473/32 , C07F9/09
CPC分类号： C07D473/00 , C07F9/65583 , C07F9/6561 , C07F9/65616
摘要： This invention relates to cyclobutane derivatives represented by the following general formula (1) and physiologically acceptable salts thereof: ##STR1## wherein B represents a nucleic acid base derivative, R.sup.1 and R.sup.2 independently represent hydrogen atom, dialkylaminoacyl group, 1,4-dihydro-1-methylnicotinoyl group or substituted phosphoric acid group, provided that either one of R.sup.1 and R.sup.2 is a group other than hydrogen atom.The compounds of this invention exhibit a high oral absorbability and are metabolized in vivo into the compounds of formula (1a). Accordingly, the compounds of this invention are expectedly useful as antiviral agent.
摘要翻译：本发明涉及由以下通式（1）表示的环丁烷衍生物及其生理学上可接受的盐：其中B表示核酸碱基衍生物，R1和R2独立地表示氢原子，二烷基氨基酰基，1,4 - 二氢-1-甲基烟酰基或取代的磷酸基，条件是R 1和R 2中的任一个是除氢原子之外的基团。本发明的化合物表现出高的口服吸收性，并且在体内被代谢为式（1a）的化合物。因此，预期本发明的化合物可用作抗病毒剂。

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