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1. 发明公开

US20230270846A1 REPLICATION-COMPETENT CONTROLLED ALPHA-HERPESVIRUS VECTORS AND USES THEREFORE 审中-公开
公开(公告)号：US20230270846A1
公开(公告)日：2023-08-31
申请号：US17300287
申请日：2019-11-04
申请人： HSF Pharmaceuticals SA
发明人： Richard W Voellmy
IPC分类号： A61K39/245 , C12N15/86 , A61P31/12
CPC分类号： A61K39/245 , C12N15/86 , A61P31/12 , C12N2710/16621 , C12N2710/16634 , C12N2710/16643 , C12N2710/16651 , C12N2710/16662 , C12N2710/16671 , C12N2830/002 , A61K2039/5254
摘要： The present disclosure relates to replication-competent controlled herpesviruses whose transient replication in a desired inoculation site region of a subject can be activated by the delivery of an appropriate heat dose to the inoculation site region. In related recombinant viruses, activation requires delivery of a heat dose in the presence in the inoculation site region of an effective concentration of a small-molecule regulator. The viruses are further engineered to be capable of replicating efficiently in the desired inoculation site region but essentially not in nerve ganglia and other nerve cells.

2. 发明授权

US09744199B2 Herpes simplex virus (HSV) with modified tropism, uses and process of preparation thereof 有权
公开(公告)号：US09744199B2
公开(公告)日：2017-08-29
申请号：US14864098
申请日：2015-09-24
申请人： ALMA MATER STUDIORUM—UNIVERSITA DI BOLOGNA
发明人： Gabriella Campadelli , Laura Menotti
IPC分类号： A61K35/00 , A61K35/76 , A61K49/04 , C07K14/005 , C12N7/00 , A61K39/245 , C07K14/035 , A61K35/763
CPC分类号： A61K35/763 , A61K49/04 , C07K14/005 , C07K2317/622 , C07K2319/33 , C07K2319/61 , C07K2319/74 , C12N7/00 , C12N2710/16621 , C12N2710/16622 , C12N2710/16632 , C12N2710/16633 , C12N2710/16651 , C12N2710/16722 , C12N2810/85 , Y02A50/407
摘要： A modified Herpes Simplex Virus (HSV), which has a portion of gD (glycoprotein D) of the glycoproteic envelope deleted and a heterologous single chain antibody inserted in place of such deleted portion; the modified HSV is capable of infecting cells through receptor HER2/ErbB2 but not through receptors HVEM/HveA and nectin1/HveC; uses of the modified HSV and a process of the preparation thereof are also disclosed.

3. 发明授权

US09085777B2 Mutant HSV, materials and methods for generation of mutant HSV 有权
标题翻译：突变体HSV，用于产生突变HSV的材料和方法
公开(公告)号：US09085777B2
公开(公告)日：2015-07-21
申请号：US12299965
申请日：2007-05-04
申请人： Joe Conner
发明人： Joe Conner
IPC分类号： C12N15/86 , C12Q1/70 , C12N7/01 , C12N15/869
CPC分类号： C12N15/86 , C12N15/869 , C12N15/8695 , C12N2710/16034 , C12N2710/16041 , C12N2710/16061 , C12N2710/16611 , C12N2710/16634 , C12N2710/16643 , C12N2710/16651
摘要： The present invention includes a method of generating a mutant Herpes Simplex Virus (HSV). In one embodiment, the generated HSV genome includes nucleic acid encoding a nucleic acid sequence of interest. In one step, a nucleic acid vector is provided which includes a nucleic acid encoding first and second site specific recombination sequences and a nucleic acid encoding a nucleic acid sequence of interest between said site specific recombination sequences an HSV is provided, the genome of which comprises third and fourth site specific recombination sequences In another step, the nucleic acid vector and HSV are contacted together with one or more recombinase enzymes capable of catalyzing site specific recombination between the site specific recombination sequences of said nucleic acid vector and said HSV. Another step includes identifying HSV containing the nucleic acid sequence of interest. In some embodiments, the methods are conducted in a cell-free system.
摘要翻译：本发明包括产生突变型单纯疱疹病毒（HSV）的方法。在一个实施方案中，产生的HSV基因组包括编码感兴趣的核酸序列的核酸。在一个步骤中，提供核酸载体，其包括编码第一和第二位点特异性重组序列的核酸和编码所述位点特异性重组序列之间的目标核酸序列的核酸，其提供HSV，其基因组包含第三和第四位点特异性重组序列在另一步骤中，将核酸载体和HSV与能够催化所述核酸载体的位点特异性重组序列和所述HSV之间的位点特异性重组的一种或多种重组酶接触。另一步骤包括鉴定含有感兴趣的核酸序列的HSV。在一些实施方案中，所述方法在无细胞系统中进行。

4. 发明申请

US20150150964A1 HERPESVIRUS COMPOSITIONS AND RELATED METHODS 审中-公开
标题翻译： HERPESVIRUS组合物及相关方法
公开(公告)号：US20150150964A1
公开(公告)日：2015-06-04
申请号：US14402678
申请日：2013-05-21
申请人： SANOFI PASTEUR LIMITED , SANOFI PASTEUR BIOLOGICS, LLC
发明人： Stephen Anderson , Simon Delagrave , John Hamberger , Qinglian Li , Sophia Mundle , Nausheen Rahman
IPC分类号： A61K39/245 , C12N7/00
CPC分类号： A61K39/245 , A61K9/0019 , A61K39/12 , A61K47/183 , A61K47/26 , A61K2039/5254 , C12N7/00 , C12N2710/16034 , C12N2710/16611 , C12N2710/16634 , C12N2710/16651
摘要： The present disclosure relates to liquid and dried compositions comprising a live, attenuated or genetically modified herpesvirus and methods of preparing such compositions, in one aspect, the composition comprises at least two or more pharmaceutically acceptable excepients, at least one of which is histidine and at least one of which is a sugar or sugar alcohol. The compositions retain a sufficiently high infectious titre following storage or large-scale manufacturing steps, such as lyophilization.
摘要翻译：本公开涉及包含活的，减毒的或遗传修饰的疱疹病毒的液体和干燥的组合物以及制备这样的组合物的方法。一方面，组合物包含至少两种或更多种药学上可接受的优异剂，其中至少一种是组氨酸，其中最少的一种是糖或糖醇。组合物在储存或大规模制备步骤如冻干后保持足够高的感染滴度。

5. 发明申请

US20150004195A1 PURIFICATION OF HERPES VIRUS 有权
标题翻译：净化病毒
公开(公告)号：US20150004195A1
公开(公告)日：2015-01-01
申请号：US14369844
申请日：2013-01-09
申请人： SANOFI PASTEUR BIOLOGICS, LLC
发明人： Sophia Mundle , Stephen Anderson , Simon Delagrave
IPC分类号： C12N7/00
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/5254 , B01D15/363 , C12N7/00 , C12N2710/16634 , C12N2710/16651 , C12N2710/16671
摘要： The present disclosure provides a method to prepare purified enveloped viral particle preparations employing ion ex change chromatography and tangential flow filtration.
摘要翻译：本公开提供了使用离子交换层析和切向流过滤来制备纯化的包膜病毒颗粒制剂的方法。

6. 发明申请

US20090176203A1 Mutant HSV, Materials and Methods for Generation of Mutant HSV 有权
标题翻译：突变HSV，产生突变HSV的材料和方法
公开(公告)号：US20090176203A1
公开(公告)日：2009-07-09
申请号：US12299965
申请日：2007-05-04
申请人： Joe Conner
发明人： Joe Conner
IPC分类号： C12Q1/70 , C12N7/01
CPC分类号： C12N15/86 , C12N15/869 , C12N15/8695 , C12N2710/16034 , C12N2710/16041 , C12N2710/16061 , C12N2710/16611 , C12N2710/16634 , C12N2710/16643 , C12N2710/16651
摘要： A method of generating a mutant Herpes Simplex Virus (HSV) is disclosed, wherein the generated HSV genome comprises nucleic acid encoding a nucleic acid sequence of interest, the method comprising the steps of: i. providing a nucleic acid vector comprising nucleic acid encoding first and second site specific recombination sequences and a nucleic acid encoding a nucleic acid sequence of interest between said site specific recombination sequences; ii. providing an HSV, the genome of which comprises third and fourth site specific recombination sequences; iii. contacting said nucleic acid vector of (i) with said HSV of (ii) together with one or more recombinase enzymes capable of catalysing site specific recombination between the site specific recombination sequences of said nucleic acid vector and said HSV; iv. identifying HSV containing the nucleic acid sequence of interest, wherein steps i-iii are conducted in a cell-free system.
摘要翻译：公开了一种产生突变型单纯疱疹病毒（HSV）的方法，其中产生的HSV基因组包含编码感兴趣的核酸序列的核酸，该方法包括以下步骤：提供核酸载体，其包含编码第一和第二位点特异性重组序列的核酸和编码所述位点特异性重组序列之间的目的核酸序列的核酸; ii。提供HSV，其基因组包含第三和第四位点特异性重组序列; iii。使（i）的所述核酸载体与（ii）的所述HSV一起与一种或多种能够催化所述核酸载体的位点特异性重组序列和所述HSV之间的位点特异性重组的重组酶一起接触; iv。鉴定含有感兴趣的核酸序列的HSV，其中步骤i-iii在无细胞系统中进行。

7. 发明申请

US20080138362A1 Cell Strain Capable of Being Cultured Without Ingredients Derived From Animals, Method of Producing the Same, Method of Producing Virus Using the Same, and Method of Producing Vaccine 有权
标题翻译：能够在没有来源于动物的成分的情况下培养的细胞株，使用其生产病毒的方法以及产生疫苗的方法
公开(公告)号：US20080138362A1
公开(公告)日：2008-06-12
申请号：US11885833
申请日：2005-03-10
申请人： Masami Mochizuki
发明人： Masami Mochizuki
IPC分类号： A61P39/00 , C12N5/00 , C12N7/00 , C12Q1/70 , A61K39/00
CPC分类号： C12N7/00 , C12N5/0686 , C12N2500/92 , C12N2501/11 , C12N2710/10351 , C12N2710/16651 , C12N2750/14351 , C12N2760/18451
摘要： [Abstract] The invention relates to a cell strain induced from MDCK cells as dog kidney-derived cells, and being able to be cultured without ingredients derived from animals. The cell strain is produced by adapting a MDCK cell to a medium without a serum but with a cell growth factor; and culturing the cell in a medium with an RPMI 1640 medium and a soybean-derived peptone but without ingredients derived from animals.
摘要翻译： [摘要]本发明涉及从MDCK细胞诱导的作为狗肾来源的细胞的细胞株，并且能够在不含动物成分的情况下培养。通过使MDCK细胞适应于没有血清但具有细胞生长因子的培养基来产生细胞株; 并在RPMI1640培养基和大豆衍生的蛋白胨培养基中培养细胞，但不含动物成分。

8. 发明授权

US07264814B2 Composition and method for treating cancer using herpes virus 有权
标题翻译：使用疱疹病毒治疗癌症的组合物和方法
公开(公告)号：US07264814B2
公开(公告)日：2007-09-04
申请号：US10477444
申请日：2002-05-09
申请人： Yukihiro Nishiyama
发明人： Yukihiro Nishiyama
IPC分类号： A61K39/12
CPC分类号： C12N7/00 , A61K31/337 , A61K31/4745 , A61K31/522 , A61K35/763 , A61K2039/541 , C12N15/86 , C12N2710/16032 , C12N2710/16062 , C12N2710/16632 , C12N2710/16643 , C12N2710/16651 , A61K2300/00
摘要： The present invention provides a herpes virus in which a non-essential gene for replication is inactivated More particularly, the present invention provides a herpes virus in which a non-essential gene for replication present in a UL or US region is inactivated. More preferably, the non-essential gene for replication contains US3 or UL56. The herpes virus may be preferably a herpes simplex virus, and more preferably herpes simplex virus 1 or herpes simplex virus 2. The present invention provides a method, composition and use for treating various diseases or disorders including tumor and infectious diseases. The present invention also provides a method, composition and use for activating a prodrug.
摘要翻译：本发明提供其中非必需基因用于复制的疱疹病毒更特别地，本发明提供了其中存在于UL或US区域中的非必需基因用于失活的疱疹病毒。更优选地，用于复制的非必需基因包含US3或UL56。疱疹病毒可以优选为单纯疱疹病毒，更优选为单纯疱疹病毒1或单纯疱疹病毒2.本发明提供治疗各种疾病或病症（包括肿瘤和感染性疾病）的方法，组合物和用途。本发明还提供了用于活化前药的方法，组合物和用途。

9. 发明申请

US20070111309A1 Vero cell line adapted to grow in suspension 审中-公开
标题翻译： Vero细胞系适应于悬浮生长
公开(公告)号：US20070111309A1
公开(公告)日：2007-05-17
申请号：US11540055
申请日：2006-09-29
申请人： Marcelo Daelli
发明人： Marcelo Daelli
IPC分类号： C12N5/06
CPC分类号： A61K39/12 , A61K39/13 , A61K39/245 , A61K2039/525 , C12N5/0686 , C12N7/00 , C12N2500/95 , C12N2510/02 , C12N2710/16634 , C12N2710/16651 , C12N2760/20251 , C12N2770/32634 , C12N2770/32651 , Y02A50/386 , Y02A50/466
摘要： A Vero cell line that can be grown in serum-free and protein-free culture and in suspension culture in the absence of supporting materials for its adherence, a process to obtain said Vero cell line and a process for producing viral vaccines with said cell line, a virus obtainable by said process and vaccines formulated by said virus.
摘要翻译： Vero细胞系，其可在无血清和无蛋白质培养物和悬浮培养物中生长，不存在用于其粘附的支持材料，获得所述Vero细胞系的方法和用所述细胞系生产病毒疫苗的方法，由所述方法可获得的病毒和由所述病毒配制的疫苗。

10. 发明公开

US20240360115A1 COMPOSITIONS AND METHODS FOR VIRAL SENSITIZATION 审中-公开
公开(公告)号：US20240360115A1
公开(公告)日：2024-10-31
申请号：US18764292
申请日：2024-07-04
申请人： Ottawa Hospital Research Institute , University of Ottawa
发明人： Jean-Simon Diallo , Christopher Noyce Boddy , Mark Dornan , Ramya Krishnan , Rozanne Arulanandam , Fabrice Le Boeuf , Jeffrey Smith , Andrew Macklin
IPC分类号： C07D413/06 , A61K31/341 , A61K31/501 , A61K45/06 , A61P35/02 , C07D207/36 , C07D207/38 , C07D207/456 , C07D209/48 , C07D231/08 , C07D237/14 , C07D307/30 , C07D307/58 , C07D307/60 , C07D307/66 , C07D317/64 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/06 , C07D417/06 , C07D471/04 , C12N7/00
CPC分类号： C07D413/06 , A61K31/501 , A61K45/06 , A61P35/02 , C07D207/36 , C07D207/38 , C07D207/456 , C07D209/48 , C07D231/08 , C07D237/14 , C07D307/30 , C07D307/58 , C07D307/60 , C07D307/66 , C07D317/64 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/06 , C07D417/06 , C07D471/04 , C12N7/00 , A61K31/341 , A61K2300/00 , C12N2710/10334 , C12N2710/10351 , C12N2710/10352 , C12N2710/16651 , C12N2710/24151 , C12N2750/14151 , C12N2760/16134 , C12N2760/16151 , C12N2760/16152 , C12N2760/20234 , C12N2760/20251 , C12N2760/20252
摘要： Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.

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