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1. 发明申请

US20050130135A1 Hepatitis a virus nucleotide sequences, recombinant proteins and uses thereof 审中-公开
标题翻译：甲型肝炎病毒核苷酸序列，重组蛋白及其用途
公开(公告)号：US20050130135A1
公开(公告)日：2005-06-16
申请号：US11051613
申请日：2005-02-04
申请人： Sergio Pichuantes
发明人： Sergio Pichuantes
IPC分类号： G01N33/576 , A61K39/00 , A61K39/29 , A61P31/14 , C07H21/04 , C07K14/02 , C07K14/10 , C12N5/06 , C12N7/00 , C12N15/09 , C12N15/51 , C12P21/02 , C12Q1/68 , C12Q1/70 , C12R1/93 , G01N21/78
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/32422 , C12Q1/706 , Y02A50/464 , Y02A50/54
摘要： Hepatitis A virus primers and probes derived from the capsid proteins and junction between the capsid precursor P1 and 2A of the HAV genome are disclosed. Also disclosed are nucleic acid-based assays using the primers and probes, antigen detection of HAV, and immunoassay for detecting the antibodies that bind to HAV.
摘要翻译：公开了甲型肝炎病毒引物和衍生自衣壳蛋白的探针和HAV基因组的衣壳前体P1和2A之间的连接。还公开了使用引物和探针的基于核酸的测定，HAV的抗原检测和用于检测结合HAV的抗体的免疫测定。

2. 发明申请

US20050095713A1 Vectors for gene mutagenesis and gene discovery 审中-公开
标题翻译：用于基因突变和基因发现的载体
公开(公告)号：US20050095713A1
公开(公告)日：2005-05-05
申请号：US10916782
申请日：2004-08-11
申请人： Brian Zambrowicz , Glenn Friedrich , Stan Lilleberg , Arthur Sands
发明人： Brian Zambrowicz , Glenn Friedrich , Stan Lilleberg , Arthur Sands
IPC分类号： A01K67/027 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/10 , C12N15/85 , C12N15/867 , C12R1/93 , C40B40/02
CPC分类号： C12N15/85 , C12N15/1034 , C12N15/1037 , C12N15/1051 , C12N15/86 , C12N2740/10043 , C12N2740/13043 , C12N2800/30 , C12N2800/60 , C12N2840/20 , C12N2840/203 , C12N2840/44 , C40B40/02
摘要： Novel vectors are described that incorporate, inter alia, a novel 3′ gene trap cassette which can be used to efficiently trap and identify previously unknown cellular genes. Vectors incorporating the described 3′ gene trap cassette find particular application in gene discovery and in the production of mutated cells and animals.
摘要翻译：描述了新颖的载体，其特别包含一种新的3'基因捕获盒，其可用于有效捕获和鉴定先前未知的细胞基因。结合所述3'基因捕获盒的载体在基因发现和突变的细胞和动物的产生中具有特殊应用。

3. 发明申请

US20050095692A1 Method of extracting virus from cell culture 有权
标题翻译：从细胞培养中提取病毒的方法
公开(公告)号：US20050095692A1
公开(公告)日：2005-05-05
申请号：US10916378
申请日：2004-08-10
申请人： Matthew Coffey , Bradley Thompson
发明人： Matthew Coffey , Bradley Thompson
IPC分类号： A61K35/76 , A61P35/00 , A61P35/02 , C12N7/02 , C12R1/93
CPC分类号： C12N7/00 , A61K35/765 , C12N2720/12232 , C12N2720/12251
摘要： The present invention is directed to a method of extracting virus, particularly reovirus, from a culture of cells. Infectious virus can be extracted from the culture with a detergent at a convenient temperature such as 25° C. or 37° C. to produce high virus titers. Both ionic and non-ionic detergents can be used in the present invention.
摘要翻译：本发明涉及从细胞培养物中提取病毒，特别是呼肠弧病毒的方法。感染性病毒可以用诸如25℃或37℃的方便温度的洗涤剂从培养物中提取，以产生高病毒效价。离子和非离子洗涤剂都可用于本发明。

4. 发明授权

US06884576B2 Methods of monitoring HIV drug resistance 失效
标题翻译：监测艾滋病毒耐药性的方法
公开(公告)号：US06884576B2
公开(公告)日：2005-04-26
申请号：US10112090
申请日：2002-03-29
申请人： Jian-yung Dong
发明人： Jian-yung Dong
IPC分类号： G01N33/50 , A01N63/00 , A61K39/12 , A61K39/23 , A61K39/235 , A61K48/00 , C07H21/04 , C12N5/00 , C12N5/02 , C12N5/06 , C12N5/10 , C12N5/16 , C12N13/00 , C12N15/00 , C12N15/09 , C12N15/12 , C12N15/63 , C12N15/70 , C12N15/74 , C12N15/85 , C12N15/87 , C12P21/06 , C12Q1/68 , C12Q1/70 , C12R1/93 , G01N33/15 , G01N33/569
CPC分类号： C12Q1/6883 , C12Q1/703 , C12Q2600/158 , G01N33/56988
摘要： A method is provided for detecting a presence of HIV virus in a sample comprising: taking a culture of recombinant cells which (a) are capable of cell division, (b) express CD4 receptor and one or more additional cell surface receptors necessary to allow the HIV virus to infect, (c) enable the HIV virus to replicate and infect the noninfected cells in the cell culture, and (d) comprise a reporter sequence introduced into the recombinant cells comprising a reporter gene whose expression is regulated by a protein specific to HIV viruses which is expressed from a genome of an HIV virus upon infection of the recombinant cell by the HIV virus; contacting the cell culture with a sample to be analyzed for the presence of HIV virus in the sample; and detecting a change in a level of expression of the reporter gene in cells in the recombinant cell culture. The method can be used to detect the presence of HIV virus in a sample, detect the presence of different strains of HIV virus in a sample, detect HIV drug resistance in a sample, determine what combination of one or more anti-HIV agents would be effective in treating a patient, and screen compositions for anti-HIV activity.
摘要翻译：提供了一种用于检测样品中HIV病毒存在的方法，其包括：获取（a）能够细胞分裂的重组细胞的培养物，（b）表达CD4受体和一种或多种另外的细胞表面受体， HIV病毒感染，（c）使HIV病毒复制并感染细胞培养物中的未感染细胞，和（d）包含引入重组细胞的报道序列，其包含报道基因，其表达受特异性蛋白质 HIV病毒在HIV病毒感染重组细胞时由HIV病毒基因组表达的HIV病毒; 使细胞培养物与待分析样品中样品中HIV病毒的存在接触; 并检测重组细胞培养物中细胞中报道基因表达水平的变化。该方法可用于检测样品中HIV病毒的存在，检测样品中HIV病毒的不同菌株的存在，检测样品中的HIV耐药性，确定一种或多种抗HIV药物的组合将是有效治疗患者，筛选组合物用于抗HIV活性。

5. 发明授权

US5597691C1 Hepatitus c virus protease 失效
标题翻译：肝病c蛋白酶
公开(公告)号：US5597691C1
公开(公告)日：2001-12-11
申请号：US44054895
申请日：1995-05-12
申请人： CHIRON CORP
发明人： HOUGHTON MICHAEL , CHOO QUI-LIM , KUO GEORGE
IPC分类号： C12N15/09 , A61K38/00 , C07K14/00 , C07K14/18 , C12N9/02 , C12N9/50 , C12N9/90 , C12N15/57 , C12Q1/18 , C12Q1/37 , C12R1/93 , C12N15/51
CPC分类号： C12N9/0089 , A61K38/00 , C07K14/00 , C07K14/005 , C07K2319/00 , C07K2319/02 , C07K2319/95 , C12N9/506 , C12N9/90 , C12N2770/24222

6. 发明授权

US5371017A Hepatitis C virus protease 失效
标题翻译：丙型肝炎病毒蛋白酶
公开(公告)号：US5371017A
公开(公告)日：1994-12-06
申请号：US680296
申请日：1991-04-04
申请人： Michael Houghton , Qui-Lim Choo , George Kuo
发明人： Michael Houghton , Qui-Lim Choo , George Kuo
IPC分类号： C12N15/09 , A61K38/00 , C07K14/00 , C07K14/18 , C12N9/02 , C12N9/50 , C12N9/90 , C12N15/57 , C12Q1/18 , C12Q1/37 , C12R1/93 , C12N15/00
CPC分类号： C12N9/0089 , C07K14/00 , C07K14/005 , C12N9/506 , C12N9/90 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/95 , C12N2770/24222
摘要： The protease necessary for polyprotein processing in Hepatitis C virus is identified, cloned, and expressed. Proteases, truncated protease, and altered proteases are disclosed which are useful for cleavage of specific polypeptides, and for assay and design of antiviral agents specific for HCV.
摘要翻译：鉴定，克隆和表达丙型肝炎病毒中多蛋白加工所需的蛋白酶。公开了蛋白酶，截短的蛋白酶和改变的蛋白酶，其可用于特异性多肽的切割，以及用于HCV特异性的抗病毒剂的测定和设计。

7. 发明申请

US20050250105A1 Multiple viral replicon culture systems 审中-公开
标题翻译：多重病毒复制子培养系统
公开(公告)号：US20050250105A1
公开(公告)日：2005-11-10
申请号：US10809226
申请日：2004-03-25
申请人： Julie Dyall , Charles Romano , Paul Olivo , Robert Roth
发明人： Julie Dyall , Charles Romano , Paul Olivo , Robert Roth
IPC分类号： A01N43/04 , A61K20060101 , A61K31/70 , C12N5/06 , C12N5/08 , C12N5/10 , C12N5/16 , C12N7/00 , C12N7/01 , C12N15/09 , C12P19/34 , C12P21/06 , C12Q1/02 , C12Q1/25 , C12Q1/68 , C12Q1/70 , C12R1/93 , G01N33/15 , G01N33/50 , G01N33/53
CPC分类号： G01N33/502 , G01N33/5008 , G01N2500/10
摘要： Methods and compositions are provided for screening candidate antiviral agents using cells containing subgenomic viral replication systems such as replicons and minigenomes. The methods involve the simultaneous assay of more than one subgenomic viral replication system. Compositions useful for these methods are also provided.
摘要翻译：提供了使用含有亚基因组病毒复制系统（例如复制子和小基因组）的细胞筛选候选抗病毒剂的方法和组合物。该方法涉及同时测定多于一个亚基因组病毒复制系统。还提供了对这些方法有用的组合物。

8. 发明申请

US20050221489A1 Recombinant negative strand virus rna expression systems and vaccines 有权
标题翻译：重组负链病毒rna表达系统和疫苗
公开(公告)号：US20050221489A1
公开(公告)日：2005-10-06
申请号：US10505613
申请日：2003-02-21
申请人： Adolfo Garcia-Sastre , Peter Palese
发明人： Adolfo Garcia-Sastre , Peter Palese
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/12 , A61K48/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , C07K14/125 , C12N7/00 , C12N7/02 , C12N15/83 , C12N15/86 , C12N15/867 , C12R1/93
CPC分类号： C12N7/00 , A61K48/00 , A61K2039/5256 , C07K14/005 , C12N15/86 , C12N2760/00034 , C12N2760/18122 , C12N2760/18143 , C12N2830/00 , C12N2830/60
摘要： The present invention relates to recombinant RNA virus templates derived from and applicable to negative strand naturally non-segmented viruses, including the families Bornaviridae, Filoviridae, and Paramyxoviridae, and methods for generating such recombinant RNA virus templates, wherein the templates are RNA generated from two or more recombinant RNA molecules. The invention relates to the use of segmented recombinant RNA virus templates for naturally non-segmented RNA viruses to express heterologous gene products in appropriate host cell systems and/or to construct recombinant viruses taken from that family and that express, package, and/or present the heterologous gene product. The invention includes the expression products and recombinant and chimeric viruses thus prepared and vaccine and therapeutic formulations comprising the recombinant RNA viruses.
摘要翻译：本发明涉及衍生自和适用于负链天然非分段病毒的重组RNA病毒模板，包括家族病毒科，非病病毒科和副粘病毒科，以及产生这种重组RNA病毒模板的方法，其中模板是由两个或更多的重组RNA分子。本发明涉及分段重组RNA病毒模板在天然非分段RNA病毒中的用途，以在合适的宿主细胞系统中表达异源基因产物和/或构建从该家族获取的重组病毒，并表达，包装和/或呈递异源基因产物。本发明包括如此制备的表达产物和重组和嵌合病毒以及包含重组RNA病毒的疫苗和治疗剂型。

9. 发明申请

US20050032693A1 Novel polypeptides, their nucleic acids, and methods for their use in angiogenesis and vascularization 审中-公开
标题翻译：新型多肽，其核酸，及其用于血管生成和血管形成的方法
公开(公告)号：US20050032693A1
公开(公告)日：2005-02-10
申请号：US10811080
申请日：2004-03-26
申请人： Mary Gerritsen , Audrey Goddard , J. Grimaldi , Fuad Mehraban
发明人： Mary Gerritsen , Audrey Goddard , J. Grimaldi , Fuad Mehraban
IPC分类号： G01N33/50 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P7/00 , A61P9/10 , A61P17/00 , A61P35/00 , C07K14/47 , C07K16/18 , C07K16/46 , C12M1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/91 , C12R1/93 , G01N33/15 , G01N33/53 , G01N33/566 , G01N37/00 , A61K38/17 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/00 , C12N2799/027
摘要： The present invention is directed to novel polypeptides critical for angiogenesis and vascularization, and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or neo- or cardio-vascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds; various cancers, and disorders of the vessels including atherosclerosis.
摘要翻译：本发明涉及对血管生成和血管形成临界的新型多肽以及编码这些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。公开了用于刺激或抑制哺乳动物（包括人）中的血管发生和/或新生血管或心脏血管形成的组合物和方法。药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如伤口; 各种癌症和包括动脉粥样硬化的血管紊乱。

10. 发明申请

US20050032044A1 Composition for viral preservation 审中-公开
标题翻译：用于病毒保存的组合物
公开(公告)号：US20050032044A1
公开(公告)日：2005-02-10
申请号：US10855594
申请日：2004-05-28
申请人： Kerrie Setiwan
发明人： Kerrie Setiwan
IPC分类号： C12N7/00 , A61K35/76 , A61K35/761 , A61K39/12 , A61K39/235 , A61K39/275 , A61K47/10 , A61K47/16 , A61K47/18 , A61K47/26 , A61K47/34 , A61K48/00 , A61P31/12 , C12N15/861 , C12R1/93 , C12Q1/70 , C12Q1/68
CPC分类号： A61K35/761 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2710/10151 , C12N2710/10332 , C12N2710/10343 , Y10T436/10
摘要： This invention relates to a composition for the preservation of a virus, the composition including a virus and a lipid.
摘要翻译：本发明涉及一种用于保存病毒的组合物，该组合物包括病毒和脂质。

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