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1. 发明申请

US20120165401A1 APTAMER FOR CHYMASE, AND USE THEREOF 有权
标题翻译：乙酰胺和其使用的APTAMER
公开(公告)号：US20120165401A1
公开(公告)日：2012-06-28
申请号：US13377201
申请日：2010-06-11
申请人： Yoshikazu Nakamura , Ling Jin , Satoko Yamazaki , Hisako Ikeda , Masahiro Muraguchi
发明人： Yoshikazu Nakamura , Ling Jin , Satoko Yamazaki , Hisako Ikeda , Masahiro Muraguchi
IPC分类号： A61K31/7105 , C12N9/96 , A61P43/00 , C12N9/64 , A61P9/00 , C07H21/02 , C12Q1/68
CPC分类号： C12N15/115 , A61K31/7105 , C12N2310/16 , C12N2310/322 , C12Y304/21039 , C12N2310/3533
摘要： Provided are an aptamer bound to chymase to inhibit activity of chymase; an aptamer containing a nucleotide sequence represented by X1GAUAGAN1N2UAAX2 wherein X1 and X2 are the same or different and each is A or G, and N1 and N2 are the same or different and each is A, G, C, U or T; a complex containing the aptamer and a functional substance (e.g., affinity substance, labeling substance, enzyme, drug delivery medium, drug and the like); a pharmaceutical or a reagent containing the aptamer or complex; a detection and a purification methods of chymase using the aptamer or complex and the like.
摘要翻译：提供与胃促胰酶结合以抑制胃促胰酶的活性的适体; 含有由X1GAUAGAN1N2UAAX2表示的核苷酸序列的适体，其中X1和X2相同或不同，分别为A或G，N1和N2相同或不同，分别为A，G，C，U或T; 含有适体和功能性物质（例如亲和性物质，标记物质，酶，药物传递介质，药物等）的复合物; 含有适体或复合物的药物或试剂; 使用适体或复合物等的胃促胰酶的检测和纯化方法。

2. 发明授权

US09012420B2 Aptamer for chymase, and use thereof 有权
标题翻译：胃酸酶的适配体及其用途
公开(公告)号：US09012420B2
公开(公告)日：2015-04-21
申请号：US13377201
申请日：2010-06-11
申请人： Yoshikazu Nakamura , Ling Jin , Satoko Yamazaki , Hisako Ikeda , Masahiro Muraguchi
发明人： Yoshikazu Nakamura , Ling Jin , Satoko Yamazaki , Hisako Ikeda , Masahiro Muraguchi
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04 , C12N15/115 , A61K31/7105 , C12Q1/68
CPC分类号： C12N15/115 , A61K31/7105 , C12N2310/16 , C12N2310/322 , C12Y304/21039 , C12N2310/3533
摘要： Provided are an aptamer bound to chymase to inhibit activity of chymase; an aptamer containing a nucleotide sequence represented by X1GAUAGAN1N2UAAX2 wherein X1 and X2 are the same or different and each is A or G, and N1 and N2 are the same or different and each is A, G, C, U or T; a complex containing the aptamer and a functional substance (e.g., affinity substance, labeling substance, enzyme, drug delivery medium, drug and the like); a pharmaceutical or a reagent containing the aptamer or complex; a detection and a purification methods of chymase using the aptamer or complex and the like.
摘要翻译：提供与胃促胰酶结合以抑制胃促胰酶的活性的适体; 含有由X1GAUAGAN1N2UAAX2表示的核苷酸序列的适体，其中X1和X2相同或不同，分别为A或G，N1和N2相同或不同，分别为A，G，C，U或T; 含有适体和功能性物质（例如亲和性物质，标记物质，酶，药物传递介质，药物等）的复合物; 含有适体或复合物的药物或试剂; 使用适体或复合物等的胃促胰酶的检测和纯化方法。

3. 发明授权

US10260070B2 Aptamer for NGF and use thereof 有权
公开(公告)号：US10260070B2
公开(公告)日：2019-04-16
申请号：US13120650
申请日：2009-09-18
申请人： Ling Jin , Shin Miyakawa , Masatoshi Fujiwara , Yoshikazu Nakamura , Hisanao Hiramatsu
发明人： Ling Jin , Shin Miyakawa , Masatoshi Fujiwara , Yoshikazu Nakamura , Hisanao Hiramatsu
IPC分类号： C12N15/11 , C12N15/115 , C07K1/22
摘要： Provided are an aptamer having an inhibitory activity against NGF; a complex containing an aptamer having a binding activity or inhibitory activity against NGF and a functional substance (e.g., affinity substances, labeling substances, enzymes, drug delivery vehicles, drugs and the like); a medicament, a diagnostic agent, a labeling agent and the like containing an aptamer having a binding activity or inhibitory activity against NGF, or a complex containing the aptamer and the functional substance; and the like.

4. 发明申请

US20130052176A1 APTAMER FOR NGF AND USE THEREOF 有权
标题翻译：用于NGF的APTAMER及其用途
公开(公告)号：US20130052176A1
公开(公告)日：2013-02-28
申请号：US13636974
申请日：2011-03-24
申请人： Yoshikazu Nakamura , Ling Jin , Hisanao Hiramatsu
发明人： Yoshikazu Nakamura , Ling Jin , Hisanao Hiramatsu
IPC分类号： C07H21/02 , A61P29/00 , A61K38/43 , A61K31/7105 , C12N9/96 , A61K31/7088
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/3515
摘要： Provided is a higher quality aptamer having a binding activity to NGF.An aptamer binding to NGF, which satisfies the following (1) and (2): (1) containing the sequence represented by UGAAARAAACC (SEQ ID NO: 64) or CGAAMRAAACU (SEQ ID NO: 65), and (2) having a base length of not more than 73.
摘要翻译：提供了对NGF具有结合活性的更高质量的适体。与NGF结合的适体，其满足以下（1）和（2）：（1），含有由UGAAARAAACC（SEQ ID NO：64）或CGAAMRAAACU（SEQ ID NO：65）表示的序列，和（2）具有基地长度不超过73。

5. 发明申请

US20110251266A1 APTAMER FOR NGF AND USE THEREOF 审中-公开
标题翻译：用于NGF的APTAMER及其用途
公开(公告)号：US20110251266A1
公开(公告)日：2011-10-13
申请号：US13120650
申请日：2009-09-18
申请人： Ling Jin , Shin Miyakawa , Masatoshi Fujiwara , Yoshikazu Nakamura , Hisanao Hiramatsu
发明人： Ling Jin , Shin Miyakawa , Masatoshi Fujiwara , Yoshikazu Nakamura , Hisanao Hiramatsu
IPC分类号： A61K31/7088 , C07H21/04 , A61P29/00 , G01N33/566 , C07K1/14 , C07H21/02 , C12N9/96
CPC分类号： C12N15/115 , C07K1/22 , C12N2310/16
摘要： Provided are an aptamer having an inhibitory activity against NGF; a complex containing an aptamer having a binding activity or inhibitory activity against NGF and a functional substance (e.g., affinity substances, labeling substances, enzymes, drug delivery vehicles, drugs and the like); a medicament, a diagnostic agent, a labeling agent and the like containing an aptamer having a binding activity or inhibitory activity against NGF, or a complex containing the aptamer and the functional substance; and the like.
摘要翻译：提供对NGF具有抑制活性的适体; 含有对NGF和功能性物质（例如亲和性物质，标记物质，酶，药物输送载体，药物等）具有结合活性或抑制活性的适体的复合物; 含有对NGF具有结合活性或抑制活性的适体的药剂，诊断剂，标记试剂等，或含有适体和功能性物质的复合物; 等等。

6. 发明授权

US09175292B2 Aptamer for NGF and use thereof 有权
标题翻译： NGF的适配器及其用途
公开(公告)号：US09175292B2
公开(公告)日：2015-11-03
申请号：US13636974
申请日：2011-03-24
申请人： Yoshikazu Nakamura , Ling Jin , Hisanao Hiramatsu
发明人： Yoshikazu Nakamura , Ling Jin , Hisanao Hiramatsu
IPC分类号： C07H21/02 , A61K48/00 , C12N15/115
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/3515
摘要： Provided is a higher quality aptamer having a binding activity to NGF.An aptamer binding to NGF, which satisfies the following (1) and (2): (1) containing the sequence represented by UGAAARAAACC (SEQ ID NO: 64) or CGAAMRAAACU (SEQ ID NO: 65), and (2) having a base length of not more than 73.
摘要翻译：提供了对NGF具有结合活性的更高质量的适体。与NGF结合的适体，其满足以下（1）和（2）：（1），含有由UGAAARAAACC（SEQ ID NO：64）或CGAAMRAAACU（SEQ ID NO：65）表示的序列，和（2）具有基地长度不超过73。

7. 发明授权

US08080649B2 Aptamer against midkine and use thereof 有权
标题翻译：适应中期因子和使用它
公开(公告)号：US08080649B2
公开(公告)日：2011-12-20
申请号：US12312519
申请日：2007-11-14
申请人： Shin Miyakawa , Masatoshi Fujiwara , Yoshikazu Nakamura , Takashi Matsui , Sadatoshi Sakuma
发明人： Shin Miyakawa , Masatoshi Fujiwara , Yoshikazu Nakamura , Takashi Matsui , Sadatoshi Sakuma
IPC分类号： C07H21/02 , C07H21/04 , C12N15/11
CPC分类号： C12N15/115 , A61K38/00 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12N2310/3521
摘要： Provided is a high-quality aptamer against midkine.An aptamer possessing an inhibitory activity against midkine; a complex comprising an aptamer possessing a binding activity or inhibitory activity against midkine and a functional substance (for example, affinity substances, substances for labeling, enzymes, drug delivery vehicles, drugs and the like); a pharmaceutical drug, cell migration inhibitor, diagnostic reagent, labeling agent and the like comprising an aptamer possessing a binding activity or inhibitory activity against midkine, or a complex comprising the aptamer and a functional substance; a cell migration inhibitor, a diagnostic reagent, a labeling agent and the like.
摘要翻译：提供了针对midkine的高品质适配体。具有抑制中期因子活性的适体; 包含具有对midkine的结合活性或抑制活性的适体和功能性物质（例如亲和性物质，标记物质，酶，药物递送载体，药物等）的配合物的复合物。包含对midkine具有结合活性或抑制活性的适体的药物，细胞迁移抑制剂，诊断试剂，标记试剂等，或包含适体和功能性物质的复合物; 细胞迁移抑制剂，诊断试剂，标记试剂等。

8. 发明申请

US20100004432A1 APTAMER AGAINST MIDKINE AND USE THEREOF 有权
标题翻译： APTAMER反对MIDKINE及其使用
公开(公告)号：US20100004432A1
公开(公告)日：2010-01-07
申请号：US12312519
申请日：2007-11-14
申请人： Shin Miyakawa , Masatoshi Fujiwara , Yoshikazu Nakamura , Takashi Matsui , Sadatoshi Sakuma
发明人： Shin Miyakawa , Masatoshi Fujiwara , Yoshikazu Nakamura , Takashi Matsui , Sadatoshi Sakuma
IPC分类号： C12N15/12
CPC分类号： C12N15/115 , A61K38/00 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12N2310/3521
摘要： Provided is a high-quality aptamer against midkine.An aptamer possessing an inhibitory activity against midkine; a complex comprising an aptamer possessing a binding activity or inhibitory activity against midkine and a functional substance (for example, affinity substances, substances for labeling, enzymes, drug delivery vehicles, drugs and the like); a pharmaceutical drug, cell migration inhibitor, diagnostic reagent, labeling agent and the like comprising an aptamer possessing a binding activity or inhibitory activity against midkine, or a complex comprising the aptamer and a functional substance; a cell migration inhibitor, a diagnostic reagent, a labeling agent and the like.
摘要翻译：提供了针对midkine的高品质适配体。具有抑制中期因子活性的适体; 包含具有对midkine的结合活性或抑制活性的适体和功能性物质（例如亲和性物质，标记物质，酶，药物递送载体，药物等）的配合物的复合物。包含对midkine具有结合活性或抑制活性的适体的药物，细胞迁移抑制剂，诊断试剂，标记试剂等，或包含适体和功能性物质的复合物; 细胞迁移抑制剂，诊断试剂，标记试剂等。

9. 发明申请

US20060223421A1 POLISHING APPARATUS 有权
标题翻译：抛光装置
公开(公告)号：US20060223421A1
公开(公告)日：2006-10-05
申请号：US11392697
申请日：2006-03-30
申请人： Tadakazu Miyashita , Yoshikazu Nakamura , Yoshiyuki Nomura
发明人： Tadakazu Miyashita , Yoshikazu Nakamura , Yoshiyuki Nomura
IPC分类号： B24B51/00 , B24B29/00
CPC分类号： H01L21/68728 , B24B37/345 , H01L21/68735 , H01L21/68785
摘要： The polishing apparatus is capable of transferring a work piece to a top ring without moving the work piece from the center and capable of precisely polishing the work piece. The polishing apparatus has a transfer unit for transferring the work piece to the top ring. The transfer unit comprises: a guide member having a receiving section, which centers the work piece; a mounting table vertically moving with respect to the guide member, the mounting table having a mounting section, which receives the centered work piece; and a supporting mechanism supporting the mounting table and allowing the mounting table to move downward. The mounting table is relatively moved close to the top ring and presses the work piece onto the top ring so as to transfer the work piece to the top ring.
摘要翻译：抛光装置能够将工件传送到顶环而不将工件从中心移动并能够精确地抛光工件。抛光装置具有用于将工件传送到顶环的转印单元。传送单元包括：引导构件，其具有使工件居中的接收部分; 相对于引导构件垂直移动的安装台，所述安装台具有容纳所述中心工件的安装部; 以及支撑安装台并使安装台向下移动的支撑机构。安装台相对移动靠近顶环，并将工件压在顶环上，以将工件传送到顶环。

10. 发明授权

US06484609B2 Method of producing press-forming punch and die 失效
标题翻译：生产冲压成形冲模的方法
公开(公告)号：US06484609B2
公开(公告)日：2002-11-26
申请号：US09782846
申请日：2001-02-14
申请人： Teiji Watanabe , Masafumi Nakamura , Yoshikazu Nakamura
发明人： Teiji Watanabe , Masafumi Nakamura , Yoshikazu Nakamura
IPC分类号： B21K520
CPC分类号： B21D37/20 , B23P15/24
摘要： An economical method of producing a press-forming die is disclosed wherein a master die and a master punch are relatively reciprocated with a full stroke and a shorter stroke to produce a press-formed panel and a half-pressed panel. After an elastic material is applied to one surface of the half-pressed panel, the press-formed panel is fitted over the master punch, and the half-pressed panel is forced against the press-formed panel with the elastic material facing away from the press-formed panel, whereby the half-pressed panel is shaped into a die panel complementary in contour to the shape of the press-formed panel. A back-up material such as high-strength cement is then applied to the rear surface of the die panel whereby a press-forming die is produced.
摘要翻译：公开了一种生产压制成形模的经济方法，其中主模和主冲头在全行程和较短行程上相对往复运动以产生压制成形板和半压板。在将弹性材料施加到半压板的一个表面上之后，将压制成形的面板安装在主冲头上，并将半压板压在压制成形板上，使弹性材料背向压制成形板，由此将半压板成型为与压制成形板的形状在轮廓上互补的模板。然后将诸如高强度水泥的支撑材料施加到模板的后表面，由此制造压制成型模具。

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