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1. 发明授权

US10260070B2 Aptamer for NGF and use thereof 有权
公开(公告)号：US10260070B2
公开(公告)日：2019-04-16
申请号：US13120650
申请日：2009-09-18
申请人： Ling Jin , Shin Miyakawa , Masatoshi Fujiwara , Yoshikazu Nakamura , Hisanao Hiramatsu
发明人： Ling Jin , Shin Miyakawa , Masatoshi Fujiwara , Yoshikazu Nakamura , Hisanao Hiramatsu
IPC分类号： C12N15/11 , C12N15/115 , C07K1/22
摘要： Provided are an aptamer having an inhibitory activity against NGF; a complex containing an aptamer having a binding activity or inhibitory activity against NGF and a functional substance (e.g., affinity substances, labeling substances, enzymes, drug delivery vehicles, drugs and the like); a medicament, a diagnostic agent, a labeling agent and the like containing an aptamer having a binding activity or inhibitory activity against NGF, or a complex containing the aptamer and the functional substance; and the like.

2. 发明申请

US20110251266A1 APTAMER FOR NGF AND USE THEREOF 审中-公开
标题翻译：用于NGF的APTAMER及其用途
公开(公告)号：US20110251266A1
公开(公告)日：2011-10-13
申请号：US13120650
申请日：2009-09-18
申请人： Ling Jin , Shin Miyakawa , Masatoshi Fujiwara , Yoshikazu Nakamura , Hisanao Hiramatsu
发明人： Ling Jin , Shin Miyakawa , Masatoshi Fujiwara , Yoshikazu Nakamura , Hisanao Hiramatsu
IPC分类号： A61K31/7088 , C07H21/04 , A61P29/00 , G01N33/566 , C07K1/14 , C07H21/02 , C12N9/96
CPC分类号： C12N15/115 , C07K1/22 , C12N2310/16
摘要： Provided are an aptamer having an inhibitory activity against NGF; a complex containing an aptamer having a binding activity or inhibitory activity against NGF and a functional substance (e.g., affinity substances, labeling substances, enzymes, drug delivery vehicles, drugs and the like); a medicament, a diagnostic agent, a labeling agent and the like containing an aptamer having a binding activity or inhibitory activity against NGF, or a complex containing the aptamer and the functional substance; and the like.
摘要翻译：提供对NGF具有抑制活性的适体; 含有对NGF和功能性物质（例如亲和性物质，标记物质，酶，药物输送载体，药物等）具有结合活性或抑制活性的适体的复合物; 含有对NGF具有结合活性或抑制活性的适体的药剂，诊断剂，标记试剂等，或含有适体和功能性物质的复合物; 等等。

3. 发明申请

US20130052176A1 APTAMER FOR NGF AND USE THEREOF 有权
标题翻译：用于NGF的APTAMER及其用途
公开(公告)号：US20130052176A1
公开(公告)日：2013-02-28
申请号：US13636974
申请日：2011-03-24
申请人： Yoshikazu Nakamura , Ling Jin , Hisanao Hiramatsu
发明人： Yoshikazu Nakamura , Ling Jin , Hisanao Hiramatsu
IPC分类号： C07H21/02 , A61P29/00 , A61K38/43 , A61K31/7105 , C12N9/96 , A61K31/7088
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/3515
摘要： Provided is a higher quality aptamer having a binding activity to NGF.An aptamer binding to NGF, which satisfies the following (1) and (2): (1) containing the sequence represented by UGAAARAAACC (SEQ ID NO: 64) or CGAAMRAAACU (SEQ ID NO: 65), and (2) having a base length of not more than 73.
摘要翻译：提供了对NGF具有结合活性的更高质量的适体。与NGF结合的适体，其满足以下（1）和（2）：（1），含有由UGAAARAAACC（SEQ ID NO：64）或CGAAMRAAACU（SEQ ID NO：65）表示的序列，和（2）具有基地长度不超过73。

4. 发明授权

US09175292B2 Aptamer for NGF and use thereof 有权
标题翻译： NGF的适配器及其用途
公开(公告)号：US09175292B2
公开(公告)日：2015-11-03
申请号：US13636974
申请日：2011-03-24
申请人： Yoshikazu Nakamura , Ling Jin , Hisanao Hiramatsu
发明人： Yoshikazu Nakamura , Ling Jin , Hisanao Hiramatsu
IPC分类号： C07H21/02 , A61K48/00 , C12N15/115
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/3515
摘要： Provided is a higher quality aptamer having a binding activity to NGF.An aptamer binding to NGF, which satisfies the following (1) and (2): (1) containing the sequence represented by UGAAARAAACC (SEQ ID NO: 64) or CGAAMRAAACU (SEQ ID NO: 65), and (2) having a base length of not more than 73.
摘要翻译：提供了对NGF具有结合活性的更高质量的适体。与NGF结合的适体，其满足以下（1）和（2）：（1），含有由UGAAARAAACC（SEQ ID NO：64）或CGAAMRAAACU（SEQ ID NO：65）表示的序列，和（2）具有基地长度不超过73。

5. 发明申请

US20120165401A1 APTAMER FOR CHYMASE, AND USE THEREOF 有权
标题翻译：乙酰胺和其使用的APTAMER
公开(公告)号：US20120165401A1
公开(公告)日：2012-06-28
申请号：US13377201
申请日：2010-06-11
申请人： Yoshikazu Nakamura , Ling Jin , Satoko Yamazaki , Hisako Ikeda , Masahiro Muraguchi
发明人： Yoshikazu Nakamura , Ling Jin , Satoko Yamazaki , Hisako Ikeda , Masahiro Muraguchi
IPC分类号： A61K31/7105 , C12N9/96 , A61P43/00 , C12N9/64 , A61P9/00 , C07H21/02 , C12Q1/68
CPC分类号： C12N15/115 , A61K31/7105 , C12N2310/16 , C12N2310/322 , C12Y304/21039 , C12N2310/3533
摘要： Provided are an aptamer bound to chymase to inhibit activity of chymase; an aptamer containing a nucleotide sequence represented by X1GAUAGAN1N2UAAX2 wherein X1 and X2 are the same or different and each is A or G, and N1 and N2 are the same or different and each is A, G, C, U or T; a complex containing the aptamer and a functional substance (e.g., affinity substance, labeling substance, enzyme, drug delivery medium, drug and the like); a pharmaceutical or a reagent containing the aptamer or complex; a detection and a purification methods of chymase using the aptamer or complex and the like.
摘要翻译：提供与胃促胰酶结合以抑制胃促胰酶的活性的适体; 含有由X1GAUAGAN1N2UAAX2表示的核苷酸序列的适体，其中X1和X2相同或不同，分别为A或G，N1和N2相同或不同，分别为A，G，C，U或T; 含有适体和功能性物质（例如亲和性物质，标记物质，酶，药物传递介质，药物等）的复合物; 含有适体或复合物的药物或试剂; 使用适体或复合物等的胃促胰酶的检测和纯化方法。

6. 发明授权

US09012420B2 Aptamer for chymase, and use thereof 有权
标题翻译：胃酸酶的适配体及其用途
公开(公告)号：US09012420B2
公开(公告)日：2015-04-21
申请号：US13377201
申请日：2010-06-11
申请人： Yoshikazu Nakamura , Ling Jin , Satoko Yamazaki , Hisako Ikeda , Masahiro Muraguchi
发明人： Yoshikazu Nakamura , Ling Jin , Satoko Yamazaki , Hisako Ikeda , Masahiro Muraguchi
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04 , C12N15/115 , A61K31/7105 , C12Q1/68
CPC分类号： C12N15/115 , A61K31/7105 , C12N2310/16 , C12N2310/322 , C12Y304/21039 , C12N2310/3533
摘要： Provided are an aptamer bound to chymase to inhibit activity of chymase; an aptamer containing a nucleotide sequence represented by X1GAUAGAN1N2UAAX2 wherein X1 and X2 are the same or different and each is A or G, and N1 and N2 are the same or different and each is A, G, C, U or T; a complex containing the aptamer and a functional substance (e.g., affinity substance, labeling substance, enzyme, drug delivery medium, drug and the like); a pharmaceutical or a reagent containing the aptamer or complex; a detection and a purification methods of chymase using the aptamer or complex and the like.
摘要翻译：提供与胃促胰酶结合以抑制胃促胰酶的活性的适体; 含有由X1GAUAGAN1N2UAAX2表示的核苷酸序列的适体，其中X1和X2相同或不同，分别为A或G，N1和N2相同或不同，分别为A，G，C，U或T; 含有适体和功能性物质（例如亲和性物质，标记物质，酶，药物传递介质，药物等）的复合物; 含有适体或复合物的药物或试剂; 使用适体或复合物等的胃促胰酶的检测和纯化方法。

7. 发明授权

US08529882B2 Peptidomimetic protease inhibitors 失效
标题翻译：拟肽蛋白酶抑制剂
公开(公告)号：US08529882B2
公开(公告)日：2013-09-10
申请号：US13541436
申请日：2012-07-03
申请人： Robert Edward Babine , Shu Hui Chen , Ivan Collado , Cristina Garcia-Paredes , John Irvin Glass , Ling Jin , Jason Eric Lamar , Raymond Samuel Parker, III , Nancy June Snyder , Xicheng David Sun , Deqi Guo , Yvonne Yee Mai Yip , Q. May Wang , Frantz Victor , Mark Joseph Tebbe , Robert B. Perni , Luc Farmer
发明人： Robert Edward Babine , Shu Hui Chen , Ivan Collado , Cristina Garcia-Paredes , John Irvin Glass , Ling Jin , Jason Eric Lamar , Raymond Samuel Parker, III , Nancy June Snyder , Xicheng David Sun , Deqi Guo , Yvonne Yee Mai Yip , Q. May Wang , Frantz Victor , Mark Joseph Tebbe , Robert B. Perni , Luc Farmer
IPC分类号： A61K38/07 , A61K38/20 , A61K38/21 , C07D209/52 , C12N5/073 , C12N9/99 , A61P31/14 , C07K5/117
CPC分类号： C07K7/02 , A61K38/07 , A61K38/08 , A61K38/21 , A61K38/212 , A61K38/215 , A61K45/06 , C07D209/02 , C07D209/52 , C07K5/0202 , C07K5/0205 , C07K5/06052 , C07K5/0808 , C07K5/101 , C07K5/1016 , C07K7/06 , C07K14/005 , C12N2770/24222 , Y02P20/55 , A61K2300/00
摘要： The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel stereoselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.
摘要翻译：本发明涉及可用作蛋白酶抑制剂的肽模拟化合物，特别是作为丝氨酸蛋白酶抑制剂，更具体地说，涉及丙型肝炎NS3蛋白酶抑制剂; 中间体; 它们的制备包括对中间体的新的立体选择性方法。本发明还涉及药物组合物以及使用该化合物抑制HCV蛋白酶或治疗患有HCV感染或感染相关生理状况的患者的方法。还提供了药物组合，除一种或多种HCV丝氨酸蛋白酶抑制剂外还包含一种或多种表现出抗HCV活性的干扰素和/或一种或多种具有抗HCV活性的化合物和药学上可接受的载体，以及用于治疗或预防的方法使用该组合物的患者中的HCV感染。本发明还涉及用于治疗或预防患者HCV感染的试剂盒或药物包装。

8. 发明授权

US08015195B2 Modifying entry names in directory server 有权
标题翻译：修改目录服务器中的条目名称
公开(公告)号：US08015195B2
公开(公告)日：2011-09-06
申请号：US12109556
申请日：2008-04-25
申请人： Chen Wang , Zhi Guo Gao , Ling Jin , Xiao Yan Chen
发明人： Chen Wang , Zhi Guo Gao , Ling Jin , Xiao Yan Chen
IPC分类号： G06F17/30
CPC分类号： G06F17/30589 , H04L29/12084 , H04L29/12132 , H04L29/12594 , H04L61/1523 , H04L61/1552 , H04L61/30
摘要： The present invention provides a system and a computer-implemented method for modifying an entry name in a directory database. The method comprises the steps of: modifying, in response to a request for modifying operation of entry names, entry mapping information in accordance with the modification that is requested for modifying operation of entry names, wherein each piece of entry mapping information is used for indicating the correspondence relation between pre-modification entry name information and post-modification entry name information; asynchronously performing modifying operation of a corresponding entry name in accordance with respective pieces of entry mapping information when a predetermined condition for updating the directory database is met.
摘要翻译：本发明提供了一种用于修改目录数据库中的条目名称的系统和计算机实现的方法。该方法包括以下步骤：响应于修改条目名称的操作的请求，修改根据修改条目映射信息，其中每个条目映射信息被用于指示预修改条目名称信息和修改后条目名称信息之间的对应关系; 当满足用于更新目录数据库的预定条件时，根据各条目条目映射信息异步执行相应条目名称的修改操作。

9. 发明申请

US20080095330A1 ENHANCING INTERACTIVE VOICE RESPONSE SYSTEMS VIA MESSAGING 审中-公开
标题翻译：通过消息传递增强交互式语音响应系统
公开(公告)号：US20080095330A1
公开(公告)日：2008-04-24
申请号：US11877952
申请日：2007-10-24
申请人： Ling Jin , Yu Fei Ma , Pei Sun , Jun Shen , Chun Sheng Chu
发明人： Ling Jin , Yu Fei Ma , Pei Sun , Jun Shen , Chun Sheng Chu
IPC分类号： H04M11/00
CPC分类号： H04M3/493 , H04M7/0048 , H04M2203/251
摘要： Disclosed are a method, information processing system, and computer storage program product for providing communication between a user electronic device and an Interactive Voice Response (“IVR”) system. At least one selection from a user corresponding to at least one menu in an IVR system is received. The selection comprises an instruction selection sequence. At least one voice message and at least one visual message associated with the voice message, each corresponding to the instruction sequence are generated in response to the receiving. The voice message and visual message are transmitted to the electronic device associated with the user. The visual message is to be displayed to the user on an electronic device associated with the user while the voice message is being played to the user.
摘要翻译：公开了一种用于在用户电子设备和交互式语音响应（“IVR”）系统之间提供通信的方法，信息处理系统和计算机存储程序产品。接收来自与IVR系统中的至少一个菜单对应的用户的至少一个选择。选择包括指令选择序列。响应于接收，生成与语音消息相关联的至少一个语音消息和至少一个与消息对应的视讯。语音消息和可视消息被发送到与用户相关联的电子设备。在向用户播放语音消息的同时，在与用户相关联的电子设备上向用户显示视觉消息。

10. 发明申请

US20100003794A1 METHOD FOR DEFECT REDUCTION FOR MEMORY CELL CAPACITORS 有权
标题翻译：用于存储单元电容器的减少缺陷的方法
公开(公告)号：US20100003794A1
公开(公告)日：2010-01-07
申请号：US12259138
申请日：2008-10-27
申请人： Ling Jin , Dah Cheng Lin , Chin Hsing Yu , Meng Jan Cherng , Huan Sung Fu
发明人： Ling Jin , Dah Cheng Lin , Chin Hsing Yu , Meng Jan Cherng , Huan Sung Fu
IPC分类号： H01L21/8242
CPC分类号： H01L28/91 , H01L27/10852 , H01L27/10894
摘要： A method for forming a cylindrical stack capacitor structure. A semiconductor substrate is provided. Storage node structures are formed in a memory cell region. A dielectric layer is formed overlying the storage node structures. A patterning and a first etching process expose the storage nodes. A polysilicon layer and a rugged polysilicon layer are formed overlying the exposed storage nodes. The memory cell region is masked, exposing a peripheral region. A chemical dry etch process removes the rugged polysilicon and the polysilicon layers in the peripheral region. The rugged polysilicon and the polysilicon layers are planarized followed by a dielectric recess. The resulting cylindrical stack capacitor structures are substantially free of defects from rugged polysilicon remaining in the peripheral region thereby improving device yield and process window.
摘要翻译：一种形成圆柱形堆叠电容器结构的方法。提供半导体衬底。存储节点结构形成在存储单元区域中。在存储节点结构上形成介电层。图案化和第一蚀刻工艺暴露存储节点。在暴露的存储节点上形成多晶硅层和坚固的多晶硅层。掩蔽存储单元区域，暴露外围区域。化学干蚀刻工艺去除了外围区域中的坚固的多晶硅和多晶硅层。凹凸多晶硅和多晶硅层被平坦化，随后是电介质凹陷。所得到的圆柱形堆叠电容器结构基本上没有残留在外围区域中的粗糙多晶硅的缺陷，从而提高了器件产量和工艺窗口。

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