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1. 发明授权

US09557339B2 Nucleic acid molecule having binding affinity to rodent-derived IgG antibody, binder, detection reagent, and detection kit 有权
标题翻译：对啮齿动物IgG抗体具有结合亲和力的核酸分子，粘合剂，检测试剂和检测试剂盒
公开(公告)号：US09557339B2
公开(公告)日：2017-01-31
申请号：US14336723
申请日：2014-07-21
申请人： Hiromi Takenaka , Yoshihito Yoshida , Katsunori Horii , Makio Furuichi , Hirotaka Yagi , Jou Akitomi , Mineko Yamaguchi , Shintarou Katou , Kensaku Nishikata , Iwao Waga
发明人： Hiromi Takenaka , Yoshihito Yoshida , Katsunori Horii , Makio Furuichi , Hirotaka Yagi , Jou Akitomi , Mineko Yamaguchi , Shintarou Katou , Kensaku Nishikata , Iwao Waga
IPC分类号： C12N15/115 , G01N33/68 , G01N33/53
CPC分类号： G01N33/6854 , C12N15/115 , C12N2310/16 , G01N33/5308
摘要： The present invention is to provide a nucleic acid molecule having a binding affinity to a rodent-derived IgG antibody, which can be prepared easier than an antibody and has a binding affinity equivalent or superior to that of an antibody, a binder using the nucleic acid molecule, a detection reagent, and a detection kit. The nucleic acid molecule of the present invention has a binding affinity to a rodent-derived IgG antibody and has a dissociation constant of 1 μM or less. The binder for a rodent-derived IgG antibody of the present invention includes the nucleic acid molecule of the present invention. The detection reagent for detecting a rodent-derived IgG antibody of the present invention includes the binder for a rodent-derived IgG antibody of the present invention. The detection kit for detecting a rodent-derived IgG antibody of the present invention includes the detection reagent for detecting a rodent-derived IgG antibody of the present invention.
摘要翻译：本发明提供一种对啮齿动物IgG抗体具有结合亲和力的核酸分子，其可以比抗体更容易制备并具有与抗体相当或优于其抗体的结合亲和力，使用该核酸的粘合剂分子，检测试剂和检测试剂盒。本发明的核酸分子与啮齿动物IgG抗体具有结合亲和力，解离常数为1μM以下。本发明的啮齿动物IgG抗体的粘合剂包括本发明的核酸分子。用于检测本发明的啮齿动物IgG抗体的检测试剂包括本发明的啮齿动物IgG抗体的粘合剂。用于检测本发明的啮齿动物IgG抗体的检测试剂盒包括用于检测本发明的啮齿动物的IgG抗体的检测试剂。

2. 发明申请

US20130022967A1 NUCLEIC ACID MOLECULE HAVING AFFINITY TO RODENT-DERIVED IgG ANTIBODY, BINDER, DETECTION REAGENT, AND DETECTION KIT 有权
标题翻译：具有转染IgG抗体，粘合剂，检测试剂和检测试剂盒的亲和力的核酸分子
公开(公告)号：US20130022967A1
公开(公告)日：2013-01-24
申请号：US13511618
申请日：2009-08-21
申请人： Hiromi Takenaka , Yoshihito Yoshida , Katsunori Horii , Makio Furuichi , Hirotaka Yagi , Jou Akitomi , Mineko Yamaguchi , Shintarou Katou , Kensaku Nishikata , Iwao Waga
发明人： Hiromi Takenaka , Yoshihito Yoshida , Katsunori Horii , Makio Furuichi , Hirotaka Yagi , Jou Akitomi , Mineko Yamaguchi , Shintarou Katou , Kensaku Nishikata , Iwao Waga
IPC分类号： C12N15/115 , C12Q1/68 , G01N33/566
CPC分类号： G01N33/6854 , C12N15/115 , C12N2310/16 , G01N33/5308
摘要： The invention provides a nucleic acid molecule having a binding affinity to a rodent-derived IgG antibody, which can be prepared easier than an antibody and has a binding affinity equivalent or superior to that of an antibody, a binder using the nucleic acid molecule, a detection reagent, and a detection kit. The nucleic acid molecule of the invention has a binding affinity to a rodent-derived IgG antibody and has a dissociation constant of 1 μM or less. The binder for a rodent-derived IgG antibody of the present invention includes the nucleic acid molecule of the present invention. The detection reagent for detecting a rodent-derived IgG antibody of the invention includes the binder for a rodent-derived IgG antibody of the invention. The detection kit for detecting a rodent-derived IgG antibody of the invention includes the detection reagent for detecting a rodent-derived IgG antibody of the invention.
摘要翻译：本发明提供了一种对啮齿动物来源的IgG抗体具有结合亲和力的核酸分子，其可以比抗体更容易制备并且具有与抗体相当或优于其抗体的结合亲和力，使用核酸分子的粘合剂，检测试剂和检测试剂盒。本发明的核酸分子对啮齿动物来源的IgG抗体具有结合亲和力，解离常数为1μM以下。本发明的啮齿动物IgG抗体的粘合剂包括本发明的核酸分子。用于检测本发明的啮齿动物IgG抗体的检测试剂包括本发明的啮齿动物IgG抗体的粘合剂。用于检测本发明的啮齿动物IgG抗体的检测试剂盒包括用于检测本发明的啮齿动物IgG抗体的检测试剂。

3. 发明申请

US20120003749A1 NUCLEIC ACID MOLECULE CAPABLE OF BINDING TO 2,4,6-TRINITROPHENYL SKELETON, METHOD FOR DETECTING COMPOUND HAVING 2,4,6-TRINITROPHENYL SKELETON USING THE NUCLEIC ACID MOLECULE, AND USE OF THE NUCLEIC ACID MOLECULE 审中-公开
标题翻译：能与2,4,6-三硝基苯乙烯结合的核酸分子，使用核酸分子检测2,4,6-三硝基苯甲酸的化合物的方法，以及核酸分子的使用
公开(公告)号：US20120003749A1
公开(公告)日：2012-01-05
申请号：US12993790
申请日：2009-05-12
申请人： Yoshihito Yoshida , Katsunori Horii , Jou Akitomi , Makio Furuichi , Iwao Waga
发明人： Yoshihito Yoshida , Katsunori Horii , Jou Akitomi , Makio Furuichi , Iwao Waga
IPC分类号： G01N33/22 , C07H21/02
CPC分类号： C07H21/00 , C12N15/115 , C12N2310/16
摘要： The present invention relates to a nucleic acid molecule capable of binding to a 2,4,6-trinitrophenyl skeleton, a method for detecting a compound having the 2,4,6-trinitrophenyl skeleton using the nucleic acid molecule, use of the nucleic acid molecule for detecting a compound having the 2,4,6-trinitrophenyl skeleton, and a method for detecting a compound having the 2,4,6-trinitrophenyl skeleton.
摘要翻译：本发明涉及能够结合2,4,6-三硝基苯骨架的核酸分子，使用该核酸分子检测具有2,4,6-三硝基苯基骨架的化合物的方法，使用该核酸用于检测具有2,4,6-三硝基苯基骨架的化合物的分子，以及用于检测具有2,4,6-三硝基苯基骨架的化合物的方法。

4. 发明授权

US08852954B2 Nucleic acid molecule having binding affinity to rodent-derived IgG antibody, binder, detection reagent, and detection kit 有权
标题翻译：对啮齿动物IgG抗体具有结合亲和力的核酸分子，粘合剂，检测试剂和检测试剂盒
公开(公告)号：US08852954B2
公开(公告)日：2014-10-07
申请号：US13511618
申请日：2009-08-21
申请人： Hiromi Takenaka , Yoshihito Yoshida , Katsunori Horii , Makio Furuichi , Hirotaka Yagi , Jou Akitomi , Mineko Yamaguchi , Shintarou Katou , Kensaku Nishikata , Iwao Waga
发明人： Hiromi Takenaka , Yoshihito Yoshida , Katsunori Horii , Makio Furuichi , Hirotaka Yagi , Jou Akitomi , Mineko Yamaguchi , Shintarou Katou , Kensaku Nishikata , Iwao Waga
IPC分类号： G01N33/567 , C12Q1/68 , C07H21/02 , G01N33/53 , C12N15/115
CPC分类号： G01N33/6854 , C12N15/115 , C12N2310/16 , G01N33/5308
摘要： The invention provides a nucleic acid molecule having a binding affinity to a rodent-derived IgG antibody, which can be prepared easier than an antibody and has a binding affinity equivalent or superior to that of an antibody, a binder using the nucleic acid molecule, a detection reagent, and a detection kit. The nucleic acid molecule of the invention has a binding affinity to a rodent-derived IgG antibody and has a dissociation constant of 1 μM or less. The binder for a rodent-derived IgG antibody of the present invention includes the nucleic acid molecule of the present invention. The detection reagent for detecting a rodent-derived IgG antibody of the invention includes the binder for a rodent-derived IgG antibody of the invention. The detection kit for detecting a rodent-derived IgG antibody of the invention includes the detection reagent for detecting a rodent-derived IgG antibody of the invention.
摘要翻译：本发明提供了一种对啮齿动物来源的IgG抗体具有结合亲和力的核酸分子，其可以比抗体更容易制备并且具有与抗体相当或优于其抗体的结合亲和力，使用核酸分子的粘合剂，检测试剂和检测试剂盒。本发明的核酸分子对啮齿动物来源的IgG抗体具有结合亲和力，解离常数为1μM以下。本发明的啮齿动物IgG抗体的粘合剂包括本发明的核酸分子。用于检测本发明的啮齿动物IgG抗体的检测试剂包括本发明的啮齿动物IgG抗体的粘合剂。用于检测本发明的啮齿动物IgG抗体的检测试剂盒包括用于检测本发明的啮齿动物IgG抗体的检测试剂。

5. 发明授权

US09689025B2 Nucleic acid element for use in analysis, and analytical method, analytical reagent, and analytical instrument using same 有权
公开(公告)号：US09689025B2
公开(公告)日：2017-06-27
申请号：US13389222
申请日：2010-08-06
申请人： Iwao Waga , Jou Akitomi , Makio Furuichi
发明人： Iwao Waga , Jou Akitomi , Makio Furuichi
IPC分类号： C12N15/11 , C12Q1/68 , C12N15/115
CPC分类号： C12Q1/6825 , C12N15/115 , C12N2310/3519 , C12N2320/10 , C12Q2565/101 , C12Q2525/301 , C12Q2525/205 , C12Q1/6823 , C12Q2563/125
摘要： The technique by which simple analysis of an intended subject to be analyzed can be carried out is provided. In this technique, a nucleic acid element 16 for use in analysis including: a first nucleic acid part 12; and a second nucleic acid part 13 is used. In the nucleic acid element 16, the first nucleic acid part 12 is a binding part that can bind to a subject 11 to be analyzed, and the second nucleic acid part 13 is a labeling part that can distinguish between binding and non-binding of the first nucleic acid part 12 to the subject 11. It is preferred that the first nucleic acid part 12 is an aptamer against the subject 11. The subject 11 can be analyzed easily by using the nucleic acid element 16, binding the subject 11 to the first nucleic acid part 12, and then analyzing the binding with the second nucleic acid part 13.

6. 发明申请

US20120202195A1 NUCLEIC ACID ELEMENT FOR USE IN ANALYSIS, AND ANALYTICAL METHOD, ANALYTICAL REAGENT, AND ANALYTICAL INSTRUMENT USING SAME 有权
标题翻译：用于分析的核酸元件，分析方法，分析试剂和使用分析试剂的分析仪器
公开(公告)号：US20120202195A1
公开(公告)日：2012-08-09
申请号：US13389222
申请日：2010-08-06
申请人： Iwao Waga , Jou Akitomi , Makio Furuichi
发明人： Iwao Waga , Jou Akitomi , Makio Furuichi
IPC分类号： G01N33/53 , G01N27/26 , C12N9/96 , G01N21/75 , C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6825 , C12N15/115 , C12N2310/3519 , C12N2320/10 , C12Q2565/101 , C12Q2525/301 , C12Q2525/205 , C12Q1/6823 , C12Q2563/125
摘要： The technique by which simple analysis of an intended subject to be analyzed can be carried out is provided. In this technique, a nucleic acid element 16 for use in analysis including: a first nucleic acid part 12; and a second nucleic acid part 13 is used. In the nucleic acid element 16, the first nucleic acid part 12 is a binding part that can bind to a subject 11 to be analyzed, and the second nucleic acid part 13 is a labeling part that can distinguish between binding and non-binding of the first nucleic acid part 12 to the subject 11. It is preferred that the first nucleic acid part 12 is an aptamer against the subject 11. The subject 11 can be analyzed easily by using the nucleic acid element 16, binding the subject 11 to the first nucleic acid part 12, and then analyzing the binding with the second nucleic acid part 13.
摘要翻译：提供了可以进行要分析的目标对象的简单分析的技术。在该技术中，用于分析的核酸元件16包括：第一核酸部分12; 并且使用第二核酸部分13。在核酸元件16中，第一核酸部分12是可以结合待分析对象11的结合部分，第二核酸部分13是可以区分结合部分和非结合的标记部分优选的是，第一核酸部分12是针对受试者11的适体。可以通过使用核酸元件16容易地分析受试者11，将受试者11结合到第一核酸部分核酸部分12，然后分析与第二核酸部分13的结合。

7. 发明申请

US20140128589A1 METHOD FOR EVALUATING REDOX ACTIVITY OF NUCLEIC ACID MOLECULE AND NUCLEIC ACID MOLECULE HAVING REDOX ACTIVITY 有权
标题翻译：用于评估具有还原活性的核酸分子和核酸分子的还原活性的方法
公开(公告)号：US20140128589A1
公开(公告)日：2014-05-08
申请号：US14129392
申请日：2012-07-02
申请人： Naoto Kaneko , Katsunori Horii , Jou Akitomi , Shintarou Katou , Iwao Waga
发明人： Naoto Kaneko , Katsunori Horii , Jou Akitomi , Shintarou Katou , Iwao Waga
IPC分类号： C12N15/113 , G01N27/26 , G01N33/58
CPC分类号： C12N15/113 , C12N15/1034 , C12N15/111 , C12N15/115 , C12N2310/127 , C12N2310/16 , C12N2310/351 , C12N2320/10 , C12N2330/31 , C12Q1/26 , C12Q1/6825 , G01N27/26 , G01N33/581 , C12Q2304/80 , C12Q2525/205 , C12Q2563/113
摘要： The present invention provides a novel technique by which the redox activity of a nucleic acid molecule can be evaluated. An evaluation method of the present invention includes: a detection step of electrochemically detecting a redox reaction to a substrate, the redox reaction being catalyzed by a nucleic acid molecule to be evaluated, using a device that electrochemically detects a redox reaction; and an evaluation step of evaluating redox activity of the nucleic acid molecule from a result of the detection of the redox reaction. As the device, a device in which a base provided with a detection portion is included, the detection portion.includes an electrode system, and the nucleic acid molecule to be evaluated is arranged on the base is used. In the present invention, it is preferred that a plurality of kinds of nucleic acid molecule to be evaluated is arranged on the base, and the plurality of kinds of nucleic acid molecules to be evaluated is evaluated by a single device.
摘要翻译：本发明提供可以评价核酸分子的氧化还原活性的新技术。本发明的评价方法包括：使用电化学检测氧化还原反应的装置电化学检测对基底的氧化还原反应的检测步骤，所述氧化还原反应由待评价的核酸分子催化; 以及从检测氧化还原反应的结果来评价核酸分子的氧化还原活性的评价步骤。作为该装置，包括具有检测部的基部的检测部。包括电极系统，并且使用要评估的核酸分子设置在基底上。在本发明中，优选在基材上排列要评价的多种核酸分子，通过单个装置评价要评价的多种核酸分子。

8. 发明申请

US20130273530A1 ANALYTICAL DEVICE AND ANALYTICAL METHOD 审中-公开
标题翻译：分析装置和分析方法
公开(公告)号：US20130273530A1
公开(公告)日：2013-10-17
申请号：US13996389
申请日：2011-12-22
申请人： Katsunori Horii , Shintarou Katou , Jou Akitomi , Iwao Waga
发明人： Katsunori Horii , Shintarou Katou , Jou Akitomi , Iwao Waga
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , C12N15/111 , C12N2310/16 , C12N2320/10 , C12Q1/6834 , G01N33/54306 , C12Q2525/205 , C12Q2563/131
摘要： The present invention provides a technique capable of simply analyzing a target to be analyzed. An analytical device of the present invention includes a basal plate; a nucleic acid element; and a detection section of detecting a signal. The nucleic acid element and the detection section are arranged on the basal plate. The nucleic acid element includes a first nucleic acid molecule and a second nucleic acid molecule. The first nucleic acid molecule is a nucleic acid molecule capable of binding to a target. The second nucleic acid molecule is a nucleic acid molecule capable of binding to streptavidin. When the target does not bind to the first nucleic acid molecule, a binding capacity of the second nucleic acid molecule to the streptavidin is inactivated. When the target binds to the first nucleic acid molecule, a binding capacity of the second nucleic acid molecule to the streptavidin is activated. The detection section detects binding between the second nucleic acid molecule and the streptavidin. The target is bound to the first nucleic acid molecule, so that the streptavidin is bound to the second nucleic acid molecule. Thus, the target can be analyzed through detecting the binding between the second nucleic acid molecule and the streptavidin using the detection device.
摘要翻译：本发明提供能够简单地分析要分析的靶的技术。本发明的分析装置包括基板; 核酸元件; 以及检测信号的检测部。核酸元件和检测部设置在基板上。核酸元件包括第一核酸分子和第二核酸分子。第一核酸分子是能够结合靶的核酸分子。第二核酸分子是能够结合链霉亲和素的核酸分子。当靶不与第一核酸分子结合时，第二核酸分子与链霉抗生物素蛋白的结合能力失活。当靶标与第一核酸分子结合时，第二核酸分子与链亲和素的结合能力被激活。检测部分检测第二核酸分子和链霉抗生物素蛋白之间的结合。靶标与第一核酸分子结合，使得链亲和素与第二核酸分子结合。因此，可以使用检测装置通过检测第二核酸分子和链霉亲和素之间的结合来分析靶。

9. 发明申请

US20150086980A1 DEVICE AND METHOD FOR ANALYZING STREPTAVIDIN 有权
标题翻译：用于分析STREPTAVIDIN的装置和方法
公开(公告)号：US20150086980A1
公开(公告)日：2015-03-26
申请号：US14387431
申请日：2013-03-21
申请人： Katsunori Horii , Naoto Kaneko , Jou Akitomi , Shintaro Kato , Iwao Waga
发明人： Katsunori Horii , Naoto Kaneko , Jou Akitomi , Shintaro Kato , Iwao Waga
IPC分类号： G01N33/543 , G01N33/58 , G01N33/68 , C12N15/113 , C12N15/115
CPC分类号： G01N33/54306 , C12N9/0065 , C12N15/113 , C12N15/115 , C12Y111/01007 , G01N33/542 , G01N33/58 , G01N33/68 , G01N2333/36
摘要： The present invention provides a novel sensor for detecting streptavidin (SA). The nucleic acid sensor for analyzing SA of the present invention includes the following nucleic acid element that includes a catalyst nucleic acid molecule (D) that exerts a catalytic function and a binding nucleic acid molecule (A) that binds to SA. The nucleic acid element is a double-stranded nucleic acid element including a first strand and a second strand. The first strand (ss1) includes the binding nucleic acid molecule (A), a loop-forming sequence (L1), and the catalyst nucleic acid molecule (D) linked in this order. The second strand (ss2) includes a stem-forming sequence (SA), a loop-forming sequence (L2), and a stem-forming sequence (SD) linked in this order. In this nucleic acid element, in the absence of SA, the catalytic function of the catalyst nucleic acid molecule (D) is inhibited by stem formation in each of the stem-forming sequences (SA) and (SD), and in the presence of SA, the stem formation is released by a binding of the binding nucleic acid molecule (A) with the SA, and the catalytic function of the catalyst nucleic acid molecule (D) is exerted.
摘要翻译：本发明提供了用于检测链霉亲和素（SA）的新型传感器。用于分析本发明的SA的核酸传感器包括以下核酸元件，其包含发挥催化功能的催化剂核酸分子（D）和与SA结合的结合核酸分子（A）。核酸元件是包含第一链和第二链的双链核酸元件。第一链（ss1）包括依次连接的结合核酸分子（A），环形成序列（L1）和催化剂核酸分子（D）。第二链（ss2）包括以此顺序连接的茎形成序列（SA），环形成序列（L2）和茎形成序列（SD）。在该核酸元件中，在不存在SA的情况下，催化剂核酸分子（D）的催化功能受到每个茎形成序列（SA）和（SD）中的茎形成的抑制，并且在 SA，通过结合核酸分子（A）与SA的结合释放茎的形成，并且发挥催化剂核酸分子（D）的催化功能。

10. 发明授权

US09880174B2 Device and method for analyzing target 有权
公开(公告)号：US09880174B2
公开(公告)日：2018-01-30
申请号：US14387389
申请日：2012-12-12
申请人： Katsunori Horii , Naoto Kaneko , Jou Akitomi , Shintarou Katou , Iwao Waga
发明人： Katsunori Horii , Naoto Kaneko , Jou Akitomi , Shintarou Katou , Iwao Waga
IPC分类号： G01N33/68 , C12Q1/00 , C12N9/08 , G01N21/59 , G01N33/53
CPC分类号： G01N33/6845 , C12N9/0065 , C12Q1/008 , C12Y111/01007 , G01N21/59 , G01N33/5308 , G01N33/6812
摘要： The present invention provides a novel sensor for detecting a target. The nucleic acid sensor of the present invention includes a nucleic acid element that includes a catalyst nucleic acid molecule (D) that exerts a catalytic function and a binding nucleic acid molecule (A) that binds to a target. The nucleic acid element is a double-stranded nucleic acid element including a first strand and a second strand. The first strand (ss1) includes the binding nucleic acid molecule (A), a loop-forming sequence (L1), and the catalyst nucleic acid molecule (D) linked in this order. The second strand (ss2) includes a stem-forming sequence (SA), a loop-forming sequence (L2), and a stem-forming sequence (SD) linked in this order. In this nucleic acid element, in the absence of a target, the catalytic function of the catalyst nucleic acid molecule (D) is inhibited by stem formation in each of the stem-forming sequences (SA) and (SD), and in the presence of ATP/target, the stem formation is released by a binding of the binding nucleic acid molecule (A) with the target, and the catalytic function is exerted.

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