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1. 发明授权

US09557339B2 Nucleic acid molecule having binding affinity to rodent-derived IgG antibody, binder, detection reagent, and detection kit 有权
标题翻译：对啮齿动物IgG抗体具有结合亲和力的核酸分子，粘合剂，检测试剂和检测试剂盒
公开(公告)号：US09557339B2
公开(公告)日：2017-01-31
申请号：US14336723
申请日：2014-07-21
申请人： Hiromi Takenaka , Yoshihito Yoshida , Katsunori Horii , Makio Furuichi , Hirotaka Yagi , Jou Akitomi , Mineko Yamaguchi , Shintarou Katou , Kensaku Nishikata , Iwao Waga
发明人： Hiromi Takenaka , Yoshihito Yoshida , Katsunori Horii , Makio Furuichi , Hirotaka Yagi , Jou Akitomi , Mineko Yamaguchi , Shintarou Katou , Kensaku Nishikata , Iwao Waga
IPC分类号： C12N15/115 , G01N33/68 , G01N33/53
CPC分类号： G01N33/6854 , C12N15/115 , C12N2310/16 , G01N33/5308
摘要： The present invention is to provide a nucleic acid molecule having a binding affinity to a rodent-derived IgG antibody, which can be prepared easier than an antibody and has a binding affinity equivalent or superior to that of an antibody, a binder using the nucleic acid molecule, a detection reagent, and a detection kit. The nucleic acid molecule of the present invention has a binding affinity to a rodent-derived IgG antibody and has a dissociation constant of 1 μM or less. The binder for a rodent-derived IgG antibody of the present invention includes the nucleic acid molecule of the present invention. The detection reagent for detecting a rodent-derived IgG antibody of the present invention includes the binder for a rodent-derived IgG antibody of the present invention. The detection kit for detecting a rodent-derived IgG antibody of the present invention includes the detection reagent for detecting a rodent-derived IgG antibody of the present invention.
摘要翻译：本发明提供一种对啮齿动物IgG抗体具有结合亲和力的核酸分子，其可以比抗体更容易制备并具有与抗体相当或优于其抗体的结合亲和力，使用该核酸的粘合剂分子，检测试剂和检测试剂盒。本发明的核酸分子与啮齿动物IgG抗体具有结合亲和力，解离常数为1μM以下。本发明的啮齿动物IgG抗体的粘合剂包括本发明的核酸分子。用于检测本发明的啮齿动物IgG抗体的检测试剂包括本发明的啮齿动物IgG抗体的粘合剂。用于检测本发明的啮齿动物IgG抗体的检测试剂盒包括用于检测本发明的啮齿动物的IgG抗体的检测试剂。

2. 发明授权

US09278108B2 HMGB1 binding nucleic acid molecule and applications thereof 有权
标题翻译： HMGB1结合核酸分子及其应用
公开(公告)号：US09278108B2
公开(公告)日：2016-03-08
申请号：US13383826
申请日：2010-07-16
申请人： Hiromi Takenaka , Jou Akitomi , Shintarou Katou , Shotaro Tsuji , Takashi Ohtsu , Iwao Waga
发明人： Hiromi Takenaka , Jou Akitomi , Shintarou Katou , Shotaro Tsuji , Takashi Ohtsu , Iwao Waga
IPC分类号： C12N15/115 , A61K31/7088 , A61K31/7105 , C07K14/47 , G01N33/68
CPC分类号： A61K31/7088 , A61K31/7105 , C07K14/4703 , C12N15/115 , C12N2310/16 , G01N33/6863
摘要： A nucleic acid molecule that can bind to HMGB1 protein and applications thereof are provided. A nucleic acid molecule having a dissociation constant for HMGB1 protein of 5×10−7 or less can be used as the nucleic acid molecule that can bind to HMGB1 protein. The HMGB1 binding nucleic acid molecule can bind to HMGB1 protein that is known to be a cause of diseases such as cancer and inflammation, and it is therefore possible to obtain an effect to prevent and an effect to treat such diseases by allowing the HMGB1 binding nucleic acid molecule to bind to HMGB1 protein in a living body.
摘要翻译：提供可结合HMGB1蛋白的核酸分子及其应用。具有5×10 -7以下的HMGB1蛋白的解离常数的核酸分子可以用作能结合HMGB1蛋白的核酸分子。 HMGB1结合核酸分子可以结合已知是诸如癌症和炎症等疾病的原因的HMGB1蛋白，因此可以通过使HMGB1结合核酸分子获得预防和治疗这些疾病的效果，酸分子结合活体中的HMGB1蛋白。

3. 发明授权

US08822667B2 Nucleic acid molecule capable of binding to c-Met and use thereof 有权
标题翻译：能够结合c-Met的核酸分子及其用途
公开(公告)号：US08822667B2
公开(公告)日：2014-09-02
申请号：US13812190
申请日：2011-07-26
申请人： Naomi Hirabayashi , Shotaro Tsuji , Jou Akitomi , Shintarou Katou , Iwao Waga , Takashi Ohtsu
发明人： Naomi Hirabayashi , Shotaro Tsuji , Jou Akitomi , Shintarou Katou , Iwao Waga , Takashi Ohtsu
IPC分类号： C07H21/04 , C07H21/02 , A61K48/00
CPC分类号： C07H21/02 , A61K31/52 , A61K31/7105 , C12N15/115 , C12N2310/16 , C12Q1/6883 , C12Q2525/301 , C12Q2527/125 , A61K2300/00
摘要： The present invention provides a nucleic acid molecule capable of binding to c-Met as a substance that can be used for clarification of the pathogenic mechanism of diseases caused by c-Met, diagnosis and treatment of the diseases, and the like, and also the use thereof. The c-Met binding nucleic acid molecule of the present invention is any one of the following nucleic acid molecules (A1), (A2), (B1), and (B2). (A1) a nucleic acid molecule including the base sequence of any one of SEQ ID NOs: 1 to 38 (A2) a nucleic acid molecule that is capable of binding to c-Met and includes a base sequence obtained by substitution, deletion, addition, and/or insertion of one or more bases in the base sequence of any one of SEQ ID NOs: 1 to 38 (B1) a nucleic acid molecule including the base sequence of any one of SEQ ID NOs: 39 to 76 (B2) a nucleic acid molecule that is capable of binding to c-Met and includes a base sequence obtained by substitution, deletion, addition, and/or insertion of one or more bases in the base sequence of any one of SEQ ID NOs: 39 to 76.
摘要翻译：本发明提供能够结合c-Met的核酸分子，作为能够用于澄清由c-Met，疾病的诊断和治疗等引起的疾病的致病机制的物质，以及使用它。本发明的c-Met结合核酸分子是以下核酸分子（A1），（A2），（B1）和（B2）中的任一种。（A1）包含SEQ ID NO：1至38（A2）中任一个的碱基序列的核酸分子，其能够结合c-Met并包含通过取代，缺失，加成获得的碱基序列，（SEQ ID NO：39）至（38）中的任何一个的碱基序列的核酸分子，和/或在SEQ ID NO：1至38（B1）中任一个的碱基序列中插入一个或多个碱基，能够结合c-Met的核酸分子，并且包含通过SEQ ID NO：39至76中任一个的碱基序列中的一个或多个碱基的取代，缺失，添加和/或插入获得的碱基序列。

4. 发明授权

US09880174B2 Device and method for analyzing target 有权
公开(公告)号：US09880174B2
公开(公告)日：2018-01-30
申请号：US14387389
申请日：2012-12-12
申请人： Katsunori Horii , Naoto Kaneko , Jou Akitomi , Shintarou Katou , Iwao Waga
发明人： Katsunori Horii , Naoto Kaneko , Jou Akitomi , Shintarou Katou , Iwao Waga
IPC分类号： G01N33/68 , C12Q1/00 , C12N9/08 , G01N21/59 , G01N33/53
CPC分类号： G01N33/6845 , C12N9/0065 , C12Q1/008 , C12Y111/01007 , G01N21/59 , G01N33/5308 , G01N33/6812
摘要： The present invention provides a novel sensor for detecting a target. The nucleic acid sensor of the present invention includes a nucleic acid element that includes a catalyst nucleic acid molecule (D) that exerts a catalytic function and a binding nucleic acid molecule (A) that binds to a target. The nucleic acid element is a double-stranded nucleic acid element including a first strand and a second strand. The first strand (ss1) includes the binding nucleic acid molecule (A), a loop-forming sequence (L1), and the catalyst nucleic acid molecule (D) linked in this order. The second strand (ss2) includes a stem-forming sequence (SA), a loop-forming sequence (L2), and a stem-forming sequence (SD) linked in this order. In this nucleic acid element, in the absence of a target, the catalytic function of the catalyst nucleic acid molecule (D) is inhibited by stem formation in each of the stem-forming sequences (SA) and (SD), and in the presence of ATP/target, the stem formation is released by a binding of the binding nucleic acid molecule (A) with the target, and the catalytic function is exerted.

5. 发明授权

US09880161B2 Device and method for analyzing streptavidin 有权
公开(公告)号：US09880161B2
公开(公告)日：2018-01-30
申请号：US14387431
申请日：2013-03-21
申请人： Katsunori Horii , Naoto Kaneko , Jou Akitomi , Shintaro Kato , Iwao Waga
发明人： Katsunori Horii , Naoto Kaneko , Jou Akitomi , Shintaro Kato , Iwao Waga
IPC分类号： C12Q1/68 , C07H21/00 , G01N33/50 , C12N15/115 , G01N33/543 , G01N33/542 , G01N33/68 , C12N9/08 , C12N15/113 , G01N33/58
CPC分类号： G01N33/54306 , C12N9/0065 , C12N15/113 , C12N15/115 , C12Y111/01007 , G01N33/542 , G01N33/58 , G01N33/68 , G01N2333/36
摘要： The present invention provides a novel sensor for detecting streptavidin (SA). The nucleic acid sensor for analyzing SA of the present invention includes the following nucleic acid element that includes a catalyst nucleic acid molecule (D) that exerts a catalytic function and a binding nucleic acid molecule (A) that binds to SA. The nucleic acid element is a double-stranded nucleic acid element including a first strand and a second strand. The first strand (ss1) includes the binding nucleic acid molecule (A), a loop-forming sequence (L1), and the catalyst nucleic acid molecule (D) linked in this order. The second strand (ss2) includes a stem-forming sequence (SA), a loop-forming sequence (L2), and a stem-forming sequence (SD) linked in this order. In this nucleic acid element, in the absence of SA, the catalytic function of the catalyst nucleic acid molecule (D) is inhibited by stem formation in each of the stem-forming sequences (SA) and (SD), and in the presence of SA, the stem formation is released by a binding of the binding nucleic acid molecule (A) with the SA, and the catalytic function of the catalyst nucleic acid molecule (D) is exerted.

6. 发明授权

US08852954B2 Nucleic acid molecule having binding affinity to rodent-derived IgG antibody, binder, detection reagent, and detection kit 有权
标题翻译：对啮齿动物IgG抗体具有结合亲和力的核酸分子，粘合剂，检测试剂和检测试剂盒
公开(公告)号：US08852954B2
公开(公告)日：2014-10-07
申请号：US13511618
申请日：2009-08-21
申请人： Hiromi Takenaka , Yoshihito Yoshida , Katsunori Horii , Makio Furuichi , Hirotaka Yagi , Jou Akitomi , Mineko Yamaguchi , Shintarou Katou , Kensaku Nishikata , Iwao Waga
发明人： Hiromi Takenaka , Yoshihito Yoshida , Katsunori Horii , Makio Furuichi , Hirotaka Yagi , Jou Akitomi , Mineko Yamaguchi , Shintarou Katou , Kensaku Nishikata , Iwao Waga
IPC分类号： G01N33/567 , C12Q1/68 , C07H21/02 , G01N33/53 , C12N15/115
CPC分类号： G01N33/6854 , C12N15/115 , C12N2310/16 , G01N33/5308
摘要： The invention provides a nucleic acid molecule having a binding affinity to a rodent-derived IgG antibody, which can be prepared easier than an antibody and has a binding affinity equivalent or superior to that of an antibody, a binder using the nucleic acid molecule, a detection reagent, and a detection kit. The nucleic acid molecule of the invention has a binding affinity to a rodent-derived IgG antibody and has a dissociation constant of 1 μM or less. The binder for a rodent-derived IgG antibody of the present invention includes the nucleic acid molecule of the present invention. The detection reagent for detecting a rodent-derived IgG antibody of the invention includes the binder for a rodent-derived IgG antibody of the invention. The detection kit for detecting a rodent-derived IgG antibody of the invention includes the detection reagent for detecting a rodent-derived IgG antibody of the invention.
摘要翻译：本发明提供了一种对啮齿动物来源的IgG抗体具有结合亲和力的核酸分子，其可以比抗体更容易制备并且具有与抗体相当或优于其抗体的结合亲和力，使用核酸分子的粘合剂，检测试剂和检测试剂盒。本发明的核酸分子对啮齿动物来源的IgG抗体具有结合亲和力，解离常数为1μM以下。本发明的啮齿动物IgG抗体的粘合剂包括本发明的核酸分子。用于检测本发明的啮齿动物IgG抗体的检测试剂包括本发明的啮齿动物IgG抗体的粘合剂。用于检测本发明的啮齿动物IgG抗体的检测试剂盒包括用于检测本发明的啮齿动物IgG抗体的检测试剂。

7. 发明申请

US20130123350A1 NUCLEIC ACID MOLECULE CAPABLE OF BINDING TO c-MET AND USE THEREOF 有权
标题翻译：可以与C-MET结合的核酸分子和其使用
公开(公告)号：US20130123350A1
公开(公告)日：2013-05-16
申请号：US13812190
申请日：2011-07-26
申请人： Naomi Hirabayashi , Shotaro Tsuji , Jou Akitomi , Shintarou Katou , Iwao Waga , Takashi Ohtsu
发明人： Naomi Hirabayashi , Shotaro Tsuji , Jou Akitomi , Shintarou Katou , Iwao Waga , Takashi Ohtsu
IPC分类号： C07H21/02
CPC分类号： C07H21/02 , A61K31/52 , A61K31/7105 , C12N15/115 , C12N2310/16 , C12Q1/6883 , C12Q2525/301 , C12Q2527/125 , A61K2300/00
摘要： The present invention provides a nucleic acid molecule capable of binding to c-Met as a substance that can be used for clarification of the pathogenic mechanism of diseases caused by c-Met, diagnosis and treatment of the diseases, and the like, and also the use thereof. The c-Met binding nucleic acid molecule of the present invention is any one of the following nucleic acid molecules (A1), (A2), (B1), and (B2).(A1) a nucleic acid molecule including the base sequence of any one of SEQ ID NOs: 1 to 38 (A2) a nucleic acid molecule that is capable of binding to c-Met and includes a base sequence obtained by substitution, deletion, addition, and/or insertion of one or more bases in the base sequence of any one of SEQ ID NOs: 1 to 38 (B1) a nucleic acid molecule including the base sequence of any one of SEQ ID NOs: 39 to 76 (B2) a nucleic acid molecule that is capable of binding to c-Met and includes a base sequence obtained by substitution, deletion, addition, and/or insertion of one or more bases in the base sequence of any one of SEQ ID NOs: 39 to 76
摘要翻译：本发明提供能够结合c-Met的核酸分子，作为能够用于澄清由c-Met，疾病的诊断和治疗等引起的疾病的致病机制的物质，以及使用它。本发明的c-Met结合核酸分子是以下核酸分子（A1），（A2），（B1）和（B2）中的任一种。（A1）包含SEQ ID NO：1至38（A2）中任一个的碱基序列的核酸分子，其能够结合c-Met并包含通过取代，缺失，加成获得的碱基序列，（SEQ ID NO：39）至（38）中的任何一个的碱基序列的核酸分子，和/或在SEQ ID NO：1至38（B1）中任一个的碱基序列中插入一个或多个碱基，能够结合c-Met的核酸分子，并且包含通过SEQ ID NO：39至76中任一个的碱基序列中的一个或多个碱基的取代，缺失，添加和/或插入获得的碱基序列

8. 发明申请

US20120202195A1 NUCLEIC ACID ELEMENT FOR USE IN ANALYSIS, AND ANALYTICAL METHOD, ANALYTICAL REAGENT, AND ANALYTICAL INSTRUMENT USING SAME 有权
标题翻译：用于分析的核酸元件，分析方法，分析试剂和使用分析试剂的分析仪器
公开(公告)号：US20120202195A1
公开(公告)日：2012-08-09
申请号：US13389222
申请日：2010-08-06
申请人： Iwao Waga , Jou Akitomi , Makio Furuichi
发明人： Iwao Waga , Jou Akitomi , Makio Furuichi
IPC分类号： G01N33/53 , G01N27/26 , C12N9/96 , G01N21/75 , C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6825 , C12N15/115 , C12N2310/3519 , C12N2320/10 , C12Q2565/101 , C12Q2525/301 , C12Q2525/205 , C12Q1/6823 , C12Q2563/125
摘要： The technique by which simple analysis of an intended subject to be analyzed can be carried out is provided. In this technique, a nucleic acid element 16 for use in analysis including: a first nucleic acid part 12; and a second nucleic acid part 13 is used. In the nucleic acid element 16, the first nucleic acid part 12 is a binding part that can bind to a subject 11 to be analyzed, and the second nucleic acid part 13 is a labeling part that can distinguish between binding and non-binding of the first nucleic acid part 12 to the subject 11. It is preferred that the first nucleic acid part 12 is an aptamer against the subject 11. The subject 11 can be analyzed easily by using the nucleic acid element 16, binding the subject 11 to the first nucleic acid part 12, and then analyzing the binding with the second nucleic acid part 13.
摘要翻译：提供了可以进行要分析的目标对象的简单分析的技术。在该技术中，用于分析的核酸元件16包括：第一核酸部分12; 并且使用第二核酸部分13。在核酸元件16中，第一核酸部分12是可以结合待分析对象11的结合部分，第二核酸部分13是可以区分结合部分和非结合的标记部分优选的是，第一核酸部分12是针对受试者11的适体。可以通过使用核酸元件16容易地分析受试者11，将受试者11结合到第一核酸部分核酸部分12，然后分析与第二核酸部分13的结合。

9. 发明申请

US20100222559A1 NUCLEIC ACID MOLECULE CAPABLE OF BINDING TO RABBIT-DERIVED lgG ANTIBODY 有权
标题翻译：能够结合RABBI衍生的IgG抗体的核酸分子
公开(公告)号：US20100222559A1
公开(公告)日：2010-09-02
申请号：US12516293
申请日：2007-11-22
申请人： Yoshihito Yoshida , Makio Furuichi , Iwao Waga , Hiroshi Mizuno
发明人： Yoshihito Yoshida , Makio Furuichi , Iwao Waga , Hiroshi Mizuno
IPC分类号： C07H21/02
CPC分类号： C12Q1/6883 , C12N15/115 , C12N2310/16
摘要： The present invention provides a nucleic acid molecule having an ability to bind to a rabbit anti-mouse IgG antibody, which can be prepared more easily than an antibody and has a binding ability equal to or higher than that of an antibody. The nucleic acid molecule according to the present invention may have the sequences set forth in SEQ ID NOS: 1 to 5. The nucleic acid molecule according to the present invention may be a nucleic acid having an ability to bind to a rabbit IgG antibody, which substantially has homology to its sequence. The nucleic acid molecule according to the present invention may have a binding constant (KD) of 1.18×10−7 (M) or less to the rabbit IgG antibody.
摘要翻译：本发明提供具有与兔抗小鼠IgG抗体结合的能力的核酸分子，其可以比抗体更容易制备并且具有等于或高于抗体的结合能力。根据本发明的核酸分子可以具有SEQ ID NO：1至5所示的序列。根据本发明的核酸分子可以是具有结合兔IgG抗体的能力的核酸，其中与其序列基本上具有同源性。本发明的核酸分子与兔IgG抗体的结合常数（KD）可以为1.18×10 -7（M）以下。

10. 发明申请

US20100043104A1 APPLICATION OF FLUORESCENT PROTEIN TO GARDEN PLANT 有权
标题翻译：荧光蛋白应用于园艺植物
公开(公告)号：US20100043104A1
公开(公告)日：2010-02-18
申请号：US12374995
申请日：2007-07-25
申请人： Iwao Waga , Hiromi Takenaka , Shu Muto
发明人： Iwao Waga , Hiromi Takenaka , Shu Muto
IPC分类号： C12N15/82
CPC分类号： C12N15/8212 , C07K14/43509
摘要： The present invention provides a process for generation of a transformed plant capable of emitting fluorescence by introducing a gene encoding a non-plant-derived fluorescent protein into a plant such that the fluorescent protein is recombinantly expressed in the active form of its mature protein in the leaf or petal of the plant, and also provides a transformed garden plant capable of emitting fluorescence that is generated by using the process. For example, cDNA encoding the full-length amino acid sequence of a Chiridius poppei-derived fluorescent protein CpYGFP or its H52F modified protein CpYGFP H52F is inserted into a T-DNA-based expression vector system, which is in turn introduced into the chromosomal DNA of a plant. As a result, the transformed plant thus generated can exhibit fluorescence attributed to these fluorescent proteins and exhibit no substantial difference in the other phenotypes from wild-type one of the plant.
摘要翻译：本发明提供一种通过将编码非植物来源的荧光蛋白的基因导入植物而产生能够发射荧光的转化植物的方法，使得荧光蛋白以其成熟蛋白的活性形式重组表达植物的叶或花瓣，并且还提供能够发射通过使用该过程产生的荧光的转化的花园植物。例如，将编码Chiridius Poppei衍生的荧光蛋白CpYGFP或其H52F修饰的蛋白质CpYGFP H52F的全长氨基酸序列的cDNA插入到基于T-DNA的表达载体系统中，其进而导入染色体DNA 的植物。结果，由此产生的转化植物可以表现出归因于这些荧光蛋白的荧光，并且在野生型植物中的其它表型中没有显示实质性差异。

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