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1. 发明授权

US09557339B2 Nucleic acid molecule having binding affinity to rodent-derived IgG antibody, binder, detection reagent, and detection kit 有权
标题翻译：对啮齿动物IgG抗体具有结合亲和力的核酸分子，粘合剂，检测试剂和检测试剂盒
公开(公告)号：US09557339B2
公开(公告)日：2017-01-31
申请号：US14336723
申请日：2014-07-21
申请人： Hiromi Takenaka , Yoshihito Yoshida , Katsunori Horii , Makio Furuichi , Hirotaka Yagi , Jou Akitomi , Mineko Yamaguchi , Shintarou Katou , Kensaku Nishikata , Iwao Waga
发明人： Hiromi Takenaka , Yoshihito Yoshida , Katsunori Horii , Makio Furuichi , Hirotaka Yagi , Jou Akitomi , Mineko Yamaguchi , Shintarou Katou , Kensaku Nishikata , Iwao Waga
IPC分类号： C12N15/115 , G01N33/68 , G01N33/53
CPC分类号： G01N33/6854 , C12N15/115 , C12N2310/16 , G01N33/5308
摘要： The present invention is to provide a nucleic acid molecule having a binding affinity to a rodent-derived IgG antibody, which can be prepared easier than an antibody and has a binding affinity equivalent or superior to that of an antibody, a binder using the nucleic acid molecule, a detection reagent, and a detection kit. The nucleic acid molecule of the present invention has a binding affinity to a rodent-derived IgG antibody and has a dissociation constant of 1 μM or less. The binder for a rodent-derived IgG antibody of the present invention includes the nucleic acid molecule of the present invention. The detection reagent for detecting a rodent-derived IgG antibody of the present invention includes the binder for a rodent-derived IgG antibody of the present invention. The detection kit for detecting a rodent-derived IgG antibody of the present invention includes the detection reagent for detecting a rodent-derived IgG antibody of the present invention.
摘要翻译：本发明提供一种对啮齿动物IgG抗体具有结合亲和力的核酸分子，其可以比抗体更容易制备并具有与抗体相当或优于其抗体的结合亲和力，使用该核酸的粘合剂分子，检测试剂和检测试剂盒。本发明的核酸分子与啮齿动物IgG抗体具有结合亲和力，解离常数为1μM以下。本发明的啮齿动物IgG抗体的粘合剂包括本发明的核酸分子。用于检测本发明的啮齿动物IgG抗体的检测试剂包括本发明的啮齿动物IgG抗体的粘合剂。用于检测本发明的啮齿动物IgG抗体的检测试剂盒包括用于检测本发明的啮齿动物的IgG抗体的检测试剂。

2. 发明授权

US09689025B2 Nucleic acid element for use in analysis, and analytical method, analytical reagent, and analytical instrument using same 有权
公开(公告)号：US09689025B2
公开(公告)日：2017-06-27
申请号：US13389222
申请日：2010-08-06
申请人： Iwao Waga , Jou Akitomi , Makio Furuichi
发明人： Iwao Waga , Jou Akitomi , Makio Furuichi
IPC分类号： C12N15/11 , C12Q1/68 , C12N15/115
CPC分类号： C12Q1/6825 , C12N15/115 , C12N2310/3519 , C12N2320/10 , C12Q2565/101 , C12Q2525/301 , C12Q2525/205 , C12Q1/6823 , C12Q2563/125
摘要： The technique by which simple analysis of an intended subject to be analyzed can be carried out is provided. In this technique, a nucleic acid element 16 for use in analysis including: a first nucleic acid part 12; and a second nucleic acid part 13 is used. In the nucleic acid element 16, the first nucleic acid part 12 is a binding part that can bind to a subject 11 to be analyzed, and the second nucleic acid part 13 is a labeling part that can distinguish between binding and non-binding of the first nucleic acid part 12 to the subject 11. It is preferred that the first nucleic acid part 12 is an aptamer against the subject 11. The subject 11 can be analyzed easily by using the nucleic acid element 16, binding the subject 11 to the first nucleic acid part 12, and then analyzing the binding with the second nucleic acid part 13.

3. 发明申请

US20130022967A1 NUCLEIC ACID MOLECULE HAVING AFFINITY TO RODENT-DERIVED IgG ANTIBODY, BINDER, DETECTION REAGENT, AND DETECTION KIT 有权
标题翻译：具有转染IgG抗体，粘合剂，检测试剂和检测试剂盒的亲和力的核酸分子
公开(公告)号：US20130022967A1
公开(公告)日：2013-01-24
申请号：US13511618
申请日：2009-08-21
申请人： Hiromi Takenaka , Yoshihito Yoshida , Katsunori Horii , Makio Furuichi , Hirotaka Yagi , Jou Akitomi , Mineko Yamaguchi , Shintarou Katou , Kensaku Nishikata , Iwao Waga
发明人： Hiromi Takenaka , Yoshihito Yoshida , Katsunori Horii , Makio Furuichi , Hirotaka Yagi , Jou Akitomi , Mineko Yamaguchi , Shintarou Katou , Kensaku Nishikata , Iwao Waga
IPC分类号： C12N15/115 , C12Q1/68 , G01N33/566
CPC分类号： G01N33/6854 , C12N15/115 , C12N2310/16 , G01N33/5308
摘要： The invention provides a nucleic acid molecule having a binding affinity to a rodent-derived IgG antibody, which can be prepared easier than an antibody and has a binding affinity equivalent or superior to that of an antibody, a binder using the nucleic acid molecule, a detection reagent, and a detection kit. The nucleic acid molecule of the invention has a binding affinity to a rodent-derived IgG antibody and has a dissociation constant of 1 μM or less. The binder for a rodent-derived IgG antibody of the present invention includes the nucleic acid molecule of the present invention. The detection reagent for detecting a rodent-derived IgG antibody of the invention includes the binder for a rodent-derived IgG antibody of the invention. The detection kit for detecting a rodent-derived IgG antibody of the invention includes the detection reagent for detecting a rodent-derived IgG antibody of the invention.
摘要翻译：本发明提供了一种对啮齿动物来源的IgG抗体具有结合亲和力的核酸分子，其可以比抗体更容易制备并且具有与抗体相当或优于其抗体的结合亲和力，使用核酸分子的粘合剂，检测试剂和检测试剂盒。本发明的核酸分子对啮齿动物来源的IgG抗体具有结合亲和力，解离常数为1μM以下。本发明的啮齿动物IgG抗体的粘合剂包括本发明的核酸分子。用于检测本发明的啮齿动物IgG抗体的检测试剂包括本发明的啮齿动物IgG抗体的粘合剂。用于检测本发明的啮齿动物IgG抗体的检测试剂盒包括用于检测本发明的啮齿动物IgG抗体的检测试剂。

4. 发明申请

US20120003749A1 NUCLEIC ACID MOLECULE CAPABLE OF BINDING TO 2,4,6-TRINITROPHENYL SKELETON, METHOD FOR DETECTING COMPOUND HAVING 2,4,6-TRINITROPHENYL SKELETON USING THE NUCLEIC ACID MOLECULE, AND USE OF THE NUCLEIC ACID MOLECULE 审中-公开
标题翻译：能与2,4,6-三硝基苯乙烯结合的核酸分子，使用核酸分子检测2,4,6-三硝基苯甲酸的化合物的方法，以及核酸分子的使用
公开(公告)号：US20120003749A1
公开(公告)日：2012-01-05
申请号：US12993790
申请日：2009-05-12
申请人： Yoshihito Yoshida , Katsunori Horii , Jou Akitomi , Makio Furuichi , Iwao Waga
发明人： Yoshihito Yoshida , Katsunori Horii , Jou Akitomi , Makio Furuichi , Iwao Waga
IPC分类号： G01N33/22 , C07H21/02
CPC分类号： C07H21/00 , C12N15/115 , C12N2310/16
摘要： The present invention relates to a nucleic acid molecule capable of binding to a 2,4,6-trinitrophenyl skeleton, a method for detecting a compound having the 2,4,6-trinitrophenyl skeleton using the nucleic acid molecule, use of the nucleic acid molecule for detecting a compound having the 2,4,6-trinitrophenyl skeleton, and a method for detecting a compound having the 2,4,6-trinitrophenyl skeleton.
摘要翻译：本发明涉及能够结合2,4,6-三硝基苯骨架的核酸分子，使用该核酸分子检测具有2,4,6-三硝基苯基骨架的化合物的方法，使用该核酸用于检测具有2,4,6-三硝基苯基骨架的化合物的分子，以及用于检测具有2,4,6-三硝基苯基骨架的化合物的方法。

5. 发明授权

US08852954B2 Nucleic acid molecule having binding affinity to rodent-derived IgG antibody, binder, detection reagent, and detection kit 有权
标题翻译：对啮齿动物IgG抗体具有结合亲和力的核酸分子，粘合剂，检测试剂和检测试剂盒
公开(公告)号：US08852954B2
公开(公告)日：2014-10-07
申请号：US13511618
申请日：2009-08-21
申请人： Hiromi Takenaka , Yoshihito Yoshida , Katsunori Horii , Makio Furuichi , Hirotaka Yagi , Jou Akitomi , Mineko Yamaguchi , Shintarou Katou , Kensaku Nishikata , Iwao Waga
发明人： Hiromi Takenaka , Yoshihito Yoshida , Katsunori Horii , Makio Furuichi , Hirotaka Yagi , Jou Akitomi , Mineko Yamaguchi , Shintarou Katou , Kensaku Nishikata , Iwao Waga
IPC分类号： G01N33/567 , C12Q1/68 , C07H21/02 , G01N33/53 , C12N15/115
CPC分类号： G01N33/6854 , C12N15/115 , C12N2310/16 , G01N33/5308
摘要： The invention provides a nucleic acid molecule having a binding affinity to a rodent-derived IgG antibody, which can be prepared easier than an antibody and has a binding affinity equivalent or superior to that of an antibody, a binder using the nucleic acid molecule, a detection reagent, and a detection kit. The nucleic acid molecule of the invention has a binding affinity to a rodent-derived IgG antibody and has a dissociation constant of 1 μM or less. The binder for a rodent-derived IgG antibody of the present invention includes the nucleic acid molecule of the present invention. The detection reagent for detecting a rodent-derived IgG antibody of the invention includes the binder for a rodent-derived IgG antibody of the invention. The detection kit for detecting a rodent-derived IgG antibody of the invention includes the detection reagent for detecting a rodent-derived IgG antibody of the invention.
摘要翻译：本发明提供了一种对啮齿动物来源的IgG抗体具有结合亲和力的核酸分子，其可以比抗体更容易制备并且具有与抗体相当或优于其抗体的结合亲和力，使用核酸分子的粘合剂，检测试剂和检测试剂盒。本发明的核酸分子对啮齿动物来源的IgG抗体具有结合亲和力，解离常数为1μM以下。本发明的啮齿动物IgG抗体的粘合剂包括本发明的核酸分子。用于检测本发明的啮齿动物IgG抗体的检测试剂包括本发明的啮齿动物IgG抗体的粘合剂。用于检测本发明的啮齿动物IgG抗体的检测试剂盒包括用于检测本发明的啮齿动物IgG抗体的检测试剂。

6. 发明申请

US20120202195A1 NUCLEIC ACID ELEMENT FOR USE IN ANALYSIS, AND ANALYTICAL METHOD, ANALYTICAL REAGENT, AND ANALYTICAL INSTRUMENT USING SAME 有权
标题翻译：用于分析的核酸元件，分析方法，分析试剂和使用分析试剂的分析仪器
公开(公告)号：US20120202195A1
公开(公告)日：2012-08-09
申请号：US13389222
申请日：2010-08-06
申请人： Iwao Waga , Jou Akitomi , Makio Furuichi
发明人： Iwao Waga , Jou Akitomi , Makio Furuichi
IPC分类号： G01N33/53 , G01N27/26 , C12N9/96 , G01N21/75 , C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6825 , C12N15/115 , C12N2310/3519 , C12N2320/10 , C12Q2565/101 , C12Q2525/301 , C12Q2525/205 , C12Q1/6823 , C12Q2563/125
摘要： The technique by which simple analysis of an intended subject to be analyzed can be carried out is provided. In this technique, a nucleic acid element 16 for use in analysis including: a first nucleic acid part 12; and a second nucleic acid part 13 is used. In the nucleic acid element 16, the first nucleic acid part 12 is a binding part that can bind to a subject 11 to be analyzed, and the second nucleic acid part 13 is a labeling part that can distinguish between binding and non-binding of the first nucleic acid part 12 to the subject 11. It is preferred that the first nucleic acid part 12 is an aptamer against the subject 11. The subject 11 can be analyzed easily by using the nucleic acid element 16, binding the subject 11 to the first nucleic acid part 12, and then analyzing the binding with the second nucleic acid part 13.
摘要翻译：提供了可以进行要分析的目标对象的简单分析的技术。在该技术中，用于分析的核酸元件16包括：第一核酸部分12; 并且使用第二核酸部分13。在核酸元件16中，第一核酸部分12是可以结合待分析对象11的结合部分，第二核酸部分13是可以区分结合部分和非结合的标记部分优选的是，第一核酸部分12是针对受试者11的适体。可以通过使用核酸元件16容易地分析受试者11，将受试者11结合到第一核酸部分核酸部分12，然后分析与第二核酸部分13的结合。

7. 发明授权

US09278108B2 HMGB1 binding nucleic acid molecule and applications thereof 有权
标题翻译： HMGB1结合核酸分子及其应用
公开(公告)号：US09278108B2
公开(公告)日：2016-03-08
申请号：US13383826
申请日：2010-07-16
申请人： Hiromi Takenaka , Jou Akitomi , Shintarou Katou , Shotaro Tsuji , Takashi Ohtsu , Iwao Waga
发明人： Hiromi Takenaka , Jou Akitomi , Shintarou Katou , Shotaro Tsuji , Takashi Ohtsu , Iwao Waga
IPC分类号： C12N15/115 , A61K31/7088 , A61K31/7105 , C07K14/47 , G01N33/68
CPC分类号： A61K31/7088 , A61K31/7105 , C07K14/4703 , C12N15/115 , C12N2310/16 , G01N33/6863
摘要： A nucleic acid molecule that can bind to HMGB1 protein and applications thereof are provided. A nucleic acid molecule having a dissociation constant for HMGB1 protein of 5×10−7 or less can be used as the nucleic acid molecule that can bind to HMGB1 protein. The HMGB1 binding nucleic acid molecule can bind to HMGB1 protein that is known to be a cause of diseases such as cancer and inflammation, and it is therefore possible to obtain an effect to prevent and an effect to treat such diseases by allowing the HMGB1 binding nucleic acid molecule to bind to HMGB1 protein in a living body.
摘要翻译：提供可结合HMGB1蛋白的核酸分子及其应用。具有5×10 -7以下的HMGB1蛋白的解离常数的核酸分子可以用作能结合HMGB1蛋白的核酸分子。 HMGB1结合核酸分子可以结合已知是诸如癌症和炎症等疾病的原因的HMGB1蛋白，因此可以通过使HMGB1结合核酸分子获得预防和治疗这些疾病的效果，酸分子结合活体中的HMGB1蛋白。

8. 发明授权

US08822667B2 Nucleic acid molecule capable of binding to c-Met and use thereof 有权
标题翻译：能够结合c-Met的核酸分子及其用途
公开(公告)号：US08822667B2
公开(公告)日：2014-09-02
申请号：US13812190
申请日：2011-07-26
申请人： Naomi Hirabayashi , Shotaro Tsuji , Jou Akitomi , Shintarou Katou , Iwao Waga , Takashi Ohtsu
发明人： Naomi Hirabayashi , Shotaro Tsuji , Jou Akitomi , Shintarou Katou , Iwao Waga , Takashi Ohtsu
IPC分类号： C07H21/04 , C07H21/02 , A61K48/00
CPC分类号： C07H21/02 , A61K31/52 , A61K31/7105 , C12N15/115 , C12N2310/16 , C12Q1/6883 , C12Q2525/301 , C12Q2527/125 , A61K2300/00
摘要： The present invention provides a nucleic acid molecule capable of binding to c-Met as a substance that can be used for clarification of the pathogenic mechanism of diseases caused by c-Met, diagnosis and treatment of the diseases, and the like, and also the use thereof. The c-Met binding nucleic acid molecule of the present invention is any one of the following nucleic acid molecules (A1), (A2), (B1), and (B2). (A1) a nucleic acid molecule including the base sequence of any one of SEQ ID NOs: 1 to 38 (A2) a nucleic acid molecule that is capable of binding to c-Met and includes a base sequence obtained by substitution, deletion, addition, and/or insertion of one or more bases in the base sequence of any one of SEQ ID NOs: 1 to 38 (B1) a nucleic acid molecule including the base sequence of any one of SEQ ID NOs: 39 to 76 (B2) a nucleic acid molecule that is capable of binding to c-Met and includes a base sequence obtained by substitution, deletion, addition, and/or insertion of one or more bases in the base sequence of any one of SEQ ID NOs: 39 to 76.
摘要翻译：本发明提供能够结合c-Met的核酸分子，作为能够用于澄清由c-Met，疾病的诊断和治疗等引起的疾病的致病机制的物质，以及使用它。本发明的c-Met结合核酸分子是以下核酸分子（A1），（A2），（B1）和（B2）中的任一种。（A1）包含SEQ ID NO：1至38（A2）中任一个的碱基序列的核酸分子，其能够结合c-Met并包含通过取代，缺失，加成获得的碱基序列，（SEQ ID NO：39）至（38）中的任何一个的碱基序列的核酸分子，和/或在SEQ ID NO：1至38（B1）中任一个的碱基序列中插入一个或多个碱基，能够结合c-Met的核酸分子，并且包含通过SEQ ID NO：39至76中任一个的碱基序列中的一个或多个碱基的取代，缺失，添加和/或插入获得的碱基序列。

9. 发明授权

US09454642B2 Prediction device, prediction method, program, and recording medium 有权
标题翻译：预测装置，预测方法，程序和记录介质
公开(公告)号：US09454642B2
公开(公告)日：2016-09-27
申请号：US13807876
申请日：2011-07-02
申请人： Jou Akitomi , Shintarou Katou , Shotaro Tsuji , Iwao Waga
发明人： Jou Akitomi , Shintarou Katou , Shotaro Tsuji , Takashi Ohtsu , Iwao Waga
IPC分类号： G01N33/50 , G06F19/16 , C12N15/115 , G06F19/18
CPC分类号： G06F19/16 , C12N15/115 , C12N2310/16 , G06F19/18
摘要： The present invention provides a prediction device, a prediction method, a program, and a recording medium, with which whether or not desired aptamer sequences are enriched can be predicted easily. The prediction device of the present invention 10 includes an input unit 11, a calculation unit 12, and a prediction unit 13. The input unit 11 is a unit through which sequence information on a target aptamer sequence group including selected aptamers in a target pool and a reference aptamer sequence group including reference aptamer sequences are inputted. The calculation unit 12 calculates the free energy of the target aptamer sequence group and the free energy of the reference aptamer sequence group. The prediction unit 13 compares the free energy of these sequence groups, and predicts that the target pool is an enriched pool when the free energy of the target aptamer sequence group is lower than the free energy of the reference aptamer sequence group. The reference aptamer sequence group is a candidate aptamer sequence group including a plurality of candidate aptamer sequences or a virtual aptamer sequence group that is derived from the target aptamer sequence group and includes virtual aptamer sequences having the same base composition as the target aptamer sequence group.
摘要翻译：本发明提供一种预测装置，预测方法，程序和记录介质，可以容易地预测其中是否需要富集需要的适体序列。本发明的预测装置10包括输入单元11，计算单元12和预测单元13.输入单元11是通过目标池中包括所选择的适配体的目标适体序列组的序列信息和输入包括参考适体序列的参照适体序列组。计算单元12计算目标适体序列组的自由能和参考适体序列组的自由能。预测单元13比较这些序列组的自由能，并且当靶适体序列组的自由能低于参考适体序列组的自由能时，预测目标池是富集池。参照适体序列组是包含从目标适体序列组得到的多个候选适体序列或虚拟适体序列组的候选适体序列组，并且具有与靶适体序列组相同的基本组成的虚拟适配子序列。

10. 发明申请

US20140128589A1 METHOD FOR EVALUATING REDOX ACTIVITY OF NUCLEIC ACID MOLECULE AND NUCLEIC ACID MOLECULE HAVING REDOX ACTIVITY 有权
标题翻译：用于评估具有还原活性的核酸分子和核酸分子的还原活性的方法
公开(公告)号：US20140128589A1
公开(公告)日：2014-05-08
申请号：US14129392
申请日：2012-07-02
申请人： Naoto Kaneko , Katsunori Horii , Jou Akitomi , Shintarou Katou , Iwao Waga
发明人： Naoto Kaneko , Katsunori Horii , Jou Akitomi , Shintarou Katou , Iwao Waga
IPC分类号： C12N15/113 , G01N27/26 , G01N33/58
CPC分类号： C12N15/113 , C12N15/1034 , C12N15/111 , C12N15/115 , C12N2310/127 , C12N2310/16 , C12N2310/351 , C12N2320/10 , C12N2330/31 , C12Q1/26 , C12Q1/6825 , G01N27/26 , G01N33/581 , C12Q2304/80 , C12Q2525/205 , C12Q2563/113
摘要： The present invention provides a novel technique by which the redox activity of a nucleic acid molecule can be evaluated. An evaluation method of the present invention includes: a detection step of electrochemically detecting a redox reaction to a substrate, the redox reaction being catalyzed by a nucleic acid molecule to be evaluated, using a device that electrochemically detects a redox reaction; and an evaluation step of evaluating redox activity of the nucleic acid molecule from a result of the detection of the redox reaction. As the device, a device in which a base provided with a detection portion is included, the detection portion.includes an electrode system, and the nucleic acid molecule to be evaluated is arranged on the base is used. In the present invention, it is preferred that a plurality of kinds of nucleic acid molecule to be evaluated is arranged on the base, and the plurality of kinds of nucleic acid molecules to be evaluated is evaluated by a single device.
摘要翻译：本发明提供可以评价核酸分子的氧化还原活性的新技术。本发明的评价方法包括：使用电化学检测氧化还原反应的装置电化学检测对基底的氧化还原反应的检测步骤，所述氧化还原反应由待评价的核酸分子催化; 以及从检测氧化还原反应的结果来评价核酸分子的氧化还原活性的评价步骤。作为该装置，包括具有检测部的基部的检测部。包括电极系统，并且使用要评估的核酸分子设置在基底上。在本发明中，优选在基材上排列要评价的多种核酸分子，通过单个装置评价要评价的多种核酸分子。

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