专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06291198B1 Antibody that recognizes pyrazine derivative and method for measuring 1,2-dicarbonyl derivative using said antibody 失效
标题翻译：识别吡嗪衍生物的抗体和使用所述抗体测量1,2-二羰基衍生物的方法
公开(公告)号：US06291198B1
公开(公告)日：2001-09-18
申请号：US09134388
申请日：1998-08-14
申请人： Yoshiaki Uchida , Yoshihiro Kurano , Satoru Ito
发明人： Yoshiaki Uchida , Yoshihiro Kurano , Satoru Ito
IPC分类号： G01N33545
CPC分类号： G01N33/5308 , C07K16/44 , G01N33/6893 , Y10S530/807
摘要： A method for simply measuring a 1,2-dicarbonyl derivative in multiple specimens is provided, which comprises converting a 1,2-dicarbonyl derivative to a pyrazine derivative represented by the formula (I): wherein R1 and R2 independently represent a hydrogen atom, a methyl group, a hydroxymethyl group, a hydroxyethyl group, a dihydroxyethyl group, a dihydroxypropyl group, a trihydroxypropyl group, or a trihydroxybutyl group, A represents a group that binds to the pyrazine ring to form a 6-membered aromatic hydrocarbon group, a 5- or 6-membered aromatic heterocyclic group, or a 5- or 6-membered alicyclic hydrocarbon group, and R3 represents a linking residue, wherein said 5-membered ring formed by A may have 1 or 2 substituents and said 6-membered ring may have 1 to 3 substituents, in addition to R3 and measuring the pyrazine derivative by an immunological method using an antibody that recognizes the pyrazine derivative.
摘要翻译：提供简单测定多个试样中的1,2-二羰基衍生物的方法，其包括将1,2-二羰基衍生物转化为由式（I）表示的吡嗪衍生物：其中R1和R2独立地表示氢原子，甲基，羟甲基，羟乙基，二羟基乙基，二羟丙基，三羟基丙基或三羟基丁基，A表示与吡嗪环结合形成6元芳族烃基的基团， 5元或6元芳族杂环基，或5元或6元脂环烃基，R3表示连接残基，其中由A形成的所述5元环可以具有1或2个取代基，所述6元环除了R3之外还可以具有1至3个取代基，并且通过使用识别吡嗪衍生物的抗体的免疫学方法测量吡嗪衍生物。

2. 发明授权

US5470759A Anti-glycated hemoglobin monoclonal antibody and method for measuring glycated hemoglobin 失效
标题翻译：抗糖化血红蛋白单克隆抗体及测定糖化血红蛋白的方法
公开(公告)号：US5470759A
公开(公告)日：1995-11-28
申请号：US73340
申请日：1993-06-07
申请人： Masami Sugiyama , Yoshiaki Uchida , Yoshihiro Kurano , Aiko Tanaka , Tetsuji Tanimoto
发明人： Masami Sugiyama , Yoshiaki Uchida , Yoshihiro Kurano , Aiko Tanaka , Tetsuji Tanimoto
IPC分类号： G01N33/50 , C07K16/18 , C12P21/08 , G01N33/72 , G01N33/538
CPC分类号： C07K16/18 , G01N33/723
摘要： A method for measuring glycated hemoglobin is disclosed, which comprises contacting a sample with an anti-hemoglobin antibody being bound to a solid phase, adding thereto an anti-glycated hemoglobin antibody, and then measuring the anti-glycated hemoglobin antibody bound to the solid phase via glycated hemoglobin and the anti-hemoglobin antibody. A method for measuring glycated hemoglobin is further disclosed, which comprises mixing a sample with particles on which an anti-glycated hemoglobin antibody is bound to cause immunoagglutination reaction. A method for measuring glycated hemoglobin is furthermore disclosed, which comprises mixing a sample with a solution containing a monoclonal antibody specific for glycated hemoglobin, and then measuring the change in the turbidity of the resulting mixture. A method is disclosed for measuring glycated hemoglobin which comprises mixing a sample with unsensitized latex particles and an anti-glycated hemoglobin antibody, to cause immunoagglutination reaction. There is disclosed a method for measuring glycated hemoglobin which comprises mixing a sample with unsensitized latex particles and particles on which an anti-glycated hemoglobin antibody is bound, to cause immunoagglutination reaction. Still furthermore, an anti-glycated hemoglobin monoclonal antibody having a high specificity for human glycated hemoglobin is disclosed.
摘要翻译：公开了一种测定糖化血红蛋白的方法，其包括将样品与结合于固相的抗血红蛋白抗体接触，向其中加入抗糖化血红蛋白抗体，然后测定与固相结合的抗糖化血红蛋白抗体通过糖化血红蛋白和抗血红蛋白抗体。进一步公开了测定糖化血红蛋白的方法，其包括将样品与其上结合有抗糖基化血红蛋白抗体的颗粒混合以引起免疫凝集反应。还公开了一种测定糖化血红蛋白的方法，其包括将样品与含有糖化血红蛋白特异性的单克隆抗体的溶液混合，然后测量所得混合物的浊度变化。公开了一种用于测量糖化血红蛋白的方法，其包括将样品与未敏化的胶乳颗粒和抗糖化血红蛋白抗体混合以引起免疫凝集反应。公开了一种测定糖化血红蛋白的方法，其包括将样品与未敏化的胶乳颗粒和抗糖基化血红蛋白抗体结合的颗粒混合，引起免疫凝集反应。此外，公开了对人糖化血红蛋白具有高特异性的抗糖化血红蛋白单克隆抗体。

3. 发明申请

US20080254440A1 Anti-Sars Virus Antibody, Hybridoma Producing the Antibody and Immunoassay Reagent Using the Antibody 审中-公开
标题翻译：抗Sars病毒抗体，使用抗体产生抗体和免疫测定试剂的杂交瘤
公开(公告)号：US20080254440A1
公开(公告)日：2008-10-16
申请号：US10577310
申请日：2004-10-29
申请人： Yoshiaki Uchida , Nobuyuki Fujii , Yoshihiro Kurano , Masahisa Okada , Hiroyuki Kogaki , Yasuji Kido , Kazushige Miyake
发明人： Yoshiaki Uchida , Nobuyuki Fujii , Yoshihiro Kurano , Masahisa Okada , Hiroyuki Kogaki , Yasuji Kido , Kazushige Miyake
IPC分类号： C12Q1/70 , C07K16/18 , C12M1/00 , C12N5/06
CPC分类号： G01N33/56983 , C07K16/10
摘要： A monoclonal antibody which specifically recognizes SARS virus is provided, and an immunoassay, immunoassay reagent and immunoassay device for detecting the SARS virus using the monoclonal antibody are disclosed. The monoclonal antibody according to the present invention is a monoclonal antibody against a nucleoprotein of a corona virus causing severe acute respiratory syndrome (SARS).
摘要翻译：提供特异性识别SARS病毒的单克隆抗体，并公开了使用单克隆抗体检测SARS病毒的免疫测定，免疫测定试剂和免疫测定装置。根据本发明的单克隆抗体是针对引起严重急性呼吸综合征（SARS）的电晕病毒的核蛋白的单克隆抗体。

4. 发明授权

US07052855B2 Anti-APO-B-48 monoclonal antibody, hybridoma producing the same, and method for measuring APO-B-48 using the same 有权
标题翻译：抗APO-B-48单克隆抗体，产生该抗体的杂交瘤以及使用其的APO-B-48的测定方法
公开(公告)号：US07052855B2
公开(公告)日：2006-05-30
申请号：US10682992
申请日：2003-10-14
申请人： Yoshiaki Uchida , Yoshihiro Kurano
发明人： Yoshiaki Uchida , Yoshihiro Kurano
IPC分类号： G01N33/53
CPC分类号： C07K16/18 , Y10S435/805 , Y10S435/96 , Y10S435/961 , Y10S435/971 , Y10S436/808 , Y10T436/104165
摘要： A novel monoclonal antibody which specifically binds to apo-B-48 is disclosed. The monoclonal antibody specifically binds to apo-B-48 but does not bind to apo-B-100.
摘要翻译：公开了特异性结合载脂蛋白-B-48的新型单克隆抗体。单克隆抗体特异性结合载脂蛋白-B-48，但不结合载脂蛋白-B-100。

5. 发明授权

US06309844B1 Anti-apo-B-48 monoclonal antibody, hybridoma producing the same, and method for measuring apo-B-48 using the same 失效
标题翻译：抗apo-B-48单克隆抗体，产生相同的杂交瘤，以及使用该抗体的apo-B-48的测定方法
公开(公告)号：US06309844B1
公开(公告)日：2001-10-30
申请号：US09172661
申请日：1998-10-15
申请人： Yoshiaki Uchida , Yoshihiro Kurano
发明人： Yoshiaki Uchida , Yoshihiro Kurano
IPC分类号： G01N3353
CPC分类号： C07K16/18 , Y10S435/805 , Y10S435/96 , Y10S435/961 , Y10S435/971 , Y10S436/808 , Y10T436/104165
摘要： A novel monoclonal antibody which specifically binds to apo-B-48 is disclosed. The monoclonal antibody specifically binds to apo-B-48 but does not bind to apo-B-100.
摘要翻译：公开了特异性结合载脂蛋白-B-48的新型单克隆抗体。单克隆抗体特异性结合载脂蛋白-B-48，但不结合载脂蛋白-B-100。

6. 发明授权

US5306617A Phenytoin derivatives 失效
标题翻译：苯妥英衍生物
公开(公告)号：US5306617A
公开(公告)日：1994-04-26
申请号：US744411
申请日：1991-08-13
申请人： Takafumi Uchida , Hiroshi Ishikawa , Koichi Koyama , Yoshihiro Kurano , Yoshiaki Uchida
发明人： Takafumi Uchida , Hiroshi Ishikawa , Koichi Koyama , Yoshihiro Kurano , Yoshiaki Uchida
IPC分类号： C12Q1/68 , C07H19/10 , C07H21/00 , C07H5/04 , C07H17/00 , C07H19/06
CPC分类号： C07H21/00
摘要： A phenytoin derivative represented by formula (I) ##STR1## wherein Ph denotes a phenyl group,X denotes --O--, --NH-- or --CH.sub.2 --,Y denotes --CO-- or --CH.sub.2 --,Z denotes a hydrogen atom or a hydroxyl group,M denotes a salt-forming cation, andm and n are each an integer of 0 to 8 and m+n is at least 2.Said compound is useful to produce a phenytoin-labelled DNA or RNA probe. When using such a probe, DNA or RNA in the specimen can be detected with high sensitivity.
摘要翻译：式（I）表示的苯妥英衍生物（*化学结构*）（I）（*化学结构*）其中Ph表示苯基，X表示-O-，-NH-或-CH2-，Y表示-CO- 或-CH 2 - ，Z表示氢原子或羟基，M表示形成盐的阳离子，m和n各自为0至8的整数，m + n至少为2.所述化合物可用于产生苯妥英标记的DNA或RNA探针。当使用这样的探针时，可以高灵敏度地检测样品中的DNA或RNA。

7. 发明授权

US06601152B1 Storage apparatus, an access control apparatus for a recording medium and an access control method for a recording medium 失效
标题翻译：存储装置，用于记录介质的访问控制装置和用于记录介质的访问控制方法
公开(公告)号：US06601152B1
公开(公告)日：2003-07-29
申请号：US09497444
申请日：2000-02-03
申请人： Yoshiaki Uchida
发明人： Yoshiaki Uchida
IPC分类号： G06F1214
CPC分类号： G06F21/78 , G11B20/00086 , G11B20/00137 , G11B20/00152 , G11B20/00702
摘要： In a storage apparatus, a recording medium has a first recording region and a second recording region. A command executor sets a first and second password in the first and second recording region respectively for performing access control so as to restrict unauthorized access to the recording medium by a third party. An access controller performs the access control on the basis of the first password and the second password. When initializing the recording medium, only the first recording region can be initialized. It is possible to effectively perform the access control on the recording medium all the time by an authorized user and to maintain the security.
摘要翻译：在存储装置中，记录介质具有第一记录区和第二记录区。命令执行器分别在第一和第二记录区域中设置第一和第二密码以执行访问控制，以便限制第三方对记录介质的未经授权的访问。访问控制器基于第一密码和第二密码执行访问控制。当初始化记录介质时，只能初始化第一记录区域。可以由授权用户有效地对记录介质进行访问控制，并且保持安全性。

8. 发明授权

US4433743A Control circuit for vehicle level adjusting apparatus 失效
标题翻译：车辆液位调节装置控制电路
公开(公告)号：US4433743A
公开(公告)日：1984-02-28
申请号：US351856
申请日：1982-02-24
申请人： Taiji Ohmori , Toshio Kasahara , Yoshiaki Uchida
发明人： Taiji Ohmori , Toshio Kasahara , Yoshiaki Uchida
IPC分类号： B60G17/00 , B60G17/015 , B60G17/017
CPC分类号： B60G17/017 , B60G2500/30 , B60G2600/02 , B60G2800/18 , B60G2800/20
摘要： A control circuit for a vehicle level adjusting apparatus which avoids performing vehicle level adjustment in response to momentary changes in the vehicle level during driving of the vehicle, and at the same time provides a prompt vehicle level adjustment in response to essential or substantial changes in the vehicle level during a halt or rest state. The control circuit includes a first circuit which receives at least one first signal based on a comparison between a reference vehicle level range and an actual vehicle level to make a judgment as to the necessity of an adjustment of the vehicle level and issues a second signal having a first signal status when the adjustment is judged to be necessary and a second signal status when the adjustment is judged to be unnecessary. A second circuit receives the second signal and issues a third signal based in a normal state of the second circuit on the second signal status as prolonged by a predetermined time and in a reset state of the second circuit on the second signal status as not prolonged. A third circuit receives the third signal and issues a control signal to the vehicle level adjusting apparatus. The control circuit is further provided with a fourth circuit which receives a fourth signal based on a halt or rest state of the vehicle and resets the second circuit.
摘要翻译：一种用于车辆等级调节装置的控制电路，其避免在车辆驾驶期间响应于车辆水平的瞬时变化执行车辆水位调整，并且同时响应于车辆的基本或实质性变化而提供迅速的车辆水平调整在停止或休息状态下的车辆水平。控制电路包括：第一电路，其基于参考车辆电平范围和实际车辆电平之间的比较来接收至少一个第一信号，以判断关于车辆电平的调整的必要性，并发出具有当判断为必要的调整时的第一信号状态和当判断为不必要的第二信号状态。第二电路在第二信号状态下接收第二信号并基于第二电路的正常状态发出延迟预定时间的第三信号，并且在第二信号状态的第二电路的复位状态下不延长。第三电路接收第三信号并向车辆等级调节装置发出控制信号。控制电路还设置有第四电路，其接收基于车辆的停止或静止状态的第四信号并复位第二电路。

9. 发明授权

US4068486A Automatic tunnel face hydraulic pressure controlling apparatus in shield type hydraulic tunnel boring system 失效
标题翻译：盾构式液压隧道镗孔自动隧道面液压控制装置
公开(公告)号：US4068486A
公开(公告)日：1978-01-17
申请号：US767038
申请日：1977-02-09
申请人： Yoshiaki Uchida , Akira Nakaya , Kunitaka Saito
发明人： Yoshiaki Uchida , Akira Nakaya , Kunitaka Saito
IPC分类号： E21D9/13 , E21D9/06 , E21D9/12 , E21D9/00
CPC分类号： E21D9/12 , E21D9/093
摘要： An apparatus for automatically controlling tunnel face hydraulic pressure in a hydraulic chamber defined by a rotary cutter head and bulkhead in a shield type excavator used in hydraulic tunnel boring system including a pipe for feeding a hydraulic material with a feeding pump from a reservoir to the chamber and a pipe for discharging a mixture of the fed hydraulic material with ground formations excavated by the cutter head from the chamber to the reservoir with a discharging pump. The apparatus substantially comprises a first pressure gauge for measuring actual tunnel face hydraulic pressure in the chamber, a feeding-pipe bypass provided close to the chamber, a first pressure regulating valve provided in the bypass, a second pressure regulating valve in the feeding pipe bypassed by the bypass, a first pressure regulator in which a first predetermined feeding pressure is preset for comparing the actual pressure measured by the first gauge with the first predetermined feeding pressure and controlling the second valve responsive to any differences between the both pressures compared in the first regulator, a second pressure gauge for measuring fed-hydraulic-material pressure upstream the bypass a third pressure regulating valve provided in the feeding pipe upstream the second pressure gauge, and a second pressure regulator in which a second predetermined feeding pressure is preset for comparing the measured fed-hydraulic-material pressure with the second predetermined pressure and controlling the third valve responsive to any differences between the both pressures compared in the second regulator. The second predetermined feeding pressure is preferrably made slightly higher than the first predetermined feeding pressure.
摘要翻译：一种用于在液压隧道掘进系统中使用的屏蔽型挖掘机中由旋转刀头和隔板限定的液压室中的隧道面液压自动控制的装置，包括用于将液压材料与供给泵从储存器供给到室的管以及管道，用于将所输送的液压材料与由切割头从所述腔室挖掘的地层的混合物排出到具有排出泵的储存器。该设备基本上包括用于测量腔室中的实际隧道面液压的第一压力计，靠近腔室设置的进料管旁路，设置在旁路中的第一压力调节阀，旁路输送管中的第二压力调节阀通过旁路，第一压力调节器，其中预设第一预定进料压力以将由第一量规测量的实际压力与第一预定进料压力进行比较，并且响应于在第一压力下比较的两个压力之间的任何差异来控制第二阀调节器，用于在旁路上游测量供给液压材料压力的第二压力表，设置在第二压力表上游的进料管中的第三压力调节阀，以及第二压力调节器，其中预设第二预定进料压力以比较测量进料液压材料压力与第二预热响应于在第二调节器中比较的两个压力之间的任何差异来控制第三阀。优选地将第二预定进料压力略高于第一预定进料压力。

10. 发明申请

US20110065095A1 ANTI-(INFLUENZA A VIRUS SUBTYPE H5 HEMAGGLUTININ) MONOCLONAL ANTIBODY 失效
标题翻译： ANTI-（流感病毒亚型H5 HEMAGGLUTININ）单克隆抗体
公开(公告)号：US20110065095A1
公开(公告)日：2011-03-17
申请号：US12934908
申请日：2009-03-26
申请人： Hiroshi Kida , Yoshihiro Sakoda , Eiji Miyagawa , Nobuyuki Fujii , Yoshiaki Uchida , Takashi Shirakawa , Hiroyuki Kogaki
发明人： Hiroshi Kida , Yoshihiro Sakoda , Eiji Miyagawa , Nobuyuki Fujii , Yoshiaki Uchida , Takashi Shirakawa , Hiroyuki Kogaki
IPC分类号： C12Q1/70 , C07K16/10
CPC分类号： G01N33/56983 , C07K16/1018 , C07K2317/34 , G01N2333/11
摘要： A method of immunoassay of H5 subtype influenza A virus by which the virus can be accurately assayed even in cases where a certain level of mutation has occurred in the H5 subtype influenza A virus, and a kit therefor, and a novel anti-H5 subtype influenza A virus monoclonal antibody which can be used for the immunoassay are disclosed. The antibody or an antigen-binding fragment thereof of the present invention undergoes antigen-antibody reaction with hemagglutinin of H5 subtype influenza A virus, and the corresponding epitope of the antibody or an antigen-binding fragment thereof is located in a region other than the receptor subdomain (excluding C-terminal region thereof consisting of 11 amino acids), which antibody or an antigen-binding fragment thereof does not have neutralizing activity against the influenza A virus.
摘要翻译：一种H5亚型甲型流感病毒的免疫测定方法，即使在H5亚型甲型流感病毒中发生一定程度的突变的情况下也能够准确测定病毒，以及其用于该药物的试剂盒，以及新的抗H5亚型流感公开了可用于免疫测定的病毒单克隆抗体。本发明的抗体或其抗原结合片段与H5亚型甲型流感病毒的血凝素进行抗原抗体反应，抗体或其抗原结合片段的相应表位位于受体以外的区域子结构域（不包括由11个氨基酸组成的C末端区域），该抗体或其抗原结合片段不具有针对甲型流感病毒的中和活性。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式