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1. 发明授权

US06291198B1 Antibody that recognizes pyrazine derivative and method for measuring 1,2-dicarbonyl derivative using said antibody 失效
标题翻译：识别吡嗪衍生物的抗体和使用所述抗体测量1,2-二羰基衍生物的方法
公开(公告)号：US06291198B1
公开(公告)日：2001-09-18
申请号：US09134388
申请日：1998-08-14
申请人： Yoshiaki Uchida , Yoshihiro Kurano , Satoru Ito
发明人： Yoshiaki Uchida , Yoshihiro Kurano , Satoru Ito
IPC分类号： G01N33545
CPC分类号： G01N33/5308 , C07K16/44 , G01N33/6893 , Y10S530/807
摘要： A method for simply measuring a 1,2-dicarbonyl derivative in multiple specimens is provided, which comprises converting a 1,2-dicarbonyl derivative to a pyrazine derivative represented by the formula (I): wherein R1 and R2 independently represent a hydrogen atom, a methyl group, a hydroxymethyl group, a hydroxyethyl group, a dihydroxyethyl group, a dihydroxypropyl group, a trihydroxypropyl group, or a trihydroxybutyl group, A represents a group that binds to the pyrazine ring to form a 6-membered aromatic hydrocarbon group, a 5- or 6-membered aromatic heterocyclic group, or a 5- or 6-membered alicyclic hydrocarbon group, and R3 represents a linking residue, wherein said 5-membered ring formed by A may have 1 or 2 substituents and said 6-membered ring may have 1 to 3 substituents, in addition to R3 and measuring the pyrazine derivative by an immunological method using an antibody that recognizes the pyrazine derivative.
摘要翻译：提供简单测定多个试样中的1,2-二羰基衍生物的方法，其包括将1,2-二羰基衍生物转化为由式（I）表示的吡嗪衍生物：其中R1和R2独立地表示氢原子，甲基，羟甲基，羟乙基，二羟基乙基，二羟丙基，三羟基丙基或三羟基丁基，A表示与吡嗪环结合形成6元芳族烃基的基团， 5元或6元芳族杂环基，或5元或6元脂环烃基，R3表示连接残基，其中由A形成的所述5元环可以具有1或2个取代基，所述6元环除了R3之外还可以具有1至3个取代基，并且通过使用识别吡嗪衍生物的抗体的免疫学方法测量吡嗪衍生物。

2. 发明授权

US06620628B2 Analytical elements having a surface charge 有权
标题翻译：具有表面电荷的分析元件
公开(公告)号：US06620628B2
公开(公告)日：2003-09-16
申请号：US09797817
申请日：2001-03-02
申请人： Richard Sutton , Susan Danielson , Jerome Swartz , Linda Mauck
发明人： Richard Sutton , Susan Danielson , Jerome Swartz , Linda Mauck
IPC分类号： G01N33545
CPC分类号： G01N33/54393 , Y10S436/805 , Y10S436/815 , Y10S436/826
摘要： An assay element for analyzing a charged analyte employs an immobilized receptor and a material having a net charge which is the same as that of the analyte. In a preferred embodiment, the analyte is an aminoglycoside and the material is a polymer having a net positive charge.
摘要翻译：用于分析带电分析物的测定元件使用固定化受体和具有与分析物相同的净电荷的材料。在优选的实施方案中，分析物是氨基糖苷类，并且该材料是具有净正电荷的聚合物。

3. 发明授权

US06653153B2 Methods for encoding combinatorial libraries 失效
公开(公告)号：US06653153B2
公开(公告)日：2003-11-25
申请号：US09898142
申请日：2001-07-03
申请人： Yusheng Xiong , Kevin Chapman , Tiebang Wang
发明人： Yusheng Xiong , Kevin Chapman , Tiebang Wang
IPC分类号： G01N33545
CPC分类号： G01N33/585 , B01J2219/00497 , B01J2219/005 , B01J2219/0054 , B01J2219/00572 , B01J2219/0059 , B01J2219/00596 , B01J2219/00707 , B01J2219/0072 , C07B2200/11 , C40B50/16 , C40B70/00 , G01N33/54313 , Y10T436/182
摘要： A combinatorial library comprises a plurality of ligand-bearing support units, where the ligand-bearing support units comprise (a) a solid carrier, (b) one or more ligands covalently bound to the solid carrier, and (c) one or more encoding metal salts impregnated on the support unit, where the distribution of the cations of the encoding metal salts provides a code for identifying the ligand or ligands that are attached to the support units, and the cations have been stabilized against dissolution by treatment with one or more anions that form insoluble or poorly soluble salts of the cations.

4. 发明授权

US06833276B2 Polymer brushes for immobilizing molecules to a surface and having water-soluble or water-dispersible segments therein and probes bonded thereto 失效
标题翻译：用于将分子固定在表面上并具有水溶性或水分散性区段的聚合物刷和与其结合的探针
公开(公告)号：US06833276B2
公开(公告)日：2004-12-21
申请号：US09911683
申请日：2001-07-24
申请人： Gerrit Klaerner , Ralph B. Nielsen , Paul Mansky , Didier Benoit , Dominique Charmot , Bernd Jandeleit , Laura T. Mazzola
发明人： Gerrit Klaerner , Ralph B. Nielsen , Paul Mansky , Didier Benoit , Dominique Charmot , Bernd Jandeleit , Laura T. Mazzola
IPC分类号： G01N33545
CPC分类号： G01N33/54353 , C08F4/00 , C08F220/54 , C08F220/58 , G01N27/44747 , Y10T428/8305 , Y10T436/10
摘要： Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, and in particular the use of an iniferter initiator, which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.
摘要翻译：用于确定生物样品中生物分子的存在和浓度的传感器以聚合物刷的形式提供，所述聚合物刷包含具有表面的基底，所述基底具有用水分散性或水溶性聚合物链段修饰，所述水分散性或水溶性聚合物链段具有结合探针。合成这种传感器的方法优选包括使用受控的自由基聚合技术，特别是使用引发剂，其允许可控结构聚合物改性基材的表面。以这种方式，从表面去除聚合物链中的官能团，这允许溶液化学更具体地再现，具有固体结合探针的优点。

5. 发明授权

US06391655B1 Oxidized styrenic polymers for DNA binding 失效
标题翻译：用于DNA结合的氧化苯乙烯聚合物
公开(公告)号：US06391655B1
公开(公告)日：2002-05-21
申请号：US09124352
申请日：1998-07-29
申请人： Dana C. Bookbinder , Leroy S. Hersh , Xinying Xie
发明人： Dana C. Bookbinder , Leroy S. Hersh , Xinying Xie
IPC分类号： G01N33545
CPC分类号： C07H21/00 , C12Q1/6834 , G01N33/54393
摘要： A method of immobilizing aminated DNA to a substrate surface is provided for use in DNA hybridization assays. The surface can be widely employed in a variety of molded laboratory products including multiwell plates, cell culture dishes, and biological containers. The method comprises the steps of providing a polystyrene substrate having a surface content of between 0.3 and 4.0% atomic percent oxygen, and attaching amine modified oligonucleotide to the surface of the substrate. A resultant product comprising a polystyrene substrate having a surface oxygen content of between 0.3 and 4.0% atomic percent, and a plurality of amine modified oligonucleotides directly attached to the surface of the substrate, is also disclosed.
摘要翻译：提供将胺化的DNA固定到底物表面的方法用于DNA杂交测定。该表面可广泛用于各种模制实验室产品，包括多孔板，细胞培养皿和生物容器。该方法包括以下步骤：提供具有0.3至4.0％原子百分比氧的表面含量的聚苯乙烯底物，并将胺修饰的寡核苷酸连接到基底的表面。还公开了一种包含表面氧含量为0.3-4.0％原子百分比的聚苯乙烯底物和直接附着在基材表面上的多个胺修饰的寡核苷酸的产物。

6. 发明授权

US06753191B2 Polymerized crystalline colloidal array chemical sensing materials for use in high ionic strength solutions 失效
标题翻译：用于高离子强度溶液的聚合晶体胶体阵列化学传感材料
公开(公告)号：US06753191B2
公开(公告)日：2004-06-22
申请号：US09953646
申请日：2001-09-17
申请人： Sanford A. Asher , Chad E Reese
发明人： Sanford A. Asher , Chad E Reese
IPC分类号： G01N33545
CPC分类号： B01J13/00 , B01J13/0065 , G01J3/18 , G01N21/4788 , G01N21/77 , G01N21/78 , G01N31/222 , G02B26/002 , Y10S436/805
摘要： A novel method is disclosed wherein polymerized crystalline colloidal array (PCCA) chemical sensing materials are used to detect the presence of certain chemical species in high ionic strength solutions, such as bodily fluids. The PCCA sensors consist of a mesoscopically periodic array of colloidal particles polymerized into a hydrogel. The array of colloidal particles diffracts light in the visible spectral region due to the periodic spacing of the particles. The PCCA materials also contain molecular recognition components that bind to the chemical species being detected. The binding or the chelation of the chemical species of interest results in a Donnan potential that swells the hydrogel and in turn red shifts the diffracted light proportionately to the concentration of the chemical species. However, no significant red shift response may occur for PCCA chemical sensors in high ionic strength solutions containing chemical species of interest. Thus, the method of the present invention provides for incubating the PCCA chemical sensor in the sample solution, subsequently exposing the PCCA to a low ionic strength solution, such as pure water, and measuring the transient diffraction shift response of the PCCA upon the exposure to the low ionic strength solution. The non-chelated or non-bound ions (such as salt ions in high ionic strength solutions) diffuse out of the PCCA hydrogel more quickly than the chemical species ions bound to the molecular recognition component. Thus, the resulting transient PCCA diffraction red shift is proportional to the concentration of the chemical species in the sample solution. The present invention also discloses using the PCCA chemical sensors in an optrode for detecting certain chemical species in high ionic strength solutions, such as bodily fluids.
摘要翻译：公开了一种新的方法，其中使用聚合的结晶胶体阵列（PCCA）化学感测材料来检测高离子强度溶液例如体液中某些化学物质的存在。 PCCA传感器由聚合成水凝胶的胶体颗粒的中视周期阵列组成。由于颗粒的周期性间隔，胶体颗粒阵列在可见光谱区域衍射光。 PCCA材料还含有结合待检测化学物质的分子识别组分。感兴趣的化学物质的结合或螯合导致Donnan电位，其使水凝胶膨胀，并且依次将衍射光与化学物质的浓度成比例地变换。然而，在含有感兴趣化学物质的高离子强度溶液中，PCCA化学传感器不会发生显着的红移响应。因此，本发明的方法提供了将PCCA化学传感器温育在样品溶液中，随后将PCCA暴露于低离子强度溶液（例如纯水），并测量了PCCA在曝光后的瞬态衍射平移响应低离子强度溶液。非螯合或非结合离子（如高离子强度溶液中的盐离子）比与分子识别组分结合的化学物质离子更快地扩散出PCCA水凝胶。因此，所得到的瞬时PCCA衍射红移与样品溶液中化学物质的浓度成比例。本发明还公开了将PCCA化学传感器用于检测诸如体液的高离子强度溶液中的某些化学物质的光学特性。

7. 发明授权

US06573110B1 Combinatorial chemistry system and method of use 失效
标题翻译：组合化学体系和使用方法
公开(公告)号：US06573110B1
公开(公告)日：2003-06-03
申请号：US09674900
申请日：1999-12-15
申请人： Robert J. Hessler , Robert Braun , Nicholas Winograd
发明人： Robert J. Hessler , Robert Braun , Nicholas Winograd
IPC分类号： G01N33545
CPC分类号： C07K1/047 , B01J19/0046 , B01J2219/00459 , B01J2219/00468 , B01J2219/005 , B01J2219/00702 , B01L3/5085 , B01L2200/0647 , B01L2300/0893 , C40B40/00 , Y10T436/11 , Y10T436/24
摘要： A combinatorial chemistry system allows for the dual processing of different molecules coated on a library of beads. The system includes beads coated with different molecules on each bead, a bead holder, screening equipment and characterization equipment. Molecules on the beads are both screened and characterized simultaneously.
摘要翻译：组合化学系统允许涂覆在磁珠库上的不同分子的双重加工。该系统包括在每个珠粒上涂覆有不同分子的珠子，珠子保持器，筛选设备和表征设备。珠子上的分子同时进行筛选和表征。

8. 发明授权

US06544800B2 Polymerized crystalline colloidal arrays 有权
标题翻译：聚合晶体胶体阵列
公开(公告)号：US06544800B2
公开(公告)日：2003-04-08
申请号：US09753592
申请日：2001-01-03
申请人： Sanford A. Asher
发明人： Sanford A. Asher
IPC分类号： G01N33545
CPC分类号： B01J13/00 , B01J13/0065 , G01J3/18 , G01N21/4788 , G01N21/77 , G01N31/222 , G01N2021/772 , G01N2021/7723 , G02B26/002 , Y10S436/805 , Y10S436/811 , Y10T436/144444 , Y10T436/204998 , Y10T436/205831 , Y10T436/207497 , Y10T436/209163
摘要： Novel sensor devices composed of a crystalline colloidal array (CCA) polymerized in a hydrogel are disclosed. The hydrogels are characterized as being capable of shrinking and swelling in response to specific stimuli applied thereto. As the hydrogels shrink or swell, the lattice structure of the CCA embedded therein changes, thereby changing the wavelength of light diffracted by the CCA. Thus by monitoring the change in diffracted wavelength, the concentration of a stimulus is determined. The gels can be modified to sense numerous different stimuli. The sensor devices are specific in that they are modified to react with only one species or family of species. These sensors have various applications in areas including, for example, environmental and chemical systems, chemomechanical systems, sensor devices and medical diagnostic tools. Various methods for making and using these devices are also disclosed.
摘要翻译：公开了由在水凝胶中聚合的结晶胶体阵列（CCA）组成的新型传感器装置。水凝胶的特征在于能够响应于施加于其上的特定刺激而收缩和膨胀。当水凝胶收缩或膨胀时，嵌入其中的CCA的晶格结构发生变化，从而改变由CCA衍射的光的波长。因此，通过监测衍射波长的变化，确定刺激的浓度。可以修改凝胶以感测许多不同的刺激。传感器装置是特定的，因为它们被修改为仅与一个物种或一系列物种反应。这些传感器在包括例如环境和化学系统，化学机械系统，传感器装置和医疗诊断工具的领域中具有各种应用。还公开了制造和使用这些装置的各种方法。

9. 发明授权

US06187599B1 Polymerized crystalline colloidal arrays 失效
标题翻译：聚合晶体胶体阵列
公开(公告)号：US06187599B1
公开(公告)日：2001-02-13
申请号：US09111610
申请日：1998-07-07
申请人： Sanford A. Asher , John H. Holtz
发明人： Sanford A. Asher , John H. Holtz
IPC分类号： G01N33545
CPC分类号： B01J13/00 , B01J13/0065 , G01J3/18 , G01N21/4788 , G01N21/77 , G01N31/222 , G01N2021/772 , G01N2021/7723 , G02B26/002 , Y10S436/805 , Y10S436/811 , Y10T436/144444 , Y10T436/204998 , Y10T436/205831 , Y10T436/207497 , Y10T436/209163
摘要： Novel sensor devices composed of a crystalline colloidal array (CCA) polymerized in a hydrogel are disclosed. The hydrogels are characterized as being capable of shrinking and swelling in response to specific stimuli applied thereto. As the hydrogels shrink or swell, the lattice structure of the CCA embedded therein changes, thereby changing the wavelength of light diffracted by the CCA. Thus by monitoring the change in diffracted wavelength, the concentration of a stimulus is determined. The gels can be modified to sense numerous different stimuli. The sensor devices are specific in that they are modified to react with only one species or family of species. These sensors have various applications in areas including, for example, environmental and chemical systems, chemomechanical systems, sensor devices and medical diagnostic tools. Various methods for making and using these devices are also disclosed.
摘要翻译：公开了由在水凝胶中聚合的结晶胶体阵列（CCA）组成的新型传感器装置。水凝胶的特征在于能够响应于施加于其上的特定刺激而收缩和膨胀。当水凝胶收缩或膨胀时，嵌入其中的CCA的晶格结构发生变化，从而改变由CCA衍射的光的波长。因此，通过监测衍射波长的变化，确定刺激的浓度。可以修改凝胶以感测许多不同的刺激。传感器装置是特定的，因为它们被修改为仅与一个物种或一系列物种反应。这些传感器在包括例如环境和化学系统，化学机械系统，传感器装置和医疗诊断工具的领域中具有各种应用。还公开了制造和使用这些装置的各种方法。

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