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1. 发明申请

US20080254440A1 Anti-Sars Virus Antibody, Hybridoma Producing the Antibody and Immunoassay Reagent Using the Antibody 审中-公开
标题翻译：抗Sars病毒抗体，使用抗体产生抗体和免疫测定试剂的杂交瘤
公开(公告)号：US20080254440A1
公开(公告)日：2008-10-16
申请号：US10577310
申请日：2004-10-29
申请人： Yoshiaki Uchida , Nobuyuki Fujii , Yoshihiro Kurano , Masahisa Okada , Hiroyuki Kogaki , Yasuji Kido , Kazushige Miyake
发明人： Yoshiaki Uchida , Nobuyuki Fujii , Yoshihiro Kurano , Masahisa Okada , Hiroyuki Kogaki , Yasuji Kido , Kazushige Miyake
IPC分类号： C12Q1/70 , C07K16/18 , C12M1/00 , C12N5/06
CPC分类号： G01N33/56983 , C07K16/10
摘要： A monoclonal antibody which specifically recognizes SARS virus is provided, and an immunoassay, immunoassay reagent and immunoassay device for detecting the SARS virus using the monoclonal antibody are disclosed. The monoclonal antibody according to the present invention is a monoclonal antibody against a nucleoprotein of a corona virus causing severe acute respiratory syndrome (SARS).
摘要翻译：提供特异性识别SARS病毒的单克隆抗体，并公开了使用单克隆抗体检测SARS病毒的免疫测定，免疫测定试剂和免疫测定装置。根据本发明的单克隆抗体是针对引起严重急性呼吸综合征（SARS）的电晕病毒的核蛋白的单克隆抗体。

2. 发明申请

US20110065095A1 ANTI-(INFLUENZA A VIRUS SUBTYPE H5 HEMAGGLUTININ) MONOCLONAL ANTIBODY 失效
标题翻译： ANTI-（流感病毒亚型H5 HEMAGGLUTININ）单克隆抗体
公开(公告)号：US20110065095A1
公开(公告)日：2011-03-17
申请号：US12934908
申请日：2009-03-26
申请人： Hiroshi Kida , Yoshihiro Sakoda , Eiji Miyagawa , Nobuyuki Fujii , Yoshiaki Uchida , Takashi Shirakawa , Hiroyuki Kogaki
发明人： Hiroshi Kida , Yoshihiro Sakoda , Eiji Miyagawa , Nobuyuki Fujii , Yoshiaki Uchida , Takashi Shirakawa , Hiroyuki Kogaki
IPC分类号： C12Q1/70 , C07K16/10
CPC分类号： G01N33/56983 , C07K16/1018 , C07K2317/34 , G01N2333/11
摘要： A method of immunoassay of H5 subtype influenza A virus by which the virus can be accurately assayed even in cases where a certain level of mutation has occurred in the H5 subtype influenza A virus, and a kit therefor, and a novel anti-H5 subtype influenza A virus monoclonal antibody which can be used for the immunoassay are disclosed. The antibody or an antigen-binding fragment thereof of the present invention undergoes antigen-antibody reaction with hemagglutinin of H5 subtype influenza A virus, and the corresponding epitope of the antibody or an antigen-binding fragment thereof is located in a region other than the receptor subdomain (excluding C-terminal region thereof consisting of 11 amino acids), which antibody or an antigen-binding fragment thereof does not have neutralizing activity against the influenza A virus.
摘要翻译：一种H5亚型甲型流感病毒的免疫测定方法，即使在H5亚型甲型流感病毒中发生一定程度的突变的情况下也能够准确测定病毒，以及其用于该药物的试剂盒，以及新的抗H5亚型流感公开了可用于免疫测定的病毒单克隆抗体。本发明的抗体或其抗原结合片段与H5亚型甲型流感病毒的血凝素进行抗原抗体反应，抗体或其抗原结合片段的相应表位位于受体以外的区域子结构域（不包括由11个氨基酸组成的C末端区域），该抗体或其抗原结合片段不具有针对甲型流感病毒的中和活性。

3. 发明授权

US08658354B2 Anti-(influenza a virus subtype H5 hemagglutinin) monoclonal antibody 失效
标题翻译：抗 - （流感病毒亚型H5血凝素）单克隆抗体
公开(公告)号：US08658354B2
公开(公告)日：2014-02-25
申请号：US12934908
申请日：2009-03-26
申请人： Hiroshi Kida , Yoshihiro Sakoda , Eiji Miyagawa , Nobuyuki Fujii , Yoshiaki Uchida , Takashi Shirakawa , Hiroyuki Kogaki
发明人： Hiroshi Kida , Yoshihiro Sakoda , Eiji Miyagawa , Nobuyuki Fujii , Yoshiaki Uchida , Takashi Shirakawa , Hiroyuki Kogaki
IPC分类号： C12Q1/70
CPC分类号： G01N33/56983 , C07K16/1018 , C07K2317/34 , G01N2333/11
摘要： A method of immunoassay of H5 subtype influenza A virus by which the virus can be accurately assayed even in cases where a certain level of mutation has occurred in the H5 subtype influenza A virus, and a kit therefor, and a novel anti-H5 subtype influenza A virus monoclonal antibody which can be used for the immunoassay are disclosed. The antibody or an antigen-binding fragment thereof of the present invention undergoes antigen-antibody reaction with hemagglutinin of H5 subtype influenza A virus, and the corresponding epitope of the antibody or an antigen-binding fragment thereof is located in a region other than the receptor subdomain (excluding C-terminal region thereof consisting of 11 amino acids), which antibody or an antigen-binding fragment thereof does not have neutralizing activity against the influenza A virus.
摘要翻译：一种H5亚型甲型流感病毒的免疫测定方法，即使在H5亚型甲型流感病毒中发生一定程度的突变的情况下，也能够准确测定病毒，以及其用途，以及新的抗H5亚型流感公开了可用于免疫测定的病毒单克隆抗体。本发明的抗体或其抗原结合片段与H5亚型甲型流感病毒的血凝素进行抗原抗体反应，抗体或其抗原结合片段的相应表位位于受体以外的区域子结构域（不包括由11个氨基酸组成的C末端区域），该抗体或其抗原结合片段不具有针对甲型流感病毒的中和活性。

4. 发明授权

US06291198B1 Antibody that recognizes pyrazine derivative and method for measuring 1,2-dicarbonyl derivative using said antibody 失效
标题翻译：识别吡嗪衍生物的抗体和使用所述抗体测量1,2-二羰基衍生物的方法
公开(公告)号：US06291198B1
公开(公告)日：2001-09-18
申请号：US09134388
申请日：1998-08-14
申请人： Yoshiaki Uchida , Yoshihiro Kurano , Satoru Ito
发明人： Yoshiaki Uchida , Yoshihiro Kurano , Satoru Ito
IPC分类号： G01N33545
CPC分类号： G01N33/5308 , C07K16/44 , G01N33/6893 , Y10S530/807
摘要： A method for simply measuring a 1,2-dicarbonyl derivative in multiple specimens is provided, which comprises converting a 1,2-dicarbonyl derivative to a pyrazine derivative represented by the formula (I): wherein R1 and R2 independently represent a hydrogen atom, a methyl group, a hydroxymethyl group, a hydroxyethyl group, a dihydroxyethyl group, a dihydroxypropyl group, a trihydroxypropyl group, or a trihydroxybutyl group, A represents a group that binds to the pyrazine ring to form a 6-membered aromatic hydrocarbon group, a 5- or 6-membered aromatic heterocyclic group, or a 5- or 6-membered alicyclic hydrocarbon group, and R3 represents a linking residue, wherein said 5-membered ring formed by A may have 1 or 2 substituents and said 6-membered ring may have 1 to 3 substituents, in addition to R3 and measuring the pyrazine derivative by an immunological method using an antibody that recognizes the pyrazine derivative.
摘要翻译：提供简单测定多个试样中的1,2-二羰基衍生物的方法，其包括将1,2-二羰基衍生物转化为由式（I）表示的吡嗪衍生物：其中R1和R2独立地表示氢原子，甲基，羟甲基，羟乙基，二羟基乙基，二羟丙基，三羟基丙基或三羟基丁基，A表示与吡嗪环结合形成6元芳族烃基的基团， 5元或6元芳族杂环基，或5元或6元脂环烃基，R3表示连接残基，其中由A形成的所述5元环可以具有1或2个取代基，所述6元环除了R3之外还可以具有1至3个取代基，并且通过使用识别吡嗪衍生物的抗体的免疫学方法测量吡嗪衍生物。

5. 发明授权

US5470759A Anti-glycated hemoglobin monoclonal antibody and method for measuring glycated hemoglobin 失效
标题翻译：抗糖化血红蛋白单克隆抗体及测定糖化血红蛋白的方法
公开(公告)号：US5470759A
公开(公告)日：1995-11-28
申请号：US73340
申请日：1993-06-07
申请人： Masami Sugiyama , Yoshiaki Uchida , Yoshihiro Kurano , Aiko Tanaka , Tetsuji Tanimoto
发明人： Masami Sugiyama , Yoshiaki Uchida , Yoshihiro Kurano , Aiko Tanaka , Tetsuji Tanimoto
IPC分类号： G01N33/50 , C07K16/18 , C12P21/08 , G01N33/72 , G01N33/538
CPC分类号： C07K16/18 , G01N33/723
摘要： A method for measuring glycated hemoglobin is disclosed, which comprises contacting a sample with an anti-hemoglobin antibody being bound to a solid phase, adding thereto an anti-glycated hemoglobin antibody, and then measuring the anti-glycated hemoglobin antibody bound to the solid phase via glycated hemoglobin and the anti-hemoglobin antibody. A method for measuring glycated hemoglobin is further disclosed, which comprises mixing a sample with particles on which an anti-glycated hemoglobin antibody is bound to cause immunoagglutination reaction. A method for measuring glycated hemoglobin is furthermore disclosed, which comprises mixing a sample with a solution containing a monoclonal antibody specific for glycated hemoglobin, and then measuring the change in the turbidity of the resulting mixture. A method is disclosed for measuring glycated hemoglobin which comprises mixing a sample with unsensitized latex particles and an anti-glycated hemoglobin antibody, to cause immunoagglutination reaction. There is disclosed a method for measuring glycated hemoglobin which comprises mixing a sample with unsensitized latex particles and particles on which an anti-glycated hemoglobin antibody is bound, to cause immunoagglutination reaction. Still furthermore, an anti-glycated hemoglobin monoclonal antibody having a high specificity for human glycated hemoglobin is disclosed.
摘要翻译：公开了一种测定糖化血红蛋白的方法，其包括将样品与结合于固相的抗血红蛋白抗体接触，向其中加入抗糖化血红蛋白抗体，然后测定与固相结合的抗糖化血红蛋白抗体通过糖化血红蛋白和抗血红蛋白抗体。进一步公开了测定糖化血红蛋白的方法，其包括将样品与其上结合有抗糖基化血红蛋白抗体的颗粒混合以引起免疫凝集反应。还公开了一种测定糖化血红蛋白的方法，其包括将样品与含有糖化血红蛋白特异性的单克隆抗体的溶液混合，然后测量所得混合物的浊度变化。公开了一种用于测量糖化血红蛋白的方法，其包括将样品与未敏化的胶乳颗粒和抗糖化血红蛋白抗体混合以引起免疫凝集反应。公开了一种测定糖化血红蛋白的方法，其包括将样品与未敏化的胶乳颗粒和抗糖基化血红蛋白抗体结合的颗粒混合，引起免疫凝集反应。此外，公开了对人糖化血红蛋白具有高特异性的抗糖化血红蛋白单克隆抗体。

6. 发明授权

US07052855B2 Anti-APO-B-48 monoclonal antibody, hybridoma producing the same, and method for measuring APO-B-48 using the same 有权
标题翻译：抗APO-B-48单克隆抗体，产生该抗体的杂交瘤以及使用其的APO-B-48的测定方法
公开(公告)号：US07052855B2
公开(公告)日：2006-05-30
申请号：US10682992
申请日：2003-10-14
申请人： Yoshiaki Uchida , Yoshihiro Kurano
发明人： Yoshiaki Uchida , Yoshihiro Kurano
IPC分类号： G01N33/53
CPC分类号： C07K16/18 , Y10S435/805 , Y10S435/96 , Y10S435/961 , Y10S435/971 , Y10S436/808 , Y10T436/104165
摘要： A novel monoclonal antibody which specifically binds to apo-B-48 is disclosed. The monoclonal antibody specifically binds to apo-B-48 but does not bind to apo-B-100.
摘要翻译：公开了特异性结合载脂蛋白-B-48的新型单克隆抗体。单克隆抗体特异性结合载脂蛋白-B-48，但不结合载脂蛋白-B-100。

7. 发明授权

US06309844B1 Anti-apo-B-48 monoclonal antibody, hybridoma producing the same, and method for measuring apo-B-48 using the same 失效
标题翻译：抗apo-B-48单克隆抗体，产生相同的杂交瘤，以及使用该抗体的apo-B-48的测定方法
公开(公告)号：US06309844B1
公开(公告)日：2001-10-30
申请号：US09172661
申请日：1998-10-15
申请人： Yoshiaki Uchida , Yoshihiro Kurano
发明人： Yoshiaki Uchida , Yoshihiro Kurano
IPC分类号： G01N3353
CPC分类号： C07K16/18 , Y10S435/805 , Y10S435/96 , Y10S435/961 , Y10S435/971 , Y10S436/808 , Y10T436/104165
摘要： A novel monoclonal antibody which specifically binds to apo-B-48 is disclosed. The monoclonal antibody specifically binds to apo-B-48 but does not bind to apo-B-100.
摘要翻译：公开了特异性结合载脂蛋白-B-48的新型单克隆抗体。单克隆抗体特异性结合载脂蛋白-B-48，但不结合载脂蛋白-B-100。

8. 发明授权

US5306617A Phenytoin derivatives 失效
标题翻译：苯妥英衍生物
公开(公告)号：US5306617A
公开(公告)日：1994-04-26
申请号：US744411
申请日：1991-08-13
申请人： Takafumi Uchida , Hiroshi Ishikawa , Koichi Koyama , Yoshihiro Kurano , Yoshiaki Uchida
发明人： Takafumi Uchida , Hiroshi Ishikawa , Koichi Koyama , Yoshihiro Kurano , Yoshiaki Uchida
IPC分类号： C12Q1/68 , C07H19/10 , C07H21/00 , C07H5/04 , C07H17/00 , C07H19/06
CPC分类号： C07H21/00
摘要： A phenytoin derivative represented by formula (I) ##STR1## wherein Ph denotes a phenyl group,X denotes --O--, --NH-- or --CH.sub.2 --,Y denotes --CO-- or --CH.sub.2 --,Z denotes a hydrogen atom or a hydroxyl group,M denotes a salt-forming cation, andm and n are each an integer of 0 to 8 and m+n is at least 2.Said compound is useful to produce a phenytoin-labelled DNA or RNA probe. When using such a probe, DNA or RNA in the specimen can be detected with high sensitivity.
摘要翻译：式（I）表示的苯妥英衍生物（*化学结构*）（I）（*化学结构*）其中Ph表示苯基，X表示-O-，-NH-或-CH2-，Y表示-CO- 或-CH 2 - ，Z表示氢原子或羟基，M表示形成盐的阳离子，m和n各自为0至8的整数，m + n至少为2.所述化合物可用于产生苯妥英标记的DNA或RNA探针。当使用这样的探针时，可以高灵敏度地检测样品中的DNA或RNA。

9. 发明申请

US20130109010A1 METHOD FOR DETECTION OF INFECTION WITH HUMAN CYTOMEGALOVIRUS 审中-公开
标题翻译：用人类细胞病毒检测感染的方法
公开(公告)号：US20130109010A1
公开(公告)日：2013-05-02
申请号：US13808465
申请日：2011-07-05
申请人： Nobuyuki Fujii , Hideo Honda , Yoshiaki Uchida , Kazuya Omi
发明人： Nobuyuki Fujii , Hideo Honda , Yoshiaki Uchida , Kazuya Omi
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , C07K14/005 , C12N2710/16122 , G01N33/56994 , G01N2333/045 , G01N2469/20
摘要： A novel means by which HCMV infection can be detected with a high sensitivity and whose practicality is high is disclosed. The present inventors synthesized as many as 15 kinds of HCMV proteins in their full length forms, and intensively studied their reactivities with sera from HCMV-infected patients to find that all the infected patients can be detected without fail when using the pp28 full length protein as an antigen. The pp28 full length protein can be synthesized and purified as a recombinant protein in a large scale by using Escherichia coli, and can be commercially used as an antigen for HCMV tests.
摘要翻译：公开了一种以高灵敏度检测HCMV感染并且其实用性高的新颖手段。本发明人以其全长形式合成了多达15种HCMV蛋白，并且深入研究了与HCMV感染患者的血清的反应性，发现使用pp28全长蛋白时所有感染的患者都可以被检测到，抗原。通过使用大肠杆菌可以大量合成和纯化pp28全长蛋白质作为重组蛋白质，并且可以商业上用作HCMV测试的抗原。

10. 发明授权

US06601152B1 Storage apparatus, an access control apparatus for a recording medium and an access control method for a recording medium 失效
标题翻译：存储装置，用于记录介质的访问控制装置和用于记录介质的访问控制方法
公开(公告)号：US06601152B1
公开(公告)日：2003-07-29
申请号：US09497444
申请日：2000-02-03
申请人： Yoshiaki Uchida
发明人： Yoshiaki Uchida
IPC分类号： G06F1214
CPC分类号： G06F21/78 , G11B20/00086 , G11B20/00137 , G11B20/00152 , G11B20/00702
摘要： In a storage apparatus, a recording medium has a first recording region and a second recording region. A command executor sets a first and second password in the first and second recording region respectively for performing access control so as to restrict unauthorized access to the recording medium by a third party. An access controller performs the access control on the basis of the first password and the second password. When initializing the recording medium, only the first recording region can be initialized. It is possible to effectively perform the access control on the recording medium all the time by an authorized user and to maintain the security.
摘要翻译：在存储装置中，记录介质具有第一记录区和第二记录区。命令执行器分别在第一和第二记录区域中设置第一和第二密码以执行访问控制，以便限制第三方对记录介质的未经授权的访问。访问控制器基于第一密码和第二密码执行访问控制。当初始化记录介质时，只能初始化第一记录区域。可以由授权用户有效地对记录介质进行访问控制，并且保持安全性。

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