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1. 发明申请

US20110152305A1 FILMS AND PARTICLES 有权
标题翻译：胶片和颗粒
公开(公告)号：US20110152305A1
公开(公告)日：2011-06-23
申请号：US12690607
申请日：2010-01-20
申请人： Yolonda Colson , Solomon Azouz , Mark Grinstaff , Jesse Wolinsky , Aaron Griset
发明人： Yolonda Colson , Solomon Azouz , Mark Grinstaff , Jesse Wolinsky , Aaron Griset
IPC分类号： A61K31/475 , A61K31/337 , A61P35/00 , A61P29/00 , A61P31/00 , A61P17/02 , C08G63/08 , C07C69/96 , B32B5/00 , B82Y30/00
CPC分类号： A61K47/32 , A61K31/337 , A61K31/519 , A61K38/14 , A61K38/50 , C07D319/06 , C08F124/00 , Y10T428/2982
摘要： Described herein are compounds and processes that can be used to prepare polymer-based films, particles, gels and related compositions, and processes for delivery of agents, and other uses.
摘要翻译：本文描述了可用于制备聚合物基膜，颗粒，凝胶和相关组合物的化合物和方法，以及用于递送试剂的方法和其它用途。

2. 发明授权

US07671095B2 Films and particles 有权
标题翻译：薄膜和颗粒
公开(公告)号：US07671095B2
公开(公告)日：2010-03-02
申请号：US11756587
申请日：2007-05-31
申请人： Yolonda Colson , Solomon Azouz , Mark Grinstaff , Jesse Wolinsky , Aaron Griset
发明人： Yolonda Colson , Solomon Azouz , Mark Grinstaff , Jesse Wolinsky , Aaron Griset
IPC分类号： A61K47/06
CPC分类号： A61K47/32 , A61K31/337 , A61K31/519 , A61K38/14 , A61K38/50 , C07D319/06 , C08F124/00 , Y10T428/2982
摘要： Described herein are compounds and processes that can be used to prepare polymer-based films, particles, gels and related compositions, and processes for delivery of agents, and other uses.
摘要翻译：本文描述了可用于制备聚合物基膜，颗粒，凝胶和相关组合物的化合物和方法，以及用于递送试剂的方法和其它用途。

3. 发明申请

US20120107365A1 FILMS AND PARTICLES 有权
标题翻译：胶片和颗粒
公开(公告)号：US20120107365A1
公开(公告)日：2012-05-03
申请号：US12818693
申请日：2010-06-18
申请人： Yolonda Colson , Solomon Azouz , Mark Grinstaff , Jesse Wolinsky , Aaron Griset
发明人： Yolonda Colson , Solomon Azouz , Mark Grinstaff , Jesse Wolinsky , Aaron Griset
IPC分类号： A61K47/32 , A61K31/404 , A61K31/4745 , A61P35/00 , A61P11/06 , A61P31/00 , A61P31/12 , A61P21/06 , A61P23/00 , A61K9/00 , A61P35/02
CPC分类号： A61K47/32 , A61K31/337 , A61K31/519 , A61K38/14 , A61K38/50 , C07D319/06 , C08F124/00 , Y10T428/2982
摘要： Described herein are compounds and processes that can be used to prepare polymer-based films, particles, gels and related compositions, and processes for delivery of agents, and other uses.
摘要翻译：本文描述了可用于制备聚合物基膜，颗粒，凝胶和相关组合物的化合物和方法，以及用于递送试剂的方法和其它用途。

4. 发明申请

US20080075718A1 Films and Particles 有权
标题翻译：电影和粒子
公开(公告)号：US20080075718A1
公开(公告)日：2008-03-27
申请号：US11756587
申请日：2007-05-31
申请人： Yolonda Colson , Solomon Azouz , Mark Grinstaff , Jesse Wolinsky , Aaron Griset
发明人： Yolonda Colson , Solomon Azouz , Mark Grinstaff , Jesse Wolinsky , Aaron Griset
IPC分类号： A61K39/395 , A61K31/131 , A61K31/135 , A61K31/164 , A61K31/17 , A61K31/192 , A61K31/28 , A61K31/336 , A61K31/337 , A61K31/35 , A61K31/357 , A61K31/407 , A61K31/4164 , A61K31/445 , A61K31/496 , A61K31/4985 , A61K31/505 , A61K31/52 , C08G75/26 , C08G63/08 , C07D313/04 , A61K31/551 , A61K31/65 , A61K31/66 , A61K38/08 , A61K38/50
CPC分类号： A61K47/32 , A61K31/337 , A61K31/519 , A61K38/14 , A61K38/50 , C07D319/06 , C08F124/00 , Y10T428/2982
摘要： Described herein are compounds and processes that can be used to prepare polymer-based films, particles, gels and related compositions, and processes for delivery of agents, and other uses.
摘要翻译：本文描述了可用于制备聚合物基膜，颗粒，凝胶和相关组合物的化合物和方法，以及用于递送试剂的方法和其它用途。

5. 发明申请

US20100304357A1 UNIVERSAL DRINKING ADAPTER FOR BEVERAGE BOTTLES, AND DEVICES AND KITS FOR DETERMINING SMALL MOLECULES, METAL IONS, ENDOTOXINS, AND BACTERIA, AND METHODS OF USE THEREOF 审中-公开
标题翻译：用于饮料瓶的通用饮用适配器，以及用于确定小分子，金属离子，内毒素和细菌的装置和试剂盒及其使用方法
公开(公告)号：US20100304357A1
公开(公告)日：2010-12-02
申请号：US12718604
申请日：2010-03-05
申请人： Steven Meyers , Michel Wathier , Mark Grinstaff
发明人： Steven Meyers , Michel Wathier , Mark Grinstaff
IPC分类号： G01N33/04 , A61J9/04 , A47G19/22 , B65D69/00 , G01N33/06 , C12M1/00 , G01N21/00 , C12Q1/00
CPC分类号： A61J11/04 , G01N33/52
摘要： Certain features, aspects, examples and embodiments described herein relate to adapters for securing drinking apparatuses for individuals of all ages (infants, children, adults, and seniors) such as nipples, sippers, and straws, to commercially available beverage containers to aid in the consumption of the contained liquid. Other features, aspects, examples and embodiments relate to devices and kits useful for the detection of analytes in milk samples such as small molecules, metal ions, endotoxins, and bacteria.
摘要翻译：本文所述的某些特征，方面，示例和实施例涉及用于将所有年龄的个体（婴儿，儿童，成年人和老年人）的饮用设备（例如乳头，拖鞋和吸管）固定到商业上可获得的饮料容器的适配器，以帮助所含液体的消耗。其他特征，方面，实施例和实施方案涉及可用于检测牛奶样品（例如小分子，金属离子，内毒素和细菌）中的分析物的装置和试剂盒。

6. 发明申请

US20060263831A1 Interfacial biomaterials for binding ceramic substrates 审中-公开
标题翻译：用于粘结陶瓷基材的界面生物材料
公开(公告)号：US20060263831A1
公开(公告)日：2006-11-23
申请号：US11346855
申请日：2006-02-03
申请人： Mark Grinstaff , Daniel Kenan , Elisabeth Walsh , Crystan Middleton
发明人： Mark Grinstaff , Daniel Kenan , Elisabeth Walsh , Crystan Middleton
IPC分类号： G01N33/567 , C12M1/34 , G01N33/543 , G01N33/53
CPC分类号： G01N33/543 , A61L27/227 , A61L27/34 , C08L89/00
摘要： An interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a first ligand that specifically binds a non-biological substrate and a second ligand that specifically binds a biological substrate. Also provided Is an interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a ligand that specifically binds a non-biological substrate and a non-binding domain that shows substantially no binding to a biological substrate. Also provided are methods for preparing a binding agent, methods for preparing an interfacial biomaterial, and methods for using interfacial biomaterials.
摘要翻译：使用多种结合剂制备的界面生物材料，每种结合剂包括特异性结合非生物底物的第一配体和特异性结合生物底物的第二配体。还提供了使用多种结合剂制备的界面生物材料，每种结合剂包括特异性结合非生物底物的配体和基本上不与生物底物结合的非结合结构域。还提供了制备粘合剂的方法，制备界面生物材料的方法以及使用界面生物材料的方法。

7. 发明申请

US20060241071A1 Functional synthetic molecules and macromolecules for gene delivery 失效
公开(公告)号：US20060241071A1
公开(公告)日：2006-10-26
申请号：US10559349
申请日：2004-06-16
申请人： Mark Grinstaff , Philippe Barthelemy , Carla Prata , Louis Moreau
发明人： Mark Grinstaff , Philippe Barthelemy , Carla Prata , Louis Moreau
IPC分类号： A61K48/00 , C07H19/12 , C07C69/66 , C07C229/02
CPC分类号： C12N15/88 , A61K47/542 , A61K47/549 , A61K47/58 , A61K47/593 , A61K47/60 , A61K48/0025 , C07C219/06 , C07C233/36 , C07C271/22 , C07D311/16 , C07H19/12
摘要： The present invention describes a synthetic non-viral vector composition for gene therapy and the use of such compositions for in vitro, ex vivo and/or in vivo transfer of genetic material. The invention proposes a pharmaceutical composition containing 1) a non-cationic amphiphilic molecule or macromolecule and its use for delivery of nucleic acids or 2) a cationic amphiphilic molecule or macromolecule that transforms from a cationic entity to an anionic, neutral, or zwitterionic entity by a chemical, photochemical, or biological reaction and its use for delivery of nucleic acids. Moreover this invention describes the use of these non-viral vector compositions in conjunction with a surface to mediate the delivery of nucleic acids. An additional embodiment is the formation of a hydrogel with these compositions and the use of this hydrogel for the delivery of genetic material. A further embodiment of this invention is the use of a change in ionic strength for the delivery of genetic material.

8. 发明申请

US20060216772A1 Interfacial biomaterials for binding metal substrates 审中-公开
标题翻译：用于结合金属底物的界面生物材料
公开(公告)号：US20060216772A1
公开(公告)日：2006-09-28
申请号：US11329292
申请日：2006-01-10
申请人： Mark Grinstaff , Daniel Kenan , Elisabeth Walsh , Crystan Middleton
发明人： Mark Grinstaff , Daniel Kenan , Elisabeth Walsh , Crystan Middleton
IPC分类号： G01N33/558 , C07K7/08 , C07K7/06
CPC分类号： G01N33/543 , A61L27/227 , A61L27/34 , C08L89/00
摘要： An interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a first ligand that specifically binds a non-biological substrate and a second ligand that specifically binds a biological substrate. Also provided is an interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a ligand that specifically binds a non-biological substrate and a non-binding domain that shows substantially no binding to a biological substrate. Also provided are methods for preparing a binding agent, methods for preparing an interfacial biomaterial, and methods for using interfacial biomaterials.
摘要翻译：使用多个结合剂制备的界面生物材料，每个结合剂包括特异性结合非生物底物的第一配体和特异性结合生物底物的第二配体。还提供了使用多种结合剂制备的界面生物材料，每种结合剂包括特异性结合非生物底物的配体和基本上不与生物底物结合的非结合结构域。还提供了制备粘合剂的方法，制备界面生物材料的方法以及使用界面生物材料的方法。

9. 发明授权

US07608581B2 Biofunctional, antimicrobial coatings for medical devices 失效
标题翻译：用于医疗器械的生物功能性抗菌涂层
公开(公告)号：US07608581B2
公开(公告)日：2009-10-27
申请号：US11638973
申请日：2006-12-14
申请人： Paul Hamilton , Daniel Kenan , Mark Grinstaff
发明人： Paul Hamilton , Daniel Kenan , Mark Grinstaff
IPC分类号： C07K14/00
CPC分类号： A61L27/227 , A61K38/00 , A61L27/34 , A61L27/54 , A61L2300/404 , A61L2300/606 , C07K7/08 , C07K14/001 , C08L89/00
摘要： The present invention provides compositions and methods for an improved coating for medical devices. Provided is an interfacial biomaterial or biofunctional coating composition comprising at least one binding domain that has bind specificity for a surface material of a medical device, and at least one binding domain that has binding specificity for an antimicrobial composition. Methods for coating a surface of a medical device, and for manufacturing of a medical device, comprise contacting the surface to be coated with the biofunctional coating material in an amount effective to form a coating.
摘要翻译：本发明提供用于医疗装置的改进涂层的组合物和方法。本发明提供了一种界面生物材料或生物功能性涂料组合物，其包含至少一个对医疗器械的表面材料具有结合特异性的结合结构域和至少一个对抗微生物组合物具有结合特异性的结合结构域。用于涂覆医疗装置的表面和用于制造医疗装置的方法包括以有效形成涂层的量使待涂覆的表面与生物功能性涂层接触。

10. 发明申请

US20070196454A1 Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices 有权
公开(公告)号：US20070196454A1
公开(公告)日：2007-08-23
申请号：US11653433
申请日：2007-01-11
申请人： Kenneth Stockman , Michael Carnahan , Keith D'Alessio , Mark Grinstaff
发明人： Kenneth Stockman , Michael Carnahan , Keith D'Alessio , Mark Grinstaff
IPC分类号： A61K31/785 , A61K31/787
CPC分类号： A61L26/0019 , A61B2017/0065 , A61B2017/00951 , A61K31/785 , A61K31/787 , A61K51/1279 , A61L24/0031 , A61L24/0036 , A61L24/043 , A61L24/046 , A61L26/0052 , A61L26/008 , A61L26/0085 , A61L27/18 , A61L27/26 , A61L27/52 , A61L27/56 , C08L79/02
摘要： One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneamine. In a preferred embodiment, the polyalkyleneamine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer. In certain instances, the polyethyleneimine is mixed with a second polymer, such as a polyethylene glycol containing nucleophilic groups. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneamine bearing electrophilic groups with a cross-linking reagent containing nucleophilic groups. In certain instances, the electrophilic groups on the polyalkyleneamine are activated esters, such as N-hydroxy succinimide ester. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneamine bearing photopolymerizable groups with ultraviolet or visibile light. Compositions used to seal the wound which contain PEI or a derivative of PEI are found to adhere tightly to the tissue. Other aspects of the present invention relate to methods of filling a void of a patient or adhering tissue. In certain instances, the methods use a polyalkyleneamine. In a preferred embodiment, the polyalkyleneamine is polyethyleneimine. Another aspect of the present invention relates to a polymeric composition formed by exposing a polyalkyleneamine to an activated polyalkylene glycol. In certain instances, the composition is attached to mammalian tissue.

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