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1. 发明授权

US07608581B2 Biofunctional, antimicrobial coatings for medical devices 失效
标题翻译：用于医疗器械的生物功能性抗菌涂层
公开(公告)号：US07608581B2
公开(公告)日：2009-10-27
申请号：US11638973
申请日：2006-12-14
申请人： Paul Hamilton , Daniel Kenan , Mark Grinstaff
发明人： Paul Hamilton , Daniel Kenan , Mark Grinstaff
IPC分类号： C07K14/00
CPC分类号： A61L27/227 , A61K38/00 , A61L27/34 , A61L27/54 , A61L2300/404 , A61L2300/606 , C07K7/08 , C07K14/001 , C08L89/00
摘要： The present invention provides compositions and methods for an improved coating for medical devices. Provided is an interfacial biomaterial or biofunctional coating composition comprising at least one binding domain that has bind specificity for a surface material of a medical device, and at least one binding domain that has binding specificity for an antimicrobial composition. Methods for coating a surface of a medical device, and for manufacturing of a medical device, comprise contacting the surface to be coated with the biofunctional coating material in an amount effective to form a coating.
摘要翻译：本发明提供用于医疗装置的改进涂层的组合物和方法。本发明提供了一种界面生物材料或生物功能性涂料组合物，其包含至少一个对医疗器械的表面材料具有结合特异性的结合结构域和至少一个对抗微生物组合物具有结合特异性的结合结构域。用于涂覆医疗装置的表面和用于制造医疗装置的方法包括以有效形成涂层的量使待涂覆的表面与生物功能性涂层接触。

2. 发明申请

US20070104758A1 Biofunctional, antimicrobial coatings for medical devices 失效
标题翻译：用于医疗器械的生物功能性抗菌涂层
公开(公告)号：US20070104758A1
公开(公告)日：2007-05-10
申请号：US11638973
申请日：2006-12-14
申请人： Paul Hamilton , Daniel Kenan , Mark Grinstaff
发明人： Paul Hamilton , Daniel Kenan , Mark Grinstaff
IPC分类号： A61F2/02
CPC分类号： A61L27/227 , A61K38/00 , A61L27/34 , A61L27/54 , A61L2300/404 , A61L2300/606 , C07K7/08 , C07K14/001 , C08L89/00
摘要： The present invention provides compositions and methods for an improved coating for medical devices. Provided is an interfacial biomaterial or biofunctional coating composition comprising at least one binding domain that has bind specificity for a surface material of a medical device, and at least one binding domain that has binding specificity for an antimicrobial composition. Methods for coating a surface of a medical device, and for manufacturing of a medical device, comprise contacting the surface to be coated with the biofunctional coating material in an amount effective to form a coating.
摘要翻译：本发明提供用于医疗装置的改进涂层的组合物和方法。本发明提供了一种界面生物材料或生物功能性涂料组合物，其包含至少一个对医疗器械的表面材料具有结合特异性的结合结构域和至少一个对抗微生物组合物具有结合特异性的结合结构域。用于涂覆医疗装置的表面和用于制造医疗装置的方法包括以有效形成涂层的量使待涂覆的表面与生物功能性涂层接触。

3. 发明申请

US20060263830A1 Interfacial biomaterials 审中-公开
公开(公告)号：US20060263830A1
公开(公告)日：2006-11-23
申请号：US11346669
申请日：2006-02-03
申请人： Mark Grinstaff , Daniel Kenan , Elisabeth Walsh , Crystan Middleton
发明人： Mark Grinstaff , Daniel Kenan , Elisabeth Walsh , Crystan Middleton
IPC分类号： G01N33/543 , G01N33/567 , C12M1/34 , G01N33/53
CPC分类号： G01N33/543 , A61L27/227 , A61L27/34 , C08L89/00
摘要： An interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a first ligand that specifically binds a non-biological substrate and a second ligand that specifically binds a biological substrate. Also provided is an interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a ligand that specifically binds a non-biological substrate and a non-binding domain that shows substantially no binding to a biological substrate. Also provided are methods for preparing a binding agent, methods for preparing an interfacial biomaterial, and methods for using interfacial biomaterials.

4. 发明申请

US20060234210A1 Filtration device and method for removing selected materials from biological fluids 审中-公开
标题翻译：用于从生物流体中去除所选材料的过滤装置和方法
公开(公告)号：US20060234210A1
公开(公告)日：2006-10-19
申请号：US11105202
申请日：2005-04-13
申请人： Daniel Kenan , Dale Christensen , Mark Grinstaff
发明人： Daniel Kenan , Dale Christensen , Mark Grinstaff
IPC分类号： C12Q1/70 , G01N33/53
CPC分类号： A61M1/3633 , Y10T436/25375
摘要： A filter and method for removing selected materials from a biological fluid sample are provided. The filter comprises an outer housing, inlet, and outlet. A plurality of filter surfaces are provided within the outer housing, and at least one coating is applied to the filter surfaces. The at least one coating comprises at least two binding modules that are in turn selectively bound to one another. One binding module is selectively bound to the filter surfaces and another binding module is configured to bind selectively to the selected materials that are to be removed from the fluid sample. As the fluid sample is allowed to pass through the inlet, outer housing, and outlet, the selected materials are selectively bound to the filter surfaces via the coating, thus producing a filtered product at the outlet.
摘要翻译：提供了用于从生物流体样品中去除所选材料的过滤器和方法。过滤器包括外壳，入口和出口。多个过滤器表面设置在外壳体内，并且至少一个涂层被施加到过滤器表面。所述至少一个涂层包括至少两个结合模块，所述至少两个结合模块又选择性地结合到另一个上。一个装订模块选择性地结合到过滤器表面，另一个装订模块被配置成选择性地结合待从流体样品中移除的所选择的材料。当流体样品被允许通过入口，外部壳体和出口时，所选择的材料通过涂层选择性地结合到过滤表面，从而在出口处产生过滤产物。

5. 发明申请

US20060051396A1 Biofunctional coatings 审中-公开
标题翻译：生物功能性涂料
公开(公告)号：US20060051396A1
公开(公告)日：2006-03-09
申请号：US11153143
申请日：2005-06-15
申请人： Paul Hamilton , Mark Grinstaff , Daniel Kenan , Dale Christensen
发明人： Paul Hamilton , Mark Grinstaff , Daniel Kenan , Dale Christensen
IPC分类号： A61K38/16 , A61K38/05 , A61F2/00
CPC分类号： A61L27/227 , A61K38/00 , A61L27/34 , A61L27/54 , A61L2300/404 , A61L2300/606 , C07K7/08 , C07K14/001 , C08L89/00
摘要： The present invention provides compositions and methods for an improved coating for medical devices. The coating is an interfacial biomaterial (“IFBM”) which comprises at least one binding module that binds to the surface of a device (“surface-binding module”) and at least one binding module that performs another function (“affector module”) and which acts to inhibit biofilm formation.
摘要翻译：本发明提供用于医疗装置的改进涂层的组合物和方法。该涂层是界面生物材料（“IFBM”），其包括至少一个结合到装置表面的结合模块（“表面结合模块”）和至少一个执行另一功能的装订模块（“影响模块”））并且其作用是抑制生物膜形成。

6. 发明申请

US20070166350A1 Compositions and methods for promoting attachment of cells of endothelial cell lineage to medical devices 失效
标题翻译：促进内皮细胞谱系细胞附着于医疗器械的组合物和方法
公开(公告)号：US20070166350A1
公开(公告)日：2007-07-19
申请号：US11649935
申请日：2007-01-05
申请人： Paul Hamilton , Daniel Kenan , Amy Solan
发明人： Paul Hamilton , Daniel Kenan , Amy Solan
IPC分类号： A61F2/02 , C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： C07K14/705 , A61K38/00 , A61L27/34 , A61L31/10 , C07K7/06 , C07K7/08 , C07K2319/00
摘要： The present invention provides compositions and methods for an improved coating for medical devices. Provided is a biofunctional coating composition comprising at least one binding domain that has binding specificity for a metallic surface material of a medical device, and at least one binding domain that has binding specificity for cells of endothelial cell lineage. Methods for coating a metallic surface of a medical device, and for manufacturing of a medical device, comprise contacting the metallic surface to be coated with the biofunctional coating material in an amount effective to form a coating, and may further comprise contacting the coated surface with cells of endothelial cell lineage to bind the cells of endothelial cell lineage to the coated surface.
摘要翻译：本发明提供用于医疗装置的改进涂层的组合物和方法。本发明提供一种生物功能性涂料组合物，其包含至少一个对医疗器械的金属表面材料具有结合特异性的结合结构域和至少一个对内皮细胞谱系细胞具有结合特异性的结合结构域。用于涂覆医疗装置的金属表面和用于制造医疗装置的方法包括以有效形成涂层的量使待涂覆的金属表面与生物功能性涂层接触，并且还可以包括使涂覆的表面与内皮细胞谱系的细胞将内皮细胞谱系的细胞结合到包被的表面。

7. 发明申请

US20070160644A1 Methods and compositions for promoting attachment of cells of endothelial cell lineage to medical devices 失效
标题翻译：促进内皮细胞谱系细胞附着于医疗器械的方法和组合物
公开(公告)号：US20070160644A1
公开(公告)日：2007-07-12
申请号：US11649950
申请日：2007-01-05
申请人： Daniel Kenan , Paul Hamilton
发明人： Daniel Kenan , Paul Hamilton
IPC分类号： A61F2/02 , C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： C07K14/705 , A61K38/00 , A61L27/34 , A61L31/10 , C07K7/06 , C07K7/08
摘要： The present invention provides compositions and methods for an improved coating for medical devices. Provided is a biofunctional coating composition comprising at least one binding domain that has binding specificity for a surface material of a medical device, and at least one binding domain that has binding specificity for cells of endothelial cell lineage. Methods for coating a surface of a medical device, and for manufacturing of a medical device, comprise contacting the surface to be coated with the biofunctional coating material in an amount effective to form a coating, and may further comprise contacting the coated surface with cells of endothelial cell lineage to bind the cells of endothelial cell lineage to the coated surface.
摘要翻译：本发明提供用于医疗装置的改进涂层的组合物和方法。本发明提供一种生物功能性涂料组合物，其包含至少一个对医疗装置的表面材料具有结合特异性的结合结构域和至少一个对内皮细胞谱系细胞具有结合特异性的结合结构域。用于涂覆医疗装置的表面和用于制造医疗装置的方法包括以有效形成涂层的量使待涂覆的表面与生物功能性涂层材料接触，并且还可以包括使涂覆的表面与内皮细胞谱系将内皮细胞谱系的细胞与涂层表面结合。

8. 发明申请

US20060263831A1 Interfacial biomaterials for binding ceramic substrates 审中-公开
标题翻译：用于粘结陶瓷基材的界面生物材料
公开(公告)号：US20060263831A1
公开(公告)日：2006-11-23
申请号：US11346855
申请日：2006-02-03
申请人： Mark Grinstaff , Daniel Kenan , Elisabeth Walsh , Crystan Middleton
发明人： Mark Grinstaff , Daniel Kenan , Elisabeth Walsh , Crystan Middleton
IPC分类号： G01N33/567 , C12M1/34 , G01N33/543 , G01N33/53
CPC分类号： G01N33/543 , A61L27/227 , A61L27/34 , C08L89/00
摘要： An interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a first ligand that specifically binds a non-biological substrate and a second ligand that specifically binds a biological substrate. Also provided Is an interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a ligand that specifically binds a non-biological substrate and a non-binding domain that shows substantially no binding to a biological substrate. Also provided are methods for preparing a binding agent, methods for preparing an interfacial biomaterial, and methods for using interfacial biomaterials.
摘要翻译：使用多种结合剂制备的界面生物材料，每种结合剂包括特异性结合非生物底物的第一配体和特异性结合生物底物的第二配体。还提供了使用多种结合剂制备的界面生物材料，每种结合剂包括特异性结合非生物底物的配体和基本上不与生物底物结合的非结合结构域。还提供了制备粘合剂的方法，制备界面生物材料的方法以及使用界面生物材料的方法。

9. 发明申请

US20060216772A1 Interfacial biomaterials for binding metal substrates 审中-公开
标题翻译：用于结合金属底物的界面生物材料
公开(公告)号：US20060216772A1
公开(公告)日：2006-09-28
申请号：US11329292
申请日：2006-01-10
申请人： Mark Grinstaff , Daniel Kenan , Elisabeth Walsh , Crystan Middleton
发明人： Mark Grinstaff , Daniel Kenan , Elisabeth Walsh , Crystan Middleton
IPC分类号： G01N33/558 , C07K7/08 , C07K7/06
CPC分类号： G01N33/543 , A61L27/227 , A61L27/34 , C08L89/00
摘要： An interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a first ligand that specifically binds a non-biological substrate and a second ligand that specifically binds a biological substrate. Also provided is an interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a ligand that specifically binds a non-biological substrate and a non-binding domain that shows substantially no binding to a biological substrate. Also provided are methods for preparing a binding agent, methods for preparing an interfacial biomaterial, and methods for using interfacial biomaterials.
摘要翻译：使用多个结合剂制备的界面生物材料，每个结合剂包括特异性结合非生物底物的第一配体和特异性结合生物底物的第二配体。还提供了使用多种结合剂制备的界面生物材料，每种结合剂包括特异性结合非生物底物的配体和基本上不与生物底物结合的非结合结构域。还提供了制备粘合剂的方法，制备界面生物材料的方法以及使用界面生物材料的方法。

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