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1. 发明授权

US07797036B2 Cardiac activation sequence monitoring for ischemia detection 有权
标题翻译：心脏激活序列监测缺血检测
公开(公告)号：US07797036B2
公开(公告)日：2010-09-14
申请号：US11079744
申请日：2005-03-14
申请人： Yi Zhang , Scott A. Meyer , Jeffrey E. Stahmann , Carlos Alberto Ricci , Marina Brockway , Aaron R. McCabe , Yinghong Yu , Donald I. Hopper
发明人： Yi Zhang , Scott A. Meyer , Jeffrey E. Stahmann , Carlos Alberto Ricci , Marina Brockway , Aaron R. McCabe , Yinghong Yu , Donald I. Hopper
IPC分类号： A61B5/04
CPC分类号： A61N1/3702 , A61B5/0452 , A61B5/7203
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend ischemia using cardiac activation sequence information. Ischemia detection may involve sensing composite cardiac signals using implantable electrodes, and performing a signal separation that produces one or more cardiac activation signal vectors associated with one or more cardiac activation sequences. A change in the signal vector may be detected using subsequent separations. The change may be an elevation or depression of the ST segment of a cardiac cycle or other change indicative of myocardial ischemia, myocardial infarction, or other pathological change. The change may be used to predict, quantify, and/or qualify an event such as an arrhythmia, a myocardial infarction, or other pathologic change. Information associated with the vectors may be stored and used to track the vectors.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。使用心脏信号分离来使用心脏激活序列信息来检测，监测，跟踪和/或趋势性缺血。缺血检测可以涉及使用可植入电极感测复合心脏信号，并且执行产生与一个或多个心脏激活序列相关联的一个或多个心脏激活信号载体的信号分离。可以使用后续分离来检测信号矢量的变化。该变化可以是心脏周期的ST段的升高或抑制或指示心肌缺血，心肌梗死或其他病理变化的其它变化。该变化可用于预测，量化和/或限定诸如心律失常，心肌梗死或其它病理变化的事件。与矢量相关联的信息可以被存储并用于跟踪矢量。

2. 发明授权

US08626276B2 Cardiac activation sequence monitoring for ischemia detection 失效
标题翻译：心脏激活序列监测缺血检测
公开(公告)号：US08626276B2
公开(公告)日：2014-01-07
申请号：US12847657
申请日：2010-07-30
申请人： Yi Zhang , Scott A. Meyer , Jeffrey E. Stahmann , Carlos Alberto Ricci , Marina Brockway , Aaron R. McCabe , Yinghong Yu , Donald L. Hopper
发明人： Yi Zhang , Scott A. Meyer , Jeffrey E. Stahmann , Carlos Alberto Ricci , Marina Brockway , Aaron R. McCabe , Yinghong Yu , Donald L. Hopper
IPC分类号： A61B5/04
CPC分类号： A61N1/3702 , A61B5/0452 , A61B5/7203
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend ischemia using cardiac activation sequence information. Ischemia detection may involve sensing composite cardiac signals using implantable electrodes, and performing a signal separation that produces one or more cardiac activation signal vectors associated with one or more cardiac activation sequences. A change in the signal vector may be detected using subsequent separations. The change may be an elevation or depression of the ST segment of a cardiac cycle or other change indicative of myocardial ischemia, myocardial infarction, or other pathological change. The change may be used to predict, quantify, and/or qualify an event such as an arrhythmia, a myocardial infarction, or other pathologic change. Information associated with the vectors may be stored and used to track the vectors.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。使用心脏信号分离来使用心脏激活序列信息来检测，监测，跟踪和/或趋势性缺血。缺血检测可以涉及使用可植入电极感测复合心脏信号，并且执行产生与一个或多个心脏激活序列相关联的一个或多个心脏激活信号载体的信号分离。可以使用后续分离来检测信号矢量的变化。该变化可以是心脏周期的ST段的升高或抑制或指示心肌缺血，心肌梗死或其他病理变化的其它变化。该变化可用于预测，量化和/或限定诸如心律失常，心肌梗死或其它病理变化的事件。与矢量相关联的信息可以被存储并用于跟踪矢量。

3. 发明申请

US20100298729A1 Cardiac Activation Sequence Monitoring for Ischemia Detection 失效
标题翻译：缺血检测心脏激活序列监测
公开(公告)号：US20100298729A1
公开(公告)日：2010-11-25
申请号：US12847657
申请日：2010-07-30
申请人： Yi Zhang , Scott A. Meyer , Jeffrey E. Stahmann , Carlos Alberto Ricci , Marina Brockway , Aaron R. McCabe , Yinghong Yu , Donald L. Hopper
发明人： Yi Zhang , Scott A. Meyer , Jeffrey E. Stahmann , Carlos Alberto Ricci , Marina Brockway , Aaron R. McCabe , Yinghong Yu , Donald L. Hopper
IPC分类号： A61B5/0452
CPC分类号： A61N1/3702 , A61B5/0452 , A61B5/7203
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend ischemia using cardiac activation sequence information. Ischemia detection may involve sensing composite cardiac signals using implantable electrodes, and performing a signal separation that produces one or more cardiac activation signal vectors associated with one or more cardiac activation sequences. A change in the signal vector may be detected using subsequent separations. The change may be an elevation or depression of the ST segment of a cardiac cycle or other change indicative of myocardial ischemia, myocardial infarction, or other pathological change. The change may be used to predict, quantify, and/or qualify an event such as an arrhythmia, a myocardial infarction, or other pathologic change. Information associated with the vectors may be stored and used to track the vectors.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。使用心脏信号分离来使用心脏激活序列信息来检测，监测，跟踪和/或趋势性缺血。缺血检测可以涉及使用可植入电极感测复合心脏信号，并且执行产生与一个或多个心脏激活序列相关联的一个或多个心脏激活信号载体的信号分离。可以使用后续分离来检测信号矢量的变化。该变化可以是心脏周期的ST段的升高或抑制或指示心肌缺血，心肌梗死或其他病理变化的其它变化。该变化可用于预测，量化和/或限定诸如心律失常，心肌梗死或其它病理变化的事件。与矢量相关联的信息可以被存储并用于跟踪矢量。

4. 发明授权

US07941206B2 Automatic orientation determination for ECG measurements using multiple electrodes 有权
标题翻译：使用多个电极的ECG测量的自动取向确定
公开(公告)号：US07941206B2
公开(公告)日：2011-05-10
申请号：US12694833
申请日：2010-01-27
申请人： Yi Zhang , Marina Brockway , Carlos Alberto Ricci , Ronald W. Heil , Douglas R. Daum , Robert J. Sweeney , Aaron R. McCabe
发明人： Yi Zhang , Marina Brockway , Carlos Alberto Ricci , Ronald W. Heil , Douglas R. Daum , Robert J. Sweeney , Aaron R. McCabe
IPC分类号： A61B5/04
CPC分类号： A61B5/0006 , A61B5/0031 , A61B5/04011 , A61B5/0422 , A61B5/7207 , A61B5/7217 , A61N1/3756 , G06K9/624
摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, separates a signal using a source separation algorithm, and identifies a cardiac signal using a selected vector. The signal processor may iteratively separate signals from the plurality of composite signals until the cardiac signal is identified. The selected vector may be updated if desired or necessary. A method of signal separation involves detecting a plurality of composite signals at a plurality of locations, separating a signal using source separation, and selecting a vector that provides a cardiac signal. The separation may include a principal component analysis and/or an independent component analysis. Vectors may be selected and updated based on changes of position and/or orientation of implanted components and changes in patient parameters such as patient condition, cardiac signal-to-noise ratio, and disease progression.
摘要翻译：心脏监测和/或刺激方法和系统提供监测，除颤和/或起搏治疗。信号处理器接收与多个源相关联的多个复合信号，使用源分离算法分离信号，并使用所选择的向量来识别心脏信号。信号处理器可以迭代地分离来自多个复合信号的信号，直到识别出心脏信号。如果需要或必要，可以更新所选择的向量。信号分离的方法包括在多个位置检测多个复合信号，使用源分离分离信号，以及选择提供心脏信号的向量。分离可以包括主成分分析和/或独立成分分析。可以基于植入组件的位置和/或取向的改变以及患者参数（例如患者状况，心脏信噪比和疾病进展）的变化来选择和更新载体。

5. 发明授权

US07706866B2 Automatic orientation determination for ECG measurements using multiple electrodes 有权
标题翻译：使用多个电极的ECG测量的自动取向确定
公开(公告)号：US07706866B2
公开(公告)日：2010-04-27
申请号：US10876008
申请日：2004-06-24
申请人： Yi Zhang , Marina Brockway , Carlos Alberto Ricci , Ron Heil , Douglas R. Daum , Robert J. Sweeney , Aaron McCabe
发明人： Yi Zhang , Marina Brockway , Carlos Alberto Ricci , Ron Heil , Douglas R. Daum , Robert J. Sweeney , Aaron McCabe
IPC分类号： A61B5/04
CPC分类号： A61B5/0006 , A61B5/0031 , A61B5/04011 , A61B5/0422 , A61B5/7207 , A61B5/7217 , A61N1/3756 , G06K9/624
摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, separates a signal using a source separation algorithm, and identifies a cardiac signal using a selected vector. The signal processor may iteratively separate signals from the plurality of composite signals until the cardiac signal is identified. The selected vector may be updated if desired or necessary. A method of signal separation involves detecting a plurality of composite signals at a plurality of locations, separating a signal using source separation, and selecting a vector that provides a cardiac signal. The separation may include a principal component analysis and/or an independent component analysis. Vectors may be selected and updated based on changes of position and/or orientation of implanted components and changes in patient parameters such as patient condition, cardiac signal-to-noise ratio, and disease progression.
摘要翻译：心脏监测和/或刺激方法和系统提供监测，除颤和/或起搏治疗。信号处理器接收与多个源相关联的多个复合信号，使用源分离算法分离信号，并使用所选择的向量来识别心脏信号。信号处理器可以迭代地分离来自多个复合信号的信号，直到识别出心脏信号。如果需要或必要，可以更新所选择的向量。信号分离的方法包括在多个位置检测多个复合信号，使用源分离分离信号，以及选择提供心脏信号的向量。分离可以包括主成分分析和/或独立成分分析。可以基于植入组件的位置和/或取向的改变以及患者参数（例如患者状况，心脏信噪比和疾病进展）的变化来选择和更新载体。

6. 发明申请

US20100198283A1 Automatic Orientation Determination for ECG Measurements Using Multiple Electrodes 有权
标题翻译：使用多个电极进行心电图测量的自动测向
公开(公告)号：US20100198283A1
公开(公告)日：2010-08-05
申请号：US12694833
申请日：2010-01-27
申请人： Yi Zhang , Marina Brockway , Carlos Alberto Ricci , Ron Heil , Douglas R. Daum , Robert J. Sweeney , Aaron McCabe
发明人： Yi Zhang , Marina Brockway , Carlos Alberto Ricci , Ron Heil , Douglas R. Daum , Robert J. Sweeney , Aaron McCabe
IPC分类号： A61N1/362 , A61N1/39 , A61B5/04
CPC分类号： A61B5/0006 , A61B5/0031 , A61B5/04011 , A61B5/0422 , A61B5/7207 , A61B5/7217 , A61N1/3756 , G06K9/624
摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, separates a signal using a source separation algorithm, and identifies a cardiac signal using a selected vector. The signal processor may iteratively separate signals from the plurality of composite signals until the cardiac signal is identified. The selected vector may be updated if desired or necessary. A method of signal separation involves detecting a plurality of composite signals at a plurality of locations, separating a signal using source separation, and selecting a vector that provides a cardiac signal. The separation may include a principal component analysis and/or an independent component analysis. Vectors may be selected and updated based on changes of position and/or orientation of implanted components and changes in patient parameters such as patient condition, cardiac signal-to-noise ratio, and disease progression.
摘要翻译：心脏监测和/或刺激方法和系统提供监测，除颤和/或起搏治疗。信号处理器接收与多个源相关联的多个复合信号，使用源分离算法分离信号，并使用所选择的向量来识别心脏信号。信号处理器可以迭代地分离来自多个复合信号的信号，直到识别出心脏信号。如果需要或必要，可以更新所选择的向量。信号分离的方法包括在多个位置检测多个复合信号，使用源分离分离信号，以及选择提供心脏信号的向量。分离可以包括主成分分析和/或独立成分分析。可以基于植入组件的位置和/或取向的改变以及患者参数（例如患者状况，心脏信噪比和疾病进展）的变化来选择和更新载体。

7. 发明授权

US08696589B2 Method and system for heart failure status evaluation based on a disordered breathing index 有权
标题翻译：基于无序呼吸指数的心衰状态评估方法和系统
公开(公告)号：US08696589B2
公开(公告)日：2014-04-15
申请号：US12847698
申请日：2010-07-30
申请人： Jonathan T. Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey E. Stahmann , Yi Zhang , Jesse W. Hartley
发明人： Jonathan T. Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey E. Stahmann , Yi Zhang , Jesse W. Hartley
IPC分类号： A61B5/08
CPC分类号： A61B5/091 , A61B5/0031 , A61B5/0809 , A61B5/0816 , A61B5/113 , A61B5/4818 , A61N1/3627 , A61N1/36521 , A61N1/36535
摘要： An evaluation of heart failure status is provided based on a disordered breathing index. Patient respiration is sensed and a respiration signal is generated. Disordered breathing episodes are detected based on the respiration signal. A disordered breathing index is determined based on the disordered breathing episodes. The disordered breathing index is trended and used to evaluate heart failure status. The disordered breathing index may be combined with additional information and/or may take into account patient activity, posture, sleep stage, or other patient information.
摘要翻译：基于无序呼吸指数提供心力衰竭状态评估。感测患者呼吸并产生呼吸信号。基于呼吸信号检测到无序呼吸事件。基于无序呼吸发作确定无序呼吸指数。无序呼吸指数趋向并用于评估心力衰竭状态。无序呼吸指数可以与附加信息组合和/或可以考虑患者活动，姿势，睡眠阶段或其他患者信息。

8. 发明申请

US20080139951A1 Detection of Stenosis 审中-公开
标题翻译：狭窄检测
公开(公告)号：US20080139951A1
公开(公告)日：2008-06-12
申请号：US11608578
申请日：2006-12-08
申请人： Abhilash Patangay , Marina Brockway , Jeffrey E. Stahmann , Yi Zhang , Gerrard M. Carlson
发明人： Abhilash Patangay , Marina Brockway , Jeffrey E. Stahmann , Yi Zhang , Gerrard M. Carlson
IPC分类号： A61B5/026 , A61F2/82
CPC分类号： A61B5/411 , A61B5/0031 , A61B5/02007 , A61B5/02158 , A61B5/026 , A61B5/0402 , A61B5/076 , A61B2562/0204 , A61B2562/0219 , A61F2/02 , A61F2/91 , A61F2250/0002
摘要： A system for detecting stenosis in a patient. The system includes an implantable sensing unit having a turbulence sensor and a communication device for transmitting a signal from the turbulence sensor. The system also includes a cardiac sensor for generating a signal corresponding to cardiac activity and a processing device configured to receive signals from the sensing unit and from the cardiac sensor. The processing device is configured to determine a time window corresponding to cardiac activity, to determine a turbulence level from the turbulence signal within the time window, and to detect the presence of stenosis from the turbulence level.
摘要翻译：一种用于检测患者狭窄的系统。该系统包括具有湍流传感器的可植入感测单元和用于从湍流传感器发送信号的通信装置。该系统还包括用于产生对应于心脏活动的信号的心脏传感器和被配置为从感测单元和心脏传感器接收信号的处理装置。处理装置被配置为确定对应于心脏活动的时间窗口，以确定在时间窗口内的湍流信号的湍流水平，并且从湍流水平检测狭窄的存在。

9. 发明申请

US20060116593A1 Cardiac activation sequence monitoring for ischemia detection 有权
标题翻译：心脏激活序列监测缺血检测
公开(公告)号：US20060116593A1
公开(公告)日：2006-06-01
申请号：US11079744
申请日：2005-03-14
申请人： Yi Zhang , Scott Meyer , Jeffrey Stahmann , Carlos Ricci , Marina Brockway , Aaron McCabe , Yinghong Yu , Donald Hopper
发明人： Yi Zhang , Scott Meyer , Jeffrey Stahmann , Carlos Ricci , Marina Brockway , Aaron McCabe , Yinghong Yu , Donald Hopper
IPC分类号： A61B5/04
CPC分类号： A61N1/3702 , A61B5/0452 , A61B5/7203
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend ischemia using cardiac activation sequence information. Ischemia detection may involve sensing composite cardiac signals using implantable electrodes, and performing a signal separation that produces one or more cardiac activation signal vectors associated with one or more cardiac activation sequences. A change in the signal vector may be detected using subsequent separations. The change may be an elevation or depression of the ST segment of a cardiac cycle or other change indicative of myocardial ischemia, myocardial infarction, or other pathological change. The change may be used to predict, quantify, and/or qualify an event such as an arrhythmia, a myocardial infarction, or other pathologic change. Information associated with the vectors may be stored and used to track the vectors.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。使用心脏信号分离来使用心脏激活序列信息来检测，监测，跟踪和/或趋势性缺血。缺血检测可以涉及使用可植入电极感测复合心脏信号，并且执行产生与一个或多个心脏激活序列相关联的一个或多个心脏激活信号载体的信号分离。可以使用后续分离来检测信号矢量的变化。该变化可以是心脏周期的ST段的升高或抑制或指示心肌缺血，心肌梗死或其他病理变化的其它变化。该变化可用于预测，量化和/或限定诸如心律失常，心肌梗死或其它病理变化的事件。与矢量相关联的信息可以被存储并用于跟踪矢量。

10. 发明授权

US07236819B2 Separation of a subcutaneous cardiac signal from a plurality of composite signals 有权
标题翻译：从多个复合信号中分离皮下心脏信号
公开(公告)号：US07236819B2
公开(公告)日：2007-06-26
申请号：US10741814
申请日：2003-12-19
申请人： Marina Brockway , Carlos Alberto Ricci
发明人： Marina Brockway , Carlos Alberto Ricci
IPC分类号： A61B5/04
CPC分类号： A61N1/0568 , A61N1/05 , A61N1/0587 , A61N1/08 , A61N1/36542 , A61N1/36585 , A61N1/3956 , A61N1/3962
摘要： A cardiac monitoring and/or stimulation method and systems provide monitoring, defibrillation and/or pacing therapies, including systems detecting and/or treating cardiac arrhythmia. A system includes a housing coupled to a plurality of electrodes configured for subcutaneous non-intrathoracic sensing. A signal processor receives a plurality of composite signals associated with a plurality of sources, separates a signal from the plurality of composite signals using blind source separation, and identifies a cardiac signal. The signal processor may iteratively separate signals from the plurality of composite signals until the cardiac signal is identified. A method of signal separation includes detecting a plurality of composite signals at a plurality of locations, separating a signal using blind source separation, and identifying a cardiac signal. The separation may include a principal component analysis and/or an independent component analysis. The composite signals may be filtered before separation using band-pass filtering, adaptive, or other filters.
摘要翻译：心脏监测和/或刺激方法和系统提供监测，除颤和/或起搏疗法，包括检测和/或治疗心律失常的系统。系统包括耦合到被配置用于皮下非胸内感测的多个电极的壳体。信号处理器接收与多个源相关联的多个复合信号，使用盲源分离从多个复合信号中分离信号，并识别心脏信号。信号处理器可以迭代地分离来自多个复合信号的信号，直到识别出心脏信号。一种信号分离方法包括在多个位置检测多个复合信号，使用盲源分离分离信号，以及识别心脏信号。分离可以包括主成分分析和/或独立成分分析。复合信号可以在分离之前使用带通滤波，自适应滤波器或其他滤波器进行滤波。

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