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1. 发明授权

US07797036B2 Cardiac activation sequence monitoring for ischemia detection 有权
标题翻译：心脏激活序列监测缺血检测
公开(公告)号：US07797036B2
公开(公告)日：2010-09-14
申请号：US11079744
申请日：2005-03-14
申请人： Yi Zhang , Scott A. Meyer , Jeffrey E. Stahmann , Carlos Alberto Ricci , Marina Brockway , Aaron R. McCabe , Yinghong Yu , Donald I. Hopper
发明人： Yi Zhang , Scott A. Meyer , Jeffrey E. Stahmann , Carlos Alberto Ricci , Marina Brockway , Aaron R. McCabe , Yinghong Yu , Donald I. Hopper
IPC分类号： A61B5/04
CPC分类号： A61N1/3702 , A61B5/0452 , A61B5/7203
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend ischemia using cardiac activation sequence information. Ischemia detection may involve sensing composite cardiac signals using implantable electrodes, and performing a signal separation that produces one or more cardiac activation signal vectors associated with one or more cardiac activation sequences. A change in the signal vector may be detected using subsequent separations. The change may be an elevation or depression of the ST segment of a cardiac cycle or other change indicative of myocardial ischemia, myocardial infarction, or other pathological change. The change may be used to predict, quantify, and/or qualify an event such as an arrhythmia, a myocardial infarction, or other pathologic change. Information associated with the vectors may be stored and used to track the vectors.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。使用心脏信号分离来使用心脏激活序列信息来检测，监测，跟踪和/或趋势性缺血。缺血检测可以涉及使用可植入电极感测复合心脏信号，并且执行产生与一个或多个心脏激活序列相关联的一个或多个心脏激活信号载体的信号分离。可以使用后续分离来检测信号矢量的变化。该变化可以是心脏周期的ST段的升高或抑制或指示心肌缺血，心肌梗死或其他病理变化的其它变化。该变化可用于预测，量化和/或限定诸如心律失常，心肌梗死或其它病理变化的事件。与矢量相关联的信息可以被存储并用于跟踪矢量。

2. 发明授权

US08626276B2 Cardiac activation sequence monitoring for ischemia detection 失效
标题翻译：心脏激活序列监测缺血检测
公开(公告)号：US08626276B2
公开(公告)日：2014-01-07
申请号：US12847657
申请日：2010-07-30
申请人： Yi Zhang , Scott A. Meyer , Jeffrey E. Stahmann , Carlos Alberto Ricci , Marina Brockway , Aaron R. McCabe , Yinghong Yu , Donald L. Hopper
发明人： Yi Zhang , Scott A. Meyer , Jeffrey E. Stahmann , Carlos Alberto Ricci , Marina Brockway , Aaron R. McCabe , Yinghong Yu , Donald L. Hopper
IPC分类号： A61B5/04
CPC分类号： A61N1/3702 , A61B5/0452 , A61B5/7203
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend ischemia using cardiac activation sequence information. Ischemia detection may involve sensing composite cardiac signals using implantable electrodes, and performing a signal separation that produces one or more cardiac activation signal vectors associated with one or more cardiac activation sequences. A change in the signal vector may be detected using subsequent separations. The change may be an elevation or depression of the ST segment of a cardiac cycle or other change indicative of myocardial ischemia, myocardial infarction, or other pathological change. The change may be used to predict, quantify, and/or qualify an event such as an arrhythmia, a myocardial infarction, or other pathologic change. Information associated with the vectors may be stored and used to track the vectors.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。使用心脏信号分离来使用心脏激活序列信息来检测，监测，跟踪和/或趋势性缺血。缺血检测可以涉及使用可植入电极感测复合心脏信号，并且执行产生与一个或多个心脏激活序列相关联的一个或多个心脏激活信号载体的信号分离。可以使用后续分离来检测信号矢量的变化。该变化可以是心脏周期的ST段的升高或抑制或指示心肌缺血，心肌梗死或其他病理变化的其它变化。该变化可用于预测，量化和/或限定诸如心律失常，心肌梗死或其它病理变化的事件。与矢量相关联的信息可以被存储并用于跟踪矢量。

3. 发明申请

US20100298729A1 Cardiac Activation Sequence Monitoring for Ischemia Detection 失效
标题翻译：缺血检测心脏激活序列监测
公开(公告)号：US20100298729A1
公开(公告)日：2010-11-25
申请号：US12847657
申请日：2010-07-30
申请人： Yi Zhang , Scott A. Meyer , Jeffrey E. Stahmann , Carlos Alberto Ricci , Marina Brockway , Aaron R. McCabe , Yinghong Yu , Donald L. Hopper
发明人： Yi Zhang , Scott A. Meyer , Jeffrey E. Stahmann , Carlos Alberto Ricci , Marina Brockway , Aaron R. McCabe , Yinghong Yu , Donald L. Hopper
IPC分类号： A61B5/0452
CPC分类号： A61N1/3702 , A61B5/0452 , A61B5/7203
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend ischemia using cardiac activation sequence information. Ischemia detection may involve sensing composite cardiac signals using implantable electrodes, and performing a signal separation that produces one or more cardiac activation signal vectors associated with one or more cardiac activation sequences. A change in the signal vector may be detected using subsequent separations. The change may be an elevation or depression of the ST segment of a cardiac cycle or other change indicative of myocardial ischemia, myocardial infarction, or other pathological change. The change may be used to predict, quantify, and/or qualify an event such as an arrhythmia, a myocardial infarction, or other pathologic change. Information associated with the vectors may be stored and used to track the vectors.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。使用心脏信号分离来使用心脏激活序列信息来检测，监测，跟踪和/或趋势性缺血。缺血检测可以涉及使用可植入电极感测复合心脏信号，并且执行产生与一个或多个心脏激活序列相关联的一个或多个心脏激活信号载体的信号分离。可以使用后续分离来检测信号矢量的变化。该变化可以是心脏周期的ST段的升高或抑制或指示心肌缺血，心肌梗死或其他病理变化的其它变化。该变化可用于预测，量化和/或限定诸如心律失常，心肌梗死或其它病理变化的事件。与矢量相关联的信息可以被存储并用于跟踪矢量。

4. 发明授权

US07917196B2 Arrhythmia discrimination using electrocardiograms sensed from multiple implanted electrodes 有权
标题翻译：使用从多个植入电极感测的心电图的心律失常辨别
公开(公告)号：US07917196B2
公开(公告)日：2011-03-29
申请号：US11125020
申请日：2005-05-09
申请人： Yi Zhang , Carlos Alberto Ricci , Jeffrey E. Stahmann , Aaron R. McCabe , Scott A. Meyer , Yinghong Yu
发明人： Yi Zhang , Carlos Alberto Ricci , Jeffrey E. Stahmann , Aaron R. McCabe , Scott A. Meyer , Yinghong Yu
IPC分类号： A61B5/0464
CPC分类号： A61B5/04011 , A61B5/7203
摘要： Cardiac monitoring and/or stimulation methods and systems provide for monitoring, diagnosing, defibrillation and pacing therapies, or a combination of these capabilities, including cardiac systems incorporating or cooperating with neuro-stimulating devices, drug pumps, or other therapies. Embodiments relate generally to implantable medical devices employing automated cardiac activation sequence monitoring and/or tracking for arrhythmia discrimination. Embodiments are directed to devices and methods involving sensing a plurality of composite cardiac signals using a plurality of implantable electrodes. A source separation is performed using the sensed plurality of composite cardiac signals and the separation produces one or more cardiac signal vectors associated with one or more cardiac activation sequences that is indicative of ischemia. A change of the one or more cardiac signal vectors is detected using the one or more cardiac signal vectors. Cardiac arrhythmias are discriminated using the one or more cardiac signal vectors.
摘要翻译：心脏监测和/或刺激方法和系统提供监测，诊断，除颤和起搏治疗，或这些能力的组合，包括结合或与神经刺激装置，药物泵或其他疗法组合的心脏系统。实施例一般涉及使用自动心脏激活序列监测和/或跟踪用于心律失常鉴别的可植入医疗装置。实施例涉及使用多个可植入电极感测多个复合心脏信号的装置和方法。使用感测的多个复合心脏信号进行源分离，并且分离产生与指示缺血的一个或多个心脏激活序列相关联的一个或多个心脏信号载体。使用一个或多个心脏信号矢量检测一个或多个心脏信号矢量的改变。使用一个或多个心脏信号载体来区分心律失常。

5. 发明授权

US07457664B2 Closed loop cardiac resynchronization therapy using cardiac activation sequence information 有权
标题翻译：闭环心脏再同步治疗使用心脏激活序列信息
公开(公告)号：US07457664B2
公开(公告)日：2008-11-25
申请号：US11125068
申请日：2005-05-09
申请人： Yi Zhang , Yinghong Yu , Aaron R. McCabe , Jiang Ding , Jeffrey E. Stahmann , Carlos Alberto Ricci , Scott A. Meyer
发明人： Yi Zhang , Yinghong Yu , Aaron R. McCabe , Jiang Ding , Jeffrey E. Stahmann , Carlos Alberto Ricci , Scott A. Meyer
IPC分类号： A61N1/365
CPC分类号： A61N1/3712 , A61N1/3627 , A61N1/365 , G06F19/00
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track, and/or trend closed-loop cardiac resynchronization therapy using cardiac activation sequence information. Devices and methods involve sensing a plurality of composite cardiac signals using a plurality of electrodes, the electrodes configured for implantation in a patient. A source separation is performed using the sensed plurality of composite cardiac signals, producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences. A cardiac resynchronization therapy is adjusted using one or both of the one or more cardiac signal vectors and the signals associated with the one or more cardiac signal vectors. In further embodiments, the cardiac resynchronization therapy may be initiated, terminated, or one or more parameters of the resynchronization therapy may be altered.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。心脏信号分离用于使用心脏激活序列信息来检测，监测，跟踪和/或趋向闭环心脏再同步治疗。设备和方法包括使用多个电极感测多个复合心脏信号，所述电极被配置用于植入患者体内。使用所感测的多个复合心脏信号进行源分离，产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号载体。使用一个或多个心脏信号向量和与一个或多个心脏信号载体相关联的信号中的一个或两个来调整心脏再同步治疗。在另外的实施方案中，心脏再同步治疗可以被启动，终止，或者可以改变再同步治疗的一个或多个参数。

6. 发明申请

US20110137192A1 Arrhythmia Discrimination using ECG's Sensed from Multiple Implanted Electrodes 有权
标题翻译：使用从多个植入电极感应的ECG的心律失常鉴别
公开(公告)号：US20110137192A1
公开(公告)日：2011-06-09
申请号：US13027608
申请日：2011-02-15
申请人： Yi Zhang , Carlos Alberto Ricci , Jeffrey E. Stahmann , Aaron R. McCabe , Scott A. Meyer , Yinghong Yu
发明人： Yi Zhang , Carlos Alberto Ricci , Jeffrey E. Stahmann , Aaron R. McCabe , Scott A. Meyer , Yinghong Yu
IPC分类号： A61B5/0402
CPC分类号： A61B5/04011 , A61B5/7203
摘要： Cardiac monitoring and/or stimulation methods and systems provide for monitoring, diagnosing, defibrillation and pacing therapies, or a combination of these capabilities, including cardiac systems incorporating or cooperating with neuro-stimulating devices, drug pumps, or other therapies. Embodiments of the present invention relate generally to implantable medical devices employing automated cardiac activation sequence monitoring and/or tracking for arrhythmia discrimination. Embodiments of the invention are directed to devices and methods involving sensing a plurality of composite cardiac signals using a plurality of implantable electrodes. A source separation is performed using the sensed plurality of composite cardiac signals and the separation produces one or more cardiac signal vectors associated with one or more cardiac activation sequences that is indicative of ischemia. A change of the one or more cardiac signal vectors is detected using the one or more cardiac signal vectors. Cardiac arrhythmias are discriminated using the one or more cardiac signal vectors.
摘要翻译：心脏监测和/或刺激方法和系统提供监测，诊断，除颤和起搏治疗，或这些功能的组合，包括结合或与神经刺激装置，药物泵或其他疗法组合的心脏系统。本发明的实施方案一般涉及使用自动心脏激活序列监测和/或跟踪用于心律失常鉴别的可植入医疗装置。本发明的实施例涉及使用多个可植入电极感测多个复合心脏信号的装置和方法。使用感测的多个复合心脏信号进行源分离，并且分离产生与指示缺血的一个或多个心脏激活序列相关联的一个或多个心脏信号载体。使用一个或多个心脏信号矢量检测一个或多个心脏信号矢量的改变。使用一个或多个心脏信号载体来区分心律失常。

7. 发明申请

US20090076557A1 Closed Loop Cardiac Resynchronization Therapy Using Cardiac Activation Sequence Information 有权
标题翻译：闭环心脏再同步治疗使用心脏激活序列信息
公开(公告)号：US20090076557A1
公开(公告)日：2009-03-19
申请号：US12276070
申请日：2008-11-21
申请人： Yi Zhang , Yinghong Yu , Aaron R. McCabe , Jiang Ding , Jeffrey E. Stahmann , Carlos Alberto Ricci , Scott A. Meyer
发明人： Yi Zhang , Yinghong Yu , Aaron R. McCabe , Jiang Ding , Jeffrey E. Stahmann , Carlos Alberto Ricci , Scott A. Meyer
IPC分类号： A61N1/39 , A61N1/368
CPC分类号： A61N1/3712 , A61N1/3627 , A61N1/365 , G06F19/00
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend closed-loop cardiac resynchronization therapy using cardiac activation sequence information. Devices and methods involve sensing a plurality of composite cardiac signals using a plurality of electrodes, the electrodes configured for implantation in a patient. A source separation is performed using the sensed plurality of composite cardiac signals, producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences. A cardiac resynchronization therapy is adjusted using one or both of the one or more cardiac signal vectors and the signals associated with the one or more cardiac signal vectors. In further embodiments, the cardiac resynchronization therapy may be initiated, terminated, or one or more parameters of the resynchronization therapy may be altered.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。心脏信号分离用于使用心脏激活序列信息来检测，监测，跟踪和/或趋势闭环心脏再同步治疗。设备和方法包括使用多个电极感测多个复合心脏信号，所述电极被配置用于植入患者体内。使用所感测的多个复合心脏信号进行源分离，产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号载体。使用一个或多个心脏信号向量和与一个或多个心脏信号载体相关联的信号中的一个或两个来调整心脏再同步治疗。在另外的实施方案中，心脏再同步治疗可以被启动，终止，或者可以改变再同步治疗的一个或多个参数。

8. 发明申请

US20110144511A1 Cardiac Activation Sequence Monitoring and Tracking 有权
标题翻译：心脏激活序列监测和跟踪
公开(公告)号：US20110144511A1
公开(公告)日：2011-06-16
申请号：US13027612
申请日：2011-02-15
申请人： Yi Zhang , Scott A. Meyer , Aaron McCabe , Jeffrey E. Stahmann , Yinghong Yu , Carlos Alberto Ricci
发明人： Yi Zhang , Scott A. Meyer , Aaron McCabe , Jeffrey E. Stahmann , Yinghong Yu , Carlos Alberto Ricci
IPC分类号： A61B5/0402
CPC分类号： A61B5/04011 , A61B5/7203
摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, diagnosis, and defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, performs a source separation, and produces one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences based on the source separation. A method of signal separation involves detecting a change in a characteristic of the cardiac signal vector relative to a baseline. One or more vectors and/or activation sequences may be selected, and information associated with the vectors and/or activation sequences may be stored and tracked.
摘要翻译：心脏监测和/或刺激方法和系统提供监测，诊断和除颤和/或起搏疗法。信号处理器接收与多个源相关联的多个复合信号，执行源分离，并且基于源分离产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号矢量。信号分离的方法包括检测心脏信号矢量相对于基线的特征的变化。可以选择一个或多个载体和/或激活序列，并且可以存储和跟踪与载体和/或激活序列相关联的信息。

9. 发明授权

US07890159B2 Cardiac activation sequence monitoring and tracking 有权
标题翻译：心脏激活序列监测和跟踪
公开(公告)号：US07890159B2
公开(公告)日：2011-02-15
申请号：US10955397
申请日：2004-09-30
申请人： Yi Zhang , Scott A. Meyer , Aaron McCabe , Jeffrey E. Stahmann , Yinghong Yu , Carlos Alberto Ricci
发明人： Yi Zhang , Scott A. Meyer , Aaron McCabe , Jeffrey E. Stahmann , Yinghong Yu , Carlos Alberto Ricci
IPC分类号： A61B5/0428 , A61B5/0452
CPC分类号： A61B5/04011 , A61B5/7203
摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, diagnosis, and defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, performs a source separation, and produces one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences based on the source separation. A method of signal separation involves detecting a change in a characteristic of the cardiac signal vector relative to a baseline. One or more vectors and/or activation sequences may be selected, and information associated with the vectors and/or activation sequences may be stored and tracked.
摘要翻译：心脏监测和/或刺激方法和系统提供监测，诊断和除颤和/或起搏疗法。信号处理器接收与多个源相关联的多个复合信号，执行源分离，并且基于源分离产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号矢量。信号分离的方法包括检测心脏信号矢量相对于基线的特征的变化。可以选择一个或多个载体和/或激活序列，并且可以存储和跟踪与载体和/或激活序列相关联的信息。

10. 发明授权

US07941206B2 Automatic orientation determination for ECG measurements using multiple electrodes 有权
标题翻译：使用多个电极的ECG测量的自动取向确定
公开(公告)号：US07941206B2
公开(公告)日：2011-05-10
申请号：US12694833
申请日：2010-01-27
申请人： Yi Zhang , Marina Brockway , Carlos Alberto Ricci , Ronald W. Heil , Douglas R. Daum , Robert J. Sweeney , Aaron R. McCabe
发明人： Yi Zhang , Marina Brockway , Carlos Alberto Ricci , Ronald W. Heil , Douglas R. Daum , Robert J. Sweeney , Aaron R. McCabe
IPC分类号： A61B5/04
CPC分类号： A61B5/0006 , A61B5/0031 , A61B5/04011 , A61B5/0422 , A61B5/7207 , A61B5/7217 , A61N1/3756 , G06K9/624
摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, separates a signal using a source separation algorithm, and identifies a cardiac signal using a selected vector. The signal processor may iteratively separate signals from the plurality of composite signals until the cardiac signal is identified. The selected vector may be updated if desired or necessary. A method of signal separation involves detecting a plurality of composite signals at a plurality of locations, separating a signal using source separation, and selecting a vector that provides a cardiac signal. The separation may include a principal component analysis and/or an independent component analysis. Vectors may be selected and updated based on changes of position and/or orientation of implanted components and changes in patient parameters such as patient condition, cardiac signal-to-noise ratio, and disease progression.
摘要翻译：心脏监测和/或刺激方法和系统提供监测，除颤和/或起搏治疗。信号处理器接收与多个源相关联的多个复合信号，使用源分离算法分离信号，并使用所选择的向量来识别心脏信号。信号处理器可以迭代地分离来自多个复合信号的信号，直到识别出心脏信号。如果需要或必要，可以更新所选择的向量。信号分离的方法包括在多个位置检测多个复合信号，使用源分离分离信号，以及选择提供心脏信号的向量。分离可以包括主成分分析和/或独立成分分析。可以基于植入组件的位置和/或取向的改变以及患者参数（例如患者状况，心脏信噪比和疾病进展）的变化来选择和更新载体。

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