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1. 发明授权

US08934992B2 Nerve cuff 有权
标题翻译：神经袖口
公开(公告)号：US08934992B2
公开(公告)日：2015-01-13
申请号：US13600572
申请日：2012-08-31
申请人： Blake D. Johnson , Mark Christopherson , John Rondoni , Quan Ni
发明人： Blake D. Johnson , Mark Christopherson , John Rondoni , Quan Ni
IPC分类号： A61N1/05
CPC分类号： A61N1/0556 , A61N1/0558 , A61N1/3611 , A61N1/36135 , A61N1/37217
摘要： An electrode cuff includes a first elongate portion and a second elongate portion. The first elongate portion is configured to removably contact a length of a nerve while the second elongate portion extends outwardly at an angle relative to a first side edge of the first elongate portion to at least partially wrap about the nerve. The electrode cuff includes a first series of electrodes that is spaced apart longitudinally along the first elongate portion. A width of the second elongate portion is sized to fit between adjacent branches extending from a nerve.
摘要翻译：电极套包括第一细长部分和第二细长部分。第一细长部分构造成可移除地接触一段神经，而第二细长部分相对于第一细长部分的第一侧边缘以一定角度向外延伸，以至少部分地围绕神经缠绕。电极套包括沿着第一细长部分纵向隔开的第一系列电极。第二细长部分的宽度被设计成适合于从神经延伸的相邻分支之间。

2. 发明授权

US08915741B2 Sleep quality data collection and evaluation 有权
标题翻译：睡眠质量数据收集和评估
公开(公告)号：US08915741B2
公开(公告)日：2014-12-23
申请号：US13215592
申请日：2011-08-23
申请人： John D. Hatlestad , Quan Ni , Jeffrey E. Stahmann , Jesse Hartley , Qingsheng Zhu , Bruce H. KenKnight , Douglas R. Daum , Kent Lee
发明人： John D. Hatlestad , Quan Ni , Jeffrey E. Stahmann , Jesse Hartley , Qingsheng Zhu , Bruce H. KenKnight , Douglas R. Daum , Kent Lee
IPC分类号： G09B23/28 , A61B5/0205 , A61B5/00 , A61B5/0488 , A61B5/11 , A61B5/0476 , A61N1/362 , A61B5/08 , A61B5/0496
CPC分类号： A61B5/4815 , A61B5/0031 , A61B5/0205 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/0809 , A61B5/11 , A61B5/4528 , A61B5/4818 , A61N1/3621 , G06F19/00
摘要： A sleep quality assessment approach involves collecting data based on detected physiological or non-physiological patient conditions. At least one of detecting patient conditions and collecting data is performed using an implantable device. Sleep quality may be evaluated using the collected data by an implantable or patient-external sleep quality processor. One approach to sleep quality evaluation involves computing one or more summary metrics based on occurrences of movement disorders or breathing disorders during sleep.
摘要翻译：睡眠质量评估方法包括基于检测到的生理或非生理性患者状况收集数据。使用可植入装置执行检测患者状况和收集数据中的至少一个。可以使用可植入或患者外部的睡眠质量处理器收集的数据来评估睡眠质量。睡眠质量评估的一种方法包括基于睡眠期间的运动障碍或呼吸障碍的发生来计算一个或多个总结度量。

3. 发明授权

US08725260B2 Methods of monitoring hemodynamic status for rhythm discrimination within the heart 有权
标题翻译：监测心脏内节律辨别的血液动力学状态的方法
公开(公告)号：US08725260B2
公开(公告)日：2014-05-13
申请号：US12366334
申请日：2009-02-05
申请人： Allan C. Shuros , Dan Li , Quan Ni
发明人： Allan C. Shuros , Dan Li , Quan Ni
IPC分类号： A61N1/00
CPC分类号： A61N1/36585 , A61N1/36578
摘要： Systems and methods of performing rhythm discrimination within a patient's body using sensed hemodynamic signals are disclosed. The method can include the steps of receiving an electrical activity signal from an electrode located within or near the heart, detecting an event of the heart based on the received electrical activity signal, sensing one or more mechanical measurements using a sensor located within the body, analyzing a mechanical activity signal received from the sensor, and confirming the type of event based on the mechanical and electrical activity signals. The sensor can comprise a single pressure sensor configured to sense both atrial and ventricular activity within the heart.
摘要翻译：公开了使用感测到的血液动力学信号在患者体内进行节律辨别的系统和方法。该方法可以包括以下步骤：从位于心脏内部或附近的电极接收电活动信号，基于接收到的电活动信号检测心脏的事件，使用位于体内的传感器感测一个或多个机械测量，分析从传感器接收的机械活动信号，以及基于机械和电活动信号来确认事件的类型。传感器可以包括构造成感测心脏内的心房和心室活动的单个压力传感器。

4. 发明授权

US08657756B2 Implantable device employing movement sensing for detecting sleep-related disorders 有权
标题翻译：使用移动感测来检测睡眠相关障碍的植入式装置
公开(公告)号：US08657756B2
公开(公告)日：2014-02-25
申请号：US13027445
申请日：2011-02-15
申请人： Jeffrey E. Stahmann , Jesse W. Hartley , Kent Lee , Quan Ni
发明人： Jeffrey E. Stahmann , Jesse W. Hartley , Kent Lee , Quan Ni
IPC分类号： A61B5/08 , A61B5/04 , A61B5/05
CPC分类号： A61N1/36135 , A61B5/4818 , A61M16/024 , A61M16/10 , A61M2205/3561 , A61M2205/3584 , A61M2230/04 , A61M2230/60 , A61M2230/63 , A61M2230/65 , A61N1/3601 , A61N1/3611
摘要： Methods and systems for evaluating a pathological condition include acquiring movement information, such as electromyogram (EMG) information, and sleep disordered breathing (SDB) information, and detecting the presence of a pathological condition using both movement and SDB information. Methods may involve sensing physiological signals including at least muscle movement signals. Sleep-related disorders are detected using the sensed physiological signals, the sleep-related disorders including at least an involuntary muscle movement disorder and sleep-disordered breathing. Methods and systems also provide for detecting and treating a sleep-related disorder using movement and SDB information. Cardiac, respiratory, nerve stimulation, drug, or a combination of such therapies may be delivered to treat a detected or diagnosed pathological condition.
摘要翻译：用于评估病理状况的方法和系统包括获取运动信息，例如肌电图（EMG）信息和睡眠呼吸障碍（SDB）信息，以及使用运动和SDB信息检测病态的存在。方法可以包括感测至少包括肌肉运动信号的生理信号。使用感测到的生理信号检测睡眠相关疾病，睡眠相关障碍至少包括不自主的肌肉运动障碍和睡眠呼吸紊乱。方法和系统还提供使用运动和SDB信息来检测和治疗睡眠相关疾病。可以输送心脏，呼吸，神经刺激，药物或这些疗法的组合以治疗检测或诊断的病理状况。

5. 发明授权

US08535222B2 Sleep detection using an adjustable threshold 有权
公开(公告)号：US08535222B2
公开(公告)日：2013-09-17
申请号：US11717561
申请日：2007-03-13
申请人： Quan Ni , Zoe Hajenga , Douglas R. Daum , Jeff E. Stahmann , John D. Hatlestad , Kent Lee
发明人： Quan Ni , Zoe Hajenga , Douglas R. Daum , Jeff E. Stahmann , John D. Hatlestad , Kent Lee
IPC分类号： A61B5/00
CPC分类号： A61B5/4815 , A61B5/0031 , A61B5/0205 , A61B5/021 , A61B5/085 , A61B5/1116 , A61B5/4809 , A61B5/686 , A61B5/7271 , A61B5/7282 , A61N1/362 , A61N1/365 , A61N1/36542 , G16H40/63 , G16H50/20
摘要： Devices and methods for sleep detection involve the use of an adjustable threshold for detecting sleep onset and termination. A method for detecting sleep includes adjusting a sleep threshold associated with a first sleep-related signal using a second sleep-related signal. The first sleep-related signal is compared to the adjusted threshold and sleep is detected based on the comparison. The sleep-related signals may be derived from implantable or external sensors. Additional sleep-related signals may be used to confirm the sleep condition. A sleep detector device implementing a sleep detection method may be a component of an implantable pulse generator such as a pacemaker or defibrillator.

6. 发明申请

US20130046195A1 WIRELESS ECG IN IMPLANTABLE DEVICES 有权
标题翻译：无线心电图在可植入的设备
公开(公告)号：US20130046195A1
公开(公告)日：2013-02-21
申请号：US13657224
申请日：2012-10-22
申请人： Aaron R. McCabe , Avram Scheiner , Geng Zhang , Quan Ni , Douglas R. Daum , Yi Zhang
发明人： Aaron R. McCabe , Avram Scheiner , Geng Zhang , Quan Ni , Douglas R. Daum , Yi Zhang
IPC分类号： A61B5/0408
CPC分类号： A61B5/0402 , A61N1/365 , A61N1/3756
摘要： An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.
摘要翻译：诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗装置的表面上的电极的各种组合。

7. 发明授权

US08306621B2 Cardiac cycle synchronized sampling of impedance signal 有权
标题翻译：心脏周期同步采样阻抗信号
公开(公告)号：US08306621B2
公开(公告)日：2012-11-06
申请号：US11676067
申请日：2007-02-16
申请人： Jaeho Kim , Quan Ni
发明人： Jaeho Kim , Quan Ni
IPC分类号： A61N1/365
CPC分类号： A61B5/0205 , A61N1/3601 , A61N1/36521 , A61N1/37211
摘要： A cardiac rhythm management device for obtaining transthoracic impedance. The device comprises a sensor for obtaining a signal indicative of an action of a heart, an impedance measurement circuit adapted to measure transthoracic impedance and a processor for utilizing the signal indicative of the action of the heart to sample the transthoracic impedance at sampling intervals commenced by fiducial markers in the signal indicative of the action of the heart, where the sampling of the impedance signal removes the component of a stroke volume of the heart from the signal and thereby provides lung ventilation information.
摘要翻译：用于获得经胸阻抗的心律管理装置。该装置包括用于获得指示心脏动作的信号的传感器，适于测量经胸阻抗的阻抗测量电路，以及用于利用指示心脏作用的信号以采样间隔采样经脉管阻抗的处理器，采样间隔由指示心脏动作的信号中的基准标记，其中阻抗信号的采样从信号中去除心脏的搏动体积的分量，从而提供肺通气信息。

8. 发明申请

US20120197333A1 SYSTEMS AND METHODS FOR DELIVERING VAGAL NERVE STIMULATION 有权
标题翻译：用于输送VAGAL NERVE刺激的系统和方法
公开(公告)号：US20120197333A1
公开(公告)日：2012-08-02
申请号：US13444400
申请日：2012-04-11
申请人： Weiying Zhao , Quan Ni , Stephen Ruble , Jason J. Hamann
发明人： Weiying Zhao , Quan Ni , Stephen Ruble , Jason J. Hamann
IPC分类号： A61N1/365 , A61N1/362
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/36053 , A61N1/36117 , A61N1/36592 , A61N1/3712
摘要： According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.
摘要翻译：根据各种方法实施例，指示一个人用于治疗心血管疾病的治疗，并且将该治疗递送给该人以治疗心血管疾病。提供治疗包括将迷走神经刺激治疗（VST）以对于心血管疾病的治疗有效强度的人的迷走神经递送，所述心血管疾病低于VST在VST期间的上边界降低内在心率的上边界。

9. 发明授权

US08190256B2 Methods and devices for implementing time of day pacing adjustments 有权
标题翻译：实施时间调节的方法和设备
公开(公告)号：US08190256B2
公开(公告)日：2012-05-29
申请号：US12508317
申请日：2009-07-23
申请人： Jesse W. Hartley , Kent Lee , Quan Ni , Michael A. Querimit , Kenneth L. Baker , Ankur Garg , Kenneth L. Tobacman , Corey J. Miklos
发明人： Jesse W. Hartley , Kent Lee , Quan Ni , Michael A. Querimit , Kenneth L. Baker , Ankur Garg , Kenneth L. Tobacman , Corey J. Miklos
IPC分类号： A61N1/365
CPC分类号： A61B5/4812 , A61B5/4815 , A61N1/368 , A61N1/3688 , G06F19/00
摘要： Methods and systems are directed to delivering cardiac pacing therapy to a patient. A pacing therapy associated with one or more pacing parameters is delivered. Alternate cardiac pacing therapies associated with one or more alternate pacing parameters are transitioned to, based on a sleep/wake cycle of the patient. Interactions between the pacing parameters of the pacing therapy and the alternate pacing parameters are resolved. Resolving pacing parameters may be based on analysis of lower rate limits and/or lower rate hysteresis, for example.
摘要翻译：方法和系统旨在向患者输送心脏起搏治疗。提供与一个或多个起搏参数相关的起搏疗法。与一个或多个替代起搏参数相关联的替代心脏起搏疗法基于患者的睡眠/唤醒周期而被转换。起搏治疗起搏参数与替代起搏参数之间的相互作用得到解决。例如，解析起搏参数可以基于较低速率限制和/或较低速率滞后的分析。

10. 发明申请

US20120053474A1 WIRELESS ECG IN IMPLANTABLE DEVICES 有权
标题翻译：无线心电图在可植入的设备
公开(公告)号：US20120053474A1
公开(公告)日：2012-03-01
申请号：US13288105
申请日：2011-11-03
申请人： Aaron McCabe , Avram Scheiner , Geng Zhang , Quan Ni , Douglas R. Daum , Yi Zhang
发明人： Aaron McCabe , Avram Scheiner , Geng Zhang , Quan Ni , Douglas R. Daum , Yi Zhang
IPC分类号： A61B5/0452 , A61N1/365
CPC分类号： A61B5/0402 , A61N1/365 , A61N1/3756
摘要： An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.
摘要翻译：诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗器械表面上的电极的各种组合。

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