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1. 发明申请

US20090132000A1 Method and apparatus for monitoring heart failure patients with cardiopulmonary comorbidities 有权
公开(公告)号：US20090132000A1
公开(公告)日：2009-05-21
申请号：US12319642
申请日：2009-01-08
申请人： Marina Brockway , Donald Hopper , Gerrard M. Carlson , Veerichetty Kadhiresan , Kenneth Beck
发明人： Marina Brockway , Donald Hopper , Gerrard M. Carlson , Veerichetty Kadhiresan , Kenneth Beck
IPC分类号： A61N1/365
CPC分类号： A61B5/087 , A61B5/02405 , A61B5/053 , A61B5/4878 , A61N1/3627 , A61N1/36521
摘要： A system receives signals indicative of cardiopulmonary conditions sensed by a plurality of sensors and provides for monitoring and automated differential diagnosis of the cardiopulmonary conditions based on the signals. Cardiogenic pulmonary edema is detected based on one or more signals sensed by implantable sensors. If the cardiogenic pulmonary edema is not detected, obstructive pulmonary disease and restrictive pulmonary disease are each detected based on a forced vital capacity (FVC) parameter and a forced expiratory volume (FEV) parameter measured from a respiratory signal sensed by an implantable or non-implantable sensor. In one embodiment, an implantable medical device senses signals indicative of the cardiopulmonary conditions, and an external system detects the cardiopulmonary conditions based on these signals by executing an automatic detection algorithm.

2. 发明授权

US07269458B2 Cardiopulmonary functional status assessment via heart rate response detection by implantable cardiac device 有权
标题翻译：通过植入式心脏装置的心率响应检测进行心肺功能状态评估
公开(公告)号：US07269458B2
公开(公告)日：2007-09-11
申请号：US10914632
申请日：2004-08-09
申请人： Veerichetty Kadhiresan , Donald Hopper , Richard Fogoros , Lemont Baker
发明人： Veerichetty Kadhiresan , Donald Hopper , Richard Fogoros , Lemont Baker
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A61N1/365 , A61B5/0205 , A61N1/36521 , A61N1/36542 , A61N1/3702
摘要： An implantable cardiac device is configured and programmed to assess a patient's cardiopulmonary function by evaluating the patient's heart rate response. Such evaluation may be performed by computing a heart rate response slope, defined as the ratio of an incremental change in intrinsic heart rate to an incremental change in measured activity level. The heart rate response slope may then be compared with a normal range to assess the patient's functional status.
摘要翻译：可植入心脏装置被配置和编程以通过评估患者的心率响应来评估患者的心肺功能。可以通过计算定义为内在心率的增量变化与测量的活动水平的增量变化的比率的心率响应斜率来执行这种评估。然后将心率反应斜率与正常范围进行比较以评估患者的功能状态。

3. 发明申请

US20060247704A1 SELF-CALIBRATING RATE-ADAPTIVE PACEMAKER 失效
公开(公告)号：US20060247704A1
公开(公告)日：2006-11-02
申请号：US11457382
申请日：2006-07-13
申请人： Weimin Sun , Bruce Jones , Douglas Lang , Donald Hopper
发明人： Weimin Sun , Bruce Jones , Douglas Lang , Donald Hopper
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61N1/36585
摘要： A system and method for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker. In accordance with the method, maximum exertion levels attained by the patient are measured at periodic intervals and stored. The stored maximum exertion levels may then be used to update a long-term maximal exertion level, and the slope of the rate-response curve is adjusted to map the updated long-term maximal exertion level to a maximum allowable pacing rate. The stored maximum exertion levels may also be used to update a sensor target rate which is used to adjust the slope of the rate response curve.

4. 发明申请

US20060195149A1 Implantable cardiac device with dyspnea measurement 有权
公开(公告)号：US20060195149A1
公开(公告)日：2006-08-31
申请号：US11067964
申请日：2005-02-28
申请人： Donald Hopper , John Voegele , Jesse Hartley , Avram Scheiner
发明人： Donald Hopper , John Voegele , Jesse Hartley , Avram Scheiner
IPC分类号： A61N1/378
CPC分类号： A61B5/686 , A61B5/0022 , A61B5/0024 , A61B5/02028 , A61B5/0205 , A61B5/04012 , A61B5/0402 , A61B5/076 , A61B5/0809 , A61B5/0816 , A61B5/0826 , A61B5/085 , A61B5/091 , A61B5/1118 , A61B5/4836 , A61B5/7275 , A61B5/7282 , A61B5/746 , A61B5/747 , A61N1/3627 , A61N1/36585 , A61N1/3702 , A61N1/3987 , G06F19/00 , G16H50/20 , G16H50/30
摘要： Cardiac monitoring and/or stimulation methods and systems employing dyspnea measurement. An implantable cardiac device may sense transthoracic impedance and determine a patient activity level. An index indicative of pulmonary function is implantably computed to detect an episode of dyspnea based on a change, trend, and/or value exceeding a threshold at a determined patient activity level. Trending one or more pulmonary function index values may be done to determine a patient's pulmonary function index profile, which may be used to adapt a cardiac therapy. A physician may be automatically alerted in response to a pulmonary function index value and/or a trend of the patient's pulmonary index being beyond a threshold. Computed pulmonary function index values and their associated patient's activity levels may be stored periodically in a memory and/or transmitted to a patient-external device.

5. 发明授权

US07079897B2 Self-calibrating rate-adaptive pacemaker 失效
公开(公告)号：US07079897B2
公开(公告)日：2006-07-18
申请号：US10839875
申请日：2004-05-06
申请人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald Hopper
发明人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald Hopper
IPC分类号： A61N1/18
CPC分类号： A61N1/365 , A61N1/36585
摘要： A system and method for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker. In accordance with the method, maximum exertion levels attained by the patient are measured at periodic intervals and stored. The stored maximum exertion levels may then be used to update a long-term maximal exertion level, and the slope of the rate-response curve is adjusted to map the updated long-term maximal exertion level to a maximum allowable pacing rate. The stored maximum exertion levels may also be used to update a sensor target rate which is used to adjust the slope of the rate response curve.

6. 发明申请

US20060036290A1 Cardiopulmonary functional status assessment via metabolic response detection by implantable cardiac device 有权
公开(公告)号：US20060036290A1
公开(公告)日：2006-02-16
申请号：US10917235
申请日：2004-08-12
申请人： Donald Hopper , Bruce Wilkoff , Richard Morris
发明人： Donald Hopper , Bruce Wilkoff , Richard Morris
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61N1/365 , A61N1/36521 , A61N1/36542 , A61N1/3702
摘要： An implantable cardiac device is configured and programmed to assess a patient's cardiopulmonary function by evaluating the patient's minute ventilation response. Such evaluation may be performed by computing a minute ventilation response slope, defined as the ratio of an incremental change in minute ventilation to an incremental change in measured activity level. The minute ventilation response slope may then be compared with a normal range to assess the patient's functional status.

7. 发明申请

US20060020295A1 Method and apparatus for monitoring heart failure patients with cardiopulmonary comorbidities 有权
公开(公告)号：US20060020295A1
公开(公告)日：2006-01-26
申请号：US10897856
申请日：2004-07-23
申请人： Marina Brockway , Donald Hopper , Gerrard Carlson , Veerichetty Kadhiresan , Kenneth Beck
发明人： Marina Brockway , Donald Hopper , Gerrard Carlson , Veerichetty Kadhiresan , Kenneth Beck
IPC分类号： A61N1/375 , A61B5/04
CPC分类号： A61B5/087 , A61B5/02405 , A61B5/053 , A61B5/4878 , A61N1/3627 , A61N1/36521
摘要： A system receives signals indicative of cardiopulmonary conditions sensed by a plurality of sensors and provides for monitoring and automated differential diagnosis of the cardiopulmonary conditions based on the signals. Cardiogenic pulmonary edema is detected based on one or more signals sensed by implantable sensors. If the cardiogenic pulmonary edema is not detected, obstructive pulmonary disease and restrictive pulmonary disease are each detected based on a forced vital capacity (FVC) parameter and a forced expiratory volume (FEV) parameter measured from a respiratory signal sensed by an implantable or non-implantable sensor. In one embodiment, an implantable medical device senses signals indicative of the cardiopulmonary conditions, and an external system detects the cardiopulmonary conditions based on these signals by executing an automatic detection algorithm.

8. 发明授权

US06839593B1 Rate-adaptive therapy with automatic limiting of maximum pacing rate 有权
标题翻译：速率自适应治疗，自动限制最大起搏率
公开(公告)号：US06839593B1
公开(公告)日：2005-01-04
申请号：US09657404
申请日：2000-09-08
申请人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald Hopper
发明人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald Hopper
IPC分类号： A61N1/18 , A61N1/365
CPC分类号： A61N1/365
摘要： A system and method for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker in which maximum exertion levels attained by the patient are measured at periodic intervals and stored. The stored maximum exertion levels may then be used to update a long-term maximal exertion level, and the slope of the rate-response curve is adjusted to map the updated long-term maximal exertion level to a maximum allowable pacing rate. In accordance with the invention, the rate response curve is defined such that an exertion level corresponding to the patient's maximum exercise capacity would be mapped to a physiologically favorable maximum rate that is independent from a specified maximum sensor indicated rate.
摘要翻译：用于自动调整速率自适应心脏起搏器的操作参数的系统和方法，其中以周期性间隔测量由患者达到的最大消耗水平并被存储。然后可以使用存储的最大消耗水平来更新长期最大消耗水平，并且调整速率 - 响应曲线的斜率以将更新的长期最大消耗水平映射到最大允许起搏速率。根据本发明，速率响应曲线被定义为使得与患者的最大运动能力相对应的运动水平将被映射到独立于指定的最大传感器指示速率的生理上有利的最大速率。

9. 发明授权

US09079033B2 Respiration as a trigger for therapy optimization 有权
标题翻译：呼吸作为治疗优化的触发因素
公开(公告)号：US09079033B2
公开(公告)日：2015-07-14
申请号：US12356289
申请日：2009-01-20
申请人： Richard O. Kuenzler , Donald Hopper , Mary Jane Rasmussen , Aaron McCabe , John Layton
发明人： Richard O. Kuenzler , Donald Hopper , Mary Jane Rasmussen , Aaron McCabe , John Layton
IPC分类号： A61N1/362 , A61B5/021 , A61B5/024 , A61N1/372 , G06F19/00 , A61B5/00 , A61B5/08 , A61N1/365
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/021 , A61B5/02405 , A61B5/0816 , A61N1/36521 , A61N1/36592 , A61N1/37247 , A61N1/37258 , G06F19/00 , G06F19/3418 , G16H10/20 , G16H40/63 , G16H50/30
摘要： Changes in patient status are assessed based at least in part on respiration parameters. A user can make selections regarding alert criteria options to be used in assessing patient status. Respiration is implantably sensed and respiration data is stored by an implantable device. A respiration parameter, such as respiration rate, is measured from the respiration data. The change in patient status is assessed by comparing the respiration parameter to the configured alert criteria. If the comparison of the respiration parameter and the configured alert criteria indicates a significant change in patient status, an alert signal is generated.
摘要翻译：至少部分地基于呼吸参数来评估患者状态的变化。用户可以对用于评估患者状态的警报标准选项进行选择。呼吸被植入式感测，呼吸数据由可植入装置储存。从呼吸数据测量呼吸参数，如呼吸速率。通过将呼吸参数与配置的警报标准进行比较来评估患者状态的变化。如果呼吸参数和配置的警报标准的比较表示患者状态的显着变化，则产生警报信号。

10. 发明申请

US20090299159A1 SYSTEM AND METHOD FOR MONITORING AUTONOMIC BALANCE AND PHYSICAL ACTIVITY 有权
标题翻译：用于监测自动平衡和物理活动的系统和方法
公开(公告)号：US20090299159A1
公开(公告)日：2009-12-03
申请号：US12538553
申请日：2009-08-10
申请人： Avram Scheiner , Donald Hopper , Gerrard M. Carlson
发明人： Avram Scheiner , Donald Hopper , Gerrard M. Carlson
IPC分类号： A61B5/0205
CPC分类号： A61B5/4035 , A61B5/029 , A61B5/0472 , A61N1/36585 , G06F19/00
摘要： An implantable device monitors the balance between sympathetic tone and parasympathetic tone as a function of an activity level. Cardio-neurological healthy users exhibit a generally sympathetic tone in conjunction with heavy activity level and a generally parasympathetic tone in conjunction with periods of low activity level. Deviations from expected results are associated with a health problem. Measured conditions are stored and available for subsequent reporting to a remote programmer. Therapy delivered by an implantable device is determined as a function of the relationship between autonomic balance and activity level.
摘要翻译：可植入装置监测交感神经张力和副交感神经紧张度之间的平衡，作为活动水平的函数。心脏神经系统健康用户表现出与大量活动水平和大体上副交感神经紧张以及低活动水平结合的共同心情。与预期结果的偏差与健康问题有关。测量条件存储并可用于后续报告给远程程序员。由植入式装置提供的治疗作为自主平衡与活动水平之间关系的函数确定。

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