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1. 发明授权

US06264748B1 Substrate processing apparatus 有权
标题翻译：基板加工装置
公开(公告)号：US06264748B1
公开(公告)日：2001-07-24
申请号：US09130104
申请日：1998-08-06
申请人： Yasuyuki Kuriki , Hideyuki Takamori , Kozo Hara
发明人： Yasuyuki Kuriki , Hideyuki Takamori , Kozo Hara
IPC分类号： C23C1600
CPC分类号： H01L21/67173 , C23C16/54 , H01L21/67742
摘要： A substrate processing apparatus comprises a processing section having a plurality of process units for applying a series of processes including a resist coating to a processing substrate, a developing process to an exposed substrate, and an etching to the developed processing substrate, a main transferring mechanism, moving along a transferring path, for transferring/receiving the processing substrate to/from the respective process units, and a loading/unloading portion having a transferring/receiving mechanism for transferring/receiving the processing substrate to/from the main transferring apparatus, wherein these process units, the transferring path, and the loading/unloading portion are integrally provided.
摘要翻译：一种基板处理装置，包括具有多个处理单元的处理单元，所述处理单元用于向处理基板施加包括抗蚀剂涂层的一系列处理，对曝光基板的显影处理以及对显影处理基板的蚀刻，主转印机构沿着传送路径移动，用于向/从各个处理单元传送/接收处理基板;以及装载/卸载部分，具有用于向/从主传送装置传送/接收处理基板的传送/接收机构，其中这些处理单元，传送路径和装载/卸载部分是一体的。

2. 发明授权

US07491518B2 Method of elevating yield of oligosaccharides containing α-galactosyl and anti-candida compositions 失效
标题翻译：提高含有α-半乳糖基和抗念珠菌组合物的寡糖产率的方法
公开(公告)号：US07491518B2
公开(公告)日：2009-02-17
申请号：US10362483
申请日：2001-08-08
申请人： Masamichi Okada , Shigeharu Mori , Hiroyuki Hashimoto , Koki Fujita , Kozo Hara
发明人： Masamichi Okada , Shigeharu Mori , Hiroyuki Hashimoto , Koki Fujita , Kozo Hara
IPC分类号： C12P19/14 , C12P19/12 , C12P19/18
CPC分类号： C12N9/2465 , C12P19/14 , C12Y302/01022
摘要： A novel method of very efficiently elevating the yield of oligosacchrides containing α-galactosyl, compared with the conventional methods, which comprises treating galactose or a galactose-containing material with a specific α-galactosidase and thus performing a dehydrocondensation reaction at a high substrate concentration. Anti-candida compositions originating in foods, having a high safety and excellent anti-candida effect and not being restricted in the supply, which contain as the active ingredient oligosacchrides obtained by treating galactose or a galactose-containing material with an α-galactosidase and thus performing a dehydrocondensation.
摘要翻译：与常规方法相比，非常有效地提高含有α-半乳糖苷的寡糖的产率的新方法，其包括用特定的α-半乳糖苷酶处理半乳糖或含半乳糖的材料，从而以高底物浓度进行脱氢反应。起始于食物的抗念珠菌组合物，具有高安全性和优异的抗念珠菌作用，不受供体限制，其含有通过用α-半乳糖苷酶处理半乳糖或含半乳糖的物质获得的活性成分的寡糖，因此进行脱氢。

3. 发明授权

US5763598A Branched cyclodextrins and method for producing them 失效
标题翻译：支链环糊精及其制备方法
公开(公告)号：US5763598A
公开(公告)日：1998-06-09
申请号：US876979
申请日：1997-06-16
申请人： Kenichi Hamayasu , Tetsuya Ito , Koki Fujita , Kozo Hara , Kyoko Koizumi , Toshiko Tanimoto , Hirofumi Nakano , Sumio Kitahata
发明人： Kenichi Hamayasu , Tetsuya Ito , Koki Fujita , Kozo Hara , Kyoko Koizumi , Toshiko Tanimoto , Hirofumi Nakano , Sumio Kitahata
IPC分类号： C12P19/26 , A61K47/48 , C08B37/16 , A01N43/04 , A61K31/715
CPC分类号： B82Y5/00 , A61K47/48969 , C08B37/0012
摘要： Disclosed are novel branched cyclodextrins having any of an N-acetylglucosamine group, a glucosaminyl group, an N-acetylgalactosaminyl group and a galactosaminyl group as bonded to the hydroxyl group of the cyclodextrin ring by .beta.-bonding therebetween, and their salts. The novel branched cyclodextrins are produced by reacting a solution containing a cyclodextrin and an N-acetylglucosamine or N-acetylgalactosamine with an N-acetylhexosaminidase, and optionally deacetylating the resulting product.
摘要翻译：公开了通过β键连接在环糊精环的羟基上的N-乙酰葡糖胺基，葡糖胺基，N-乙酰半乳糖胺基和半乳糖胺基中的任一种的新型支链环糊精及其盐。新型支链环糊精是通过使含有环糊精和N-乙酰葡糖胺或N-乙酰半乳糖胺的溶液与N-乙酰基己糖胺酶反应，并任选地将所得产物脱乙酰化来制备的。

4. 发明授权

US5738448A Ribbon cassette for printer 失效
标题翻译：打印机色带盒
公开(公告)号：US5738448A
公开(公告)日：1998-04-14
申请号：US652415
申请日：1996-05-23
申请人： Kozo Hara , Hajime Yamamoto
发明人： Kozo Hara , Hajime Yamamoto
IPC分类号： B41J33/14 , F16D1/06 , F16D9/00
CPC分类号： B41J33/14 , F16D1/06 , F16D9/00 , F16D2001/062
摘要： Disclosed herein is a ribbon cassette for use with a printer, including a cassette case detachably mounted in the printer and an ink ribbon stored in the cassette case and partially exposed to face a print head provided in the printer. The ribbon cassette further includes a ribbon take-up member rotatably supported in the cassette case, a driven member rotatably supported in the cassette case and meshing with the ribbon take-up member through the ink ribbon, and a power transmitting member provided in the ribbon take-up member to connect the ribbon take-up member to a ribbon driving shaft provided in the printer. A breaking strength of the power transmitting member against a load from the ink ribbon is set smaller than that of the ribbon driving shaft. Accordingly, in the event that ribbon jam occurs, the power transmitting member breaks to thereby prevent fracture of the ribbon driving shaft in the printer.
摘要翻译：本文公开了一种用于打印机的色带盒，包括可拆卸地安装在打印机中的盒壳体和存储在盒壳体中并部分地暴露于面对设置在打印机中的打印头的色带。色带盒还包括可旋转地支撑在盒壳体中的色带卷取构件，可旋转地支撑在盒壳体中并通过色带与色带卷取构件啮合的从动构件，以及设置在色带中的动力传递构件卷取构件将色带卷绕构件连接到设置在打印机中的色带驱动轴。动力传递部件相对于来自墨带的负载的断裂强度被设定为小于色带驱动轴的断裂强度。因此，在发生带状卡纸的情况下，动力传递部件断裂，从而防止打印机中的色带驱动轴断裂。

5. 发明授权

US5302036A Multi-color ribbon cassette position adjusting apparatus 失效
标题翻译：多色色带盒位置调节装置
公开(公告)号：US5302036A
公开(公告)日：1994-04-12
申请号：US930849
申请日：1992-08-14
申请人： Masahiro Akiyama , Hidekazu Ishii , Kozo Hara
发明人： Masahiro Akiyama , Hidekazu Ishii , Kozo Hara
IPC分类号： B41J32/00 , B41J35/22 , B41J33/14
CPC分类号： B41J35/22 , B41J32/00
摘要： A multi-color ribbon cassette position adjusting apparatus comprises a carrier having a print head, a cassette mounting member rockably supported on the carrier, and a fine adjustment mechanism attached to the cassette mounting member, for finely rocking the mounting member. The fine adjustment mechanism includes a guide member fixed to the cassette mounting member, a follower piece guided by the guide member to engage a helical cam for shifting the position of the cassette mounting member, and a position adjusting member for relatively moving the guide member and the follower piece.
摘要翻译：多色带盒位置调整装置包括具有打印头的托架，可滑动地支撑在托架上的盒安装构件以及安装在盒安装构件上的精细调节机构，用于使安装构件微调。微调机构包括固定在盒安装部件上的引导部件，由引导部件引导的从动部件与用于移动盒安装部件的位置的螺旋凸轮接合;以及位置调节部件，用于相对移动引导部件，随从片。

6. 发明授权

US06306893B1 Taxoid derivatives and process for producing the same 有权
标题翻译：紫杉烷衍生物及其生产方法
公开(公告)号：US06306893B1
公开(公告)日：2001-10-23
申请号：US09529208
申请日：2000-04-07
申请人： Tadakatsu Mandai , Hiroshi Okumoto , Koji Hara , Katsuhiko Mikuni , Kozo Hara , Yoshinori Tsuchiya , Kosho Nakamura , Teruhiko Umetsu
发明人： Tadakatsu Mandai , Hiroshi Okumoto , Koji Hara , Katsuhiko Mikuni , Kozo Hara , Yoshinori Tsuchiya , Kosho Nakamura , Teruhiko Umetsu
IPC分类号： A61K3335
CPC分类号： C07H15/04 , C07H15/26
摘要： An object of the invention is to develop galactose or mannose derivatives of docetaxel, etc. having improved solubility and physiological activity, to alleviate burden imposed on patients and to provide effective therapeutic drug for tumors. The present invention provides taxoid derivatives comprising any of paclitaxel, docetaxel and 10-deacetyl-baccatin III to which galactose or mannose is linked through a spacer, and methods for producing taxoid derivatives comprising reacting paclitaxel, docetaxel or 10-deacetyl-baccatin III with tetrabenzyl acetyloxygalactoside or tetrabenzyl acetyloxymannoside, subjecting the product to debenzylation reaction, and optionally to detriethylsilylation reaction.
摘要翻译：本发明的目的是开发具有改善的溶解性和生理活性的多西紫杉醇等的半乳糖或甘露糖衍生物，以减轻施加于患者的负担并为肿瘤提供有效的治疗药物。本发明提供了包含紫杉醇，多西紫杉醇和通过间隔基连接的10-脱乙酰基 - 浆果赤霉素III，以及用于制备紫杉醇，多西紫杉醇或10-脱乙酰基浆果赤霉素III与四苄基乙酰氧基半乳糖苷或四苄基乙酰氧基甘露糖苷的方法，所述方法包括使产物脱苄基反应，并任选地进行脱乙烯基硅烷化反应。

7. 发明授权

US06136990A Taxoid compound and method for producing the same 有权
标题翻译：紫杉烷类化合物及其制备方法
公开(公告)号：US06136990A
公开(公告)日：2000-10-24
申请号：US504788
申请日：2000-02-15
申请人： Tadakatsu Mandai , Hiroshi Okumoto , Katsuyoshi Nakanishi , Koji Hara , Katsuhiko Mikuni , Kozo Hara
发明人： Tadakatsu Mandai , Hiroshi Okumoto , Katsuyoshi Nakanishi , Koji Hara , Katsuhiko Mikuni , Kozo Hara
IPC分类号： C07D305/14 , C07D413/12 , C07D405/00 , C07D409/00
CPC分类号： C07D413/12 , C07D305/14
摘要： A taxoid compound represented by general formula (I) ##STR1## where the symbols R.sup.1, R.sup.2, R.sup.3, R.sup.4, Bz, and Ac have specified meanings. Also, a method for producing the taxoid derivative from a baccatin derivative having a .beta.-ketoester group at the 13-position by transesterification and a method for producing taxoid compound such as paclitaxel from the taxoid derivative under mild condition are disclosed.
摘要翻译：其中符号R1，R2，R3，R4，Bz和Ac具有特定含义的由通式（I）表示的紫杉烷类化合物。另外，公开了一种通过酯交换从具有β-酮酯基团的13位的浆果赤霉素衍生物制备紫杉烷衍生物的方法以及在温和条件下从紫杉烷衍生物制备紫杉醇类紫杉醇化合物的方法。

8. 发明授权

US5154521A Printer having ribbon mask for reducing interference with recording sheet 失效
标题翻译：打印机具有色带面罩，可减少与记录纸的干扰
公开(公告)号：US5154521A
公开(公告)日：1992-10-13
申请号：US700258
申请日：1991-05-15
申请人： Yoshiaki Tanaka , Kozo Hara , Kiyotaka Nihashi
发明人： Yoshiaki Tanaka , Kozo Hara , Kiyotaka Nihashi
IPC分类号： B41J35/26
CPC分类号： B41J35/26
摘要： In a printer having a platen, a print head disposed opposite to the platen, and a ribbon mask fixedly provided on the print head and having a masking plate provided with an aperture to expose only the front end of the print head to the platen, an ink ribbon is extended through a space between the platen and the print head, and the masking plate is disposed between the platen and the ink ribbon to shield a recording sheet wound round the platen from the ink ribbon. The aperture of the masking plate has inclined edges inclined to a direction perpendicular to the direction of movement of the print head so as to intersect a platen center obliquely. In case the side edge of a floating portion of the recording sheet is caught in the aperture of the masking plate while the print head is moved, the side edge slides along the inclined edge to escape from the aperture, so that the side edge is not caught in the aperture of the masking plate.
摘要翻译：在具有压板的打印机中，与压板相对设置的打印头和固定地设置在打印头上的色带掩模，并且具有设置有仅将打印头的前端暴露于压板的孔的掩模板，墨带延伸通过压板和打印头之间的空间，并且掩模板设置在压板和墨带之间，以将卷绕在压板上的记录纸从墨带上屏蔽。掩模板的孔径具有相对于与打印头的移动方向垂直的方向倾斜的倾斜边缘，以便倾斜地与压板中心相交。在打印头移动时记录纸的浮动部分的侧边缘被夹在掩模板的孔中的情况下，侧边缘沿着倾斜边缘滑动以从孔中逸出，使得侧边缘不卡在掩模板的孔中。

9. 发明授权

US5089401A Method for the preparation of fructose-containing oligosaccharide 失效
标题翻译：含有含葡萄糖的寡糖的制备方法
公开(公告)号：US5089401A
公开(公告)日：1992-02-18
申请号：US672388
申请日：1991-03-20
申请人： Koki Fujita , Kozo Hara , Hitoshi Hashimoto , Sumio Kitahata
发明人： Koki Fujita , Kozo Hara , Hitoshi Hashimoto , Sumio Kitahata
IPC分类号： C12P19/14 , C07H3/06 , C12N9/10 , C12N9/26 , C12P19/12 , C12P19/18 , C12P19/24 , C12R1/06
CPC分类号： C12N9/2408 , C12P19/12 , C12P19/24 , Y10S435/83
摘要： An enzymatic method for the preparation of a fructose-containing oligosaccharide, in which a .beta.-fructofuranosidase obtained by culturing Arthrobacter sp. K-1 (FERM BP-3192) as an enzyme is reacted on sucrose, raffinose or stachyose as the donor in the presence of an aldose or ketose as the receptor. The enzyme is characterized by:(1) activity on sucrose for the transglycosidation of a fructosyl group to the receptor in the presence of a monosaccharide, sugar alcohol, alkyl alcohol, glycoside or oligosaccharide;(2) activity for the decomposition of sucrose, elrose, neokestose, xylsucrose, raffinose and stachyose with inactivity on a saccharide selected from the group consisting of 1-kestose, nistose, inulobiose and levan biose;(3) optimum pH of 6.5 to 6.8 at 40.degree. C. with stability at a pH of 5.5 to 10;(4) optimum temperature of 55.degree. C. at a pH of 6.5 exhibiting at least 70% of residual activity at 60.degree. C.;(5) susceptibility to inhibition by the ions of silver, mercury, zinc, copper and tin;(6) two molecular weights of 52,000.+-.2,500 and 58,000.+-.2,500; and(7) two isoelectric points of pH 4.3 and pH 4.6.

10. 发明授权

US6075132A Ursodeoxycholic acid derivatives and methods for producing them 失效
标题翻译：熊去氧胆酸衍生物及其制备方法
公开(公告)号：US6075132A
公开(公告)日：2000-06-13
申请号：US069990
申请日：1998-04-30
申请人： Tadakatsu Mandai , Hiroshi Okumoto , Katsuyoshi Nakanishi , Koji Hara , Katsuhiko Mikuni , Kozo Hara , Teruhiko Umetsu
发明人： Tadakatsu Mandai , Hiroshi Okumoto , Katsuyoshi Nakanishi , Koji Hara , Katsuhiko Mikuni , Kozo Hara , Teruhiko Umetsu
IPC分类号： C07J9/00 , C07J17/00 , C07J75/00
CPC分类号： C07J9/005 , C07J17/005
摘要： Disclosed are ursodeoxycholic acid derivatives having an increased solubility in water, and methods for producing the derivatives. To produce the derivatives, ursodeoxycholic acid is protected at its carboxyl group with a benzyl group, then reacted with tetrabenzyl-acetic acid-oxyglucoside of the following formula (1), and de-benzylated; or ursodeoxycholic acid is protected at its hydroxyl group with a t-butyldimethylsilyl group, then reacted with tetrabenzyl-2-hydroxyethyloxyglucoside of the following formula (2), and de-t-butyldimethylsilylated and de-benzylated. ##STR1##
摘要翻译：公开了在水中溶解度增加的熊去氧胆酸衍生物及其衍生物的制造方法。为了制备衍生物，熊氧胆酸在其羧基上用苄基保护，然后与下式（1）的四苄基 - 乙酸 - 氧葡萄糖苷反应，并脱苄基化; 或熊去氧胆酸在其羟基上用叔丁基二甲基甲硅烷基保护，然后与下式（2）的四苄基-2-羟基乙氧基葡萄糖苷和去叔丁基二甲基甲硅烷基化和脱苄基化反应。

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