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1. 发明授权

US07160874B2 Phenylalanine derivatives 失效
标题翻译：苯丙氨酸衍生物
公开(公告)号：US07160874B2
公开(公告)日：2007-01-09
申请号：US10986829
申请日：2004-11-15
申请人： Yasuhiro Tanaka , Toshihiko Yoshimura , Hiroyuki Izawa , Chieko Ejima , Mitsuhiko Kojima , Yuko Satake , Eiji Nakanishi , Nobuyasu Suzuki , Shingo Makino , Manabu Suzuki , Masahiro Murata
发明人： Yasuhiro Tanaka , Toshihiko Yoshimura , Hiroyuki Izawa , Chieko Ejima , Mitsuhiko Kojima , Yuko Satake , Eiji Nakanishi , Nobuyasu Suzuki , Shingo Makino , Manabu Suzuki , Masahiro Murata
IPC分类号： C07C233/47 , C07C233/63 , C07C233/81 , A61K31/198 , C07D279/12
CPC分类号： C07D239/42 , C07C235/74 , C07C275/42 , C07C311/08 , C07C311/10 , C07C311/13 , C07C311/16 , C07C311/21 , C07C311/29 , C07C311/44 , C07C317/44 , C07C323/25 , C07C323/60 , C07C323/62 , C07C335/22 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/08 , C07C2602/42 , C07D207/12 , C07D207/14 , C07D207/16 , C07D239/38 , C07D295/185
摘要： Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
摘要翻译：指定的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗作用。它们被用作关于α4整联蛋白的各种疾病的治疗剂。

2. 发明授权

US06855706B2 Phenylalanine derivatives 失效
标题翻译：苯丙氨酸衍生物
公开(公告)号：US06855706B2
公开(公告)日：2005-02-15
申请号：US10150067
申请日：2002-05-20
申请人： Yasuhiro Tanaka , Toshihiko Yoshimura , Hiroyuki Izawa , Chieko Ejima , Mitsuhiko Kojima , Yuko Satake , Eiji Nakanishi , Nobuyasu Suzuki , Shingo Makino , Manabu Suzuki , Masahiro Murata
发明人： Yasuhiro Tanaka , Toshihiko Yoshimura , Hiroyuki Izawa , Chieko Ejima , Mitsuhiko Kojima , Yuko Satake , Eiji Nakanishi , Nobuyasu Suzuki , Shingo Makino , Manabu Suzuki , Masahiro Murata
IPC分类号： A61P1/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/06 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07C235/74 , C07C275/42 , C07C311/08 , C07C311/10 , C07C311/13 , C07C311/16 , C07C311/21 , C07C311/29 , C07C311/44 , C07C317/44 , C07C323/25 , C07C323/60 , C07C323/62 , C07C335/22 , C07D207/12 , C07D207/14 , C07D207/16 , C07D239/38 , C07D239/42 , C07D295/185 , C07C233/47 , A61K31/198 , A61K31/40 , C07C233/63 , C07C233/81
CPC分类号： C07D239/42 , C07C235/74 , C07C275/42 , C07C311/08 , C07C311/10 , C07C311/13 , C07C311/16 , C07C311/21 , C07C311/29 , C07C311/44 , C07C317/44 , C07C323/25 , C07C323/60 , C07C323/62 , C07C335/22 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/08 , C07C2602/42 , C07D207/12 , C07D207/14 , C07D207/16 , C07D239/38 , C07D295/185
摘要： Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α 4 integrin. They are used as therapeutic agents for various diseases concerning α 4 integrin.
摘要翻译：指定的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗作用。它们被用作关于α4整联蛋白的各种疾病的治疗剂。

3. 发明申请

US20050070485A1 Phenylalanine derivatives 失效
标题翻译：苯丙氨酸衍生物
公开(公告)号：US20050070485A1
公开(公告)日：2005-03-31
申请号：US10986829
申请日：2004-11-15
申请人： Yasuhiro Tanaka , Toshihiko Yoshimura , Hiroyuki Izawa , Chieko Ejima , Mitsuhiko Kojima , Yuko Satake , Eiji Nakanishi , Nobuyasu Suzuki , Shingo Makino , Manabu Suzuki , Masahiro Murata
发明人： Yasuhiro Tanaka , Toshihiko Yoshimura , Hiroyuki Izawa , Chieko Ejima , Mitsuhiko Kojima , Yuko Satake , Eiji Nakanishi , Nobuyasu Suzuki , Shingo Makino , Manabu Suzuki , Masahiro Murata
IPC分类号： A61P1/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/06 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07C235/74 , C07C275/42 , C07C311/08 , C07C311/10 , C07C311/13 , C07C311/16 , C07C311/21 , C07C311/29 , C07C311/44 , C07C317/44 , C07C323/25 , C07C323/60 , C07C323/62 , C07C335/22 , C07D207/12 , C07D207/14 , C07D207/16 , C07D239/38 , C07D239/42 , C07D295/185 , A61K38/04
CPC分类号： C07D239/42 , C07C235/74 , C07C275/42 , C07C311/08 , C07C311/10 , C07C311/13 , C07C311/16 , C07C311/21 , C07C311/29 , C07C311/44 , C07C317/44 , C07C323/25 , C07C323/60 , C07C323/62 , C07C335/22 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/08 , C07C2602/42 , C07D207/12 , C07D207/14 , C07D207/16 , C07D239/38 , C07D295/185
摘要： Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
摘要翻译：指定的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗作用。它们被用作关于α4整联蛋白的各种疾病的治疗剂。

4. 发明授权

US06610710B2 Phenylalanine derivatives 失效
标题翻译：苯丙氨酸衍生物
公开(公告)号：US06610710B2
公开(公告)日：2003-08-26
申请号：US10183729
申请日：2002-06-28
申请人： Yasuhiro Tanaka , Toshihiko Yoshimura , Chieko Ejima , Mitsuhiko Kojima , Eiji Nakanishi , Hiroyuki Izawa , Yuko Satake , Nobuyasu Suzuki , Manabu Suzuki , Masahiro Murata
发明人： Yasuhiro Tanaka , Toshihiko Yoshimura , Chieko Ejima , Mitsuhiko Kojima , Eiji Nakanishi , Hiroyuki Izawa , Yuko Satake , Nobuyasu Suzuki , Manabu Suzuki , Masahiro Murata
IPC分类号： A01N4340
CPC分类号： C07D295/185 , C07C233/63 , C07C243/36 , C07C311/21 , C07C311/46 , C07C323/40 , C07C2601/14 , C07D205/04 , C07D207/12 , C07D207/14 , C07D211/46 , C07D211/58 , C07D211/62 , C07D217/06 , C07D233/52 , C07D239/38 , C07D285/06 , C07D295/32
摘要： Phenylalanine derivatives of the following formula and analogues thereof have an antagonistic activity to &agr;4&bgr;7 integrin and a selectivity toward &agr;4&bgr;1 integrin. They are used as therapeutic agents for various diseases to which &agr;4&bgr;7 integrin relates.
摘要翻译：下式的苯丙氨酸衍生物及其类似物对α4β7整联蛋白具有拮抗作用和对α4β1整联蛋白的选择性。它们被用作α4β7整联蛋白涉及的各种疾病的治疗剂。

5. 发明授权

US07902179B2 Heterocyclic compounds 有权
标题翻译：杂环化合物
公开(公告)号：US07902179B2
公开(公告)日：2011-03-08
申请号：US10475097
申请日：2002-04-26
申请人： Yasuhiro Tanaka , Kohichi Fujita , Yoshitomo Chujoh , Syunsuke Fukuda , Yuka Ikenoue , Tomoyuki Tagami , Akira Chiba , Ariko Kodaira , Hideki Matsumoto , Tadakiyo Nakagawa , Tatsuhiro Yamada , Manabu Suzuki , Masahiro Murata
发明人： Yasuhiro Tanaka , Kohichi Fujita , Yoshitomo Chujoh , Syunsuke Fukuda , Yuka Ikenoue , Tomoyuki Tagami , Akira Chiba , Ariko Kodaira , Hideki Matsumoto , Tadakiyo Nakagawa , Tatsuhiro Yamada , Manabu Suzuki , Masahiro Murata
IPC分类号： A61K31/44
CPC分类号： C07D471/04 , A61K31/437 , Y02A50/411
摘要： A pharmaceutical composition containing a heterocyclic compound of the formula (I) wherein each symbol is as defined in the specification, an isomer thereof, a solvate thereof or a pharmaceutically acceptable salt thereof as an active ingredient has a superior TNF-α production suppressing action. Accordingly, it is useful for the prophylaxis or treatment of various diseases caused by abnormal production of TNF-α.
摘要翻译：含有式（I）的杂环化合物的药物组合物，其中每个符号如说明书中所定义，其异构体，其溶剂化物或其药学上可接受的盐作为活性成分具有优异的TNF-α产生抑制作用。因此，可以预防或治疗由TNF-α异常产生引起的各种疾病。

6. 发明授权

US07279484B2 Heterocyclic compounds 失效
标题翻译：杂环化合物
公开(公告)号：US07279484B2
公开(公告)日：2007-10-09
申请号：US11116310
申请日：2005-04-28
申请人： Tatsuhiro Yamada , Tadakiyo Nakagawa , Yasuhiro Tanaka , Kohichi Fujita , Tomoyuki Tagami , Yuka Ikenoue , Shunsuke Fukuda , Yoshitomo Chujo , Manabu Suzuki , Masahiro Murata
发明人： Tatsuhiro Yamada , Tadakiyo Nakagawa , Yasuhiro Tanaka , Kohichi Fujita , Tomoyuki Tagami , Yuka Ikenoue , Shunsuke Fukuda , Yoshitomo Chujo , Manabu Suzuki , Masahiro Murata
IPC分类号： A61K31/519 , C07D471/04 , C07D471/14 , A61P1/04 , A61P19/02
CPC分类号： C07D471/04 , A61K31/519
摘要： The inventive subject matter relates to compounds, pharmaceutical compositions, and kits containing a heterocyclic compound represented by the formula (I) wherein R is an alkyl group optionally having substituent(s) etc., X is an amino group optionally having substituent(s), Y1 and Y2 are nitrogen atoms etc., an isomer or solvate thereof or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：本发明涉及包含式（I）表示的杂环化合物的化合物，药物组合物和试剂盒，其中R是任选具有取代基的烷基等。X是任选具有取代基的氨基， Y 1和Y 2是氮原子等，其异构体或溶剂合物或其药学上可接受的盐作为活性成分。

7. 发明申请

US20050250796A1 Heterocyclic compounds 失效
标题翻译：杂环化合物
公开(公告)号：US20050250796A1
公开(公告)日：2005-11-10
申请号：US11116310
申请日：2005-04-28
申请人： Tatsuhiro Yamada , Tadakiyo Nakagawa , Yasuhiro Tanaka , Kohichi Fujita , Tomoyuki Tagami , Yuka Ikenoue , Shunsuke Fukuda , Yoshitomo Chujo , Manabu Suzuki , Masahiro Murata
发明人： Tatsuhiro Yamada , Tadakiyo Nakagawa , Yasuhiro Tanaka , Kohichi Fujita , Tomoyuki Tagami , Yuka Ikenoue , Shunsuke Fukuda , Yoshitomo Chujo , Manabu Suzuki , Masahiro Murata
IPC分类号： A61K31/519 , A61P1/00 , A61P1/04 , A61P29/00 , A61P31/04 , A61P37/02 , A61P37/06 , A61P43/00 , C07D471/04 , C07D471/02 , A61K31/4745
CPC分类号： C07D471/04 , A61K31/519
摘要： The inventive subject matter relates to compounds, pharmaceutical compositions, and kits containing a heterocyclic compound represented by the formula (I) wherein R is an alkyl group optionally having substituent(s) etc., X is an amino group optionally having substituent(s), Y1 and Y2 are nitrogen atoms etc., an isomer or solvate thereof or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：本发明涉及包含式（I）表示的杂环化合物的化合物，药物组合物和试剂盒，其中R是任选具有取代基的烷基等。X是任选具有取代基的氨基， Y 1和Y 2是氮原子等，其异构体或溶剂合物或其药学上可接受的盐作为活性成分。

8. 发明授权

US06620916B1 Modified physiologically active proteins and medicinal compositions containing the same 失效
标题翻译：改良的生理活性蛋白质和含有其的药物组合物
公开(公告)号：US06620916B1
公开(公告)日：2003-09-16
申请号：US09068987
申请日：1998-09-25
申请人： Yoshiyuki Takahara , Haruya Sato , Eiko Hayashi , Masanobu Yatagai , Manabu Suzuki , Tomoyuki Tabata , Chieko Ejima
发明人： Yoshiyuki Takahara , Haruya Sato , Eiko Hayashi , Masanobu Yatagai , Manabu Suzuki , Tomoyuki Tabata , Chieko Ejima
IPC分类号： C07K1452
CPC分类号： C07H15/08 , A61K38/00 , C07H15/04 , C07K14/00 , C07K14/52 , C07K14/55 , C07K14/56
摘要： The present invention relates to a modified physiologically active protein, modified physiologically active proteins produced by the process and pharmaceutical compositions containing the same.
摘要翻译：本发明涉及一种修饰的生理活性蛋白质，通过该方法产生的修饰的生理活性蛋白质和含有它们的药物组合物。

9. 发明授权

US08409775B2 Crosslinked resin particle dispersion liquid 有权
标题翻译：交联树脂颗粒分散液
公开(公告)号：US08409775B2
公开(公告)日：2013-04-02
申请号：US12676531
申请日：2008-09-05
申请人： Manabu Suzuki , Yutaka Murai
发明人： Manabu Suzuki , Yutaka Murai
IPC分类号： G03G9/08
CPC分类号： C08J3/246 , C08J3/05 , C08J2367/06 , G03G9/0804 , G03G9/0806 , G03G9/08793 , G03G9/08795 , G03G9/08797 , G03G9/09314 , G03G9/0935 , G03G9/09357 , G03G9/09371 , G03G9/09392
摘要： The present invention relates to a toner for electrophotography which has a small particle size and is excellent in all of low-temperature fusing ability, anti-hot offset property and image characteristics and a process for producing the toner, as well as to a dispersion of crosslinked resin particles which is used for production of the toner for electrophotography and a process for producing the dispersion of crosslinked resin particles. The dispersion of crosslinked resin particles having a volume median particle size (D50) of from 0.05 to 0.7 μm according to the present invention is produced by a process including the steps of (A) neutralizing a resin containing an acid group-containing polyester in an aqueous medium to obtain a dispersion of resin particles; and (B) mixing the dispersion of resin particles obtained in the step (A) with an oxazoline group-containing polymer at a temperature of from 60 to 100° C.
摘要翻译：本发明涉及一种电子照相用调色剂，其具有小的粒径，并且全部具有优异的低温熔合性，抗热粘合性和图像特性以及调色剂的制备方法以及分散体用于电子照相用调色剂的交联树脂颗粒和交联树脂颗粒分散体的制备方法。根据本发明的体积中值粒径（D50）为0.05〜0.7μm的交联树脂颗粒的分散体是通过包括以下步骤的方法生产的：（A）将包含含酸基的聚酯的树脂中和水性介质，得到树脂颗粒的分散体; 和（B）将步骤（A）中获得的树脂颗粒的分散体与含恶唑啉基的聚合物在60至100℃的温度下混合。

10. 发明授权

US08257574B2 Plating method 失效
标题翻译：电镀方法
公开(公告)号：US08257574B2
公开(公告)日：2012-09-04
申请号：US12398818
申请日：2009-03-05
申请人： Hitoshi Muramatsu , Seiya Kunioka , Nobuyuki Suzuki , Akira Ishibashi , Minoru Imai , Manabu Suzuki , Masahiro Ogawa
发明人： Hitoshi Muramatsu , Seiya Kunioka , Nobuyuki Suzuki , Akira Ishibashi , Minoru Imai , Manabu Suzuki , Masahiro Ogawa
IPC分类号： C25D5/02
CPC分类号： C25D7/04 , C25D17/004
摘要： A plating method for pre-plating or plating a cylinder inner peripheral surface to be treated of a cylinder block by introducing treatment liquid to the cylinder inner peripheral surface by using a plating apparatus provided with a sealing jig having a sealing member and an electrode to which the seal jig is mounted includes the steps, which are performed successively: sealing the cylinder inner peripheral surface by bringing the sealing jig into contact with the cylinder inner peripheral surface; introducing the treatment liquid to the cylinder inner peripheral surface; and treating the cylinder inner peripheral surface by applying predetermined charge to the electrode of the plating apparatus and the cylinder block to thereby perform pre-plating or plating process in a state that a liquid to be treated fills a space including the cylinder inner peripheral surface. In the method, the treatment liquid introducing step is performed after confirmation of sealing by the sealing step.
摘要翻译：一种电镀方法，用于通过使用具有密封构件和电极的电镀装置将处理液引入到缸体内周面来对汽缸体进行处理的汽缸内周面进行电镀或电镀，安装密封夹具包括依次执行的步骤：通过使密封夹具与气缸内周面接触来密封气缸内周面; 将处理液引入气缸内周面; 以及通过向镀覆设备和气缸体的电极施加预定的电荷来处理气缸内周面，从而在待处理的液体填充包括气缸内周面的空间的状态下进行预镀或电镀处理。在该方法中，在通过密封步骤确认密封之后进行处理液引入步骤。

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