专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06803451B2 Cytokine receptor zalpha11 polypeptides 有权
标题翻译：细胞因子受体zalpha11多肽
公开(公告)号：US06803451B2
公开(公告)日：2004-10-12
申请号：US10243072
申请日：2002-09-13
申请人： Scott R. Presnell , Darrell C. Conklin , Julia E. Novak , Angela K. Hammond
发明人： Scott R. Presnell , Darrell C. Conklin , Julia E. Novak , Angela K. Hammond
IPC分类号： C07K1452
CPC分类号： C07K14/715
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译：公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zalpha11，一种新的细胞因子受体。多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。配体结合受体多肽也可用于在体外和体内阻断配体活性。编码zalpha11的多核苷酸位于染色体16上，可用于鉴定与人类疾病状态相关的基因组区域。本发明还包括生产蛋白质的方法，用途及其抗体。

2. 发明授权

US06610285B1 Cytokine-like proteins that promote cell proliferation 有权
标题翻译：促进细胞增殖的细胞因子样蛋白
公开(公告)号：US06610285B1
公开(公告)日：2003-08-26
申请号：US09687637
申请日：2000-10-13
申请人： Yuichi Hirata
发明人： Yuichi Hirata
IPC分类号： C07K1452
CPC分类号： C07K14/54 , A01K2217/05 , A61K38/00 , C07K14/52
摘要： A full-length cDNA corresponding to an EST (AA418955), which does not show any homology to other proteins in the database but has a weak homology to G-CSF, has been successfully isolated by synthesizing primers based on the EST sequence, and effecting PCR-cloning from a human fetal spleen library. Sequencing of the thus-isolated cDNA and analysis of its structure revealed that the cDNA has typical characteristics of a factor belonging to the IL-6/G-CSF/MGF family. It is also found out that the culture supernatant of said sequence-transfected CHO cells shows a proliferation supporting activity towards bone marrow cells in the coexistence of kit ligand.
摘要翻译：已经通过基于EST序列的合成引物成功地分离了对应于EST（AA418955）的全长cDNA，其不与数据库中的其它蛋白质显示任何同源性，但与G-CSF具有弱同源性，并且通过来自人胎儿脾脏文库的PCR克隆。这样分离的cDNA的测序及其结构的分析显示cDNA具有属于IL-6 / G-CSF / MGF家族的因子的典型特征。还发现所述序列转染的CHO细胞的培养上清液在试剂盒配体的共存下显示对骨髓细胞的增殖支持活性。

3. 发明授权

US06359117B1 Isolated nucleic acid molecules which encode T cell inducible factors (TIFs), the proteins encoded, and uses therefor 失效
标题翻译：编码T细胞诱导因子（TIFs）的分离的核酸分子，编码的蛋白质及其用途
公开(公告)号：US06359117B1
公开(公告)日：2002-03-19
申请号：US09354243
申请日：1999-07-16
申请人： Laure Dumoutier , Jamila Louhed , Jean-Christophe Renauld
发明人： Laure Dumoutier , Jamila Louhed , Jean-Christophe Renauld
IPC分类号： C07K1452
CPC分类号： C07K14/52
摘要： The invention involves isolation of nucleic acid molecules, the expression of which are upregulated by interleukin-9. The amino acid sequences of the proteins which correspond to the nucleic acid molecules show some structural features of cytokines. In addition to the nucleic acid molecules and the proteins, various uses of the molecules are disclosed. The molecules are referred to as T cell inducible factors.
摘要翻译：本发明涉及分离核酸分子，其表达被白介素-9上调。对应于核酸分子的蛋白质的氨基酸序列显示细胞因子的一些结构特征。除了核酸分子和蛋白质之外，还公开了分子的各种用途。这些分子被称为T细胞诱导因子。

4. 发明授权

US06780973B1 Eotaxin: an eosinophil chemoattractant 失效
标题翻译：嗜酸性粒细胞趋化因子：嗜酸性粒细胞趋化因子
公开(公告)号：US06780973B1
公开(公告)日：2004-08-24
申请号：US09517204
申请日：2000-03-02
申请人： Andrew D. Luster , Philip Leder , Marc Rothenberg , Eduardo Garcia
发明人： Andrew D. Luster , Philip Leder , Marc Rothenberg , Eduardo Garcia
IPC分类号： C07K1452
CPC分类号： C07K14/523 , A61K38/00
摘要： Disclosed is substantially pure eotaxin DNA sequence and eotaxin polypeptide, and methods of using such DNA and polypeptide to direct chemotaxis of eosinophils. Methods are provided for the treatment diseases and disorders such as inflammation and tumorigenesis.
摘要翻译：公开了基本上纯的嗜酸性粒细胞趋化嗜热性嗜酸细胞活化趋化因子DNA序列和嗜酸细胞活化趋化因子多肽，以及使用这种DNA和多肽来指导嗜酸性粒细胞趋化性的方法。提供了治疗诸如炎症和肿瘤发生的疾病和病症的方法。

5. 发明授权

US06605702B2 Chemotactic cytokine 有权
标题翻译：趋化性细胞因子
公开(公告)号：US06605702B2
公开(公告)日：2003-08-12
申请号：US09195457
申请日：1998-11-18
申请人： Timothy J. Williams , Peter J. Jose , David A. Griffiths-Johnson , John J. Hsuan
发明人： Timothy J. Williams , Peter J. Jose , David A. Griffiths-Johnson , John J. Hsuan
IPC分类号： C07K1452
CPC分类号： G01N33/6863 , C07K14/523 , G01N2333/715 , G01N2800/122 , G01N2800/24 , Y10S514/885
摘要： A chemoattractant protein called “eotaxin” is capable of attracting eosinophils and of inducing eosinophil accumulation and/or activation in vitro and in vivo. Various types of agents that inhibit or otherwise hinder the production, release or activity of eotaxin may be used therapeutically in the treatment of asthma and other inflammatory diseases.
摘要翻译：称为“嗜酸细胞活化趋化因子”的化学引诱物蛋白质能够吸引嗜酸性粒细胞并在体外和体内诱导嗜酸性粒细胞积累和/或激活。抑制或以其它方式阻碍嗜酸细胞活化趋化因子的产生，释放或活性的各种试剂可用于治疗哮喘和其它炎性疾病。

6. 发明授权

US06271349B1 Receptor activator of NF-&kgr;B 有权
标题翻译： NF-κB受体激活剂
公开(公告)号：US06271349B1
公开(公告)日：2001-08-07
申请号：US09215649
申请日：1998-12-17
申请人： William C. Dougall , Laurent Galibert
发明人： William C. Dougall , Laurent Galibert
IPC分类号： C07K1452
CPC分类号： C07K14/52 , A61K38/00 , C07K14/70575 , C07K2319/00 , C07K2319/02
摘要： Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.
摘要翻译：公开了分离的受体，编码这些受体的DNA和由其制备的药物组合物。分离的受体可用于调节免疫应答。受体也可用于筛选其抑制剂。

7. 发明授权

US06261548B1 Leukaemia inhibitory factor 失效
标题翻译：白血病抑制因子
公开(公告)号：US06261548B1
公开(公告)日：2001-07-17
申请号：US08839909
申请日：1997-04-21
申请人： David Paul Gearing , Nicholas Martin Gough , Douglas James Hilton , Julie Ann King , Donald Metcalf , Edouard Collins Nice , Nicos Anthony Nicola , Richard John Simpson , Tracy Ann Willson
发明人： David Paul Gearing , Nicholas Martin Gough , Douglas James Hilton , Julie Ann King , Donald Metcalf , Edouard Collins Nice , Nicos Anthony Nicola , Richard John Simpson , Tracy Ann Willson
IPC分类号： C07K1452
CPC分类号： C12N15/86 , A61K38/00 , C07K14/5415 , C07K2319/00 , C07K2319/02 , C07K2319/23 , C07K2319/50 , C07K2319/74 , C07K2319/95 , C12N15/81 , C12N2740/13043 , C12P21/02 , C12P21/06
摘要： The present invention provides isolated DNA molecules encoding human and murine LIF and methods of producing LIF by the expression of the isolated DNA and suitable host cells. The invention further provides human and murine LIF polypeptides, pharmaceutical compositions containing LIF, and methods of use thereof.
摘要翻译：本发明提供编码人和鼠LIF的分离的DNA分子和通过分离的DNA和合适的宿主细胞的表达产生LIF的方法。本发明还提供人和鼠LIF多肽，含有LIF的药物组合物及其使用方法。

8. 发明授权

US06174995B1 Human chemokines, CK&bgr;4 and CK&bgr;10/MCP-4 失效
标题翻译：人类趋化因子，CKbeta4和CKbeta10 / MCP-4
公开(公告)号：US06174995B1
公开(公告)日：2001-01-16
申请号：US08613822
申请日：1996-02-23
申请人： Haodong Li , Mark Adams , Solange Hanschke Lima , Ralph Alderson , Yuling Li , David Parmelee , John White , Edward Applebaum
发明人： Haodong Li , Mark Adams , Solange Hanschke Lima , Ralph Alderson , Yuling Li , David Parmelee , John White , Edward Applebaum
IPC分类号： C07K1452
CPC分类号： C07K14/52 , C07K14/523 , Y10S930/14
摘要： Human chemokine polypeptides and DNA/(RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.
摘要翻译：公开了人类趋化因子多肽和编码这种趋化因子多肽的DNA /（RNA）和通过重组技术产生此类多肽的方法。还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。

9. 发明授权

US06790439B1 Thrombopoietin compositions 失效
标题翻译：血小板生成素组成
公开(公告)号：US06790439B1
公开(公告)日：2004-09-14
申请号：US08486451
申请日：1995-06-07
申请人： Richard I. Senderoff , Kathleen M. Kontor
发明人： Richard I. Senderoff , Kathleen M. Kontor
IPC分类号： C07K1452
CPC分类号： A61K9/19 , A61K9/0019 , A61K31/198 , A61K38/196 , A61K47/16 , A61K47/26 , A61K47/42 , A61K2300/00
摘要： Compositions of thrombopoietin, methods of reducing adsorption of thrombopoietin to a surface, and methods of stabilizing a composition of thrombopoietin are disclosed. The compositions comprise, in addition to thrombopoietin, a physiologically acceptable buffer, a surface adsorption inhibitor selected from the group consisting of non-ionic surfactants and polyols, and an isotonic amount of a physiologically acceptable salt.
摘要翻译：公开了血小板生成素的组合物，减少血小板生成素吸附到表面的方法，以及稳定血小板生成素组合物的方法。组合物除了血小板生成素外还包含生理上可接受的缓冲液，选自非离子表面活性剂和多元醇的表面吸附抑制剂和等渗量的生理上可接受的盐。

10. 发明授权

US06632424B1 Human FLTS3 ligand 失效
标题翻译：人FLTS3配体
公开(公告)号：US06632424B1
公开(公告)日：2003-10-14
申请号：US08444626
申请日：1995-05-19
申请人： Stewart D. Lyman , Patricia M. Beckmann
发明人： Stewart D. Lyman , Patricia M. Beckmann
IPC分类号： C07K1452
CPC分类号： C12N5/0647 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/025 , A01K2267/03 , A01K2267/0331 , A01K2267/0381 , A61K38/00 , A61K38/193 , A61K38/202 , A61K38/2046 , A61K48/00 , C07K14/475 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/50 , C07K2319/75 , C12N15/8509 , C12N2501/22 , C12N2501/23 , C12N2501/26 , C12N2510/00 , A61K2300/00
摘要： Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is directed to flt3-L as an isolated protein, the DNA encoding the flt3-L, host cells transfected with cDNAs encoding flt3-L, compositions comprising flt3-L, methods of improving gene transfer to a mammal using flt3-L, and methods of improving transplantations using flt3-L. Flt3 -L finds use in treating patients with anemia, AIDS and various cancers.
摘要翻译：公开了能够转导自我更新信号以调节祖细胞和干细胞的生长，增殖或分化的flt3受体的配体。本发明涉及作为分离蛋白质的flt3-L，编码flt3-L的DNA，编码flt3-L的cDNA转染的宿主细胞，包含flt3-L的组合物，使用flt3-L改善哺乳动物的基因转移的方法，以及使用flt3-L改善移植的方法。 Flt3 -L可用于治疗贫血，艾滋病和各种癌症患者

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式