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1. 发明申请

US20050119266A1 Pyrrolidine and piperidine derivatives as factor Xa inhibitors 审中-公开
标题翻译：吡咯烷和哌啶衍生物作为因子Xa抑制剂
公开(公告)号：US20050119266A1
公开(公告)日：2005-06-02
申请号：US10952204
申请日：2004-09-28
申请人： Yan Shi , Philip Stein , Wei Han , Timur Gungor
发明人： Yan Shi , Philip Stein , Wei Han , Timur Gungor
IPC分类号： A61K20060101 , A61K31/40 , A61K31/404 , A61K31/41 , A61K31/421 , A61K31/44 , A61K31/4427 , A61K31/454 , A61K31/498 , A61K31/502 , A61K31/517 , C07D401/14 , C07D43/02
CPC分类号： C07D401/14 , C07D401/06 , C07D409/14 , C07D417/14
摘要： The present application describes pyrrolidine and piperidine derivatives or pharmaceutically acceptable salt forms thereof. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
摘要翻译：本申请描述了吡咯烷和哌啶衍生物或其药学上可接受的盐形式。本发明的化合物可用作胰蛋白酶样丝氨酸蛋白酶的抑制剂，特别是因子Xa。

2. 发明申请

US20050171140A1 HMG-CoA reductase inhibitors and method 有权
标题翻译： HMG-CoA还原酶抑制剂及方法
公开(公告)号：US20050171140A1
公开(公告)日：2005-08-04
申请号：US10989138
申请日：2004-11-15
申请人： Stephen O'Connor , Jeffrey Robl , Saleem Ahmad , Sharon Bisaha , Natesan Murugesan , Khehyong Ngu , Yan Shi , Philip Stein , Nachimuthu Soundararajan , Kenneth Natalie , Laxma Kolla , Justin Sausker , Sandra Quinlan , Junying Fan , Dejah Petsch , Zhenrong Guo
发明人： Stephen O'Connor , Jeffrey Robl , Saleem Ahmad , Sharon Bisaha , Natesan Murugesan , Khehyong Ngu , Yan Shi , Philip Stein , Nachimuthu Soundararajan , Kenneth Natalie , Laxma Kolla , Justin Sausker , Sandra Quinlan , Junying Fan , Dejah Petsch , Zhenrong Guo
IPC分类号： A61K31/435 , A61K31/4745 , A61K31/505 , C07D211/76 , C07D213/80 , C07D401/14 , C07D471/02 , C07D471/04 , C07D491/04 , C07D498/04 , C07D513/04
CPC分类号： C07D213/80 , C07D211/76 , C07D401/14 , C07D471/04 , C07D491/04 , C07D498/04 , C07D513/04
摘要： Compounds are provided having the following structure and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, U, V, W, Y, and n are as defined above, which compounds are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids, for example, lowering LDL cholesterol and/or increasing HDL cholesterol, and treating hyperlipidemia, dyslipidemia, hypercholesterolemia, hypertriglyceridemia and atherosclerosis as well as Alzheimer's disease and osteoporosis and may be employed as hormone replacement therapy. A method for treating the above diseases employing the above compounds is also provided.
摘要翻译：提供具有以下结构的化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，其中U，V，W，Y和n如上所定义，这些化合物是HMG CoA还原酶抑制剂，因此具有抑制胆固醇生物合成，调节血清脂质的作用，例如降低LDL胆固醇和/或增加 HDL胆固醇，治疗高脂血症，血脂异常，高胆固醇血症，高甘油三酯血症和动脉粥样硬化以及阿尔茨海默病和骨质疏松症，可用作激素替代疗法。还提供了使用上述化合物治疗上述疾病的方法。

3. 发明授权

US10368843B2 Ultrasonic shear wave imaging with focused scanline beamforming 有权
公开(公告)号：US10368843B2
公开(公告)日：2019-08-06
申请号：US13511307
申请日：2010-11-15
申请人： Roy Beck Peterson , Yan Shi , Hua Xie , Jean-Luc Robert , Vijay Shamdasani , Robert Randall Entrekin , Anna Teresa Ferandez
发明人： Roy Beck Peterson , Yan Shi , Hua Xie , Jean-Luc Robert , Vijay Shamdasani , Robert Randall Entrekin , Anna Teresa Ferandez
IPC分类号： A61B5/00 , A61B8/00 , A61B8/08 , A61B8/14 , G01S7/52 , G01S15/89
摘要： An ultrasonic diagnostic imaging system produces an image of shear wave velocities by transmitting push pulses to generate shear waves. A plurality of tracking lines are transmitted and echoes received by a focusing beamformer adjacent to the location of the push pulses. The tracking lines are sampled in a time-interleaved manner. The echo data acquired along each tracking line is processed to determine the time of peak tissue displacement caused by the shear waves at points along the tracking line, and the times of peaks at adjacent tracking lines compared to compute a local shear wave velocity. The resultant map of shear wave velocity values is color-coded and displayed over an anatomical image of the region of interest.

4. 发明授权

US09901321B2 Monitoring apparatus for monitoring an ablation procedure 有权
公开(公告)号：US09901321B2
公开(公告)日：2018-02-27
申请号：US13142299
申请日：2010-01-08
申请人： Erik Harks , Szabolcs Deladi , Jan Frederik Suijver , Ladislav Jankovic , Yan Shi , Wouter Harry Jacinth Rensen , Maya Barley , Nijs Cornelis Van Der Vaart
发明人： Erik Harks , Szabolcs Deladi , Jan Frederik Suijver , Ladislav Jankovic , Yan Shi , Wouter Harry Jacinth Rensen , Maya Barley , Nijs Cornelis Van Der Vaart
IPC分类号： A61B8/08 , A61B8/12 , A61B18/02 , A61B18/14 , A61B18/18 , A61B18/20 , A61B17/00 , A61B18/00 , A61B8/00 , A61B90/00
CPC分类号： A61B8/0858 , A61B8/12 , A61B8/445 , A61B8/486 , A61B18/02 , A61B18/1442 , A61B18/1492 , A61B18/18 , A61B18/20 , A61B2017/00106 , A61B2018/00577 , A61B2018/00738 , A61B2090/376 , A61B2090/3784 , A61B2218/002
摘要： The present invention relates to a monitoring apparatus (101) for monitoring an ablation procedure. The monitoring apparatus (101) comprises an ultrasound signal providing unit for providing an ultrasound signal that depends on received echo series of an object (4) that is ablated. The monitoring apparatus (101) further comprises an ablation depth determination unit (103) for determining an ablation depth from the provided ultrasound signal. The ablation depth can be determined directly from the ultrasound signal and is an important parameter while performing an ablation procedure. For example, it can be used for determining the progress of ablation within the object (4) and for determining when the ablation has reached a desired progression.

5. 发明申请

US20130317362A1 SHEAR WAVE VELOCITY ESTIMATION USING CENTER OF MASS 审中-公开
标题翻译：使用质量中心的剪切波速度估计
公开(公告)号：US20130317362A1
公开(公告)日：2013-11-28
申请号：US13995522
申请日：2011-12-19
申请人： Yan Shi , Hua Xie , Roy Peterson , Jean-Luc Robert , Vijay Shamdasani
发明人： Yan Shi , Hua Xie , Roy Peterson , Jean-Luc Robert , Vijay Shamdasani
IPC分类号： A61B8/08 , A61B8/00
CPC分类号： A61B8/5207 , A61B5/0051 , A61B5/055 , A61B5/4244 , A61B5/7235 , A61B8/4483 , A61B8/485 , A61B2562/0204
摘要： The weighted-average-based position (244) in the temporal domain is computed based on the sampling of shear wave displacement (226) along the propagation path. The weighting is, for example, by displacement observed at times (230) corresponding to sampling and represents the time of arrival of the shear wave at the shear-wave propagation path location being sampled. In some embodiments, the computed shear-wave times of arrival at respective locations are functionally related to known inter-location distances (250) to derive shear-wave group velocity. The derived velocity can serve as input into known algorithms for estimating shear elasticity of the medium, such as body tissue, for purposes of clinical diagnosis and therapy assessment.
摘要翻译：基于沿着传播路径的剪切波位移（226）的采样来计算时域中的基于加权平均的位置（244）。加权是例如通过对应于采样的时间（230）观察到的位移，并且表示剪切波在被采样的剪切波传播路径位置处的到达时间。在一些实施例中，到达相应位置的计算的剪切波时间在功能上与已知位置间距（250）有关，以导出剪切波群速度。为了临床诊断和治疗评估的目的，导出的速度可以用作用于估计介质（例如身体组织）的剪切弹性的已知算法的输入。

6. 发明申请

US20100324071A1 NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME 有权
标题翻译：新型GLUCOKINASE激活剂及其使用方法
公开(公告)号：US20100324071A1
公开(公告)日：2010-12-23
申请号：US12871226
申请日：2010-08-30
申请人： Yan Shi , Peter T. W. Cheng , Ying Wang , Denis E. Ryono
发明人： Yan Shi , Peter T. W. Cheng , Ying Wang , Denis E. Ryono
IPC分类号： A61K31/428 , C07D277/56 , C07D213/81 , C07D241/24 , C07D231/14 , C07D277/68 , C07D233/90 , C07D249/10 , A61K31/426 , A61K31/4402 , A61K31/4965 , A61K31/415 , A61K31/4164 , A61K31/4196 , A61P3/10 , A61P9/10 , A61P3/06 , A61P3/04 , A61P9/12 , A61P35/00 , A61P25/28 , A61P19/08 , A61P27/06
CPC分类号： C07D277/56 , C07C317/22 , C07D213/81 , C07D231/14 , C07D233/90 , C07D241/24 , C07D249/10 , C07D277/68 , C07D471/04 , C07D513/04
摘要： Compounds are provided which are activators of the enzyme glucokinase and thus are useful in treating diabetes and related diseases, which compounds have the structure where Q is and R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.
摘要翻译：提供了作为葡糖激酶酶的激活剂的化合物，因此可用于治疗糖尿病和相关疾病，该化合物具有Q为结构，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义或其药学上可接受的盐。还提供了使用上述化合物治疗糖尿病和相关疾病的方法。

7. 发明申请

US20100259832A1 ADJUSTABLE LENS SYSTEM FOR REAL-TIME APPLICATIONS 失效
标题翻译：可调镜头系统实时应用
公开(公告)号：US20100259832A1
公开(公告)日：2010-10-14
申请号：US12742658
申请日：2008-12-10
申请人： Jan Frederik Suijver , Christopher Stephen Hall , Anna Teresa Fernandez , Stein Kuiper , Yan Shi
发明人： Jan Frederik Suijver , Christopher Stephen Hall , Anna Teresa Fernandez , Stein Kuiper , Yan Shi
IPC分类号： G02B3/14
CPC分类号： G02B3/14
摘要： An adjustable fluid type lens system is provided that allows e.g. ultrasound imaging through the lens during adjustment of the lens. The lens includes a container enclosing two immiscible fluids, e.g. water and oil, being in contact with each other at an interface. Incoming waves are then refracted at this interface. The shape of the interface, and thereby the refraction property, is adjustable by adjusting a voltage applied to the lens. The two fluids are selected such that they together exhibit a mechanical damping which is critical or near critical. A control circuit generates the electric voltage for adjusting the refraction from one value to another, the control circuit being arranged to change the electric voltage such that a rate of voltage change is limited to avoid oscillation of the interface, thereby adjusting refraction of incoming waves at the interface in a continuous manner. This makes it possible to use the lens while it is during adjustment from one refraction value to another, since the interface shape will at all time during the adjustment have a controlled shape. The voltage can be either a continuous voltage or a discrete stepwise (digital) voltage which is just controlled with respect to step size and temporal extension of the steps. The lens system has a number of applications e.g. within the medical field, e.g. for ‘on the fly’ high speed ultrasound imaging, or for ultrasound ablation applications where ablation can be performed during adjustment of the lens to follow a pre-defined trajectory.
摘要翻译：提供了一种可调节流体型透镜系统，超声波成像通过透镜在调整镜片期间。透镜包括容纳两个不混溶流体的容器，例如水和油在界面处彼此接触。然后在这个界面折射出来的波。通过调节施加到透镜上的电压来调节界面的形状以及由此的折射特性。选择两种流体使得它们一起显示出关键或近临界的机械阻尼。控制电路产生用于将折射率从一个值调整到另一个值的电压，控制电路被布置成改变电压，使得电压变化率被限制以避免界面的振荡，由此调节入射波的折射界面以连续的方式。这使得可以在从一个折射值到另一个折射值的调整期间使用透镜，因为在调节期间的所有时间的界面形状都具有受控的形状。电压可以是连续电压或离散的逐步（数字）电压，其仅仅相对于步长的步长和时间延长而被控制。透镜系统具有许多应用，例如，在医疗领域内。用于“飞行”高速超声成像，或用于超声消融应用，其中可以在镜片调节期间遵循预定义的轨迹进行消融。

8. 发明授权

US07812048B2 Glucokinase activators and methods of using same 有权
标题翻译：葡糖激酶活化剂及其使用方法
公开(公告)号：US07812048B2
公开(公告)日：2010-10-12
申请号：US12179648
申请日：2008-07-25
申请人： Yan Shi , Peter T. W. Cheng , Ying Wang , Denis E. Ryono
发明人： Yan Shi , Peter T. W. Cheng , Ying Wang , Denis E. Ryono
IPC分类号： C07D233/90 , A61K31/4164
CPC分类号： C07D277/56 , C07C317/22 , C07D213/81 , C07D231/14 , C07D233/90 , C07D241/24 , C07D249/10 , C07D277/68 , C07D471/04 , C07D513/04
摘要： Compounds are provided which are activators of the enzyme glucokinase and thus are useful in treating diabetes and related diseases, which compounds have the structure where Q is and R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.
摘要翻译：提供了作为葡糖激酶酶的激活剂的化合物，因此可用于治疗糖尿病和相关疾病，该化合物具有Q为结构，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义或其药学上可接受的盐。还提供了使用上述化合物治疗糖尿病和相关疾病的方法。

9. 发明授权

US07263285B2 Method, apparatus and system for the automatic provisioning of a network element 失效
标题翻译：用于自动配置网元的方法，装置和系统
公开(公告)号：US07263285B2
公开(公告)日：2007-08-28
申请号：US10447015
申请日：2003-05-28
申请人： Richard Adleman , Peter L. Bartman , Heribert Joseph Blach , Ellen Eng , Narasimhan Raghavan , Yan Shi , Mary Socratous , William A. Thompson
发明人： Richard Adleman , Peter L. Bartman , Heribert Joseph Blach , Ellen Eng , Narasimhan Raghavan , Yan Shi , Mary Socratous , William A. Thompson
IPC分类号： H04B10/08
CPC分类号： H04B10/079
摘要： A method for the automatic provisioning of a network element (NE) includes receiving a client signal at a tunable optical translator (OT) in the NE, determining the set of channels supported by the OT that are able to correspond to the client signal, eliminating the channels that have connections, that may be present on a line side of the NE in a laser off scan process, or that have not been equipped or otherwise provisioned for transmission, tuning the OT to each of the remaining channels and determining the optical power level of each channel on a line side of the NE in a laser on scan process. Subsequently, the channel with the highest power level is selected to transmit the client signal and associations for a point to point connection for that channel are added for that OT to a database of associations for the NE.
摘要翻译：一种用于自动提供网元（NE）的方法包括：在NE中的可调光转换器（OT）处接收客户端信号，确定由OT支持的能够对应于客户信号的信道集，消除具有连接的通道，其可以存在于激光关闭扫描处理中的NE的线路侧，或者尚未配备或以其他方式设置用于传输，将OT调谐到每个剩余通道并确定光功率在激光扫描过程中NE的线路侧的每个通道的电平。随后，选择具有最高功率电平的信道来发送客户端信号，并且将该频道的点对点连接的关联被添加到该OT到与NE的关联的数据库。

10. 发明申请

US20190295011A1 DISTRIBUTED COMPUTER FRAMEWORK FOR DATA ANALYSIS, RISK MANAGEMENT, AND AUTOMATED COMPLIANCE 审中-公开
公开(公告)号：US20190295011A1
公开(公告)日：2019-09-26
申请号：US16358641
申请日：2019-03-19
申请人： Xingjian Duan , Yan Shi
发明人： Yan Shi , Xingjian Duan
IPC分类号： G06Q10/06 , G06F17/50 , G06F16/25 , G06F3/0483
摘要： Introduced here are risk management platforms able to implement an automated framework designed to manage, parse, and analyze data for purposes of facilitating compliance with relevant policies in a distributed computer environment. By implementing the technology described herein, an entity can ensure that it complies with the latest regulatory policies, recognizes emerging risks, and conducts more efficient operational planning. A risk management platform can generate interfaces through which an individual (also referred to as a “user”) can interact with the risk management platform. Through these interfaces, the user can apply programmed models to financial data associated with an entity to predict the performance of the entity under various economic scenarios.

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