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    • 5. 发明授权
    • Methods for determination of haplotype dissection
    • 确定单倍型解剖的方法
    • US08759035B2
    • 2014-06-24
    • US12457697
    • 2009-06-18
    • Qing SongLi MaYan Xiao
    • Qing SongLi MaYan Xiao
    • C12P19/34C12Q1/68
    • C12Q1/6827
    • A method for molecular haplotyping of a subject is disclosed. The method comprises: randomly selecting a set of chromosomes in each of a plurality of lyzed diploid cells of the subject, collecting the selected chromosomes from said plurality of cells into a plurality of sample tubes, wherein each sample tube contains chromosomes selected from one or more cells, genotyping genomic DNA in each sample tube, and determining haplotype of the alleles based on allele nucleotide sequence information and corresponding nucleotide signal intensities from genotyping data. Other methods for molecular haplotyping using single cell lysate or single cell microdissection are also disclosed.
    • 公开了一种受试者的分子单倍型的方法。 该方法包括:在受试者的多个裂解的二倍体细胞的每一个中随机选择一组染色体,将所选择的染色体从所述多个细胞收集到多个样品管中,其中每个样品管含有选自一个或多个 细胞,每个样品管中的基因组DNA的基因分型,以及基于等位基因序列信息和来自基因分型数据的相应核苷酸信号强度确定等位基因的单元型。 还公开了使用单细胞裂解物或单细胞显微切割的分子单倍型的其它方法。
    • 10. 发明申请
    • Methods for determination of haplotype dissection
    • 确定单倍型解剖的方法
    • US20100099092A1
    • 2010-04-22
    • US12457697
    • 2009-06-18
    • Qing SongLi MaYan Xiao
    • Qing SongLi MaYan Xiao
    • C12Q1/68
    • C12Q1/6827
    • A method for molecular haplotyping of a subject is disclosed. The method comprises: randomly selecting a set of chromosomes in each of a plurality of lyzed diploid cells of the subject, collecting the selected chromosomes from said plurality of cells into a plurality of sample tubes, wherein each sample tube contains chromosomes selected from one or more cells, genotyping genomic DNA in each sample tube, and determining haplotype of the alleles based on allele nucleotide sequence information and corresponding nucleotide signal intensities from genotyping data. Other methods for molecular haplotyping using single cell lysate or single cell microdissection are also disclosed.
    • 公开了一种受试者的分子单倍型的方法。 该方法包括:在受试者的多个裂解的二倍体细胞的每一个中随机选择一组染色体,将所选择的染色体从所述多个细胞收集到多个样品管中,其中每个样品管含有选自一个或多个 细胞,每个样品管中的基因组DNA的基因分型,以及基于等位基因序列信息和来自基因分型数据的相应核苷酸信号强度确定等位基因的单元型。 还公开了使用单细胞裂解物或单细胞显微切割的分子单倍型的其它方法。