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1. 发明授权

US08710209B2 Modulation of HSP47 expression 有权
标题翻译：调节HSP47表达
公开(公告)号：US08710209B2
公开(公告)日：2014-04-29
申请号：US12963600
申请日：2010-12-08
申请人： Xiaomei Jin , Lei Yu , Hirokazu Takahashi , Yasunobu Tanaka , Yoshiro Niitsu , Elena Feinstein , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett , Shai Erlich , Elizabeth C. Squiers , Ning Chen
发明人： Xiaomei Jin , Lei Yu , Hirokazu Takahashi , Yasunobu Tanaka , Yoshiro Niitsu , Elena Feinstein , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett , Shai Erlich , Elizabeth C. Squiers , Ning Chen
IPC分类号： C07H21/04
CPC分类号： C12N15/113 , A61K31/713 , C12N2310/11 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/32 , C12N2310/321 , C12N2310/33 , C12N2310/531 , C12N2320/30 , C12N2310/3521
摘要： Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.
摘要翻译：本文提供用于调节靶基因，特别是热休克蛋白47（hsp47）的表达的组合物，方法和试剂盒。组合物，方法和试剂盒可以包括核酸分子（例如，短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）或短发夹RNA（shRNA））），其调节编码hsp47的基因，例如编码人hsp47的基因。本文公开的组合物和方法也可用于治疗与hsp47相关的病症和病症，例如肝纤维化，肺纤维化，腹膜纤维化和肾纤维化。

2. 发明申请

US20110178157A1 MODULATION OF HSP47 EXPRESSION 有权
标题翻译： HSP47表达调控
公开(公告)号：US20110178157A1
公开(公告)日：2011-07-21
申请号：US12963600
申请日：2010-12-08
申请人： Xiaomei Jin , Lei Yu , Hirokazu Takahashi , Yasunobu Tanaka , Yoshiro Niitsu , Elena Feinstein , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett , Shai Erlich , Elizabeth C. Squiers
发明人： Xiaomei Jin , Lei Yu , Hirokazu Takahashi , Yasunobu Tanaka , Yoshiro Niitsu , Elena Feinstein , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett , Shai Erlich , Elizabeth C. Squiers
IPC分类号： A61K31/713 , C07H21/02 , A61P43/00 , C07H21/00
CPC分类号： C12N15/113 , A61K31/713 , C12N2310/11 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/32 , C12N2310/321 , C12N2310/33 , C12N2310/531 , C12N2320/30 , C12N2310/3521
摘要： Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.
摘要翻译：本文提供用于调节靶基因，特别是热休克蛋白47（hsp47）的表达的组合物，方法和试剂盒。组合物，方法和试剂盒可以包括核酸分子（例如，短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）或短发夹RNA（shRNA））），其调节编码hsp47的基因，例如编码人hsp47的基因。本文公开的组合物和方法也可用于治疗与hsp47相关的病症和病症，例如肝纤维化，肺纤维化，腹膜纤维化和肾纤维化。

3. 发明申请

US20130030034A9 MODULATION OF TIMP1 AND TIMP2 EXPRESSION 审中-公开
标题翻译： TIMP1和TIMP2表达的调控
公开(公告)号：US20130030034A9
公开(公告)日：2013-01-31
申请号：US13246621
申请日：2011-09-27
申请人： Yoshiro Niitsu , Hirokazu Takahashi , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett
发明人： Yoshiro Niitsu , Hirokazu Takahashi , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett
IPC分类号： A61K31/7088 , A61P43/00 , C07H21/02
CPC分类号： C12N15/113 , A61K9/0019 , A61K31/713 , C07K14/8146 , C12N2310/14 , C12N2310/3519 , C12N2320/30 , C12N2320/32
摘要： Provided herein are compositions, methods and kits for modulating expression of target genes, particularly of tissue inhibitor of metalloproteinase 1 and of tissue inhibitor of metalloproteinase 2 (TIMP1 and TIMP2, respectively). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding TIMP1 and TIMP2, for example, the gene encoding human TIMP1 and TIMP2. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with TIMP1 and TIMP2 including fibrotic diseases and disorders including liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.
摘要翻译：本文提供用于调节靶基因，特别是金属蛋白酶1的组织抑制剂和金属蛋白酶2的组织抑制剂（分别为TIMP1和TIMP2）的表达的组合物，方法和试剂盒。组合物，方法和试剂盒可以包括核酸分子（例如，短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）或短发夹RNA（shRNA））），其调节编码TIMP1和TIMP2的基因，例如编码人TIMP1和TIMP2的基因。本文公开的组合物和方法也可用于治疗与TIMP1和TIMP2相关的病症和病症，包括纤维化疾病和病症，包括肝纤维化，肺纤维化，腹膜纤维化和肾纤维化。

4. 发明申请

US20120142754A1 MODULATION OF TIMP1 AND TIMP2 EXPRESSION 审中-公开
标题翻译： TIMP1和TIMP2表达的调控
公开(公告)号：US20120142754A1
公开(公告)日：2012-06-07
申请号：US13246621
申请日：2011-09-27
申请人： Yoshiro Niitsu , Hirokazu Takahashi , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett
发明人： Yoshiro Niitsu , Hirokazu Takahashi , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett
IPC分类号： A61K31/7088 , A61P43/00 , C07H21/02
CPC分类号： C12N15/113 , A61K9/0019 , A61K31/713 , C07K14/8146 , C12N2310/14 , C12N2310/3519 , C12N2320/30 , C12N2320/32
摘要： Provided herein are compositions, methods and kits for modulating expression of target genes, particularly of tissue inhibitor of metalloproteinase 1 and of tissue inhibitor of metalloproteinase 2 (TIMP1 and TIMP2, respectively). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding TIMP1 and TIMP2, for example, the gene encoding human TIMP1 and TIMP2. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with TIMP1 and TIMP2 including fibrotic diseases and disorders including liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.
摘要翻译：本文提供用于调节靶基因，特别是金属蛋白酶1的组织抑制剂和金属蛋白酶2的组织抑制剂（分别为TIMP1和TIMP2）的表达的组合物，方法和试剂盒。组合物，方法和试剂盒可以包括核酸分子（例如，短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）或短发夹RNA（shRNA））），其调节编码TIMP1和TIMP2的基因，例如编码人TIMP1和TIMP2的基因。本文公开的组合物和方法也可用于治疗与TIMP1和TIMP2相关的病症和病症，包括纤维化疾病和病症，包括肝纤维化，肺纤维化，腹膜纤维化和肾纤维化。

5. 发明申请

US20130011336A1 IMAGING AGENTS OF FIBROTIC DISEASES 审中-公开
标题翻译：纤维蛋白成像剂
公开(公告)号：US20130011336A1
公开(公告)日：2013-01-10
申请号：US13063193
申请日：2009-09-11
申请人： Yoshiro Niitsu , Lei Yu , Gang Zhao , Sang Van , Xinghe Wang , Jian Liu , Sanjib Kumar Das , Yasunobu Tanaka , Keiko Kajiwara , Hirokazu Takahashi , Miyono Miyazaki
发明人： Yoshiro Niitsu , Lei Yu , Gang Zhao , Sang Van , Xinghe Wang , Jian Liu , Sanjib Kumar Das , Yasunobu Tanaka , Keiko Kajiwara , Hirokazu Takahashi , Miyono Miyazaki
IPC分类号： A61K49/00 , A61K49/04 , A61K49/10 , G01N21/62 , A61K51/06 , A61K49/22 , A61P1/16 , C08G69/48 , C07C403/08 , A61K51/04
CPC分类号： A61K49/085 , A61K49/0002 , A61K49/0041 , A61K49/0052 , A61K49/0054 , A61K49/128 , A61K51/065 , C08G69/10 , C08G69/48
摘要： Agents and methods for imaging a cell and/or a portion of tissue characterized by fibrosis, as well as to agents and methods for determining and/or diagnosing fibrotic diseases are disclosed herein. Also disclosed herein are polymer conjugates that can include a detectable label, a retinoid and a polymer. The polymer conjugates can be used to image a portion of tissue, deliver a detectable label to a portion of tissue or a cell and/or diagnosis a condition or disease.
摘要翻译：本文公开了用于成像细胞和/或特征在于纤维化的组织的一部分以及用于确定和/或诊断纤维化疾病的药剂和方法的药剂和方法。本文还公开了可以包括可检测标记，类视色素和聚合物的聚合物缀合物。聚合物缀合物可用于对组织的一部分进行成像，将可检测标记递送至组织或细胞的一部分和/或诊断病症或疾病。

6. 发明授权

US10342968B2 Electrode pad used for iontophoresis treatment 有权
公开(公告)号：US10342968B2
公开(公告)日：2019-07-09
申请号：US13995720
申请日：2011-12-21
申请人： Akihiro Hasui , Atsuhiko Shiraishi , Ken-ichi Hattori , Shinji Tanaka , Hirokazu Takahashi , Makoto Takahashi
发明人： Akihiro Hasui , Atsuhiko Shiraishi , Ken-ichi Hattori , Shinji Tanaka , Hirokazu Takahashi , Makoto Takahashi
IPC分类号： A61N1/04 , A61N1/32 , A61N1/30 , A61M37/00
摘要： The present invention verifies a method of reducing skin irritation (particularly, cumulative skin irritation) caused by transdermal administration of a local anesthetic using iontophoresis, and provides an electrode pad for relief from a puncture pain which is safe not only at single administration but also at repeated administrations. The electrode pad comprises a base sheet; an electrode placed on the base sheet; an adhesive sheet placed on the base sheet and having an opening, within which the electrode being exposed; and a medicament reservoir containing a local anesthetic and placed in the opening of the adhesive sheet while being in contact with the electrode. An inner peripheral surface of the opening of the adhesive sheet and an outer peripheral surface of the medicament reservoir are prevented from coming into contact with human skin while contacting with each other, and thereby skin irritation is reduced.

7. 发明授权

US09256439B2 Parallel processing of two-dimensional data, storage of plural data of the processing results in a cache line and transfer of the data to a memory as in the cache line 有权
标题翻译：并行处理二维数据，将处理结果的多个数据存储在高速缓存行中，并将数据传送到存储器，如同高速缓存行
公开(公告)号：US09256439B2
公开(公告)日：2016-02-09
申请号：US13443465
申请日：2012-04-10
申请人： Hirokazu Takahashi
发明人： Hirokazu Takahashi
IPC分类号： G06F9/345 , G06F9/38 , G06F12/08 , G06T1/60 , G06F12/02
CPC分类号： G06F9/3885 , G06F9/345 , G06F12/0284 , G06F12/0842 , G06F12/0875 , G06F12/0886 , G06F2212/1016 , G06F2212/455 , G06T1/60
摘要： A data processing apparatus causes multiple processors to process in parallel input data that is arrayed two-dimensionally, and stores the data of the processing results in a cache line of a cache memory, where the data of the processing results includes a plurality of pieces of data of a predetermined width that is smaller than a cache line width of the cache memory. The data stored in the cache memory is then transferred together to a main memory as in the cache line.
摘要翻译：数据处理装置使得多个处理器对二维排列的并行输入数据进行处理，并将处理结果的数据存储在高速缓冲存储器的高速缓存行中，其中处理结果的数据包括多个预定宽度的数据小于高速缓存存储器的高速缓存行宽度。存储在高速缓冲存储器中的数据然后一起传送到主存储器，如在高速缓存线中那样。

8. 发明授权

US08455761B2 Coaxial cable and multicoaxial cable 有权
标题翻译：同轴电缆和多芯电缆
公开(公告)号：US08455761B2
公开(公告)日：2013-06-04
申请号：US12682437
申请日：2009-09-24
申请人： Tatsunori Hayashishita , Hirokazu Takahashi
发明人： Tatsunori Hayashishita , Hirokazu Takahashi
IPC分类号： H01B7/00
CPC分类号： H01B11/1839
摘要： A coaxial cable includes an insulator having void portions continuing in a longitudinal direction, a central conductor covered with the insulator, and an outer conductor arranged on an outer circumference of the insulator. Each of the void portions is formed to have a circular or elliptical cross section, and the void portions are evenly arranged in the insulator in a set of six to nine. In a cross section perpendicular to the longitudinal direction of the coaxial cable, a void ratio of the entire void portions is 43% or more. The void ratio is a proportion of the void portions to a sum of a total area of all the void portions and an area of the insulator.
摘要翻译：同轴电缆包括具有沿纵向连续的空隙部分的绝缘体，被绝缘体覆盖的中心导体以及布置在绝缘体的外圆周上的外导体。每个空隙部分形成为具有圆形或椭圆形横截面，并且空隙部分均匀地布置在六至九组的绝缘体中。在垂直于同轴电缆的纵向的横截面中，空隙部分的空隙率为43％以上。空隙率是空隙部分的比例与所有空隙部分的总面积和绝缘体的面积之和的总和。

9. 发明申请

US20110255136A1 APPARATUS AND METHOD FOR TRANSMITTING DATA IN A MULTI-CHANNEL SYSTEM 有权
标题翻译：用于在多通道系统中发送数据的装置和方法
公开(公告)号：US20110255136A1
公开(公告)日：2011-10-20
申请号：US12761254
申请日：2010-04-15
申请人： Akira Takahashi , Hirokazu Takahashi
发明人： Akira Takahashi , Hirokazu Takahashi
IPC分类号： H04N1/36
CPC分类号： H04N1/1938 , H04N2201/0081 , H04N2201/0458
摘要： Conventional analog front ends or AFEs for scanners are implemented using multiple integrated circuits or ICs. As a result, there is typically a problem of skew (due at least in part to manufacturing process variations) for these different ICs in the AFE. Here, an AFE is provided which serializes input data so as to compensate for skew.
摘要翻译：用于扫描仪的常规模拟前端或AFE使用多个集成电路或IC实现。因此，AFE中这些不同的IC通常存在偏斜（至少部分由于制造工艺变化）的问题。这里，提供了一种AFE，其串行化输入数据以补偿偏斜。

10. 发明授权

US07982361B2 Actuator using comb-tooth 失效
标题翻译：执行器使用梳齿
公开(公告)号：US07982361B2
公开(公告)日：2011-07-19
申请号：US12295027
申请日：2007-03-30
申请人： Takanori Maeda , Hirokazu Takahashi , Masahiro Ishimori
发明人： Takanori Maeda , Hirokazu Takahashi , Masahiro Ishimori
IPC分类号： H02N1/00
CPC分类号： H02N1/008 , B81B3/0037 , B81B2201/033 , B81B2201/034 , B81B2201/11 , B81B2203/051 , B82Y10/00 , G11B9/1454
摘要： An actuator comprises a connection section having one end rotatably connected to a connection point (C1) of a fixed section and the other end rotatably connected to a connection point (C2) of a moving section, a connection section having one end rotatably connected to a connection point (C3) of the fixed section and the other end rotatably connected to a connection point (C4) of the moving sections a comb-teeth electrode having the root section connected to a comb-teeth base point (B1) and the fore-end section extending along the turning path, and a comb-teeth electrode having the root section connected to the fixed section and the other section extending along the curve of the comb-teeth electrode and opposed to the comb-teeth electrode with a predetermined gap.
摘要翻译：致动器包括连接部分，其一端可旋转地连接到固定部分的连接点（C1），另一端可旋转地连接到移动部分的连接点（C2），连接部分的一端可旋转地连接到所述固定部分的连接点（C3）和另一端可旋转地连接到所述移动部分的连接点（C4），所述梳齿电极具有连接到梳齿基点（B1）的根部部分，所述梳齿电极具有连接到所述固定部分的所述根部部分，而所述另一部分沿着所述梳齿电极的曲线延伸并且与所述梳齿电极以预定间隙相对。

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