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1. 发明授权

US10342968B2 Electrode pad used for iontophoresis treatment 有权
公开(公告)号：US10342968B2
公开(公告)日：2019-07-09
申请号：US13995720
申请日：2011-12-21
申请人： Akihiro Hasui , Atsuhiko Shiraishi , Ken-ichi Hattori , Shinji Tanaka , Hirokazu Takahashi , Makoto Takahashi
发明人： Akihiro Hasui , Atsuhiko Shiraishi , Ken-ichi Hattori , Shinji Tanaka , Hirokazu Takahashi , Makoto Takahashi
IPC分类号： A61N1/04 , A61N1/32 , A61N1/30 , A61M37/00
摘要： The present invention verifies a method of reducing skin irritation (particularly, cumulative skin irritation) caused by transdermal administration of a local anesthetic using iontophoresis, and provides an electrode pad for relief from a puncture pain which is safe not only at single administration but also at repeated administrations. The electrode pad comprises a base sheet; an electrode placed on the base sheet; an adhesive sheet placed on the base sheet and having an opening, within which the electrode being exposed; and a medicament reservoir containing a local anesthetic and placed in the opening of the adhesive sheet while being in contact with the electrode. An inner peripheral surface of the opening of the adhesive sheet and an outer peripheral surface of the medicament reservoir are prevented from coming into contact with human skin while contacting with each other, and thereby skin irritation is reduced.

2. 发明申请

US20130310733A1 ELECTRODE PAD USED FOR IONTOPHORESIS TREATMENT 审中-公开
标题翻译：电极垫用于静电治疗
公开(公告)号：US20130310733A1
公开(公告)日：2013-11-21
申请号：US13995720
申请日：2011-12-21
申请人： Akihiro Hasui , Atsuhiko Shiraishi , Ken-ichi Hattori , Shinji Tanaka , Hirokazu Takahashi , Makoto Takahashi
发明人： Akihiro Hasui , Atsuhiko Shiraishi , Ken-ichi Hattori , Shinji Tanaka , Hirokazu Takahashi , Makoto Takahashi
IPC分类号： A61N1/04
CPC分类号： A61N1/0448 , A61M2037/0007 , A61N1/0428 , A61N1/30 , A61N1/325
摘要： The present invention verifies a method of reducing skin irritation (particularly, cumulative skin irritation) caused by transdermal administration of a local anesthetic using iontophoresis, and provides an electrode pad for relief from a puncture pain which is safe not only at single administration but also at repeated administrations. The electrode pad comprises a base sheet; an electrode placed on the base sheet; an adhesive sheet placed on the base sheet and having an opening, within which the electrode being exposed; and a medicament reservoir containing a local anesthetic and placed in the opening of the adhesive sheet while being in contact with the electrode. An inner peripheral surface of the opening of the adhesive sheet and an outer peripheral surface of the medicament reservoir are prevented from coming into contact with human skin while contacting with each other, and thereby skin irritation is reduced.
摘要翻译：本发明验证了使用离子渗透电泳法减少透皮给药局部麻醉剂引起的皮肤刺激（特别是累积性皮肤刺激）的方法，并且提供了用于缓解穿刺疼痛的电极垫，其不仅在单次给药时也是安全的，重复行政。电极垫包括基片; 放置在基片上的电极; 粘合片放置在基片上并具有开口，电极被露出; 以及含有局部麻醉剂并放置在与电极接触的粘合片的开口中的药物容器。防止粘合片的开口的内周面和药剂容器的外周面与人的皮肤接触，同时彼此接触，从而减少皮肤刺激。

3. 发明授权

US06586022B2 Therapeutic agent for treating ulcerative colitis 失效
公开(公告)号：US06586022B2
公开(公告)日：2003-07-01
申请号：US09924539
申请日：2001-08-09
申请人： Mitsuhiro Kawada , Ken-ichi Hattori , Shunji Aono
发明人： Mitsuhiro Kawada , Ken-ichi Hattori , Shunji Aono
IPC分类号： A61K3578
CPC分类号： A61K36/65 , A61K2300/00
摘要： An ulcerative colitis treating therapeutic agent which is very effective in repairing damaged tissues of ulcerative colitis and yet has no need of fear of side effects as those of steroids is provided. It is an therapeutic agent for treating ulcerative colitis which has peony root, especially, dry powders of peony root, or a Chinese medicine formulation containing peony root as an active ingredient. It is also an therapeutic agent for treating ulcerative colitis which has, as an active ingredient, an infused dry extract of peony root, an infused dry extract of a Chinese medicine formulation containing peony root, or especially an infused dry extract of Jia-Wei-Xiao-Yao-San, Dang-Gui-Shao-Yao-San, Shao-Yao-Gan-Cao-Tang, or Gui-Zhi-Fu-Ling-Wan.

4. 发明申请

US20050020658A1 Selective cyclooxygenase-2 inhibitor patch 审中-公开
标题翻译：选择性环加氧酶-2抑制剂贴片
公开(公告)号：US20050020658A1
公开(公告)日：2005-01-27
申请号：US10683623
申请日：2003-10-10
申请人： Katsuyuki Inoo , Ken-Ichi Hattori , Noriko Shimizu
发明人： Katsuyuki Inoo , Ken-Ichi Hattori , Noriko Shimizu
IPC分类号： A61K9/70 , A61K31/415 , A61K31/42 , A61K31/18
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/415 , A61K31/42
摘要： A pharmaceutical composition for application to an area of skin of a subject for local and/or systemic treatment of a COX-2 mediated disorder comprises a backing sheet that is flexibly conformable to the area of skin, the backing sheet having opposing surfaces that are respectively distal and proximal to the skin when applied; and a coating on the proximal surface of the backing sheet that comprises (a) an adhesive, (b) an active agent comprising a selective COX-2 inhibitory sulfonamide drug of low water solubility, and (c) a solvent system for the active agent, wherein the active agent is in a therapeutically effective total amount and the solvent system is selected with regard to composition and amount thereof to be effective to maintain the active agent substantially completely in solubilized form. A method of local treatment of a site of pain and/or inflammation in a subject comprises applying the composition to a skin surface of the subject, preferably at a locus overlying or adjacent to the site of pain and/or inflammation, and leaving the composition in place for a time period effective to permit delivery of a locally therapeutic amount of the active agent. A method of systemic treatment of a subject having a COX-2 mediated disorder comprises applying the composition to a skin surface of the subject, and leaving the composition in place for a time period effective to permit transdermal delivery of a therapeutic amount of the active agent.
摘要翻译：用于局部和/或全身治疗COX-2介导的病症的受试者皮肤区域的药物组合物包括柔性地适应皮肤区域的背衬片，背衬片分别具有相对的表面应用时远端和皮肤近端; 和背衬片的近侧表面上的涂层，其包含（a）粘合剂，（b）包含低水溶性的选择性COX-2抑制性磺酰胺药物的活性剂，和（c）活性剂的溶剂体系其中活性剂处于治疗有效的总量，并且关于其组成和量的选择溶剂体系以有效地维持活性剂基本上完全为溶解形式。局部治疗受试者的疼痛和/或炎症部位的方法包括将组合物施用于受试者的皮肤表面，优选在位于疼痛和/或炎症部位的上方或邻近的部位，并使组合物在一段时间内有效地允许递送局部治疗量的活性剂。具有COX-2介导的病症的受试者的全身治疗的方法包括将组合物施用于受试者的皮肤表面，并将组合物置于适当的时间段，以有效地允许经皮递送治疗量的活性剂。

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