专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06596143B1 Apparatus for switching and manipulating particles and method of use thereof 有权
标题翻译：用于切换和操纵颗粒的装置及其使用方法
公开(公告)号：US06596143B1
公开(公告)日：2003-07-22
申请号：US09678263
申请日：2000-10-03
申请人： Xiao-Bo Wang , Weiping Yang , Junquan Xu , Jing Cheng , Lei Wu
发明人： Xiao-Bo Wang , Weiping Yang , Junquan Xu , Jing Cheng , Lei Wu
IPC分类号： G01N2726
CPC分类号： H02N11/006 , B01D57/02 , B03C5/028 , H02N1/004
摘要： A device acts as a particle switch to transport and/or re-direct microparticles which are in a fluid suspension. The switch comprises at least three structural branches and the branches may be connected at a common junction. Particles can be transported along the branches as a result of the forces generated along that branch. Particles are transported into or out of the particle switch via the ends of the branches. Particles can be switched from one branch into one of the other branches. Depending on the properties of the particles, the transportation mechanism may be traveling-wave-dielectrophoresis or traveling-wave-electrophoresis.
摘要翻译：装置用作颗粒开关以运输和/或重新引导处于流体悬浮液中的微粒。开关包括至少三个结构分支，并且分支可以在公共接头处连接。由于沿该分支产生的力，颗粒可以沿着分支运输。颗粒通过分支的末端被输送进出颗粒开关。颗粒可以从一个分支切换到其他分支之一。根据颗粒的性质，运输机制可以是行波介电电泳或行波电泳。

2. 发明授权

US06881314B1 Apparatuses and methods for field flow fractionation of particles using acoustic and other forces 有权
$Apparatuses and methods for field flow fractionation of particles using acoustic and other forces$
标题翻译：使用声学和其他力对颗粒进行现场流分离的装置和方法
公开(公告)号：US06881314B1
公开(公告)日：2005-04-19
申请号：US09679023
申请日：2000-10-04
申请人： Xiao-Bo Wang , Jing Cheng , Lei Wu , Junquan Xu
发明人： Xiao-Bo Wang , Jing Cheng , Lei Wu , Junquan Xu
IPC分类号： B01J19/00 , B03C1/00 , B03C5/00 , B81B1/00 , C02F1/40 , C25B9/00 , C25B11/00 , C25B13/00 , G01N27/27
CPC分类号： B03C1/00 , B01D21/283 , B01J19/0093 , B01L2400/0415 , B01L2400/043 , B01L2400/0436 , B01L2400/0442 , B01L2400/0454 , B01L2400/0487 , B03C5/005 , G01N2030/0015
摘要： This invention relates generally to the field of field-flow-fractionation. In particular, the invention provides apparatuses and methods for the discrimination of matters utilizing acoustic force, or utilizing acoustic force with electrophoretic or dielectrophoretic force, in field flow fractionation.
摘要翻译：本发明一般涉及现场流分馏领域。特别地，本发明提供了用于区分利用声力或利用电泳或介电电泳力的声力的现场流分级的装置和方法。

3. 发明授权

US06630835B2 Apparatus and method for high throughput electrorotation analysis 有权
公开(公告)号：US06630835B2
公开(公告)日：2003-10-07
申请号：US10216003
申请日：2002-08-07
申请人： Jing Cheng , Junquan Xu , Xiaoshan Zhu , Litian Liu , Xiao-Bo Wang , Lei Wu
发明人： Jing Cheng , Junquan Xu , Xiaoshan Zhu , Litian Liu , Xiao-Bo Wang , Lei Wu
IPC分类号： G01R2708
CPC分类号： G01N33/48707 , B01J2219/00497 , B01J2219/00527 , B01J2219/00529 , B01J2219/00587 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , Y10S436/809
摘要： The present invention concerns a high throughput electrorotation chip having an array of electrorotation units and methods of use thereof. To make the high throughput electrorotation chip, a plurality of electrorotation units (EU) are fabricated on a substrate or support and each EU is capable of producing a rotating electric field upon the application of an appropriate electrical signal. Exemplary embodiments include a row-column configuration of EUs having four electrode elements realized through two conductive-layers. The electrode elements may be linear, concave, or convex. Thin plates having one or multiple holes are bound to high-throughput electrorotation chips to form assay chambers having one or multiple wells. Particles can be introduced to the wells and electrorotation measurements can be performed on the particles. The high throughput electrorotation chip and chamber may be used for cell-based screening for leading drug candidate molecules from a compound library, for high-throughput characterizing particle electric properties, and for high-throughput assaying molecular compositions of unknown solutions.

4. 发明授权

US06448794B1 Apparatus and method for high throughput electrorotation analysis 有权
标题翻译：用于高通量电磁分析的装置和方法
公开(公告)号：US06448794B1
公开(公告)日：2002-09-10
申请号：US09643362
申请日：2000-08-22
申请人： Jing Cheng , Junquan Xu , Xiaoshan Zhu , Litian Liu , Xiao-Bo Wang , Lei Wu
发明人： Jing Cheng , Junquan Xu , Xiaoshan Zhu , Litian Liu , Xiao-Bo Wang , Lei Wu
IPC分类号： G01R2708
CPC分类号： G01N33/48707 , B01J2219/00497 , B01J2219/00527 , B01J2219/00529 , B01J2219/00587 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , Y10S436/806
摘要： The present invention concerns a high throughput electrorotation chip having an array of electrorotation units and methods of use thereof. To make the high throughput electrorotation chip, a plurality of electrorotation units (EU) are fabricated on a substrate or support and each EU is capable of producing a rotating electric field upon the application of an appropriate electrical signal. Exemplary embodiments include a row-column configuration of EUs having four electrode elements realized through two conductive-layers. The electrode elements may be linear, concave, or convex. Thin plates having one or multiple holes are bound to high-throughput electrorotation chips to form assay chambers having one or multiple wells. Particles can be introduced to the wells and electrorotation measurements can be performed on the particles. The high throughput electrorotation chip and chamber may be used for cell-based screening for leading drug candidate molecules from a compound library, for high-throughput characterizing particle electric properties, and for high-throughput assaying molecular compositions of unknown solutions.
摘要翻译：本发明涉及一种具有电极单元阵列的高通量电选机芯及其使用方法。为了制造高通量电选芯片，在基板或支撑件上制造多个电极单元（EU），并且每个EU在施加适当的电信号时能够产生旋转电场。示例性实施例包括具有通过两个导电层实现的四个电极元件的EU行的列列配置。电极元件可以是线性的，凹的或凸的。具有一个或多个孔的薄板结合到高通量电旋转切片以形成具有一个或多个孔的测定室。可以将颗粒引入孔中，并且可以对颗粒进行电转化测量。高通量电刺激芯片和腔室可用于来自化合物文库的主要药物候选分子的基于细胞的筛选，用于高通量表征颗粒电性质，以及用于高通量测定未知溶液的分子组成。

5. 发明授权

US06858439B1 Compositions and methods for separation of moieties on chips 有权
标题翻译：用于分离芯片上部分的组合物和方法
公开(公告)号：US06858439B1
公开(公告)日：2005-02-22
申请号：US09686737
申请日：2000-10-10
申请人： Junquan Xu , Xiaobo Wang , Jing Cheng , Weiping Yang , Lei Wu
发明人： Junquan Xu , Xiaobo Wang , Jing Cheng , Weiping Yang , Lei Wu
IPC分类号： B01J19/00 , B01L3/00 , B03C5/02 , C40B40/06 , C40B60/14 , G01N33/543 , G01N35/00
CPC分类号： G01N33/54326 , B01J19/0046 , B01J2219/00317 , B01J2219/00468 , B01J2219/005 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B01L3/5025 , B01L3/5027 , B01L3/502761 , B01L2400/0424 , B01L2400/0496 , B03C5/028 , C40B40/06 , C40B60/14 , G01N33/5438 , G01N35/0098 , Y10S436/809 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/25625 , Y10T436/2575
摘要： The present invention recognizes that separation of components of a sample facilitate, and are often necessary for, sample analysis. Dielectrophoretic separation provides an efficient, reliable, nondisruptive, and automatable method for the separation of moieties in a sample based on their dielectric properties. The present invention provides compositions and methods for enhancing the dielectrophoretic separation of one or more moieties in a sample. A first aspect of the present invention is a solution that when mixed with a sample, modifies at least one dielectric property of one or more components of the sample and has a conductivity such that one or more moieties of the sample can be separated using dielectrophoresis. Such solutions can be used in the analysis of samples on chips, and can be used in methods that use binding partners, including microparticles that can be translocated by dielectrophoretic forces, traveling-wave dielectrophoretic forces or magnetic forces.
摘要翻译：本发明认识到样品组分的分离促进了样品分析，并且通常是样品分析所必需的。介电泳分离提供了一种有效，可靠，无中断和自动化的方法，用于基于其介电性质分离样品中的部分。本发明提供用于增强样品中一个或多个部分的介电泳分离的组合物和方法。本发明的第一方面是当与样品混合时，改变样品中一种或多种组分的至少一种介电性能并具有使得可以使用介电电泳分离样品的一个或多个部分的导电性的解决方案。这样的溶液可以用于芯片上的样品的分析，并且可以用于使用结合配偶体的方法，包括可以通过介电电泳力移动的微粒，行波介电电泳力或磁力。

6. 发明授权

US07776543B2 Microdevice containing photorecognizable coding patterns and methods of using and producing the same 有权
公开(公告)号：US07776543B2
公开(公告)日：2010-08-17
申请号：US09924428
申请日：2001-08-07
申请人： Lei Wu , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxiang Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
发明人： Lei Wu , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxiang Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
IPC分类号： G01N33/53
摘要： This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on the substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof.

7. 发明授权

US07081192B1 Methods for manipulating moieties in microfluidic systems 有权
公开(公告)号：US07081192B1
公开(公告)日：2006-07-25
申请号：US09636104
申请日：2000-08-10
申请人： Xiaobo Wang , Lei Wu , Jing Cheng , Weiping Yang , Junquan Xu
发明人： Xiaobo Wang , Lei Wu , Jing Cheng , Weiping Yang , Junquan Xu
IPC分类号： G01N27/447 , G01N33/48 , C12Q1/00
CPC分类号： G01N33/54386 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2400/0415 , B01L2400/0424 , B01L2400/043 , B01L2400/0436 , B01L2400/0439 , B01L2400/0454 , B01L2400/0496 , B03C5/028 , B03C2201/26 , G01N27/745 , G01N33/569
摘要： This invention relates generally to the field of moiety or molecule manipulation in a chip format. In particular, the invention provides a method for manipulating a moiety in a microfluidic application, which method comprises: a) coupling a moiety to be manipulated onto surface of a binding partner of said moiety to form a moiety-binding partner complex; and b) manipulating said moiety-binding partner complex with a physical force in a chip format, wherein said manipulation is effected through a combination of a structure that is external to said chip and a structure that is built-in in said chip, thereby said moiety is manipulated.

8. 发明授权

US06716642B1 Individually addressable micro-electromagnetic unit array chips in horizontal configurations 有权
标题翻译：水平配置的单独寻址微电磁单元阵列芯片
公开(公告)号：US06716642B1
公开(公告)日：2004-04-06
申请号：US09685410
申请日：2000-10-10
申请人： Lei Wu , Xiaobo Wang , Jing Cheng , Weiping Yang , YuXiang Zhou , LiTian Liu , Junquan Xu
发明人： Lei Wu , Xiaobo Wang , Jing Cheng , Weiping Yang , YuXiang Zhou , LiTian Liu , Junquan Xu
IPC分类号： G01N33543
CPC分类号： B01L3/502792 , B01J19/0046 , B01J2219/00468 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00614 , B01J2219/00619 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00648 , B01J2219/00653 , B01J2219/00655 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00734 , B01J2219/0074 , B01J2219/00743 , B01L3/5025 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/089 , B01L2400/043 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , G01N35/0098 , H01F17/0006
摘要： The present invention provides electromagnetic chips and electromagnetic biochips having arrays of individually addressable micro-electromagnetic units, as well as methods of utilizing these chips for directed manipulation of micro-particles and micro-structures such as biomolecules and chemical reagents.
摘要翻译：本发明提供具有单独寻址的微电磁单元的阵列的电磁芯片和电磁生物芯片，以及利用这些芯片来定向操纵微粒和微结构如生物分子和化学试剂的方法。

9. 发明授权

US07811768B2 Microdevice containing photorecognizable coding patterns and methods of using and producing the same 有权
标题翻译：包含光可识别编码模式的微器件及其使用和生产方法
公开(公告)号：US07811768B2
公开(公告)日：2010-10-12
申请号：US09924428
申请日：2001-08-07
申请人： Lei Wu , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxiang Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
发明人： Lei Wu , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxiang Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
IPC分类号： G01N33/53
CPC分类号： B82Y5/00 , B01J19/0046 , B01J2219/00457 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00556 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00655 , B01J2219/00659 , B01J2219/00702 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B01J2219/0074 , B01J2219/00743 , B01L3/5027 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07K1/047 , C40B40/06 , C40B40/10 , C40B40/12 , G01N33/54366 , G01N33/54386 , G06K19/06009 , G06K19/06037 , G06K19/06046 , G06K19/06131 , G06K19/06178 , G06K19/06196
摘要： This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on the substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof.
摘要翻译：本发明一般涉及部分或分子分析，分离，检测和操作以及文库合成领域。特别地，本发明提供了一种微型器件，该微型器件包括：a）衬底; 和b）在基底上的可识别的编码图案。优选地，微器件不包括阳极化金属表面层。还提供了用于分离，检测和操作部分以及使用微器件合成文库的方法和试剂盒。本发明还提供二维光学编码器及其用途。

10. 发明授权

US07718419B2 Microdevices having a preferential axis of magnetization and uses thereof 有权
标题翻译：具有优先磁化轴的微器件及其用途
公开(公告)号：US07718419B2
公开(公告)日：2010-05-18
申请号：US11841935
申请日：2007-08-20
申请人： Lei Wu , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxian Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
发明人： Lei Wu , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxian Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
IPC分类号： C12M1/34 , G01N33/553
CPC分类号： C40B40/12 , B01J19/0046 , B01J2219/00457 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00556 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00655 , B01J2219/00659 , B01J2219/00702 , B01J2219/00707 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B01J2219/0074 , B01J2219/00743 , B01L3/5027 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2300/0819 , B01L2400/0415 , B01L2400/043 , B03C5/028 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07K1/047 , C40B40/06 , C40B40/10 , G01N33/54366 , G01N33/54386 , G06K19/06009 , G06K19/06046 , G06K19/06196 , Y10T428/24917
摘要： This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.
摘要翻译：本发明一般涉及部分或分子分离，检测和操作以及文库合成领域。特别地，本发明提供一种微型装置，该微型装置包括：a）可磁化物质; 以及b）可识别的编码图案，其中所述微器件具有优先磁化轴。还提供了用于使用微器件分离，检测和操作部分和合成文库的系统和方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式