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    • 3. 发明申请
    • Bicyclic Labdane Diterpenes for Use in the Treatment of TRPC6 Associated Diseases
    • 用于治疗TRPC6相关疾病的双环Labdane二萜烯
    • US20140309300A1
    • 2014-10-16
    • US14237925
    • 2012-08-10
    • Michael SchaeferNicole UrbanWolfgang Kuebler
    • Michael SchaeferNicole UrbanWolfgang Kuebler
    • A61K31/22A61K31/047
    • A61K31/22A61K31/045A61K31/047
    • The present invention relates to bicyclic labdane diterpenes for use in the treatment of a disease associated with activation of transient receptor potential cation channel 6 (TRPC6), preferably a pulmonary or a renal disease. In one aspect the invention relates to the use of a bicyclic labdane diterpene for blocking calcium transport via TRPC6. Another aspect of the invention is a bicyclic labdane diterpene according to formula (1) for use as a medicament wherein R1 is selected from hydrogen and C1 to C4 acyl, wherein the bicyclic labdane diterpene optionally comprises at least one double bond between the carbon atoms at positions 1 and 2, 2 and 3, 5 and 6, 6 and 7 and/or 14 and 15, wherein the carbon atoms at positions 1, 2, 3, 7, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 are connected to hydrogen atoms or comprise at least one substitution.
    • 本发明涉及用于治疗与瞬时受体潜在阳离子通道6(TRPC6)活化相关的疾病,优选肺或肾脏疾病的双环实体二萜烯。 一方面,本发明涉及双环实验二烷二萜用于通过TRPC6阻断钙转运的用途。 本发明的另一方面是用作药物的根据式(1)的双环实验二烷二萜,其中R 1选自氢和C 1至C 4酰基,其中双环实体烷二萜任选地包含至少一个碳原子之间的双键 位置1和2,2和3,5和6,6和7和/或14和15,其中第1,2,3,7,11,12,13,14,15,16,17位的碳原子 ,18,19或20连接到氢原子或包含至少一个取代基。
    • 7. 发明授权
    • Bottom die for a stamping tool for producing cardboard blanks
    • 用于生产纸板坯料的冲压工具的底模
    • US5517880A
    • 1996-05-21
    • US237112
    • 1994-05-03
    • Michael Schaefer
    • Michael Schaefer
    • B26F1/44B31B50/25B31B1/25
    • B26F1/44B31B1/00B26F1/40B26F2001/4445B31B2201/252
    • A bottom die for a stamping tool for producing cardboard blanks consists of a composite plate made from a support foil and a top layer consisting of phenol-resin bonded paper with a textile insert. Scoring grooves are milled into the top layer of phenol-resin bonded paper to serve as a counter contour of the top die of the stamping tool. The bottom die can be removably disposed on the bottom tool plate of a stamping machine by means of an adhesive layer which is self-adhesive on both sides. According to the invention, the scoring grooves are formed through the top resin bonded paper layer of the bottom die to the level of the flexible support foil, whereby the bottom die is given a relatively large degree of flexibility. Thus, a repeated use of the bottom die sheet is possible. In addition, a method for producing a bottom die for a stamping tool, employing the above-described die, is disclosed.
    • 用于制造纸板坯料的冲压工具的底模包括由支撑箔制成的复合板和由具有纺织品插入物的酚醛树脂粘合纸构成的顶层。 刻痕槽被研磨到酚醛树脂粘合纸的顶层中,用作冲压工具的顶模的相对轮廓。 底模可以通过粘合剂层可拆卸地设置在冲压机的底部工具板上,该粘合剂层在两侧是自粘的。 根据本发明,通过底模的顶部树脂粘合纸层形成刻痕槽至柔性支撑箔的水平面,由此底模具有较大程度的柔性。 因此,重复使用底模板是可能的。 此外,公开了一种采用上述模具制造用于冲压工具的底模的方法。
    • 10. 发明申请
    • HIGH-VOLTAGE CONNECTOR COMPONENT FOR A HIGH-VOLTAGE CABLE, HIGH-VOLTAGE CONNECTOR, AND METHOD OF MANUFACTURING A HIGH-VOLTAGE CONNECTOR COMPONENT
    • 用于高压电缆,高压连接器的高压连接器部件以及制造高压连接器部件的方法
    • US20120208386A1
    • 2012-08-16
    • US13372607
    • 2012-02-14
    • BERND BEUSTERMichael Schaefer
    • BERND BEUSTERMichael Schaefer
    • H01R13/52B29C39/14B29C45/14
    • H01R13/53
    • A high-voltage connector component for a high-voltage cable comprises an insulator made of a polymer material which surrounds a cable end portion of the high-voltage cable, wherein the insulator is received in a housing and is made of an elastomer material, wherein the elastomer material is filled, cast or injected into the housing in order to form the insulator. The connector component is designed such that upon connection to a corresponding connector component a basically closed pressure chamber is formed between the housing, the corresponding connector component and the cable end portion, wherein the pressure chamber is basically provided for being completely occupied by the insulator. Loading the insulator with pressure results in a gap-free, high-voltage-sealed pressing of the corresponding connector component to the insulator, a gap-free, high-voltage-sealed pressing of the insulator to the housing, and a gap-free, high-voltage-sealed pressing of the insulator to the sheath surface of the cable end portion.
    • 用于高压电缆的高压连接器部件包括由聚合物材料制成的绝缘体,其围绕高压电缆的电缆端部分,其中绝缘体被容纳在壳体中并且由弹性体材料制成,其中 为了形成绝缘体,将弹性体材料填充,铸造或注入到壳体中。 连接器部件被设计成使得在连接到相应的连接器部件上时,在壳体,相应的连接器部件和电缆端部之间形成基本上闭合的压力室,其中压力室基本上被设置成被绝缘体完全占据。 用压力加载绝缘体导致相应的连接器部件到绝缘体的无间隙,高压密封的压制,绝缘体到壳体的无缝隙,高压密封的压制,以及无缝隙 将绝缘体高压密封地压到电缆端部的护套表面。