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1. 发明授权

US4353909A 6-Hydroxy-2-phenyl-imidazo[4,5-b]pyridines and salts thereof 失效
标题翻译： 6-羟基-2-苯基 - 咪唑并[4,5-b]吡啶及其盐
公开(公告)号：US4353909A
公开(公告)日：1982-10-12
申请号：US305159
申请日：1981-09-24
申请人： Willi Diederen , Axel Prox , Albert Reuter , Willy Roth , Jochen Schmid
发明人： Willi Diederen , Axel Prox , Albert Reuter , Willy Roth , Jochen Schmid
IPC分类号： A61K31/435 , A61P9/04 , C07D471/04 , A61K31/44 , C07D487/04
CPC分类号： C07D471/04
摘要： Compounds of the formula ##STR1## wherein R is methylsulfinyl or methylsulfonyl, their 3H-tautomers, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds are useful as cardiotonics.
摘要翻译：其中R是甲基亚磺酰基或甲基磺酰基，其3H-互变异构体和无毒的药理学上可接受的酸加成盐的式IMA化合物。这些化合物可用作强心剂。

2. 发明授权

US4038407A Benzisothiazoline-1,1-dioxide derivatives, compositions and methods 失效
标题翻译：苯并噻唑啉-1,1-二氧化物衍生物，组合物和方法
公开(公告)号：US4038407A
公开(公告)日：1977-07-26
申请号：US660841
申请日：1976-02-24
申请人： Wolfgang Eberlein , Eberhard Kutter , Joachim Heider , Volkhard Austel , Rudolf Kadatz , Willi Diederen , Walter Kobinger , Christian Lillie , Jurgen Dammgen
发明人： Wolfgang Eberlein , Eberhard Kutter , Joachim Heider , Volkhard Austel , Rudolf Kadatz , Willi Diederen , Walter Kobinger , Christian Lillie , Jurgen Dammgen
IPC分类号： A61K31/435 , C07D209/46 , C07D209/48 , C07D275/04 , C07D275/06 , C07D491/04 , A61K31/425 , C07D91/12
CPC分类号： C07D209/48 , C07C309/00 , C07D209/46 , C07D275/06
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl or phenyl,R.sub.2 is hydrogen, chlorine or methoxy,R.sub.3 is hydrogen or methoxy,R.sub.2 and R.sub.3, together with each other, are methylenedioxy or ethylenedioxy,R.sub.4 and R.sub.5 are each hydrogen or lower alkyl,R.sub.6 is hydrogen or lower alkoxy,R.sub.7 is lower alkoxy,R.sub.6 and R.sub.7, together with each other, are methylenedioxy or ethylenedioxy,X is carbonyl or sulfonyl, andn is 2 or 3,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful for slowing the heart rate.

3. 发明授权

US4722929A Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same 失效
标题翻译：新的2-苯基 - 咪唑和含有它们的药物组合物
公开(公告)号：US4722929A
公开(公告)日：1988-02-02
申请号：US684052
申请日：1984-12-20
申请人： Volkhard Austel , Joachim Heider , Norbert Hauel , Manfred Reiffen , Josef Nickl , Jacobus C. A. van Meel , Willi Diederen
发明人： Volkhard Austel , Joachim Heider , Norbert Hauel , Manfred Reiffen , Josef Nickl , Jacobus C. A. van Meel , Willi Diederen
IPC分类号： A61K31/435 , A61K31/50 , A61K31/53 , A61P9/00 , A61P9/04 , A61P9/12 , C07D213/75 , C07D239/54 , C07D239/545 , C07D471/04 , C07D473/00 , C07D473/04 , C07D473/06 , C07D473/28 , C07D473/30 , C07D473/40 , C07D487/04
CPC分类号： C07D213/75 , C07D239/545 , C07D471/04 , C07D473/00 , C07D473/04 , C07D473/06 , C07D473/40 , C07D487/04
摘要： The invention relates to novel 2-phenyl-imidazoles of the formula ##STR1## and the tautomers and acid addition salts thereof, particularly the pharmacologically acceptable acid addition salts, which exhibit valuable pharmacological properties, particularly an effect on the contractility of the heart muscle. The compounds of Formula I may be prepared by methods conventionally used for similar compounds.
摘要翻译：本发明涉及新颖的式（I）的2-苯基 - 咪唑及其互变异构体及其酸加成盐，特别是药理学上可接受的酸加成盐，其具有有价值的药理学性质，特别是对心脏肌肉式I的化合物可以通过常规用于类似化合物的方法制备。

4. 发明授权

US4670438A Imidazo[4,5-c]pyridazine-3-ones, imidazo[4,5-d]pyridazine-4-ones, imidazo[4,]pyrazin-5-ones, purin-2-ones, purin-6-ones, and purin-2,6-diones useful as hypotensive or cardiotonic agents 失效
标题翻译：咪唑并[4,5-c]哒嗪-3-酮，咪唑并[4,5-d]哒嗪-4-酮，咪唑并[4,5-b]吡嗪-5-酮，嘌呤-2-酮， 6-酮和嘌呤-2,6-二酮可用作降血压或强心剂
公开(公告)号：US4670438A
公开(公告)日：1987-06-02
申请号：US623718
申请日：1984-06-22
申请人： Volkhard Austel , Joachim Heider , Norbert Hauel , Manfred Reiffen , Jacobus C. A. van Meel , Willi Diederen
发明人： Volkhard Austel , Joachim Heider , Norbert Hauel , Manfred Reiffen , Jacobus C. A. van Meel , Willi Diederen
IPC分类号： A61K31/44 , A61K31/50 , A61K31/52 , A61K31/522 , A61K31/53 , A61P9/04 , A61P9/12 , C07D471/04 , C07D473/02 , C07D473/04 , C07D473/08 , C07D473/28 , C07D473/30 , C07D473/40 , C07D487/04 , A61K31/495
CPC分类号： C07D471/04 , C07D473/02 , C07D473/08 , C07D473/28 , C07D473/30 , C07D473/40 , C07D487/04
摘要： Compounds of the formula ##STR1## wherein A, B, C and D are --N.dbd., HN.dbd., R.sub.3 N.dbd., O.dbd.C.dbd., HC.tbd., HO--C.tbd. or R.sub.3 SO.sub.2 --O--C.tbd.; andR.sub.1 and R.sub.2 are substituents of various types.The compounds are useful as hypotensives and cardiotonics.
摘要翻译：其中A，B，C和D为-N + 50，HN =，R3N =，O = C =，HC 3BOND，HO-C 3BOND或R3SO2-O-C3OND的式IMA化合物; 并且R 1和R 2是各种类型的取代基。这些化合物可用作低渗剂和强心剂。

5. 发明授权

US4176184A Imidazoisoquinoline-diones and salts thereof 失效
标题翻译：咪唑并异喹啉二酮及其盐
公开(公告)号：US4176184A
公开(公告)日：1979-11-27
申请号：US925461
申请日：1978-07-17
申请人： Volkhard Austel , Eberhard Kutter , Joachim Heider , Wolfgang Eberlein , Walter Kobinger , Christian Lillie , Willi Diederen , Walter Haarmann
发明人： Volkhard Austel , Eberhard Kutter , Joachim Heider , Wolfgang Eberlein , Walter Kobinger , Christian Lillie , Willi Diederen , Walter Haarmann
IPC分类号： A61K31/47 , A61K31/4745 , A61K31/495 , A61K31/535 , A61P7/02 , A61P9/04 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P25/20 , C07D217/24 , C07D471/04
CPC分类号： C07D471/04 , C07D217/24 , Y10S514/821
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is lower alkyl; phenyl-lower alkyl; cycloalkyl of 3 to 6 carbon atoms; phenyl; mono- or di-substituted phenyl, where the substituents, which may be identical to or different from each other, are each halogen, hydroxyl, methoxy, methylmercapto, methylsulfinyl, methylsulfonyl or benzyloxy; andA is hydrogen or ##STR2## where R.sub.2 is hydrogen or lower alkyl;R.sub.3 is lower alkyl or dimethoxyphenyl-lower alkyl; orR.sub.2 and R.sub.3, together with each other and the nitrogen atom to which they are attached, are piperidino, morpholino or N'-lower alkyl-piperazino; andn is 2 or 3;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as cardiotonics, hypotensives, antithrombotics and antiarrhythmics.
摘要翻译：其中R 1是低级烷基的式IMAMA的化合物; 苯基 - 低级烷基; 3至6个碳原子的环烷基; 苯基; 羟基，甲氧基，甲基巯基，甲基亚磺酰基，甲基磺酰基或苄氧基的取代基可以相同或不同。和A是氢或者其中R 2是氢或低级烷基; R3是低级烷基或二甲氧基苯基 - 低级烷基; 或R 2和R 3彼此连接并且与它们相连的氮原子是哌啶子基，吗啉代或N'-低级烷基 - 哌嗪子基; n为2或3; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用作强心剂，低血糖剂，抗血栓药物和抗心律失常药物。

6. 发明授权

US4026891A 5- Or 6-pyridazinyl-benzimidazoles and salts thereof 失效
标题翻译： 5-或6-哒嗪基 - 苯并咪唑及其盐
公开(公告)号：US4026891A
公开(公告)日：1977-05-31
申请号：US583641
申请日：1975-06-04
申请人： Volkhard Austel , Eberhard Kutter , Joachim Heider , Wolfgang Eberlein , Rudolf Kadatz , Willi Diederen
发明人： Volkhard Austel , Eberhard Kutter , Joachim Heider , Wolfgang Eberlein , Rudolf Kadatz , Willi Diederen
IPC分类号： C07D403/04 , A61K20060101 , A61K31/415 , A61K31/495 , A61K31/50 , A61K31/535 , A61P7/02 , A61P9/04 , A61P9/12 , C07D20060101 , C07D235/04 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/14 , C07D235/18 , C07D235/24 , C07D235/28 , C07D237/00 , C07D237/02 , C07D237/04 , C07D237/08 , C07D237/12 , C07D237/14 , C07D237/20 , C07D247/00 , C07D295/12 , C07D403/02 , C07D403/10 , C07D403/14 , C07D413/14
CPC分类号： Y10S514/822
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, trifluoromethyl, alkyl of 1 to 5 carbon atoms, mercapto, lower alkyl-mercapto, phenyl, fluoro-phenyl, tolyl, hydroxy-phenyl, methylmercapto-phenyl, methylsulfinyl-phenyl, methylsulfonyl-phenyl, dimethylamino-phenyl, or mono-, di- or tri-methoxy-substituted phenyl;A is hydrogen or, together with B, a double bond,B is hydrogen, alkyl of 1 to 3 carbon atoms or, together with A, a double bond;C is, together with R.sub.2, a double bond, or, together with R.sub.3, oxygen;R.sub.2 is hydrogen, alkyl of 1 to 3 carbon atoms or, together with C, a double bond; andR.sub.3 is chlorine, methylamino, morpholino, 4-methylpiperazino or, when R.sub.2 is hydrogen or alkyl of 1 to 3 carbon atoms, together with C, oxygen;And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as hypotensives, antithrombotics and cardiotonics.
摘要翻译：其中R 1为氢，三氟甲基，1至5个碳原子的烷基，巯基，低级烷基 - 巯基，苯基，氟 - 苯基，甲苯基，羟基 - 苯基，甲基巯基 - 苯基，甲基亚磺酰基 - 苯基，甲基磺酰基苯基，二甲基氨基 - 苯基或单 - ，二 - 或三 - 甲氧基取代的苯基; A为氢或与B一起为双键，B为氢，1〜3个碳原子的烷基，或与A一起为双键; C与R2一起为双键，或与R3一起为氧; R 2是氢，1至3个碳原子的烷基，或与C一起形成双键; 并且R 3是氯，甲基氨基，吗啉代，4-甲基哌嗪基，或者当R 2是氢或有1至3个碳原子的烷基与C，氧时; 和非毒性，药理学上可接受的酸添加量; 该化合物作为有效的低分子量有机抗体，抗生素和心脏病。

7. 发明授权

US3949074A Cardiotonic pharmaceutical compositions containing a cardiac glycoside and method of use 失效
标题翻译：含有强心苷的强心药物组合物及其使用方法
公开(公告)号：US3949074A
公开(公告)日：1976-04-06
申请号：US601500
申请日：1975-08-04
申请人： Wolfgang Eberlein , Joachim Heider , Willi Diederen , Walter Kobinger
发明人： Wolfgang Eberlein , Joachim Heider , Willi Diederen , Walter Kobinger
IPC分类号： C07J17/00 , C07J41/00 , A61K31/705
CPC分类号： C07J41/0094 , C07J17/005
摘要： Pharmaceutical compositions containing as an active ingredient a compound of the formula ##SPC1##Wherein R is cyano or carbalkoxy of 2 to 4 carbon atoms; and a method of using the same as cardiotonics.
摘要翻译：含有式WHEREIN R的化合物作为活性成分的药物组合物是氰基或2至4个碳原子的烷氧基; 以及使用它们作为强心剂的方法。

8. 发明授权

US4716169A Imidazo[1,2a]pyridines and their use as cardiotonic agents 失效
标题翻译：咪唑并[1,2a]吡啶并用作强心剂
公开(公告)号：US4716169A
公开(公告)日：1987-12-29
申请号：US810008
申请日：1985-12-17
申请人： Joachim Heider , Norbert Hauel , Volkhard Austel , Klaus Noll , Andreas Bomhard , Jacques van Meel , Willi Diederen
发明人： Joachim Heider , Norbert Hauel , Volkhard Austel , Klaus Noll , Andreas Bomhard , Jacques van Meel , Willi Diederen
IPC分类号： A61K31/435 , A61K31/495 , A61P7/02 , A61P9/04 , C07D471/04 , C07D487/04 , A61K31/41
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention relates to new imidazo derivatives of the formula ##STR1## wherein "A-D and R.sup.1 -R.sup.3 are as defined in the specification". The new compounds have valuable pharmacological properties, particularly antithrombotic and cardiovascular properties such as a cardiotonic activity and/or an effect on blood pressure, and can be prepared using methods known per se.
摘要翻译：本发明涉及式（I）的新的咪唑衍生物，其中“A-D和R 1 -R 3如说明书中所定义”。新化合物具有有价值的药理学性质，特别是抗血栓形成和心血管性质，例如强心剂活性和/或对血压的作用，并且可以使用本身已知的方法制备。

9. 发明授权

US4656171A 2-phenyl-imidazo-pyrazines, useful as cardiotonics 失效
标题翻译： 2-苯基 - 咪唑并吡嗪，可用作强心剂
公开(公告)号：US4656171A
公开(公告)日：1987-04-07
申请号：US675299
申请日：1984-11-27
申请人： Volkhard Austel , Norbert Hauel , Joachim Heider , Manfred Reiffen , Jacobus C. A. Van Meel , Willi Diederen
发明人： Volkhard Austel , Norbert Hauel , Joachim Heider , Manfred Reiffen , Jacobus C. A. Van Meel , Willi Diederen
IPC分类号： A61K31/50 , A61K31/53 , A61P9/02 , A61P9/04 , C07D487/04 , A61K31/495 , C07D471/02
CPC分类号： C07D487/04
摘要： Compounds of the formula ##STR1## wherein A, B, C and D are each independently --N.dbd. or --CH.dbd., provided, however, that at least two of them must be --N.dbd., and when A and C are both --N.dbd., at least one or both of B and D must be --N.dbd.; andR.sub.1, R.sub.2 and R.sub.3 are substituents of diverse types;tautomers thereof; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds are useful as cardiotonics.
摘要翻译：其中A，B，C和D各自独立地为-N =或-CH =，但条件是其中至少两个必须为-N =，并且当A和C均为 - N =，B和D中的至少一个或两个必须为-N =; 并且R1，R2和R3是不同类型的取代基; 互变异构体和无毒的，药学上可接受的酸加成盐。这些化合物可用作强心剂。

10. 发明授权

US4616018A Benzotriazolyl-4,5-dihydro-3(2H)-pyridazinones 失效
标题翻译：苯并三唑基-4,5-二氢-3（2H） - 哒嗪酮
公开(公告)号：US4616018A
公开(公告)日：1986-10-07
申请号：US749580
申请日：1985-06-27
申请人： Norbert Hauel , Volkhard Austel , Joachim Heider , Manfred Reiffen , Willi Diederen , Walter Haarman
发明人： Norbert Hauel , Volkhard Austel , Joachim Heider , Manfred Reiffen , Willi Diederen , Walter Haarman
IPC分类号： A61K31/50 , A61K31/501 , A61P7/02 , A61P9/12 , C07D237/04 , C07D249/18 , C07D401/14 , C07D403/04 , C07D403/02
CPC分类号： C07D401/14 , C07D237/04 , C07D249/18 , C07D403/04 , Y10S514/822
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen; alkyl of 1 to 7 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; monosubstituted alkyl of 1 to 3 carbon atoms, where the substituent is pyridyl, methylpyridyl, phenyl, mono-, di- or trisubstituted phenyl, where the substituents on the phenyl ring, which may be identical to or different from each other, are selected from the group consisting of one amino, one dimethylamino, one to two hydroxyls, one to three methoxys and one to three halogens; .omega.-monosubstituted alkyl of 2 to 4 carbon atoms, where the substituent is hydroxyl or di(alkyl of 1 to 3 carbon atoms)amino; phenyl; monohalo-phenyl; unsubstituted or monosubstituted straight or branched alkanoyl of 1 to 6 carbon atoms, where the substituent is phenyl, methoxyphenyl or cycloalkyl of 3 to 7 carbon atoms; or unsubstituted or monosubstituted phenylsulfonyl, where the substituent is methyl or methoxy; and,R.sub.2 is hydrogen or alkyl of 1 to 3 carbon atoms; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as cardiotonics, hypotensives and antithrombotics.
摘要翻译：其中R 1是氢的式IMAMA的化合物; 1至7个碳原子的烷基; 3至7个碳原子的环烷基; 其中取代基是吡啶基，甲基吡啶基，苯基，单 - ，二 - 或三取代的苯基，其中可以相同或不同的苯环上的取代基选自由一个氨基，一个二甲基氨基，一至两个羟基，一至三个甲氧基和一至三个卤素组成的组; 2至4个碳原子的ω-单取代的烷基，其中取代基是羟基或二（1至3个碳原子的烷基）氨基; 苯基; 单卤代苯基; 未取代的或单取代的1至6个碳原子的直链或支链烷酰基，其中取代基是苯基，甲氧基苯基或3-7个碳原子的环烷基; 或未取代或单取代的苯基磺酰基，其中取代基是甲基或甲氧基; R2为氢或1〜3个碳原子的烷基; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用作强心剂，低血糖剂和抗血栓药物。

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