会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 9. 发明授权
    • 3-Amino-4-phenyl-1H-pyrazolo[3,4-b]pyridines and salts thereof
    • 3-氨基-4-苯基-1H-吡唑并[3,4-b]吡啶及其盐
    • US4182887A
    • 1980-01-08
    • US834114
    • 1977-09-19
    • Josef RochErich MullerBerthold NarrJosef NicklWalter Haarmann
    • Josef RochErich MullerBerthold NarrJosef NicklWalter Haarmann
    • A61K31/435A61P7/02A61P29/00C07D213/85C07D471/04
    • C07D471/04C07D213/85Y10S514/822
    • Compounds of the formula ##STR1## wherein R.sub.1 is mono- or di-substituted amino, where the substituents are selected from the group consisting of alkyl of 1 to 6 carbon atoms, cyclohexyl, allyl and benzyl; unsubstituted, mono-substituted or di-substituted pyrrolidino, piperidino, hexamethyleneimino, morpholino, piperazino, thiomorpholino, 1-oxido-thiomorpholino or 1,1-dioxido-thiomorpholino, where the substituents are selected from the group consisting of methyl, hydroxymethyl, hydroxyl, phenyl and benzyl; 1,2,5,6-tetrahydropyridino; 1,2,3,4-tetrahydroisoquinolino; indolino; or 3,6-ethylene-hexamethyleneimino;R.sub.2 is hydrogen, methyl or benzyl; andR.sub.3 is hydrogen, halogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antiphlogistics and antithrombotics.
    • 其中R 1是单取代或二取代的氨基,其中取代基选自1至6个碳原子的烷基,环己基,烯丙基和苄基; 未取代的单取代或二取代的吡咯烷子基,哌啶子基,六亚甲基亚氨基,吗啉代,哌嗪子基,硫代吗啉代,1-氧代硫代吗啉代或1,1-二氧化硫代吗啉代,其中取代基选自甲基,羟甲基,羟基 ,苯基和苄基; 1,2,5,6-四氢吡啶子; 1,2,3,4-四氢异喹啉; indolino; 或3,6-亚乙基 - 六亚甲基亚氨基; R2是氢,甲基或苄基; R3为氢,卤素,1〜3个碳原子的烷基或1〜3个碳原子的烷氧基; 和无毒的,药学上可接受的酸加成盐。 化合物及其盐可用作消炎和抗血栓形成。