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1. 发明授权

US4282222A 3-Piperidino or apiperazino-1-phenyl or 1-substituted phenyl isoquinoline and antidepressant compositions thereof 失效
标题翻译： 3-哌啶子基或哌嗪-1-基或1-取代的苯基异喹啉及其抗抑郁药组合物
公开(公告)号：US4282222A
公开(公告)日：1981-08-04
申请号：US75038
申请日：1979-09-12
申请人： Wilhelm Bartmann , Elmar Konz , Harry M. Geyer
发明人： Wilhelm Bartmann , Elmar Konz , Harry M. Geyer
IPC分类号： A61K31/47 , A61K31/472 , A61P25/08 , A61P25/24 , A61P25/26 , C07D217/22 , C07D401/04 , A61K31/495
CPC分类号： C07D217/22
摘要： Isoquinolines of the formula ##STR1## in which R.sub.1 is piperidino, piperazino or piperazino N-substituted thereof by alkyl of 1 to 4 carbon atoms, alkylene of 1 to 4 carbon atoms wherein said alkylene is substituted in turn by fluorobenzoyl, or CHO; R.sub.2 is phenyl or phenyl substituted by alkyl of 1 to 4 carbon atoms, halogen, amino or nitro; and R.sub.3 is hydrogen or halogen, a process for their preparation and medicaments containing the isoquinolines, especially the use of said medicaments as antidepressants.
摘要翻译：其中R 1是具有1至4个碳原子的烷基的哌啶子基，哌嗪子基或哌嗪基N-取代的异喹啉，其中所述亚烷基被氟代苯甲酰或CHO取代; R 2为苯基或被1至4个碳原子的烷基取代的苯基，卤素，氨基或硝基; R3为氢或卤素，其制备方法和含有异喹啉的药物，特别是所述药物用作抗抑郁药。

2. 发明授权

US4282223A Isoquinoline derivatives, processes for their manufacture and their use for the manufacture of medicaments 失效
标题翻译：异喹啉衍生物，其制造方法及其用于制造药物的用途
公开(公告)号：US4282223A
公开(公告)日：1981-08-04
申请号：US76862
申请日：1979-09-19
申请人： Wilhelm Bartmann , Elmar Konz , Hansjorg Kruse , Harry M. Geyer
发明人： Wilhelm Bartmann , Elmar Konz , Hansjorg Kruse , Harry M. Geyer
IPC分类号： A61K31/47 , A61K31/472 , A61K31/495 , A61K31/535 , A61P25/08 , A61P25/20 , C07D217/22 , C07D217/26 , C07D401/04 , C07D401/12 , C07D405/12 , C07D413/04 , C07D413/12
CPC分类号： C07D217/26 , C07D217/22
摘要： Isoquinolines of the formula ##STR1## of which representative compounds are such as 3-N-methylpiperazino-1-phenyl-isoquinoline-4-aldehyde, 3-N-methylpiperazino-1-(2-fluorophenyl)-isoquinoline-4-aldehyde, or 3-N-[3-(4-fluoro-benzoyl)-propyl]-piperazino-1-phenyl-isoquinoline-4-aldehyde and medicaments containing the isoquinolines which are useful as antidepressants.
摘要翻译：其代表性化合物为3-N-甲基哌嗪-1-基 - 异喹啉-4-醛，3-N-甲基哌嗪-1-（2-氟苯基） - 异喹啉-4-醛的式（VI）的异喹啉，或3-N- [3-（4-氟 - 苯甲酰基） - 丙基] - 哌嗪-1-基 - 异喹啉-4-醛和包含可用作抗抑郁药的异喹啉的药物。

3. 发明授权

US4260763A Isoquinoline aldehydes 失效
标题翻译：异喹啉醛
公开(公告)号：US4260763A
公开(公告)日：1981-04-07
申请号：US20410
申请日：1979-03-14
申请人： Wilhelm Bartmann , Elmar Konz , Hansjorg Kruse
发明人： Wilhelm Bartmann , Elmar Konz , Hansjorg Kruse
IPC分类号： A61K31/47 , A61K31/472 , A61P25/08 , A61P25/20 , C07D217/22 , C07D401/04 , C07D217/16
CPC分类号： C07D217/22
摘要： Isoquinoline-4-aldehydes of the formula ##STR1## in which X denotes bromine or chlorine, R.sub.1 is phenyl optionally mono- or disubstituted by halogen, hydroxy, nitro, amino, or amino substituted by one or two aliphatic, cycloaliphatic or aromatic hydrocarbon radicals having from 2 to 18 carbon atoms, the nitrogen atom possibly being included in a heterocyclic ring, acyl amino, alkyl or alkoxy each having from 1 to 6 carbon atoms, benzoyloxy, or trifluoromethyl, or is pyridyl or thienyl;R.sub.2 is hydrogen, halogen, hydroxy, alkyl or alkoxy having from 1 to 6 carbon atoms, nitro, amino, benzyloxy, methylene dioxy or ethylene dioxy andm is 1 or 2;which are effective in the treatment of spasms and as tranquilizers.
摘要翻译：式为“IMAGE”的异喹啉-4-醛，其中X表示溴或氯，R1是任选被卤素，羟基，硝基，氨基或被一个或两个脂族，脂环族或芳族烃基取代的氨基单或二取代的苯基具有2至18个碳原子，可能包含在杂环中的氮原子，各自具有1至6个碳原子的酰基氨基，烷基或烷氧基，苯甲酰氧基或三氟甲基，或者是吡啶基或噻吩基; R2是氢，卤素，羟基，具有1至6个碳原子的烷基或烷氧基，硝基，氨基，苄氧基，亚甲基二氧基或亚乙基二氧基，m是1或2; 这在治疗痉挛和止痛药方面是有效的。

4. 发明授权

US4260611A Isoquinoline derivatives 失效
标题翻译：异喹啉衍生物
公开(公告)号：US4260611A
公开(公告)日：1981-04-07
申请号：US76204
申请日：1979-09-17
申请人： Wilhelm Bartmann , Elmar Konz
发明人： Wilhelm Bartmann , Elmar Konz
IPC分类号： A61K31/47 , A61K31/472 , A61K31/495 , A61P9/06 , A61P25/18 , A61P29/00 , C07D217/22 , C07D217/24 , C07D217/26 , C07D217/14 , C07D217/16
CPC分类号： C07D217/26 , C07D217/22
摘要： Isoquinoline derivatives of the formula ##STR1## wherein the substituent is such as chlorine or bromine; R.sub.1 is phenyl etc.; R.sub.2 is hydrogen, halogen etc.; R.sub.3 is e.g. aminoalkyl and their use as medicaments, in particular as antidepressants.
摘要翻译：式（I）的异喹啉衍生物，其中取代基如氯或溴; R1是苯基等; R2是氢，卤素等; R3是例如氨基烷基及其作为药物的用途，特别是抗抑郁药。

5. 发明授权

US4296121A Novel prostaglandin derivatives of the .DELTA.2-PGF.sub.2 and .DELTA.2-PGE.sub.2 series and process for their manufacture 失效
标题翻译： DELTA 2-PGF2和DELTA 2-PGE2系列的新型前列腺素衍生物及其制造方法
公开(公告)号：US4296121A
公开(公告)日：1981-10-20
申请号：US62937
申请日：1979-08-02
申请人： Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch , Elmar Konz
发明人： Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch , Elmar Konz
IPC分类号： A61K31/23 , A61K31/19 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61P43/00 , C07C45/29 , C07C45/60 , C07C47/267 , C07C49/743 , C07C49/757 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/34 , C07D307/58 , C07D307/935 , C07D319/06 , C07D333/16 , C07D333/24 , A61K31/557 , C07C177/00 , C07D307/54
CPC分类号： C07D307/935 , C07C405/00 , C07C45/29 , C07C45/60 , C07C47/267 , C07C49/743 , C07C49/757 , C07D319/06 , Y10S514/822
摘要： What is disclosed are compounds of the formula ##STR1## which are structurally related to natural prostaglandins and a process for their manufacture. The compounds have valuable pharamacological properties and, therefore, they can be used as medicaments.
摘要翻译：公开的是具有结构上与天然前列腺素相关的式（I）＆gt; I的化合物及其制造方法。这些化合物具有宝贵的药理学性质，因此它们可以用作药物。

6. 发明授权

US4312882A Thienyoxy and furyl containing analogs of prostacyclin and their use as medicaments 失效
标题翻译：含有前列环素类似物的噻吩氧基和呋喃及其作为药物的用途
公开(公告)号：US4312882A
公开(公告)日：1982-01-26
申请号：US114684
申请日：1980-01-23
申请人： Wilhelm Bartmann , Elmar Konz , Ulrich Lerch , Bernward Scholkens
发明人： Wilhelm Bartmann , Elmar Konz , Ulrich Lerch , Bernward Scholkens
IPC分类号： C07D307/935 , A61K31/34 , A61K31/343 , A61K31/557 , A61P7/02 , C07D307/937 , C07D303/32
CPC分类号： C07D307/937
摘要： What is disclosed are prostacyclin analogs of the general formula I ##STR1## which have a more specific action and/or a longer action than the naturally occurring prostacyclin PGI.sub.2, as well as intermediate products for their preparation and a process for their preparation. The compounds of formula I are distinguished by inhibitory action on thrombocyte aggregation and by relaxation of the vascular walls, in particular of the coronary arteries. They can thus be used as medicaments.
摘要翻译：所公开的是具有比天然存在的前列环素PGI2更具体的作用和/或更长的作用的通式为I IMAGE I的前列环素类似物，以及用于其制备的中间产物及其制备方法。式I的化合物的特征在于对血小板聚集的抑制作用和通过松弛血管壁，特别是冠状动脉的抑制。因此，它们可以用作药物。

7. 发明授权

US4855323A Leukotriene antagonists, a process for the preparation thereof, and the use thereof for the treatment of diseases 失效
标题翻译：白三烯拮抗剂，其制备方法及其用于治疗疾病的用途
公开(公告)号：US4855323A
公开(公告)日：1989-08-08
申请号：US223129
申请日：1988-07-22
申请人： Gunther Wess , Wilhelm Bartmann , Gerhard Beck , Hiristo Anagnostopulos
发明人： Gunther Wess , Wilhelm Bartmann , Gerhard Beck , Hiristo Anagnostopulos
IPC分类号： A61K31/38 , A61K31/085 , A61K31/10 , A61K31/12 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/381 , A61K31/395 , A61K31/41 , A61K31/44 , A61K31/535 , A61K31/5375 , A61P1/04 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C41/00 , C07C43/00 , C07C43/178 , C07C43/20 , C07C43/235 , C07C43/263 , C07C45/00 , C07C47/52 , C07C49/84 , C07C51/00 , C07C59/125 , C07C65/21 , C07C67/00 , C07C69/007 , C07C69/025 , C07C69/675 , C07C69/92 , C07C201/00 , C07C235/06 , C07C235/16 , C07C239/00 , C07C239/14 , C07C313/00 , C07C317/00 , C07C317/04 , C07C317/18 , C07C317/22 , C07C317/24 , C07C317/44 , C07C317/46 , C07C323/16 , C07C323/19 , C07C323/22 , C07C323/52 , C07C323/56 , C07C323/60 , C07C323/65 , C07D213/30 , C07D257/04 , C07D295/18 , C07D317/36 , C07D333/16
CPC分类号： C07D317/36 , A61K31/10 , A61K31/215 , C07C323/00
摘要： Leukotriene antagonists, a process for the preparation thereof, and the use thereof for the treatment of diseases ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and X have the indicated meanings, a process for the preparation of these compounds, the use thereof as pharmaceuticals, and pharmaceutical products based on these compounds, are described.
摘要翻译：白细胞三烯拮抗剂，其制备方法及其用于治疗其中R1，R2，R3，R4，R5和X具有指定含义的疾病的用途，其制备方法化合物，其作为药物的用途，以及基于这些化合物的药物。

8. 发明授权

US4098815A Novel analogues of prostanoic acids not occurring in nature 失效
标题翻译：没有发生在自然中的先天性的新型模拟物
公开(公告)号：US4098815A
公开(公告)日：1978-07-04
申请号：US751951
申请日：1976-12-17
申请人： Milos Babej , Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch
发明人： Milos Babej , Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch
IPC分类号： C07C45/56 , C07C45/66 , C07C405/00 , C07C177/00
CPC分类号： C07C405/00 , C07C45/567 , C07C45/66 , Y10S514/826
摘要： The present invention relates to novel not naturally occurring analogues of prostanoic acids of the formula ##STR1## as well as a process for their preparation. The compounds of the invention have valuable pharmacological properties similar to those of the natural prostaglandins and therefore can be used as medicaments.

9. 发明授权

US5204351A 6-fluoro-3,5-dihydroxy carboxylic acids and derivatives thereof 失效
标题翻译： 6-氟-3,5-二羟基羧酸及其衍生物
公开(公告)号：US5204351A
公开(公告)日：1993-04-20
申请号：US389809
申请日：1989-08-04
申请人： Gerhard Beck , Wilhelm Bartmann , Gunther Wess , Ernold Granzer
发明人： Gerhard Beck , Wilhelm Bartmann , Gunther Wess , Ernold Granzer
IPC分类号： A61K31/19 , A61K31/215 , A61K31/365 , A61K31/366 , A61K31/40 , A61K31/44 , A61K31/4406 , A61K31/4418 , A61K31/443 , A61K31/4433 , A61K31/50 , A61K31/505 , A61P3/06 , A61P9/10 , A61P43/00 , C07C27/00 , C07C29/147 , C07C33/48 , C07C45/56 , C07C47/55 , C07C59/56 , C07C67/00 , C07C67/31 , C07C67/343 , C07C69/65 , C07C69/732 , C07C69/738 , C07D207/32 , C07D207/333 , C07D207/337 , C07D213/30 , C07D213/48 , C07D213/55 , C07D213/79 , C07D237/08 , C07D239/26 , C07D307/54 , C07D309/30 , C07D333/24 , C07D405/06 , C07D407/06 , C07D409/06
CPC分类号： C07D207/333 , C07C33/486 , C07C45/56 , C07C47/55 , C07D207/337 , C07D213/30 , C07D213/48 , C07D213/55 , C07D237/08 , C07D239/26 , C07D307/54 , C07D309/30 , C07D333/24 , C07D405/06 , C07D407/06 , C07D409/06
摘要： 6-Fluoro-3,5-dihydroxy carboxylic acid derivatives of the formula I and the corresponding lactones of the formula II ##STR1## in which R.sup.1 and R.sup.2 have the specified meanings, a process for the preparation of these compounds, the use thereof as medicinal agents and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formula I or formula II are described.
摘要翻译：式I的6-氟-3,5-二羟基羧酸衍生物和其中R1和R2具有特定含义的式II的相应内酯，其制备方法，其用途为描述了药物和药物。此外，描述了用于制备式I或式II化合物的新中间体。

10. 发明授权

US4925852A 3-demethylmevalonic acid derivatives, and pharmaceutical products based on these compounds 失效
标题翻译： 3-脱甲基甲基戊酸衍生物和基于这些化合物的药物产品
公开(公告)号：US4925852A
公开(公告)日：1990-05-15
申请号：US216458
申请日：1988-07-08
申请人： Kurt Kesseler , Gerhard Beck , Wilhelm Bartmann , Ernold Granzer
发明人： Kurt Kesseler , Gerhard Beck , Wilhelm Bartmann , Ernold Granzer
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/443 , A61K31/505 , A61P3/06 , A61P9/10 , C07D213/55 , C07D239/26 , C07D405/06 , C07F7/18
CPC分类号： C07D239/26 , C07D213/55 , C07D405/06 , C07F7/1856
摘要： 3-Demethylmevalonic acid derivatives of the formula I (.delta.-lactone) and II (corresponding dihydroxy carboxylic acid derivative) ##STR1## in which A--B, Z, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the indicated meanings, a process for the preparation of these compounds, their use as medicaments, and pharmaceutical products, are described. In addition, new intermediates for the preparation of the compounds of the formula I and formula II are described.
摘要翻译：其中AB，Z，R1，R2，R3和R4具有指定含义的式I（δ-内酯）和II（相应的二羟基羧酸衍生物）的3-甲基甲基戊酸衍生物，其制备方法描述了这些化合物，它们作为药物的用途和药物产品。此外，描述了用于制备式I和式II化合物的新中间体。

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