专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4282222A 3-Piperidino or apiperazino-1-phenyl or 1-substituted phenyl isoquinoline and antidepressant compositions thereof 失效
标题翻译： 3-哌啶子基或哌嗪-1-基或1-取代的苯基异喹啉及其抗抑郁药组合物
公开(公告)号：US4282222A
公开(公告)日：1981-08-04
申请号：US75038
申请日：1979-09-12
申请人： Wilhelm Bartmann , Elmar Konz , Harry M. Geyer
发明人： Wilhelm Bartmann , Elmar Konz , Harry M. Geyer
IPC分类号： A61K31/47 , A61K31/472 , A61P25/08 , A61P25/24 , A61P25/26 , C07D217/22 , C07D401/04 , A61K31/495
CPC分类号： C07D217/22
摘要： Isoquinolines of the formula ##STR1## in which R.sub.1 is piperidino, piperazino or piperazino N-substituted thereof by alkyl of 1 to 4 carbon atoms, alkylene of 1 to 4 carbon atoms wherein said alkylene is substituted in turn by fluorobenzoyl, or CHO; R.sub.2 is phenyl or phenyl substituted by alkyl of 1 to 4 carbon atoms, halogen, amino or nitro; and R.sub.3 is hydrogen or halogen, a process for their preparation and medicaments containing the isoquinolines, especially the use of said medicaments as antidepressants.
摘要翻译：其中R 1是具有1至4个碳原子的烷基的哌啶子基，哌嗪子基或哌嗪基N-取代的异喹啉，其中所述亚烷基被氟代苯甲酰或CHO取代; R 2为苯基或被1至4个碳原子的烷基取代的苯基，卤素，氨基或硝基; R3为氢或卤素，其制备方法和含有异喹啉的药物，特别是所述药物用作抗抑郁药。

2. 发明授权

US4282223A Isoquinoline derivatives, processes for their manufacture and their use for the manufacture of medicaments 失效
标题翻译：异喹啉衍生物，其制造方法及其用于制造药物的用途
公开(公告)号：US4282223A
公开(公告)日：1981-08-04
申请号：US76862
申请日：1979-09-19
申请人： Wilhelm Bartmann , Elmar Konz , Hansjorg Kruse , Harry M. Geyer
发明人： Wilhelm Bartmann , Elmar Konz , Hansjorg Kruse , Harry M. Geyer
IPC分类号： A61K31/47 , A61K31/472 , A61K31/495 , A61K31/535 , A61P25/08 , A61P25/20 , C07D217/22 , C07D217/26 , C07D401/04 , C07D401/12 , C07D405/12 , C07D413/04 , C07D413/12
CPC分类号： C07D217/26 , C07D217/22
摘要： Isoquinolines of the formula ##STR1## of which representative compounds are such as 3-N-methylpiperazino-1-phenyl-isoquinoline-4-aldehyde, 3-N-methylpiperazino-1-(2-fluorophenyl)-isoquinoline-4-aldehyde, or 3-N-[3-(4-fluoro-benzoyl)-propyl]-piperazino-1-phenyl-isoquinoline-4-aldehyde and medicaments containing the isoquinolines which are useful as antidepressants.
摘要翻译：其代表性化合物为3-N-甲基哌嗪-1-基 - 异喹啉-4-醛，3-N-甲基哌嗪-1-（2-氟苯基） - 异喹啉-4-醛的式（VI）的异喹啉，或3-N- [3-（4-氟 - 苯甲酰基） - 丙基] - 哌嗪-1-基 - 异喹啉-4-醛和包含可用作抗抑郁药的异喹啉的药物。

3. 发明授权

US4312882A Thienyoxy and furyl containing analogs of prostacyclin and their use as medicaments 失效
标题翻译：含有前列环素类似物的噻吩氧基和呋喃及其作为药物的用途
公开(公告)号：US4312882A
公开(公告)日：1982-01-26
申请号：US114684
申请日：1980-01-23
申请人： Wilhelm Bartmann , Elmar Konz , Ulrich Lerch , Bernward Scholkens
发明人： Wilhelm Bartmann , Elmar Konz , Ulrich Lerch , Bernward Scholkens
IPC分类号： C07D307/935 , A61K31/34 , A61K31/343 , A61K31/557 , A61P7/02 , C07D307/937 , C07D303/32
CPC分类号： C07D307/937
摘要： What is disclosed are prostacyclin analogs of the general formula I ##STR1## which have a more specific action and/or a longer action than the naturally occurring prostacyclin PGI.sub.2, as well as intermediate products for their preparation and a process for their preparation. The compounds of formula I are distinguished by inhibitory action on thrombocyte aggregation and by relaxation of the vascular walls, in particular of the coronary arteries. They can thus be used as medicaments.
摘要翻译：所公开的是具有比天然存在的前列环素PGI2更具体的作用和/或更长的作用的通式为I IMAGE I的前列环素类似物，以及用于其制备的中间产物及其制备方法。式I的化合物的特征在于对血小板聚集的抑制作用和通过松弛血管壁，特别是冠状动脉的抑制。因此，它们可以用作药物。

4. 发明授权

US4296121A Novel prostaglandin derivatives of the .DELTA.2-PGF.sub.2 and .DELTA.2-PGE.sub.2 series and process for their manufacture 失效
标题翻译： DELTA 2-PGF2和DELTA 2-PGE2系列的新型前列腺素衍生物及其制造方法
公开(公告)号：US4296121A
公开(公告)日：1981-10-20
申请号：US62937
申请日：1979-08-02
申请人： Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch , Elmar Konz
发明人： Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch , Elmar Konz
IPC分类号： A61K31/23 , A61K31/19 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61P43/00 , C07C45/29 , C07C45/60 , C07C47/267 , C07C49/743 , C07C49/757 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/34 , C07D307/58 , C07D307/935 , C07D319/06 , C07D333/16 , C07D333/24 , A61K31/557 , C07C177/00 , C07D307/54
CPC分类号： C07D307/935 , C07C405/00 , C07C45/29 , C07C45/60 , C07C47/267 , C07C49/743 , C07C49/757 , C07D319/06 , Y10S514/822
摘要： What is disclosed are compounds of the formula ##STR1## which are structurally related to natural prostaglandins and a process for their manufacture. The compounds have valuable pharamacological properties and, therefore, they can be used as medicaments.
摘要翻译：公开的是具有结构上与天然前列腺素相关的式（I）＆gt; I的化合物及其制造方法。这些化合物具有宝贵的药理学性质，因此它们可以用作药物。

5. 发明授权

US4260763A Isoquinoline aldehydes 失效
标题翻译：异喹啉醛
公开(公告)号：US4260763A
公开(公告)日：1981-04-07
申请号：US20410
申请日：1979-03-14
申请人： Wilhelm Bartmann , Elmar Konz , Hansjorg Kruse
发明人： Wilhelm Bartmann , Elmar Konz , Hansjorg Kruse
IPC分类号： A61K31/47 , A61K31/472 , A61P25/08 , A61P25/20 , C07D217/22 , C07D401/04 , C07D217/16
CPC分类号： C07D217/22
摘要： Isoquinoline-4-aldehydes of the formula ##STR1## in which X denotes bromine or chlorine, R.sub.1 is phenyl optionally mono- or disubstituted by halogen, hydroxy, nitro, amino, or amino substituted by one or two aliphatic, cycloaliphatic or aromatic hydrocarbon radicals having from 2 to 18 carbon atoms, the nitrogen atom possibly being included in a heterocyclic ring, acyl amino, alkyl or alkoxy each having from 1 to 6 carbon atoms, benzoyloxy, or trifluoromethyl, or is pyridyl or thienyl;R.sub.2 is hydrogen, halogen, hydroxy, alkyl or alkoxy having from 1 to 6 carbon atoms, nitro, amino, benzyloxy, methylene dioxy or ethylene dioxy andm is 1 or 2;which are effective in the treatment of spasms and as tranquilizers.
摘要翻译：式为“IMAGE”的异喹啉-4-醛，其中X表示溴或氯，R1是任选被卤素，羟基，硝基，氨基或被一个或两个脂族，脂环族或芳族烃基取代的氨基单或二取代的苯基具有2至18个碳原子，可能包含在杂环中的氮原子，各自具有1至6个碳原子的酰基氨基，烷基或烷氧基，苯甲酰氧基或三氟甲基，或者是吡啶基或噻吩基; R2是氢，卤素，羟基，具有1至6个碳原子的烷基或烷氧基，硝基，氨基，苄氧基，亚甲基二氧基或亚乙基二氧基，m是1或2; 这在治疗痉挛和止痛药方面是有效的。

6. 发明授权

US4260611A Isoquinoline derivatives 失效
标题翻译：异喹啉衍生物
公开(公告)号：US4260611A
公开(公告)日：1981-04-07
申请号：US76204
申请日：1979-09-17
申请人： Wilhelm Bartmann , Elmar Konz
发明人： Wilhelm Bartmann , Elmar Konz
IPC分类号： A61K31/47 , A61K31/472 , A61K31/495 , A61P9/06 , A61P25/18 , A61P29/00 , C07D217/22 , C07D217/24 , C07D217/26 , C07D217/14 , C07D217/16
CPC分类号： C07D217/26 , C07D217/22
摘要： Isoquinoline derivatives of the formula ##STR1## wherein the substituent is such as chlorine or bromine; R.sub.1 is phenyl etc.; R.sub.2 is hydrogen, halogen etc.; R.sub.3 is e.g. aminoalkyl and their use as medicaments, in particular as antidepressants.
摘要翻译：式（I）的异喹啉衍生物，其中取代基如氯或溴; R1是苯基等; R2是氢，卤素等; R3是例如氨基烷基及其作为药物的用途，特别是抗抑郁药。

7. 发明授权

US4547508A 1-Phenylisoquinoline derivatives, pharmaceutical products containing these compounds and their use 失效
标题翻译： 1-苯基异喹啉衍生物，含有这些化合物的药物及其用途
公开(公告)号：US4547508A
公开(公告)日：1985-10-15
申请号：US556684
申请日：1983-11-30
申请人： Elmar Konz , Hansjorg Kruse
发明人： Elmar Konz , Hansjorg Kruse
IPC分类号： A61K31/47 , A61P25/24 , A61P25/26 , B01J31/00 , C07B61/00 , C07D213/38 , C07D213/40 , C07D213/50 , C07D401/04 , C07D491/056 , A61K31/445
CPC分类号： C07D213/40 , C07D213/38 , C07D213/50 , C07D401/04
摘要： 1-Phenylisoquinoline derivatives of the general formula I ##STR1## and a process for their preparation are described. They act on the central nervous system, in particular as antidepressants.
摘要翻译：描述了通式I的1-苯基异喹啉衍生物及其制备方法。它们作用于中枢神经系统，特别是抗抑郁药。

8. 发明授权

US4204076A Hydroquinone dimethyl ether 失效
标题翻译：氢醌二甲醚
公开(公告)号：US4204076A
公开(公告)日：1980-05-20
申请号：US960857
申请日：1978-11-15
申请人： Elmar Konz , Rudolf Pistorius
发明人： Elmar Konz , Rudolf Pistorius
IPC分类号： C07C41/28 , C07C41/00
CPC分类号： C07C41/28 , C07C45/515
摘要： Cyclohexanedione-(1,4)-tetramethyl diketal of the formula ##STR1## is obtained by catalytic hydrogenation of p-benzoquinone tetramethyl diketal in a basic medium, at a temperature of from about -10.degree. to +150.degree. C. The product gives cyclohexanedione-(1,4), on acid hydrolysis, which is a valuable starting product for various syntheses, for example for tetracyanoquinodimethane, a desired compound in the field of semiconductors.Hydroquinone dimethyl ether, which is a valuable intermediate for the dyestuff preparation, is obtained from cyclohexanedione-(1,4)-tetramethyl diketal by catalytic dehydrogenation.
摘要翻译：通过在约-10℃至+ 150℃的温度下在碱性介质中对对苯醌四甲基二缩酮进行催化氢化，得到式“IMAGE”的环己二酮 - （1,4） - 四甲基二缩酮。环己二酮 - （1,4），其是酸性水解，其是用于各种合成的有价值的起始产物，例如四氰基醌二甲烷，半导体领域中期望的化合物。作为染料制备的有价值的中间体，氢醌二甲醚由环己二酮 - （1,4） - 四甲基二缩酮通过催化脱氢得到。

9. 发明授权

US4673682A Isoquinoline derivatives, pharmaceutical formulations based on these compounds and the use thereof 失效
标题翻译：异喹啉衍生物，基于这些化合物的药物制剂及其用途
公开(公告)号：US4673682A
公开(公告)日：1987-06-16
申请号：US530000
申请日：1983-09-07
申请人： Elmar Konz , Joachim Kaiser
发明人： Elmar Konz , Joachim Kaiser
IPC分类号： A61K31/47 , A61K31/472 , A61P9/06 , C07D217/26 , C07D401/12 , C07D491/056 , C07D217/16
CPC分类号： C07D401/12 , C07D217/26
摘要： Isoquinoline-4-carboxylic acid derivatives of the formula I ##STR1## in which m, n, R.sup.1, R.sup.2, R.sup.3, A and X have the meansings indicated, and physiologically acceptable acid addition salts thereof, a process for their preparation, pharmaceutical formulations based on these compounds and the use thereof as antiarrythmic agents.
摘要翻译：其中m，n，R 1，R 2，R 3，A和X具有所示含义的式I的异喹啉-4-羧酸衍生物及其生理上可接受的酸加成盐，其制备方法，药物基于这些化合物的制剂及其作为抗焦虑剂的用途。

10. 发明授权

US4590273A Isoquinoline compounds 失效
标题翻译：异喹啉化合物
公开(公告)号：US4590273A
公开(公告)日：1986-05-20
申请号：US594366
申请日：1984-03-28
申请人： Elmar Konz , Franz Hock , Joachim Kaiser , Hansjorg Kruse
发明人： Elmar Konz , Franz Hock , Joachim Kaiser , Hansjorg Kruse
IPC分类号： C07D217/14 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/55 , A61P9/12 , A61P25/00 , C07D217/22 , C07D401/04 , C07D401/12 , C07D405/02 , C07D405/12 , C07D409/12 , C07D413/12
CPC分类号： C07D217/22
摘要： New isoquinoline derivatives of the general formula ##STR1## and their physiologically acceptable salts, which exert pharmacological actions on the central nervous system and the heart circulation system, a process for the preparation of these compounds, medicaments containing them, and their use as neuroleptic, antihypertonic and antiarrhythmic agents, are described.
摘要翻译：通式（I）的新异喹啉衍生物及其生理上可接受的盐，其对中枢神经系统和心脏循环系统施加药理作用，制备这些化合物的方法，含有它们的药物及其用途作为精神安定药，抗高血压药和抗心律失常药。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式