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1. 发明授权

US06872826B2 Stereoselective alkylation of chiral 2-methyl-4-protected piperazines 失效
标题翻译：手性2-甲基-4-保护的哌嗪的立体选择性烷基化
公开(公告)号：US06872826B2
公开(公告)日：2005-03-29
申请号：US10400429
申请日：2003-03-27
申请人： Wenxue Wu , Hongbiao Liao , David J. S. Tsai , David R. Andrews , Dinesh Gala , Gary M. Lee , Martin Lawrence Schwartz , Timothy L. McAllister , Xiaoyong Fu , Donal Maloney , Tiruvettipuram K. Thiruvengadam , Chou-Hang Tann
发明人： Wenxue Wu , Hongbiao Liao , David J. S. Tsai , David R. Andrews , Dinesh Gala , Gary M. Lee , Martin Lawrence Schwartz , Timothy L. McAllister , Xiaoyong Fu , Donal Maloney , Tiruvettipuram K. Thiruvengadam , Chou-Hang Tann
IPC分类号： C07D241/04 , C07B53/00 , C07B61/00 , C07C45/51 , C07C303/28 , C07C309/73 , C07D295/084 , C07D295/088 , C07D295/185 , C07D295/192 , C07D295/205 , C07D295/067
CPC分类号： C07D295/185 , C07B2200/07 , C07C45/512 , C07C67/343 , C07C309/73 , C07D295/088 , C07D295/092 , C07D295/192 , C07D295/205 , C07C49/255 , C07C69/734 , C07C49/84
摘要： In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process:
摘要翻译：在说明性实施方案中，本发明通过新的立体选择性烷基化方法描述了具有高立体化学纯度的以下化合物和类似化合物的合成：

2. 发明授权

US07745626B2 Stereoselective alkylation of chiral 2-methyl-4-protected piperazines 失效
标题翻译：手性2-甲基-4-保护的哌嗪的立体选择性烷基化
公开(公告)号：US07745626B2
公开(公告)日：2010-06-29
申请号：US11089858
申请日：2005-03-25
申请人： Wenxue Wu , Hongbiao Liao , David J. Tsai , David R. Andrews , Dinesh Gala , Gary M. Lee , Martin Lawrence Schwartz , Timothy L. McAllister , Xiaoyong Fu , Donal Maloney , Tiruvettipuram K. Thiruvengadam , Chou-Hang Tann
发明人： Wenxue Wu , Hongbiao Liao , David J. Tsai , David R. Andrews , Dinesh Gala , Gary M. Lee , Martin Lawrence Schwartz , Timothy L. McAllister , Xiaoyong Fu , Donal Maloney , Tiruvettipuram K. Thiruvengadam , Chou-Hang Tann
IPC分类号： C07D295/023
CPC分类号： C07D295/185 , C07B2200/07 , C07C45/512 , C07C67/343 , C07C309/73 , C07D295/088 , C07D295/092 , C07D295/192 , C07D295/205 , C07C49/255 , C07C69/734 , C07C49/84
摘要： In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process:
摘要翻译：在说明性实施方案中，本发明通过新的立体选择性烷基化方法描述了具有高立体化学纯度的以下化合物和类似化合物的合成：

3. 发明申请

US20100249411A1 Stereoselective Alkylation of Chiral 2-Methly-4 Protected Piperazines 审中-公开
标题翻译：手性2-甲基-4保护的哌嗪的立体选择性烷基化
公开(公告)号：US20100249411A1
公开(公告)日：2010-09-30
申请号：US12748882
申请日：2010-03-29
申请人： Wenxue Wu , Hongbiao Liao , David J.S. Tsai , David R. Andrews , Dinesh Gala , Gary M. Lee , Martin Lawrence Schwartz , Timothy L. McAllister , Xiaoyong Fu , Donal Maloney , Tiruvettipuram K. Thiruvengadam , Chou-Hang Tann
发明人： Wenxue Wu , Hongbiao Liao , David J.S. Tsai , David R. Andrews , Dinesh Gala , Gary M. Lee , Martin Lawrence Schwartz , Timothy L. McAllister , Xiaoyong Fu , Donal Maloney , Tiruvettipuram K. Thiruvengadam , Chou-Hang Tann
IPC分类号： C07D241/04 , C07C309/73 , C07C45/54
CPC分类号： C07D295/185 , C07B2200/07 , C07C45/512 , C07C67/343 , C07C309/73 , C07D295/088 , C07D295/092 , C07D295/192 , C07D295/205 , C07C49/255 , C07C69/734 , C07C49/84
摘要： In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process:
摘要翻译：在说明性实施方案中，本发明描述了通过新的立体选择性烷基化方法合成具有高立体化学纯度的以下化合物和类似化合物：

4. 发明授权

US06992189B2 Synthesis of piperidine and piperazine compounds as CCR5 antagonists 失效
标题翻译：哌啶和哌嗪化合物作为CCR5拮抗剂的合成
公开(公告)号：US06992189B2
公开(公告)日：2006-01-31
申请号：US10401070
申请日：2003-03-27
申请人： William Leong , Minzhang Chen , Bosco A. D'sa , Man Zhu , Tong Xiao , Xiongwei Shi , Suhan Tang , Dinesh Gala , Andrew J. Goodman , Christopher M. Nielsen , Gary M. Lee , Juan A. Gamboa , Andrew D. Jones
发明人： William Leong , Minzhang Chen , Bosco A. D'sa , Man Zhu , Tong Xiao , Xiongwei Shi , Suhan Tang , Dinesh Gala , Andrew J. Goodman , Christopher M. Nielsen , Gary M. Lee , Juan A. Gamboa , Andrew D. Jones
IPC分类号： C07D403/14
CPC分类号： C07D401/06 , C07D401/14
摘要： In its several embodiments, this invention discloses novel processes to prepare the compounds of formula II and formula IV:
摘要翻译：在其几个实施方案中，本发明公开了制备式II和式IV化合物的新方法：

5. 发明授权

US06377575B1 High speed cross point switch routing circuit with word-synchronous serial back plane 失效
公开(公告)号：US06377575B1
公开(公告)日：2002-04-23
申请号：US09129662
申请日：1998-08-05
申请人： John P. Mullaney , Gary M. Lee
发明人： John P. Mullaney , Gary M. Lee
IPC分类号： H04L1250
CPC分类号： H04L12/5601 , H04J3/0685 , H04L7/04 , H04L49/1576 , H04L49/3081 , H04L2012/5652 , H04L2012/5674 , H04L2012/5679 , H04L2012/5681 , H04L2012/5684 , H04Q11/0478
摘要： An asynchronous serial crosspoint switch is word synchronized to each of a number of transceiver circuits. The crosspoint switch circuit generates both a master bit clock and a master word clock signal. A transceiver circuit recovers the master bit clock signal from an incoming high-speed serial data stream using a clock and data recovery circuit. The recovered bit clock signal is used as a timing signal by which data is serialized and transmitted to the crosspoint switch circuit. The data stream transmitted to the switch circuit is frequency locked to the master bit clock signal, such that the serial data stream need only be phase adjusted with a data recovery circuit. To recover word timing, the switch circuit issues alignment words to the transceivers during link initialization. The transceivers perform word alignment and establish a local word lock. Alignment words are then reissued to the switch circuit using the local word clock. The switch circuit compares the boundary of the received word clock to the master word clock and, if misaligned, the transceiver shifts its transmitted word by one bit and retries. Necessary edge transition density is provided by overhead bits which also designate special command words asserted between a transceiver and a switch circuit. Flow control information is routed from a receiving transceiver back to the transmitting transceiver using the overhead bits in order to assert a ready-to-receive or a not-ready-to-receive flow control signal. The overhead bits additionally provide information regarding connection requests and other information.

6. 发明授权

US5463051A Process for preparing benzazepine intermediates for the synthesis of D1 antagonists 失效
标题翻译：制备用于合成D1拮抗剂的苯并氮杂中间体的方法
公开(公告)号：US5463051A
公开(公告)日：1995-10-31
申请号：US127862
申请日：1993-09-27
申请人： Donald Hou , Richard W. Draper , Gary M. Lee , Janet L. Mas , Ingrid Mergelsberg
发明人： Donald Hou , Richard W. Draper , Gary M. Lee , Janet L. Mas , Ingrid Mergelsberg
IPC分类号： C07C215/44 , C07C217/40 , C07C217/74 , C07D203/26 , C07D223/18 , C07D223/14 , C07D405/06
CPC分类号： C07C217/40 , C07C215/44 , C07C217/74 , C07D203/26 , C07D223/18 , C07B2200/07 , C07C2102/10
摘要： Disclosed are a process and intermediates of the formulae ##STR1## wherein X.sup.- is halide, BF.sub.4.sup.-, R.sup.3 SO.sub.3.sup.-, wherein R.sup.3 is C.sub.1 -C.sub.6 alkyl, CF.sub.3, C.sub.1 -C.sub.6 alkylphenyl or phenyl, and Q is a group of the formula ##STR2## wherein R is C.sub.1 -C.sub.6 alkyl; useful for preparing benzazepine intermediates of the formula ##STR3## These benzazepine intermediates are useful for preparing benzazepines having activity as selective D1 receptor antagonists.
摘要翻译：公开了下式的方法和中间体：其中X是卤化物，BF 4 - ，R 3 SO 3 - ，其中R 3是C 1 -C 6烷基，CF 3，C 1 -C 6烷基苯基或苯基，Q是其中R是C 1 -C 6烷基; 可用于制备下式的苯并氮杂中间体这些苯并氮杂中间体可用于制备具有选择性D1受体拮抗剂活性的苯并氮杂。

7. 发明授权

US07893276B2 Process for preparing triazolones 有权
标题翻译：制备三唑酮的方法
公开(公告)号：US07893276B2
公开(公告)日：2011-02-22
申请号：US12791252
申请日：2010-06-01
申请人： Gary M. Lee , Jiang Zhu
发明人： Gary M. Lee , Jiang Zhu
IPC分类号： C07D249/12
CPC分类号： C07D249/12 , C07C17/18 , C07C45/004 , C07C253/14 , C07C253/30 , C07C25/18 , C07C47/55 , C07C255/54 , C07C255/56
摘要： The present process provides a improved method for the preparation of alkylsulfanyl substituted triazoles 2 which are useful intermediates in a new process for the preparation of triazolones 20.
摘要翻译：本发明方法提供了制备烷基硫烷基取代的三唑2的改进方法，它们是制备三唑酮20的新方法中有用的中间体。

8. 发明授权

US6078194A Logic gates for reducing power consumption of gallium arsenide integrated circuits 失效
标题翻译：用于降低砷化镓集成电路功耗的逻辑门
公开(公告)号：US6078194A
公开(公告)日：2000-06-20
申请号：US558108
申请日：1995-11-13
申请人： Gary M. Lee
发明人： Gary M. Lee
IPC分类号： H03K3/012 , H03K3/037 , H03K19/00 , H03K19/094 , H03K19/0952
CPC分类号： H03K19/0016 , H03K19/09429 , H03K19/0952 , H03K3/012 , H03K3/0372
摘要： A method and apparatus for reducing power consumption by gallium arsenide integrated circuits divides the integrated circuit into higher and lower frequency sections. The high frequency sections require a substantial portion of the system clock period to resolve their longest combinatorial paths. The lower frequency sections require a relatively small portion of the system clock period to resolve their longest combinatorial logic paths. The combinatorial logic paths of each of such lower frequency sections are designed using logic gates which are capable of being decoupled from the chip power supply by way of a power enable input. Edge triggered memory circuits such as flip-flops are also designed using the reduced power logic gates, except for their cross-coupled outputs so that they may retain their state. A dual-output one-shot multivibrator is used to generate the power enable signal used to couple and decouple the logic gates of each lower frequency section from the chip power supply, as well as the clock pulse with which to clock the flip-flops of the lower frequency section. The one-shot generates these control signals based on the positive edge of the system clock. The lower frequency sections thus dissipate virtually no power except during that portion of the system clock period necessary to resolve their longest combinatorial paths.
摘要翻译：用于降低砷化镓集成电路的功耗的方法和装置将集成电路分为更高和更低频率的部分。高频部分需要系统时钟周期的大部分来解决其最长的组合路径。较低频率部分需要系统时钟周期的较小部分来解决其最长的组合逻辑路径。这些低频段中的每一个的组合逻辑路径使用能够通过功率使能输入与芯片电源分离的逻辑门来设计。诸如触发器之类的边缘触发存储器电路也使用减少功率逻辑门来设计，除了它们的交叉耦合输出，使得它们可以保持其状态。双输出单稳态多谐振荡器用于产生功率使能信号，用于将芯片电源中每个较低频率部分的逻辑门极耦合和去耦，以及时钟脉冲较低频段。一次性根据系统时钟的上升沿产生这些控制信号。因此，除了解决其最长组合路径所需的系统时钟周期的那部分之外，较低频率部分几乎没有功率消耗。

9. 发明授权

US5461147A Process for preparing benzazepine intermediates for the synthesis of D1 antagonists 失效
标题翻译：制备用于合成D1拮抗剂的苯并氮杂中间体的方法
公开(公告)号：US5461147A
公开(公告)日：1995-10-24
申请号：US127667
申请日：1993-09-27
申请人： Donald Hou , Richard W. Draper , Gary M. Lee , Janet L. Mas
发明人： Donald Hou , Richard W. Draper , Gary M. Lee , Janet L. Mas
IPC分类号： C07C217/70 , C07C271/16 , C07C271/22 , C07C271/24 , C07D223/14 , C07D263/06
CPC分类号： C07C271/24 , C07C217/70 , C07C271/16 , C07C271/22 , C07D223/14 , C07D263/06 , C07C2102/10
摘要： Disclosed are a process and intermediates of the formula ##STR1## wherein R is --CH.sub.3 or --C(O)--OR.sup.1, and R.sup.1 is C.sub.1 -C.sub.6 alkyl or --CH.sub.2 C.sub.6 H.sub.5 ; or the formula ##STR2## wherein: R.sup.2 is H or OH, R is --C(O)OR.sup.1 and R.sup.1 is C.sub.1 -C.sub.6 alkyl or --CH.sub.2 C.sub.6 H.sub.5, or where R.sup.2 is H, R can also be CH.sub.3 ; for preparing benzazepine intermediates of the formula ##STR3## The benzazepine intermediates are useful for preparing benzazepines having activity as selective D1 receptor antagonists.
摘要翻译：公开了式（IMAGE）的方法和中间体，其中R是-CH 3或-C（O）-OR 1，R 1是C 1 -C 6烷基或-CH 2 C 6 H 5; 或其中：R 2是H或OH，R是-C（O）OR 1，R 1是C 1 -C 6烷基或-CH 2 C 6 H 5，或者其中R 2是H，R也可以是CH 3; 用于制备下式的苯并氮杂中间体苯并吖庚因中间体可用于制备具有作为选择性D1受体拮抗剂活性的苯并氮杂。

10. 发明授权

US4798978A GAAS FET logic having increased noise margin 失效
标题翻译： GAAS FET逻辑具有增加的噪声容限
公开(公告)号：US4798978A
公开(公告)日：1989-01-17
申请号：US44519
申请日：1987-04-30
申请人： Gary M. Lee , Charles M. Lee , George S. LaRue
发明人： Gary M. Lee , Charles M. Lee , George S. LaRue
IPC分类号： H03K19/017 , H03K19/0952 , H03K19/094
CPC分类号： H03K19/0952 , H03K19/01721
摘要： A high performance logic family for GaAs Enhancement/Depletion mode MESFETs is disclosed. The inventive logic family exhibits a large noise margin with little sacrifice in speed/power performance.
摘要翻译：公开了一种用于GaAs增强/消耗模式MESFET的高性能逻辑系列。本发明的逻辑系列表现出较大的噪声容限，在速度/功率性能方面几乎没有牺牲。

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