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1. 发明申请

US20060009472A1 Substituted imidazole derivatives 有权
公开(公告)号：US20060009472A1
公开(公告)日：2006-01-12
申请号：US11158574
申请日：2005-06-20
申请人： Weibo Wang , Paul Barsanti , Yi Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan Phillips , Kris Mendenhall , Kelly Wayman , Liana Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul Renhowe , Kenneth Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent Le
发明人： Weibo Wang , Paul Barsanti , Yi Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan Phillips , Kris Mendenhall , Kelly Wayman , Liana Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul Renhowe , Kenneth Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent Le
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/4439 , A61K31/427 , A61K31/4178 , C07D417/02 , C07D43/02
CPC分类号： C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10
摘要： The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:

2. 发明申请

US20050261337A1 Substituted quinoline derivatives 失效
标题翻译：取代喹啉衍生物
公开(公告)号：US20050261337A1
公开(公告)日：2005-11-24
申请号：US11133509
申请日：2005-05-19
申请人： Weibo Wang , Ryan Constantine , Liana Lagniton , Kenneth Bair
发明人： Weibo Wang , Ryan Constantine , Liana Lagniton , Kenneth Bair
IPC分类号： A61K31/47 , A61K31/4709 , C07D215/12 , C07D215/18 , C07D41/02
CPC分类号： C07D215/12 , C07D215/18
摘要： The present invention relates to new substituted quinoline compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
摘要翻译：本发明涉及新的取代喹啉化合物及其药学上可接受的盐，酯或前药，新化合物与药学上可接受的载体的组合物，以及新化合物的用途。本发明的化合物具有以下通式：

3. 发明授权

US07452996B2 Substituted quinoline derivatives 失效
标题翻译：取代喹啉衍生物
公开(公告)号：US07452996B2
公开(公告)日：2008-11-18
申请号：US11133509
申请日：2005-05-19
申请人： Weibo Wang , Ryan N. Constantine , Liana Marie Lagniton , Kenneth Bair
发明人： Weibo Wang , Ryan N. Constantine , Liana Marie Lagniton , Kenneth Bair
IPC分类号： C07D271/00
CPC分类号： C07D215/12 , C07D215/18
摘要： The present invention relates to new substituted quinoline compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
摘要翻译：本发明涉及新的取代喹啉化合物及其药学上可接受的盐，酯或前药，新化合物与药学上可接受的载体的组合物，以及新化合物的用途。本发明的化合物具有以下通式：

4. 发明申请

US20090028858A1 SUBSTITUTED QUINOLINE DERIVATIVES 审中-公开
标题翻译：取代的喹啉衍生物
公开(公告)号：US20090028858A1
公开(公告)日：2009-01-29
申请号：US12242360
申请日：2008-09-30
申请人： Weibo Wang , Ryan N. Constantine , Liana Marie Lagniton , Kenneth Bair
发明人： Weibo Wang , Ryan N. Constantine , Liana Marie Lagniton , Kenneth Bair
IPC分类号： A61K39/395 , C07D215/04 , A61P35/00 , A61K31/47
CPC分类号： C07D215/12 , C07D215/18
摘要： The present invention relates to new substituted quinoline compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
摘要翻译：本发明涉及新的取代喹啉化合物及其药学上可接受的盐，酯或前药，新化合物与药学上可接受的载体的组合物，以及新化合物的用途。本发明的化合物具有以下通式：

5. 发明申请

US20050091787A1 Upright vacuum cleaner with cyclonic airflow 有权
标题翻译：立式真空吸尘器带气旋气流
公开(公告)号：US20050091787A1
公开(公告)日：2005-05-05
申请号：US10999382
申请日：2004-11-30
申请人： Kenneth Bair , Richard Gibbs , Mark Reindle , Michael Wright
发明人： Kenneth Bair , Richard Gibbs , Mark Reindle , Michael Wright
IPC分类号： A47L5/28 , A47L5/36 , A47L9/12 , A47L9/16 , B01D39/16 , B01D45/12 , B01D50/00 , B04C5/13 , B04C9/00
CPC分类号： A47L5/28 , A47L5/365 , A47L9/127 , A47L9/1608 , A47L9/165 , A47L9/1666 , A47L9/1683 , A47L9/1691 , B01D39/1692 , B01D45/12 , B01D50/002 , B04C5/13 , B04C9/00 , B04C2009/004 , Y10S55/03
摘要： An upright vacuum cleaner (A) includes an upright housing section (B) and a nozzle section (C). A cyclonic airflow dirt and dust separating chamber (54) is defined in said upright housing section. A suction source (E) pulls air and entrained dirt, dust, and other contaminants through a main suction opening (26) formed in the underside (24) of the nozzle and into the cyclonic airflow chamber (54). The cyclonic airflow chamber causes the suction airstream to travel in a cyclonic path such that the entrained contaminants are separated therefrom and deposited into a dirt container (52) that defines the chamber (54). A main filter element (K) filters residual contaminants from the suction airstream between the chamber and the suction source. The main filter element is preferably made from high-density polyethylene porous filter media. A final filter assembly (F) filters the suction airstream discharged by the suction source to ensure that the air discharged into the atmosphere is contaminant free, including those contaminants introduced into the airstream by the suction source itself.
摘要翻译：立式吸尘器（A）包括立式收纳部分（B）和喷嘴部分（C）。在所述直立的壳体部分中限定有旋风气流污垢和灰尘分离室（54）。吸入源（E）通过形成在喷嘴的下侧（24）中的主吸入口（26）将空气和夹带的污垢，灰尘和其它污染物吸入气旋气流室（54）。气旋气流室使得吸入气流在气旋路径中行进，使得夹带的污染物从其分离并沉积到限定腔室（54）的污垢容器（52）中。主过滤元件（K）从腔室和抽吸源之间的吸入空气中过滤残留污染物。主过滤元件优选由高密度聚乙烯多孔过滤介质制成。最后的过滤器组件（F）过滤由抽吸源排出的吸入空气，以确保排放到大气中的空气是无污染的，包括由吸入源本身引入到空气流中的那些污染物。

6. 发明申请

US20060128632A1 Peptide inhibitors of smac protein binding to inhibitor of apoptosis proteins (iap) 审中-公开
标题翻译： Smac蛋白的肽抑制剂结合凋亡蛋白抑制剂（iap）
公开(公告)号：US20060128632A1
公开(公告)日：2006-06-15
申请号：US10519042
申请日：2003-07-01
申请人： Sushil Sharma , Leigh Zawel , Mark Palermo , Nagarajan Chandeamouli , Kenneth Bair
发明人： Sushil Sharma , Leigh Zawel , Mark Palermo , Nagarajan Chandeamouli , Kenneth Bair
IPC分类号： A61K38/05 , A61K38/04 , C07K5/06 , C07K5/04 , C07C237/18
CPC分类号： C07D401/12 , A61K38/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07K5/0806 , C07K5/0808 , C07K5/0821 , C07K5/1008
摘要： The present disclosure relates to XIAP inhibitor compounds of the formula I wherein the substituents are as described in the specification. The inventive compounds are useful as therapeutic agents for the treatment of proliferative disorders, including cancer.
摘要翻译：本公开涉及式I的XIAP抑制剂化合物，其中取代基如说明书中所述。本发明化合物可用作治疗增殖性疾病（包括癌症）的治疗剂。

7. 发明申请

US20060052311A1 Peptide inhibitors of smac protein binding to inhibitor of apoptosis proteins (IAP) 审中-公开
标题翻译： Smac蛋白的肽抑制剂与凋亡蛋白抑制剂（IAP）的结合
公开(公告)号：US20060052311A1
公开(公告)日：2006-03-09
申请号：US11203370
申请日：2005-08-12
申请人： Sushil Sharma , Leigh Zawel , Mark Palermo , Nagarajan Chandramouli , Kenneth Bair
发明人： Sushil Sharma , Leigh Zawel , Mark Palermo , Nagarajan Chandramouli , Kenneth Bair
IPC分类号： A61K38/06 , C07K5/06
CPC分类号： C07D401/12 , A61K38/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07K5/0806 , C07K5/0808 , C07K5/0821 , C07K5/1008
摘要： The present disclosure relates to XIAP inhibitor compounds of the formula I wherein the substituents are as described in the specification. The inventive compounds are useful as therapeutic agents for the treatment of proliferative disorders, including cancer.
摘要翻译：本公开涉及式I的XIAP抑制剂化合物

8. 发明授权

US07226941B2 Compound for treating angiogenesis 失效
标题翻译：治疗血管生成的化合物
公开(公告)号：US07226941B2
公开(公告)日：2007-06-05
申请号：US10883482
申请日：2004-06-30
申请人： Jong Wan Park , Yang-Gook Chun , Kenneth Bair , Ho Sung Cho
发明人： Jong Wan Park , Yang-Gook Chun , Kenneth Bair , Ho Sung Cho
IPC分类号： A61K31/415 , C07D231/54
CPC分类号： A61K31/416 , A61K31/4184 , C07D231/56 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention provides methods and pharmaceutical compositions for inhibiting expressions of HIF and HIF regulated genes, inhibiting angiogenesis, inducing cell cycle arrest in tumor cells, and treating cell proliferating diseases or conditions.
摘要翻译：本发明提供了抑制HIF和HIF调节基因表达，抑制血管发生，诱导肿瘤细胞中的细胞周期停滞以及治疗细胞增殖性疾病或病症的方法和药物组合物。

9. 发明申请

US20060189674A1 Deacetylase inhibitors 审中-公开
公开(公告)号：US20060189674A1
公开(公告)日：2006-08-24
申请号：US11408129
申请日：2006-04-20
申请人： Stacy Remiszewski , Kenneth Bair , Richard Versace , Lawrence Perez , Michael Green , Lidia Sambucetti , Sushil Sharma
发明人： Stacy Remiszewski , Kenneth Bair , Richard Versace , Lawrence Perez , Michael Green , Lidia Sambucetti , Sushil Sharma
IPC分类号： A61K31/405 , A61K31/381 , A61K31/343
摘要： The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.

10. 发明申请

US20050187276A1 Compounds, compositions and methods 失效
标题翻译：化合物，组合物和方法
公开(公告)号：US20050187276A1
公开(公告)日：2005-08-25
申请号：US10883482
申请日：2004-06-30
申请人： Jong-Wan Park , Yang-Sook Chun , Kenneth Bair , Ho Cho
发明人： Jong-Wan Park , Yang-Sook Chun , Kenneth Bair , Ho Cho
IPC分类号： A61K20060101 , A61K31/415 , A61K31/4172
CPC分类号： A61K31/416 , A61K31/4184 , C07D231/56 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention provides methods and pharmaceutical compositions for inhibiting expressions of HIF and HIF regulated genes, inhibiting angiogenesis, inducing cell cycle arrest in tumor cells, and treating cell proliferating diseases or conditions.
摘要翻译：本发明提供了抑制HIF和HIF调节基因表达，抑制血管发生，诱导肿瘤细胞中的细胞周期停滞以及治疗细胞增殖性疾病或病症的方法和药物组合物。

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