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1. 发明授权

US08678399B2 Gasket 有权
标题翻译：垫片
公开(公告)号：US08678399B2
公开(公告)日：2014-03-25
申请号：US13909357
申请日：2013-06-04
申请人： Mark Knapp
发明人： Mark Knapp
IPC分类号： F16J15/02
CPC分类号： F16J15/061 , F16J15/025 , F16J15/027 , F16L25/0054
摘要： A gasket is provided that forms a sealing connection between a pair of tubular members. The gasket comprises a first section shaped to fit within a recess of one of a pair of tubular members. The first section includes an anchor portion comprising first and second sides. The gasket further comprises a second section extending from the first section and is configured to make a sealing contact with the other of the tubular members. The gasket also includes at least one self-locating arm in a sealing contact within the recess and extending from one of the first or second sides of the anchor portion of the first section. The self-locating arm biases the first section such that the other of the first or second sides is in contact with the recess to form a sealing connection.
摘要翻译：提供了形成一对管状构件之间的密封连接的垫圈。垫圈包括成形为装配在一对管状构件中的一个的凹部内的第一部分。第一部分包括包括第一和第二侧面的锚固部分。垫圈还包括从第一部分延伸的第二部分，并且构造成与另一个管状部件形成密封接触。垫圈还包括位于凹部内的密封接触中的至少一个自定位臂，并且从第一部分的锚固部分的第一侧或第二侧之一延伸。自定位臂偏压第一部分，使得第一或第二侧中的另一个与凹部接触以形成密封连接。

2. 发明申请

US20120274031A1 SEALING GASKET 有权
标题翻译：密封垫圈
公开(公告)号：US20120274031A1
公开(公告)日：2012-11-01
申请号：US13458695
申请日：2012-04-27
申请人： MARK KNAPP
发明人： MARK KNAPP
IPC分类号： F16L17/06 , F16L21/02
CPC分类号： F16L25/0054 , F16J15/025
摘要： An annular sealing gasket for forming a sealing connection between a first tubular member and a second tubular member. The annular sealing gasket comprises a flexible sealing portion adapted to form a sealing connection between a first tubular member and a second tubular member and a body region adapted for supporting the flexible sealing portion and anchoring the annular sealing gasket to a secured connection. The body region further comprises spaced first and second conical legs extending convergingly away from the body region transversely from the flexible sealing portion.
摘要翻译：一种用于在第一管状构件和第二管状构件之间形成密封连接的环形密封垫圈。环形密封垫片包括适于在第一管状构件和第二管状构件之间形成密封连接的柔性密封部分和适于支撑柔性密封部分并将环形密封垫片固定到固定连接件的主体区域。身体区域还包括间隔开的第一和第二锥形腿，其横向于柔性密封部分会聚地远离身体区域延伸。

3. 发明授权

US07731884B2 Molded gasket and method of making 失效
标题翻译：成型垫圈及其制造方法
公开(公告)号：US07731884B2
公开(公告)日：2010-06-08
申请号：US11666763
申请日：2005-12-07
申请人： Mark Knapp , Jeffrey Michael Smith
发明人： Mark Knapp , Jeffrey Michael Smith
IPC分类号： B29C45/14 , B29C45/16
CPC分类号： B29C45/1676 , B29C45/1671 , B29L2031/265 , F16L21/03
摘要： The present invention is directed to an annular gasket for providing a fluid-tight seal between an inner pipe and an outer pipe, when the pipes are in a relative surrounded and surrounding relationship. The gasket includes a gasket portion configured to sealingly engage the inner and outer pipes when the pipes are in a relative surrounded and surrounding relationship. The gasket includes a low coefficient of friction surface which is applied to the gasket portion. The gasket may be formed by a method in which a low coefficient of friction film is inserted into a mold before injection of compounds used to form the gasket.
摘要翻译：本发明涉及一种用于当管道处于相对包围和周围关系时在内管和外管之间提供流体密封的环形垫圈。垫圈包括垫圈部分，其构造成当管道处于相对包围和周围的关系时密封地接合内管和外管。垫片包括施加到垫圈部分的低摩擦系数表面。垫圈可以通过在注入用于形成垫圈的化合物注入之前将低摩擦系数膜插入模具中的方法形成。

4. 发明授权

US07576221B2 Substituted imidazole derivatives 有权
公开(公告)号：US07576221B2
公开(公告)日：2009-08-18
申请号：US11158574
申请日：2005-06-20
申请人： Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
发明人： Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
IPC分类号： A61K31/4174 , C07D233/64
CPC分类号： C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10
摘要： The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:

5. 发明授权

US07469905B2 Permanently lubricated film gasket and method of manufacture 有权
标题翻译：永久润滑膜垫片及其制造方法
公开(公告)号：US07469905B2
公开(公告)日：2008-12-30
申请号：US11411551
申请日：2006-04-26
申请人： Mark Knapp
发明人： Mark Knapp
IPC分类号： F16L21/02 , F16L17/06 , F16L17/025
CPC分类号： F16L25/0054 , F16J15/027 , F16L17/025 , F16L21/035 , F16L25/0036 , Y10S285/903
摘要： A permanently lubricated film gasket for providing a fluid-tight seal between a corrugated pipe and a smooth annular section of an outer pipe or section when the corrugated pipe and the outer pipe or section are in a relative surrounded and surrounding relationship. A first portion of the gasket is shaped to fit within a groove or recess of the corrugated pipe. A second portion of the gasket extends from the first portion. The second portion is at least partially comprised of permanently lubricated film for facilitating in the connection of the pipes along a single direction.
摘要翻译：一种永久润滑的膜垫片，用于当波纹管和外管或部分处于相对包围和周围的关系时，在波纹管和外管或部分的平滑环形部分之间提供流体密封。垫圈的第一部分成形为装配在波纹管的凹槽或凹槽内。垫圈的第二部分从第一部分延伸。第二部分至少部分地由永久润滑的膜构成，以便于沿着单个方向连接管道。

6. 发明申请

US20060009472A1 Substituted imidazole derivatives 有权
公开(公告)号：US20060009472A1
公开(公告)日：2006-01-12
申请号：US11158574
申请日：2005-06-20
申请人： Weibo Wang , Paul Barsanti , Yi Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan Phillips , Kris Mendenhall , Kelly Wayman , Liana Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul Renhowe , Kenneth Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent Le
发明人： Weibo Wang , Paul Barsanti , Yi Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan Phillips , Kris Mendenhall , Kelly Wayman , Liana Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul Renhowe , Kenneth Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent Le
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/4439 , A61K31/427 , A61K31/4178 , C07D417/02 , C07D43/02
CPC分类号： C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10
摘要： The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:

7. 发明授权

US08735599B2 Substituted imidazole derivates 有权
标题翻译：取代的咪唑衍生物
公开(公告)号：US08735599B2
公开(公告)日：2014-05-27
申请号：US13613977
申请日：2012-09-13
申请人： Weibo Wang , Paul A. Barsanti , Xia Yia , Rustum S. Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagnition , Ryan N. Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
发明人： Weibo Wang , Paul A. Barsanti , Xia Yia , Rustum S. Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagnition , Ryan N. Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
IPC分类号： A61K31/4174 , C07D233/00 , C07D233/54
CPC分类号： C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10
摘要： The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
摘要翻译：本发明涉及新的取代的咪唑化合物及其药学上可接受的盐，酯或前药，新化合物的组合物和药学上可接受的载体，以及新化合物的用途。本发明的化合物具有以下通式：

8. 发明申请

US20100270753A1 HIGH STRENGTH COMPOSITE PIPE GASKET 审中-公开
标题翻译：高强度复合管垫片
公开(公告)号：US20100270753A1
公开(公告)日：2010-10-28
申请号：US12767203
申请日：2010-04-26
申请人： Mark Knapp
发明人： Mark Knapp
IPC分类号： F16J15/06
CPC分类号： F16J15/104 , F16J15/121 , F16L21/035
摘要： A composite high strength annular gasket and method of forming same is used for forming a seal between two pipe members. The gasket comprises a sealing material having a first durometer, the sealing material provides a pliable flexing surface for forming a sealing connection between a mating pipe member and adjoining pipe member during assembly. The gasket also comprises a base material forming one or more cords having a second durometer, the one or more cords embedded in and bonded with the sealing material, providing enhanced anti-compression and tensile strength to the composite annular gasket. The base material has a durometer higher than the sealing material.
摘要翻译：复合高强度环形垫圈及其形成方法用于在两个管件之间形成密封。垫圈包括具有第一硬度计的密封材料，密封材料提供柔韧的弯曲表面，用于在组装期间在配合管构件和相邻管构件之间形成密封连接。垫圈还包括形成具有第二硬度计的一个或多个帘线的基底材料，一个或多个帘线嵌入并与密封材料结合，为复合环形垫片提供增强的抗压缩和拉伸强度。基材的硬度比密封材料高。

9. 发明授权

US07662581B1 Eg5 co-crystals 失效
标题翻译： Eg5共晶体
公开(公告)号：US07662581B1
公开(公告)日：2010-02-16
申请号：US11018091
申请日：2004-12-20
申请人： Dirksen Bussiere , Mark Knapp , Vincent P. Le , Eric Martin
发明人： Dirksen Bussiere , Mark Knapp , Vincent P. Le , Eric Martin
IPC分类号： G01N33/53 , C12Q1/00 , G01N33/573 , C12N9/00 , C12N9/14 , G01N31/00 , G06G7/58
CPC分类号： C12N9/14 , C07K2299/00 , G01N2500/04 , G06F19/16
摘要： This invention provides methods of identifying an Eg5 binding ligand. The ligand is identified by using the atomic coordinates of an Eg5 crystal to generate a three dimensional structure. The three dimensional structure is used in molecular modeling techniques and docking experiments to identify ligands that bind to the binding pocket of Eg5. A novel binding pocket is identified. The invention also provides a crystallized Eg5 and ligand complex.
摘要翻译：本发明提供鉴定Eg5结合配体的方法。通过使用Eg5晶体的原子坐标来鉴定配体以产生三维结构。三维结构用于分子建模技术和对接实验以鉴定结合Eg5的结合口袋的配体。识别出新的装订口袋。本发明还提供了结晶的Eg5和配体络合物。

10. 发明申请

US20080303224A1 Gasket 有权
标题翻译：垫片
公开(公告)号：US20080303224A1
公开(公告)日：2008-12-11
申请号：US11810862
申请日：2007-06-07
申请人： Mark Knapp
发明人： Mark Knapp
IPC分类号： F16L21/02
CPC分类号： F16J15/061 , F16J15/025 , F16J15/027 , F16L25/0054
摘要： A gasket is provided that forms a sealing connection between a pair of tubular members. The gasket comprises a first section shaped to fit within a recess of one of a pair of tubular members. The first section includes an anchor portion comprising first and second sides. The gasket further comprises a second section extending from the first section and is configured to make a sealing contact with the other of the tubular members. The gasket also includes at least one self-locating arm in a sealing contact within the recess and extending from one of the first or second sides of the anchor portion of the first section. The self-locating arm biases the first section such that the other of the first or second sides is in contact with the recess to form a sealing connection.
摘要翻译：提供了形成一对管状构件之间的密封连接的垫圈。垫圈包括成形为装配在一对管状构件中的一个的凹部内的第一部分。第一部分包括包括第一和第二侧面的锚固部分。垫圈还包括从第一部分延伸的第二部分，并且构造成与另一个管状部件形成密封接触。垫圈还包括位于凹部内的密封接触中的至少一个自定位臂，并且从第一部分的锚固部分的第一侧或第二侧之一延伸。自定位臂偏压第一部分，使得第一或第二侧中的另一个与凹部接触以形成密封连接。

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