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1. 发明申请

US20060189674A1 Deacetylase inhibitors 审中-公开
公开(公告)号：US20060189674A1
公开(公告)日：2006-08-24
申请号：US11408129
申请日：2006-04-20
申请人： Stacy Remiszewski , Kenneth Bair , Richard Versace , Lawrence Perez , Michael Green , Lidia Sambucetti , Sushil Sharma
发明人： Stacy Remiszewski , Kenneth Bair , Richard Versace , Lawrence Perez , Michael Green , Lidia Sambucetti , Sushil Sharma
IPC分类号： A61K31/405 , A61K31/381 , A61K31/343
摘要： The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.

2. 发明申请

US20050085507A1 Deacetylase inhibitors 有权
标题翻译：脱乙酰酶抑制剂
公开(公告)号：US20050085507A1
公开(公告)日：2005-04-21
申请号：US10984501
申请日：2004-11-09
申请人： Stacy Remiszewski , Kenneth Bair , Richard Versace , Lawrence Perez , Michael Green , Lidia Sambucetti , Sushil Sharma
发明人： Stacy Remiszewski , Kenneth Bair , Richard Versace , Lawrence Perez , Michael Green , Lidia Sambucetti , Sushil Sharma
IPC分类号： C07D243/24 , A61K20060101 , A61K31/165 , A61K31/166 , A61K31/222 , A61K31/343 , A61K31/353 , A61K31/36 , A61K31/37 , A61K31/403 , A61K31/4045 , A61K31/405 , A61K31/41 , A61K31/417 , A61K31/4178 , A61K31/4184 , A61K31/4196 , A61K31/422 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/475 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61P20060101 , A61P35/00 , A61P43/00 , C07C20060101 , C07C259/06 , C07D20060101 , C07D209/14 , C07D209/16 , C07D209/20 , C07D209/82 , C07D233/54 , C07D233/64 , C07D235/14 , C07D295/14 , C07D295/155 , C07D307/81 , C07D311/68 , C07D317/58 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/113 , C07D211/32 , A61K31/445 , C07D211/70 , A61K31/19
CPC分类号： C07D401/12 , C04B35/632 , C07C259/06 , C07D209/16 , C07D233/64 , C07D295/155 , C07D307/81 , C07D403/12 , C07D405/12 , C07D471/04
摘要： The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.
摘要翻译：本发明提供了脱乙酰酶抑制剂的异羟肟酸酯化合物。该化合物适用于具有抗增殖性质的药物组合物。

3. 发明申请

US20060128632A1 Peptide inhibitors of smac protein binding to inhibitor of apoptosis proteins (iap) 审中-公开
标题翻译： Smac蛋白的肽抑制剂结合凋亡蛋白抑制剂（iap）
公开(公告)号：US20060128632A1
公开(公告)日：2006-06-15
申请号：US10519042
申请日：2003-07-01
申请人： Sushil Sharma , Leigh Zawel , Mark Palermo , Nagarajan Chandeamouli , Kenneth Bair
发明人： Sushil Sharma , Leigh Zawel , Mark Palermo , Nagarajan Chandeamouli , Kenneth Bair
IPC分类号： A61K38/05 , A61K38/04 , C07K5/06 , C07K5/04 , C07C237/18
CPC分类号： C07D401/12 , A61K38/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07K5/0806 , C07K5/0808 , C07K5/0821 , C07K5/1008
摘要： The present disclosure relates to XIAP inhibitor compounds of the formula I wherein the substituents are as described in the specification. The inventive compounds are useful as therapeutic agents for the treatment of proliferative disorders, including cancer.
摘要翻译：本公开涉及式I的XIAP抑制剂化合物，其中取代基如说明书中所述。本发明化合物可用作治疗增殖性疾病（包括癌症）的治疗剂。

4. 发明申请

US20060052311A1 Peptide inhibitors of smac protein binding to inhibitor of apoptosis proteins (IAP) 审中-公开
标题翻译： Smac蛋白的肽抑制剂与凋亡蛋白抑制剂（IAP）的结合
公开(公告)号：US20060052311A1
公开(公告)日：2006-03-09
申请号：US11203370
申请日：2005-08-12
申请人： Sushil Sharma , Leigh Zawel , Mark Palermo , Nagarajan Chandramouli , Kenneth Bair
发明人： Sushil Sharma , Leigh Zawel , Mark Palermo , Nagarajan Chandramouli , Kenneth Bair
IPC分类号： A61K38/06 , C07K5/06
CPC分类号： C07D401/12 , A61K38/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07K5/0806 , C07K5/0808 , C07K5/0821 , C07K5/1008
摘要： The present disclosure relates to XIAP inhibitor compounds of the formula I wherein the substituents are as described in the specification. The inventive compounds are useful as therapeutic agents for the treatment of proliferative disorders, including cancer.
摘要翻译：本公开涉及式I的XIAP抑制剂化合物

5. 发明授权

US06528948B1 Plasma valve 失效
标题翻译：等离子阀
公开(公告)号：US06528948B1
公开(公告)日：2003-03-04
申请号：US09685227
申请日：2000-10-11
申请人： Ady Hershcovitch , Sushil Sharma , John Noonan , Elbio Rotela , Ali Khounsary
发明人： Ady Hershcovitch , Sushil Sharma , John Noonan , Elbio Rotela , Ali Khounsary
IPC分类号： H01J724
CPC分类号： H05H7/14
摘要： A plasma valve includes a confinement channel and primary anode and cathode disposed therein. An ignition cathode is disposed adjacent the primary cathode. Power supplies are joined to the cathodes and anode for rapidly igniting and maintaining a plasma in the channel for preventing leakage of atmospheric pressure through the channel.
摘要翻译：等离子体阀包括限制通道和设置在其中的初级阳极和阴极。点火阴极与初级阴极相邻设置。电源连接到阴极和阳极，用于在通道中快速点燃和维持等离子体，以防止大气压力通过通道泄漏。

6. 发明申请

US20060242424A1 Identity authentication based on keystroke latencies using a genetic adaptive neural network 审中-公开
公开(公告)号：US20060242424A1
公开(公告)日：2006-10-26
申请号：US11112337
申请日：2005-04-22
申请人： Fred Kitchens , Sushil Sharma , Queen Booker
发明人： Fred Kitchens , Sushil Sharma , Queen Booker
IPC分类号： H04L9/00 , H04K1/00
CPC分类号： G06F21/32 , G06F21/316
摘要： A system and method identify the person who is using a keyboard based on keystroke latencies as the person types certain key combinations. In some embodiments the latencies are monitored as the person types a password, while in others they are monitored as the person types other information and continues to use the computer. In some embodiments the identification yields a binary result (whether the latency profile matches the profile stored for a particular user), while in others a confidence level is given. A mismatch, or a confidence level below a particular threshold, results in a request for further identity verification, creation of a log entry, immediate notification of responsible personnel, or denial of access (or continued access).

7. 发明授权

US07067551B2 Deacetylase inhibitors 有权
公开(公告)号：US07067551B2
公开(公告)日：2006-06-27
申请号：US10984501
申请日：2004-11-09
申请人： Stacy W Remiszewski , Kenneth W Bair , Richard W Versace , Lawrence B Perez , Michael A Green , Lidia C Sambucetti , Sushil Sharma
发明人： Stacy W Remiszewski , Kenneth W Bair , Richard W Versace , Lawrence B Perez , Michael A Green , Lidia C Sambucetti , Sushil Sharma
IPC分类号： A61K31/40 , A61K31/27 , C07C259/04 , C07D317/44 , C07D209/18
CPC分类号： C07D401/12 , C04B35/632 , C07C259/06 , C07D209/16 , C07D233/64 , C07D295/155 , C07D307/81 , C07D403/12 , C07D405/12 , C07D471/04
摘要： The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.

8. 发明授权

US06552065B2 Deacetylase inhibitors 有权
公开(公告)号：US06552065B2
公开(公告)日：2003-04-22
申请号：US09944275
申请日：2001-08-31
申请人： Stacy William Remiszewski , Kenneth Walter Bair , Richard William Versace , Lawrence Blas Perez , Michael Alan Green , Lidia Cristina Sambucetti , Sushil Sharma
发明人： Stacy William Remiszewski , Kenneth Walter Bair , Richard William Versace , Lawrence Blas Perez , Michael Alan Green , Lidia Cristina Sambucetti , Sushil Sharma
IPC分类号： A61K3140
CPC分类号： C07D401/12 , C04B35/632 , C07C259/06 , C07D209/16 , C07D233/64 , C07D295/155 , C07D307/81 , C07D403/12 , C07D405/12 , C07D471/04
摘要： The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.

9. 发明申请

US20090240949A9 Identity authentication based on keystroke latencies using a genetic adaptive neural network 审中-公开
标题翻译：基于使用遗传自适应神经网络的按键延迟的身份认证
公开(公告)号：US20090240949A9
公开(公告)日：2009-09-24
申请号：US11112337
申请日：2005-04-22
申请人： Fred Kitchens , Sushil Sharma , Queen Booker
发明人： Fred Kitchens , Sushil Sharma , Queen Booker
IPC分类号： H04L9/00 , H04K1/00
CPC分类号： G06F21/32 , G06F21/316
摘要： A system and method identify the person who is using a keyboard based on keystroke latencies as the person types certain key combinations. In some embodiments the latencies are monitored as the person types a password, while in others they are monitored as the person types other information and continues to use the computer. In some embodiments the identification yields a binary result (whether the latency profile matches the profile stored for a particular user), while in others a confidence level is given. A mismatch, or a confidence level below a particular threshold, results in a request for further identity verification, creation of a log entry, immediate notification of responsible personnel, or denial of access (or continued access).
摘要翻译：系统和方法根据按键延迟来识别正在使用键盘的人员，因为人们键入某些键组合。在一些实施例中，随着人们键入密码来监视延迟，而在其他实施例中，随着人们键入其他信息并继续使用计算机，它们被监视。在一些实施例中，识别产生二进制结果（等待时间配置文件是否匹配为特定用户存储的配置文件），而在其他实施例中给出置信水平。不匹配或低于特定阈值的置信水平导致进一步身份验证，创建日志条目，立即通知负责人员或拒绝访问（或持续访问）的请求。

10. 发明申请

US20080176849A1 DEACETYLASE INHIBITORS 审中-公开
标题翻译：脱乙酰酶抑制剂
公开(公告)号：US20080176849A1
公开(公告)日：2008-07-24
申请号：US12045885
申请日：2008-03-11
申请人： Stacy William Remiszewski , Kenneth Walter Bair , Richard William Versace , Lawrence Blas Perez , Michael Alan Green , Lidia Cristina Sambucetti , Sushil Sharma
发明人： Stacy William Remiszewski , Kenneth Walter Bair , Richard William Versace , Lawrence Blas Perez , Michael Alan Green , Lidia Cristina Sambucetti , Sushil Sharma
IPC分类号： A61K31/5377 , C07D209/04 , C07D209/82 , C07D217/00 , C07D471/04 , C07D413/12 , A61P35/00 , A61K31/404 , A61K31/403 , A61K31/47 , A61K31/437
摘要： The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.
摘要翻译：本发明提供了脱乙酰酶抑制剂的异羟肟酸酯化合物。该化合物适用于具有抗增殖性质的药物组合物。

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