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1. 发明授权

US06852289B2 Methods and apparatus for determining analytes in various matrices 失效
标题翻译：用于确定各种基质中分析物的方法和装置
公开(公告)号：US06852289B2
公开(公告)日：2005-02-08
申请号：US09817446
申请日：2001-03-26
申请人： Virginia C. Gordon , Bennett W. Root, Jr. , Barbara J. Peasley , John F. Elias , John T. Sorensen , Michael Mittelstein , Soheila Mirhashemi
发明人： Virginia C. Gordon , Bennett W. Root, Jr. , Barbara J. Peasley , John F. Elias , John T. Sorensen , Michael Mittelstein , Soheila Mirhashemi
IPC分类号： B01L3/00 , G01N33/52 , G01N33/543 , B01L11/00 , B01D24/00 , C12M3/00
CPC分类号： B01L3/5025 , B01L3/50255 , G01N33/52 , G01N33/54366 , Y10T436/173845 , Y10T436/18
摘要： Methods and apparatus for qualitatively or quantitatively determining one or more analytes in matrices such as foods, biological fluids, etc. An embodiment for determination of a single analyte comprises a sample receiving vessel, a first membrane and a reagent-containing well. The prepared sample passes through the first membrane whereby extraneous matter is removed, and a filtrate enters the reagent-containing well to provide a filtrate-reagent admixture from which the analyte may be determined. An embodiment for determination for multiple analytes includes one or more additional membranes in series with the first membrane, each such additional membrane being operative to capture one or more analytes. Each of the additional analytes may then be eluted from the membrane upon which it has been captured, into a separate reagent-containing well to provide eluant-reagent admixture from which each desired analyte may be determined. Formulations for preparation additives are also included. Additionally, there's provided an embodiment of above-described invention for determination of an analyte which is present in a matrix at low (e.g., sub-detectable) levels, wherein the filter of the apparatus is utilized to capture and concentrate the analyte, to provide a filtrate-reagent admixture wherein the analyte is present at detectable concentration.
摘要翻译：用于定性或定量测定诸如食品，生物流体等的基质中的一种或多种分析物的方法和装置。用于测定单个分析物的实施方案包括样品接收容器，第一膜和含有试剂的孔。制备的样品通过第一膜，除去外来物质，并且滤液进入含试剂的孔中以提供可以从其中测定分析物的滤液 - 试剂混合物。用于测定多个分析物的实施方案包括与第一膜串联的一个或多个另外的膜，每个这样的附加膜可操作以捕获一种或多种分析物。然后可以将每种附加分析物从其已被捕获的膜上洗脱出来，以分离含有试剂的孔，以提供洗脱剂 - 试剂混合物，从中可以确定每种所需的分析物。还包括制剂添加剂的配方。此外，提供了上述发明的一个实施方案，用于测定在低（例如，亚可检测）水平下存在于基质中的分析物，其中该装置的过滤器用于捕获和浓缩分析物，以提供滤液 - 试剂混合物，其中分析物以可检测的浓度存在。

2. 发明授权

US5958714A Test kits for determining at least two specific analytes in foods and other complex matrices 失效
标题翻译：用于确定食品和其他复杂基质中至少两种特异性分析物的测试工具
公开(公告)号：US5958714A
公开(公告)日：1999-09-28
申请号：US723636
申请日：1996-10-02
申请人： Virginia C. Gordon , John T. Sorensen , Soheila Mirhashemi , Michael Mittelstein , John F. Elias
发明人： Virginia C. Gordon , John T. Sorensen , Soheila Mirhashemi , Michael Mittelstein , John F. Elias
IPC分类号： G01N33/566 , G01N33/52 , G01N33/53 , G01N33/538 , G01N33/543
CPC分类号： G01N33/54366 , G01N33/52 , Y10S210/908 , Y10S436/824 , Y10S436/825 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： Methods and apparatus for qualitatively or quantitatively determining one or more analytes in matrices such as foods, biological fluids, etc. An embodiment for determination of a single analyte comprises a sample receiving vessel, a first membrane and a reagent-containing well. The prepared sample passes through the first membrane whereby extraneous matter is removed, and a filtrate enters the reagent-containing well to provide a filtrate-reagent admixture from which the analyte may be determined. An embodiment for determination for multiple analytes includes one or more additional membranes in series with the first membrane, each such additional membrane being operative to capture one or more analytes. Each of the additional analytes may then be eluted from the membrane upon which it has been captured, into a separate reagent-containing well to provide eluant-reagent admixture from which each desired analyte may be determined. Formulations for preparation additives are also included. Additionally, there's provided an embodiment of above-described invention for determination of an analyte which is present in a matrix at low (e.g., sub-detectable) levels, wherein the filter of the apparatus is utilized to capture and concentrate the analyte, to provide a filtrate-reagent admixture wherein the analyte is present at detectable concentration.
摘要翻译：用于定性或定量测定诸如食品，生物流体等的基质中的一种或多种分析物的方法和装置。用于测定单个分析物的实施方案包括样品接收容器，第一膜和含有试剂的孔。制备的样品通过第一膜，除去外来物质，并且滤液进入含试剂的孔中以提供可以从其中测定分析物的滤液 - 试剂混合物。用于测定多个分析物的实施方案包括与第一膜串联的一个或多个另外的膜，每个这样的附加膜可操作以捕获一种或多种分析物。然后可以将每种附加分析物从其已被捕获的膜上洗脱出来，以分离含有试剂的孔，以提供洗脱剂 - 试剂混合物，从中可以确定每种所需的分析物。还包括制剂添加剂的配方。此外，提供了上述发明的一个实施方案，用于测定在低（例如，亚可检测）水平下存在于基质中的分析物，其中该装置的过滤器用于捕获和浓缩分析物，以提供滤液 - 试剂混合物，其中分析物以可检测的浓度存在。

3. 发明授权

US06489132B1 Methods and apparatus for determining specific analytes in foods and other complex matrices 失效
标题翻译：用于确定食品和其他复杂基质中特定分析物的方法和设备
公开(公告)号：US06489132B1
公开(公告)日：2002-12-03
申请号：US09388974
申请日：1999-09-02
申请人： Virginia C. Gordon , John T. Sorensen , Soheila Mirhashemi , Michael Mittelstein , John F. Elias
发明人： Virginia C. Gordon , John T. Sorensen , Soheila Mirhashemi , Michael Mittelstein , John F. Elias
IPC分类号： G01N3353
CPC分类号： G01N33/54366 , G01N33/52 , Y10S210/908 , Y10S436/824 , Y10S436/825 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： Methods and apparatus for qualitatively or quantitatively determining one or more analytes in matrices such as foods, biological fluids, etc. An embodiment for determination of a single analyte comprises a sample receiving vessel, a first membrane and a reagent-containing well. The prepared sample passes through the first membrane whereby extraneous matter is removed, and a filtrate enters the reagent-containing well to provide a filtrate-reagent admixture from which the analyte may be determined. An embodiment for determination for multiple analytes includes one or more additional membranes in series with the first membrane, each such additional membrane being operative to capture one or more analytes. Each of the additional analytes may then be eluted from the membrane upon which it has been captured, into a separate reagent-containing well to provide eluant-reagent admixture from which each desired analyte may be determined. Formulations for preparation additives are also included. Additionally, there's provided an embodiment of above-described invention for determination of an analyte which is present in a matrix at low (e.g., sub-detectable) levels, wherein the filter of the apparatus is utilized to capture and concentrate the analyte, to provide a filtrate-reagent admixture wherein the analyte is present at a detectable concentration.
摘要翻译：用于定性或定量测定诸如食品，生物流体等的基质中的一种或多种分析物的方法和装置。用于测定单个分析物的实施方案包括样品接收容器，第一膜和含有试剂的孔。制备的样品通过第一膜，除去外来物质，并且滤液进入含试剂的孔中以提供可以从其中测定分析物的滤液 - 试剂混合物。用于测定多个分析物的实施方案包括与第一膜串联的一个或多个另外的膜，每个这样的附加膜可操作以捕获一种或多种分析物。然后可以将每种附加分析物从其已被捕获的膜上洗脱出来，以分离含有试剂的孔，以提供洗脱剂 - 试剂混合物，从中可以确定每种所需的分析物。还包括制剂添加剂的配方。此外，提供了上述发明的一个实施方案，用于测定在低（例如，亚可检测）水平下存在于基质中的分析物，其中该装置的过滤器用于捕获和浓缩分析物，以提供滤液 - 试剂混合物，其中分析物以可检测的浓度存在。

4. 发明授权

US5612222A In vitro test for dermal corrosive properties 失效
标题翻译：皮肤腐蚀性体外试验
公开(公告)号：US5612222A
公开(公告)日：1997-03-18
申请号：US371276
申请日：1995-01-11
申请人： Virginia C. Gordon , Soheila Mirhashemi , Rosalind W. Wei
发明人： Virginia C. Gordon , Soheila Mirhashemi , Rosalind W. Wei
IPC分类号： G01N33/50 , A61K49/00 , G01N31/22 , G01N33/15 , G01N33/48 , G01N33/483 , G01N33/68 , G01N13/00 , G01N21/29
CPC分类号： G01N33/68 , A61K49/0006 , G01N31/22 , G01N31/221 , G01N33/48 , Y10T436/10 , Y10T436/24
摘要： Methods and a device for determining the corrosivity of a substance to human skin or membrane are disclosed. In one approach, corrosivity is evaluated by measuring the time required for the test substance to transit a biobarrier that mimics human skin or membranes or the time required to cause a component of such biobarrier to break down and transit the membrane. The invention also envisions alternative approaches which involve series of layers of dyes and corrosive-resistant materials coated onto microspheres or test strips. Use of these methods provides a rapid determination of the corrosivity of test materials.
摘要翻译：公开了用于确定物质对人皮肤或膜的腐蚀性的方法和装置。在一种方法中，通过测量测试物质转移模拟人类皮肤或膜的生物屏障所需的时间或引起该生物屏障的一个组分分解和转运膜所需的时间来评估腐蚀性。本发明还设想了包括一系列染料和涂覆在微球或测试条上的耐腐蚀材料的替代方法。使用这些方法可以快速确定测试材料的腐蚀性。

5. 发明授权

US5411888A In vitro test for dermal corrosive properties 失效
标题翻译：皮肤腐蚀性体外试验
公开(公告)号：US5411888A
公开(公告)日：1995-05-02
申请号：US98735
申请日：1993-07-27
申请人： Virginia C. Gordon , Soheila Mirhashemi , Rosalind W. Wei
发明人： Virginia C. Gordon , Soheila Mirhashemi , Rosalind W. Wei
IPC分类号： G01N33/50 , A61K49/00 , G01N31/22 , G01N33/15 , G01N33/48 , G01N33/483 , G01N33/68 , G01N13/00 , G01N21/29
CPC分类号： G01N33/68 , A61K49/0006 , G01N31/22 , G01N31/221 , G01N33/48 , Y10T436/10 , Y10T436/24
摘要： Methods for determining the corrosivity of a substance to human skin or membrane are disclosed. In one approach, corrosivity is evaluated by measuring the time required for the test substance to transit a biobarrier that mimics human skin or membranes or the time required to cause a component of such biobarrier to break down and transit the membrane. The invention also envisions alternative approaches which involve series of layers of dyes and corrosive-resistant materials coated onto microspheres or test strips. Use of these methods provides a rapid determination of the corrosivity of test materials.
摘要翻译：公开了确定物质对人体皮肤或膜的腐蚀性的方法。在一种方法中，通过测量测试物质转移模拟人类皮肤或膜的生物屏障所需的时间或引起这种生物屏障的成分分解和转运膜所需的时间来评估腐蚀性。本发明还设想了包括一系列染料和涂覆在微球或测试条上的耐腐蚀材料的替代方法。使用这些方法可以快速确定测试材料的腐蚀性。

6. 外观设计

USD424457S Device for chemical analysis of foods and other substances 失效
公开(公告)号：USD424457S
公开(公告)日：2000-05-09
申请号：US103859
申请日：1999-04-22
申请人： Virginia C. Gordon , Bennett W. Root, Jr.
设计人： Virginia C. Gordon , Bennett W. Root, Jr.

7. 发明授权

US4613574A In vitro test for ocular toxic properties 失效
标题翻译：眼睛毒性的体外试验
公开(公告)号：US4613574A
公开(公告)日：1986-09-23
申请号：US607483
申请日：1984-05-04
申请人： Hyman C. Bergman , James F. Godfrey , Virginia C. Gordon
发明人： Hyman C. Bergman , James F. Godfrey , Virginia C. Gordon
IPC分类号： G01N21/75 , G01N31/22 , G01N33/00 , G01N33/50 , G01N33/68
CPC分类号： G01N33/5014
摘要： A reagent and method for in vitro determination of the eye irritating properties of individual compounds and/or mixtures is disclosed. The material to be assessed is combined with the reagent which provides a response, for example, the production of a precipitate, which is proportional to the deleterious response elicited by the material in the human eye.
摘要翻译：公开了用于体外测定单个化合物和/或混合物的眼睛刺激性质的试剂和方法。要评估的材料与提供响应的试剂结合，例如沉淀物的产生，其与人眼中的材料引起的有害反应成比例。

8. 发明授权

US5053340A In vitro test for dermal toxic properties 失效
标题翻译：进行体外毒性试验
公开(公告)号：US5053340A
公开(公告)日：1991-10-01
申请号：US315317
申请日：1989-02-24
申请人： Hyman C. Bergman , Virginia C. Gordon , Christopher P. Kelly
发明人： Hyman C. Bergman , Virginia C. Gordon , Christopher P. Kelly
IPC分类号： G01N33/00 , G01N33/50
CPC分类号： G01N33/5014
摘要： A membrane support, reagent and method determines, in vitro, skin irritation properties of individual compounds and/or mixtures is disclosed. The material to be tested is applied directly to the membrane support. The material may penetrate the membrane and diffuse into the reagent and cause a response, for example, the production of a precipitate. The test material may also alter or destroy the membrane and/or disrupt covalently linked dye molecules attached to the membrane and diffuse into the reagent to produce an additional or alternate response--for example, color. The sum of these two responses is proportional to the deleterious response elicited by the material on the human skin.
摘要翻译：膜支架，试剂和方法在体外确定了单个化合物和/或混合物的皮肤刺激性质。要测试的材料直接应用于膜支架。材料可能渗透膜并扩散到试剂中并引起反应，例如产生沉淀物。测试材料还可以改变或破坏膜和/或破坏连接到膜上的共价连接的染料分子并扩散到试剂中以产生另外的或交替的反应 - 例如颜色。这两种反应的总和与材料在人体皮肤上引起的有害反应成正比。

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